LOCUS       NM_001518               4392 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens general transcription factor IIi (GTF2I), transcript
            variant 4, mRNA.
ACCESSION   NM_001518 XM_939506
VERSION     NM_001518.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4392)
  AUTHORS   Adams,J.W., Vinokur,A., de Souza,J.S., Austria,C., Guerra,B.S.,
            Herai,R.H., Wahlin,K.J. and Muotri,A.R.
  TITLE     Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in
            human cellular models of neurodevelopment
  JOURNAL   Cell Rep 43 (3), 113867 (2024)
   PUBMED   38416640
  REMARK    GeneRIF: Loss of GTF2I promotes neuronal apoptosis and synaptic
            reduction in human cellular models of neurodevelopment.
REFERENCE   2  (bases 1 to 4392)
  AUTHORS   Nir Sade,A., Levy,G., Schokoroy Trangle,S., Elad Sfadia,G., Bar,E.,
            Ophir,O., Fischer,I., Rokach,M., Atzmon,A., Parnas,H.,
            Rosenberg,T., Marco,A., Elroy Stein,O. and Barak,B.
  TITLE     Neuronal Gtf2i deletion alters mitochondrial and autophagic
            properties
  JOURNAL   Commun Biol 6 (1), 1269 (2023)
   PUBMED   38097729
  REMARK    GeneRIF: Neuronal Gtf2i deletion alters mitochondrial and
            autophagic properties.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4392)
  AUTHORS   Roy,A.L.
  TITLE     Biochemistry and biology of the inducible multifunctional
            transcription factor TFII-I: 10 years later
  JOURNAL   Gene 492 (1), 32-41 (2012)
   PUBMED   22037610
  REMARK    Review article
REFERENCE   4  (bases 1 to 4392)
  AUTHORS   Makeyev,A.V. and Bayarsaihan,D.
  TITLE     Alternative splicing and promoter use in TFII-I genes
  JOURNAL   Gene 433 (1-2), 16-25 (2009)
   PUBMED   19111598
  REMARK    GeneRIF: analyzed promoter regions of TFII-I genes and described
            their additional exons, as well as tested tissue specificity of
            both previously reported and novel alternatively spliced isoforms
REFERENCE   5  (bases 1 to 4392)
  AUTHORS   Cheriyath,V. and Roy,A.L.
  TITLE     Alternatively spliced isoforms of TFII-I. Complex formation,
            nuclear translocation, and differential gene regulation
  JOURNAL   J Biol Chem 275 (34), 26300-26308 (2000)
   PUBMED   10854432
REFERENCE   6  (bases 1 to 4392)
  AUTHORS   Roy,A.L., Du,H., Gregor,P.D., Novina,C.D., Martinez,E. and
            Roeder,R.G.
  TITLE     Cloning of an inr- and E-box-binding protein, TFII-I, that
            interacts physically and functionally with USF1
  JOURNAL   EMBO J 16 (23), 7091-7104 (1997)
   PUBMED   9384587
REFERENCE   7  (bases 1 to 4392)
  AUTHORS   Grueneberg,D.A., Henry,R.W., Brauer,A., Novina,C.D., Cheriyath,V.,
            Roy,A.L. and Gilman,M.
  TITLE     A multifunctional DNA-binding protein that promotes the formation
            of serum response factor/homeodomain complexes: identity to TFII-I
  JOURNAL   Genes Dev 11 (19), 2482-2493 (1997)
   PUBMED   9334314
REFERENCE   8  (bases 1 to 4392)
  AUTHORS   Yang,W. and Desiderio,S.
  TITLE     BAP-135, a target for Bruton's tyrosine kinase in response to B
            cell receptor engagement
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 604-609 (1997)
   PUBMED   9012831
REFERENCE   9  (bases 1 to 4392)
  AUTHORS   Morris,C.A.
  TITLE     Williams Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301427
REFERENCE   10 (bases 1 to 4392)
  AUTHORS   Roy,A.L., Meisterernst,M., Pognonec,P. and Roeder,R.G.
