LOCUS       NM_207118               7483 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIH subunit 5 (GTF2H5),
            mRNA.
ACCESSION   NM_207118
VERSION     NM_207118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7483)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7483)
  AUTHORS   Bai,H.L., Kang,C.M., Sun,Z.Q., Li,X.H., Dai,X.Y., Huang,R.Y.,
            Zhao,J.J., Bei,Y.R., Huang,X.Z., Lu,Z.F., Wu,S.G., Lu,J.B.,
            Ping,B.H., Wang,Q. and Hu,Y.W.
  TITLE     TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in
            glioma
  JOURNAL   Exp Neurol 331, 113380 (2020)
   PUBMED   32540359
  REMARK    GeneRIF: TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2
            axis in glioma.
REFERENCE   3  (bases 1 to 7483)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7483)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 7483)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   6  (bases 1 to 7483)
  AUTHORS   Giglia-Mari,G., Miquel,C., Theil,A.F., Mari,P.O., Hoogstraten,D.,
            Ng,J.M., Dinant,C., Hoeijmakers,J.H. and Vermeulen,W.
  TITLE     Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide
            excision repair in living cells
  JOURNAL   PLoS Biol 4 (6), e156 (2006)
   PUBMED   16669699
  REMARK    GeneRIF: TTDA is the first Transcription Factor IIH subunit with a
            primarily nucleotide excision repair-dedicated role in vivo.
REFERENCE   7  (bases 1 to 7483)
  AUTHORS   Coin,F., Proietti De Santis,L., Nardo,T., Zlobinskaya,O.,
            Stefanini,M. and Egly,J.M.
  TITLE     p8/TTD-A as a repair-specific TFIIH subunit
  JOURNAL   Mol Cell 21 (2), 215-226 (2006)
   PUBMED   16427011
  REMARK    GeneRIF: p8/TTD-A, the tenth subunit of TFIIH, has a critical role
            in DNA repair where it triggers DNA opening by stimulating XPB
            ATPase activity together with the damage recognition factor
            XPC-hHR23B.
REFERENCE   8  (bases 1 to 7483)
  AUTHORS   Giglia-Mari,G., Coin,F., Ranish,J.A., Hoogstraten,D., Theil,A.,
            Wijgers,N., Jaspers,N.G., Raams,A., Argentini,M., van der
            Spek,P.J., Botta,E., Stefanini,M., Egly,J.M., Aebersold,R.,
            Hoeijmakers,J.H. and Vermeulen,W.
  TITLE     A new, tenth subunit of TFIIH is responsible for the DNA repair
            syndrome trichothiodystrophy group A
  JOURNAL   Nat Genet 36 (7), 714-719 (2004)
   PUBMED   15220921
REFERENCE   9  (bases 1 to 7483)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 7483)
  AUTHORS   Robertson,H.M. and Martos,R.
  TITLE     Molecular evolution of the second ancient human mariner transposon,
            Hsmar2, illustrates patterns of neutral evolution in the human
            genome lineage
  JOURNAL   Gene 205 (1-2), 219-228 (1997)
   PUBMED   9461396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN403888.1, BC056906.1,
            AL590703.15, AL133347.28 and BQ004444.1.
            
            On Aug 31, 2019 this sequence version replaced NM_207118.2.