  TITLE     Cooperative interaction of an initiator-binding transcription
            initiation factor and the helix-loop-helix activator USF
  JOURNAL   Nature 354 (6350), 245-248 (1991)
   PUBMED   1961251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292832.1, BC070484.1,
            CB118501.1, AF035737.1, BC099907.1 and AA641906.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001518.4.
            
            Summary: This gene encodes a phosphoprotein containing six
            characteristic repeat motifs. The encoded protein binds to the
            initiator element (Inr) and E-box element in promoters and
            functions as a regulator of transcription. This locus, along with
            several other neighboring genes, is deleted in Williams-Beuren
            syndrome. There are many closely related genes and pseudogenes for
            this gene on chromosome 7. This gene also has pseudogenes on
            chromosomes 9, 13, and 21. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed. [provided
            by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (4) lacks two alternate in-frame
            exons, compared to variant 1. The encoded isoform (4, also known as
            delta) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.75601.1,
                                           SRR1803615.243281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK292832.1         39-42
            5-2947              BC070484.1         1-2943
            2948-2948           CB118501.1         232-232
            2949-4046           AF035737.1         3032-4129
            4047-4048           BC099907.1         4089-4090
            4049-4392           AA641906.1         13-356              c
FEATURES             Location/Qualifiers
     source          1..4392
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..4392
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /note="general transcription factor IIi"
                     /db_xref="GeneID:2969"
                     /db_xref="HGNC:HGNC:4659"
                     /db_xref="MIM:601679"
     exon            1..351
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            352..455
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..3230
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /note="isoform 4 is encoded by transcript variant 4;
                     BTK-associated protein, 135kD; Bruton tyrosine
                     kinase-associated protein 135; general transcription
                     factor II-I; SRF-Phox1-interacting protein;
                     Williams-Beuren syndrome chromosome region 6"
                     /codon_start=1
                     /product="general transcription factor II-I isoform 4"
                     /protein_id="NP_001509.3"
                     /db_xref="CCDS:CCDS47614.1"
                     /db_xref="GeneID:2969"
                     /db_xref="HGNC:HGNC:4659"
                     /db_xref="MIM:601679"
                     /translation="MAQVAMSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEV
                     ACIAVYETDVFVVGTERGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTTQANRM
                     SVDAVEIETLRKTVEDYFCFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFK
                     HPENYDLATLKWILENKAGISFIIKRPFLEPKKHVGGRVMVTDADRSILSPGGSCGPI
                     KVKTEPTEDSGISLEMAAVTVKEESEDPDYYQYNIQGSHHSSEGNEGTEMEVPAEDDD
                     YSPPSKRPKANELPQPPVPEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQ
                     AIKAKGPVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVI
                     KKHELLNSTREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVP
                     YQKFEAHPNDLYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTT
                     EVTQPRTNTPVKEDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFL
                     YVEGLPEGIPFRSPTWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKA
                     LQSPKRPRSPGSNSKVPEIEVTVEGPNNNNPQTSAVRTPTQTNGSNVPFKPRGREFSF
                     EAWNAKITDLKQKVENLFNEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFR
                     RPSTFGIPRLEKILRNKAKIKFIIKKPEMFETAIKESTSSKSPPRKINSSPNVNTTAS
                     GVEDLNIIQVTIPDDDNERLSKVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKI
                     TINPGCVVVDGMPPGVSFKAPSYLEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVD
                     QSESEGPVIQESAEPSQLEVPATEEIKETDGSSQIKQEPDPTW"
     exon            456..594
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..729
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            730..913
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..942
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            943..997
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1041
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1119
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1176
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1287
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1353
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1537
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1596
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1668
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1852
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1911
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1983
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2167
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2226
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2301
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2403
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2469
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2653
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2709
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2790
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2874
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3058
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3087
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3129
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3171
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3247
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..4392
                     /gene="GTF2I"
                     /gene_synonym="BAP135; BTKAP1; DIWS; GTFII-I; IB291; SPIN;
                     TFII-I; WBS; WBSCR6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagaag ctgggagagc agagaaaagg ggccaccggt cgcccccccg cttccccgca
       61 cgcgctctcc agccgcggcc gcccgcctgc cgcggtcacc ccggcctctg cctctgtccc
      121 ccagtgatcg gatcaaggcg ctgagcgagg ccctgcctgc ggggcggcca tgcggcggtg
      181 acaggagcgc gaccgacacg cacgggcccc tcgccccctc tcgcctcccg tccgctcgcc
      241 agctcccctc agccgaggct gctccgcggc ggccgcagcc cgcgcgcggc ccacactcgc
      301 ctcccctcgg cacccccggc cccggagctg cctggaggcg gccgcactcg gggatcatgg
      361 cccaagttgc aatgtccacc ctccccgttg aagatgagga gtcctcggag agcaggatgg
      421 tggtgacatt cctcatgtca gctctcgagt ccatgtgtaa agaactggcc aagtccaaag
      481 ccgaagtggc ctgcattgca gtgtatgaaa cagacgtgtt tgtcgtcgga actgaaagag
      541 gacgtgcttt tgtcaatacc agaaaggatt ttcaaaaaga ttttgtaaaa tattgtgttg
      601 aagaagaaga aaaagctgca gagatgcata aaatgaaatc tacaacccag gcaaatcgga
      661 tgagtgtaga tgctgtagaa attgaaacac tcagaaaaac agttgaggac tatttctgct
      721 tttgctatgg gaaagcttta ggcaaatcca cagtggtacc tgtaccatat gagaagatgc
      781 tgcgagacca gtcggctgtg gtagtgcagg ggcttccgga aggtgttgcc tttaaacacc
      841 ccgagaacta tgatcttgca accctgaaat ggattttgga gaacaaagca gggatttcat
      901 tcatcattaa gagacctttt ttagagccaa agaagcatgt aggtggtcgt gtgatggtaa
      961 cagatgctga caggtcaata ctatctccag gtggaagttg tggccccatc aaagtgaaaa
     1021 ctgaacccac agaagattct ggcatttccc tggaaatggc agctgtgaca gtaaaggaag
     1081 aatcagaaga tcctgattat tatcaatata acattcaagg aagccaccat tcttcagagg
     1141 gcaatgaagg cacagaaatg gaagtaccag cagaagatga tgattattct ccaccgtcta
     1201 agagaccaaa ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga
     1261 agcggaaagt gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta
     1321 aacaagttga agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg
     1381 tgacgatccc gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc
     1441 ctgaaggaat tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat
     1501 tacttgcaaa ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac
     1561 gtgaagattt acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa
     1621 tcactaaatt aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg
     1681 ggagcactga agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt
     1741 acgtggaagg actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa
     1801 ggctggaaaa aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac
     1861 ttctgactca cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag
     1921 attggaatgt cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat
     1981 ttgctcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa
     2041 acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct
     2101 ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg
     2161 ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca
     2221 ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg
     2281 aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa
     2341 ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct
     2401 ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg
     2461 agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg
     2521 agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac
     2581 catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt
     2641 tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga
     2701 gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag
     2761 accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg
     2821 aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag
     2881 ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct
     2941 gtgtggtagt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa
     3001 tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac
     3061 catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg
     3121 tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag
     3181 agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc
     3241 tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc
     3301 tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag
     3361 atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct
     3421 ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga
     3481 cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag
     3541 ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct
     3601 cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga
     3661 aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca
     3721 gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt
     3781 tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct
     3841 cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca
     3901 aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat
     3961 gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc
     4021 tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa
     4081 ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga
     4141 cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt
     4201 gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta
     4261 tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg
     4321 ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct
     4381 ttcacacact aa
//