            
            Summary: This gene encodes a subunit of transcription/repair factor
            TFIIH, which functions in gene transcription and DNA repair. This
            protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening
            during DNA repair, and is implicated in regulating cellular levels
            of TFIIH. Mutations in this gene result in trichothiodystrophy,
            complementation group A. [provided by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055106.1, SRR14038194.3158101.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607778.2/ ENSP00000476100.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CN403888.1         7-16
            11-553              BC056906.1         1-543
            554-5915            AL590703.15        49131-54492
            5916-6866           AL133347.28        97782-98732         c
            6867-7483           BQ004444.1         18-634              c
FEATURES             Location/Qualifiers
     source          1..7483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..7483
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="general transcription factor IIH subunit 5"
                     /db_xref="GeneID:404672"
                     /db_xref="HGNC:HGNC:21157"
                     /db_xref="MIM:608780"
     exon            1..46
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /inference="alignment:Splign:2.1.0"
     exon            47..115
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..296
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="TFIIH basal transcription factor complex TTDA
                     subunit; TFB5 ortholog; TFIIH basal transcription factor
                     complex TTD-A subunit; general transcription factor IIH,
                     polypeptide 5; TFIIH subunit p8"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 5"
                     /protein_id="NP_997001.1"
                     /db_xref="CCDS:CCDS5256.1"
                     /db_xref="GeneID:404672"
                     /db_xref="HGNC:HGNC:21157"
                     /db_xref="MIM:608780"
                     /translation="MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVF
                     VIAELVNVLQERVGELMDQNAFSLTQK"
     exon            116..7483
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      535..540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="hexamer: ATTAAA"
     regulatory      540..545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="hexamer: AATACA"
     polyA_site      553
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="major polyA site"
     polyA_site      578
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
     polyA_site      610
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
     regulatory      7462..7467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
                     /note="hexamer: AATAAA"
     polyA_site      7483
                     /gene="GTF2H5"
                     /gene_synonym="bA120J8.2; C6orf175; TFB5; TFIIH; TGF2H5;
                     TTD; TTD-A; TTD3; TTDA"
ORIGIN      
        1 gcactctgcc ggcaacgccg aggcgcttct gcatctgtgg gccgagcatt cttcaggtca
       61 tctgaacctt ctgagaaaac atggtcaacg tcttgaaagg agtgcttata gaatgtgatc
      121 ctgccatgaa gcagtttctg ctgtacttgg atgagtccaa tgccctgggg aagaagttca
      181 tcattcaaga cattgatgac actcacgtct ttgtaatagc agaattggtt aatgtcctcc
      241 aggagcgagt gggtgaatta atggaccaaa atgctttttc ccttacccag aaatgaaaat
      301 actcaatatg gaccatttag gaattataag cagcaactgt gaaagacttg ccactcaata
      361 tcttaggtga ctgattagac atagagggtt gttttaggag catgccacgg gaaagactga
      421 gggatcatga tcatttgttc agaaaaaaag cccctgaact gattttgtta ccatagaatt
      481 taaaaaaaaa aaaagcttta acagttggct gtaatttggc ttttattatc ctttattaaa
      541 atacaaatgt caatgctttt cctgcctttt taataccatg tcagtgtaac ataggtattt
      601 attttgctca tccctgtgat ctgtgcattt ttgctgcgtg gatgtgattg tttggtttca
      661 gttagaaacg tcatagattt gctgtttgaa tatgccaagg tggggactta gacattatgt
      721 acgtctcaca aatcctacct gcataccagt cagctctatt gaggaagaca atgtaaaact
      781 aatgtaaact acagtttgca tttccctgaa aacagaatat tgtttttaag agggttagaa
      841 acaaccagtg ggaaaggcac atgctgcttt gtttagtttt tccttgttca aactttgttg
      901 gtcacatttt cccatctgta ttctttttta ttaagaaaac agcttaggga ggctgaggtg
      961 ggaggattgc ttgagcccag gagtccgagg ttgctacaaa aacaccattg cactctggcc
     1021 tggacaacag agagaccctg cctcaaaaaa aaaaaaaaaa aaaaaaaaaa ttctacttgt
     1081 accttattcc ctatgagaat acttatcaaa cttatctaaa aaagaaaaat aggaacagcc
     1141 atatgcaaag tcagcccaac aggaaaggac atattagatt aaaatacatt gcggcctggg
     1201 cttagtggct cacacctgta atcccagcac tttgggaggc tgaggcaggc agatcgcttg
     1261 agtccaggag tcgaaaccct gtctctacaa aaaaaaaaat acaaaaatct gcctgttgtc
     1321 ccagccactg gggaggctga ggtaggaggt caaggctgca gtgaaccttg atcattgcta
     1381 ctgccactcc agcctaggtg acagagtgag accctgtctc caaaaaaaaa agtgtatatg
     1441 tatgtgtgta tatatagcaa gagagagttc tgtgatcaat tgaaggcaaa aacagtaaca
     1501 ctgagagggg ctttgcttcc cttcctgaag atcatgtcat tggggtgggt tcctgtaaag
     1561 ggaattttcc aagagaaaag agaattttca tgacctgtag actcttacaa atccatttta
     1621 cctgcttcct tatggtatgt ttattcaaag cacctgtgta ccatatttat tcacttacac
     1681 agcattactg aatctggaaa ttttcagtta ggtatatttt acataattcc cacccatata
     1741 actcagtcca tacagttcac agttttcatt ccctcatagc aatgcaaaaa attttgatga
     1801 gttactacta ctaaaactag ttaagtaaaa gatgattctt aagaatttcc aggctgggca
     1861 cggtggctca cgcctgtaat cccagcactt tgggaggctg aggcaggcag ctcacgaggt
     1921 caggagatcg agaccatcct gctcggtgaa accccatctc tattaaaaat acaaaaaatt
     1981 agccgggcct ggtggcgggt gcctgtagtc ccatctactc aggaggctga ggcaggagaa
     2041 tggcgtgaac ccgggaggcg gagcttgcag taagctgaga ttgtgccact gcactccagc
     2101 ctgggcgaca gagggagact ccatctcaaa aaaaaaaaaa aaaaaaaatg aatttccagc
     2161 tataccaaaa tgttactaat gtatcttata tttcaggcat gtctaaatca acttttagta
     2221 tgcctcaggc atttgtcacc aaccttttat attaacatga aacttagaaa atttttgata
     2281 gaatcccaga gttcaaaagg tattaggatt tttgccactg aagtaaaaaa gagaaaaaaa
     2341 gatatttatg agaaaactat tgaacagtga ctgtgttgta cccgagcaag ttagaggaac
     2401 gccacacttt gagacgaatt taaaagtcct ttatttagct ggcagccaag aggtggctca
     2461 cacttggaat tctctcagct ccgaggaagg ggcttgattt tcctttatac tttggtttag
     2521 gaaggggacg ggagctcagt tgcaacaatt ctacagaagt aaaaacatgc aaaaaattaa
     2581 aaagacaaat ggttacagag aaacaaacag ttccaggtgc aggggctcta aatctatcat
     2641 aagatgtcag gtgtgggggc tctgccagac acaaactcaa ggctttatgg tgtatctctt
     2701 gagcgaaatc ctgggaactt cgtacattgc ttgcttcagt accttatgag ttaattggac
     2761 tctttgatat gttgagagtc agcttacaca agttaactcc ttgaggaaag ggggtgggta
     2821 aggagtcctt gatgtcctgt aaatgaagga accaaatgga gttcctccgg ctttctcagc
     2881 taagggagag cttattcaca tggaaacaag gctaggtgat taagggagaa agggacagtc
     2941 tgaaaacaag gttagtaaaa acaaggttag gtattagaac tgcaaagagt attaagtgaa
     3001 ataagtgaag gaaaatatga gctcttattt ttaaaaagtt gtgttggggc aaatgttaaa
     3061 tatctttctt tctctggaca ttattaagaa agatagagtg atgtgaatga taggaagccc
     3121 acctgtaacc acttagctga catgtccaac tatgggtgaa caggaaataa gcgacattca
     3181 cctaggctgt ttattggaat ctgactagca ttatttgatt tggcatactt tacatgtcca
     3241 gaacaaggct gttggtgctt ggcaccaaga aatttatgac tttttttttt tttttaaata
     3301 aagtcctaaa ggtagcatta aaatgactta actggaggca ggaggatcac tgaagcccag
     3361 gagtttgaag ctgcagtaag ctaagaaggt gccactgcac tgcagcctgg atgacagagt
     3421 gaaactttgt ctcttaatag aactatggac tgaagttgtg atattgagtg ttatatttct
     3481 caataaaggt tttttctttt aatactgtat taggtcaaat tcaaggtctt aattccttga
     3541 attccaattt ccttgtgaaa tttcatgtga ttaatttaaa attccaggga tcctatctaa
     3601 catcacagtt gatggatata acaatgtatt ttgagaaatc agttttggtg aacagtaaca
     3661 gcattactga taataggcaa caaacactac tgcattttat ttctgatagg cattataggt
     3721 ggtaatccaa atgattaatg attttattgc tctttacatt ttctagaaca ggtgatttga
     3781 cataattgta cttttttctg agaagttggt agtgtactta ctactctatt ttgcagttat
     3841 acaataaatc ttacttagct gacaactagg agtaaaagct ctgacaaaaa gcctctgctg
     3901 taactaaaat actgagatca ttctatctta acaaacttaa cagatgggga aggggtatat
     3961 tttaaagatg gagaaatgat gcagtttgca aatatagtca ataaatattc tcaagtgtac
     4021 gtagctcaat ttcatttgca gcaaagataa cactgaaatg tctatggatg agattattgg
     4081 ataaactttt ttaaaaacac tgttctcaag ataggcaagt gattaagagc actgactggg
     4141 ccgggcgcgg tggctcacgt ctataatcct agcactttgg gaggccgagg cgggcaaatc
     4201 acaaggtcag gagatcaaaa caatcctggc taacaaggtg aaaccccgtc tctactaaaa
     4261 atacaaaaaa attagctggg catggtggtg gacgcctgta gtcccagcta ctcgggaggc
     4321 tgaggcagga gaatggtgta atcccgggag gtggaggttg cagtgagccg agatcgtgcc
     4381 actgcactcc agccggggtg acagagcgag actcccaccc atctcaaaaa aaataaaaat
     4441 gaaaagcact gattgaatct agattccttg agtccaagtg tcagatctct gcttactagc
     4501 tctgggatct cagatgtttc gttgattgga tttctttgtg ctcatttgtg taaacaggaa
     4561 tgcccgtctt taaagactat taaaatgaat gtgagttaac acacaagagg tcttcaaaaa
     4621 gttgatggaa aatgcatatt atgaaaaaaa ttatgcatag atttcaaaaa tctttgcagc
     4681 aaaataaact catcattata acatgtctga acaggatcta gtttgaggca ctaagaagga
     4741 tatcagttta aatagagccc ctgtcagaac aatatgaatt ctgctaaaac tgaagcaaga
     4801 acaaacatca aatttatggc aaagcttagg tggaagaatg gtgcaatcat tgatgctttg
     4861 caaaaagttt atgggaacaa cgccccaagg aaatcagttt acaaatggat aattcatttt
     4921 aagaaaggac aagacaatgt tgaagatgaa acctacagca gcagaccatg ccacttcgtg
     4981 aggaaaaaat tatctcattc atgccctact tgaagaggac caatgattaa cagcagaaac
     5041 gatagccaac acaatatgct cctcagttgg ttcagctttt ataaatctga ctgaaaaatt
     5101 aaagttgagc acactttcca ctcaatggat accaaaacca tccagcccag gtcagctgca
     5161 gacaaaagca gagctttcga tggaaatgtc aaacaagtga gatcaagatc ctgaagcatt
     5221 tcttcaaaga attgtagcaa aaacagactt ttaaaacctt gaattcagag acaggtataa
     5281 agactgcttg gtgattttga aaggactgag atcattttgg gagagatcat cttcagaaaa
     5341 tgaccagata caacaagaat ttaacatggc agccaaacca acccactaac acacatttaa
     5401 ataagatacc caaatgcaga aagaaaagca cagtcgtcat gcaaaatagt cactactcat
     5461 tcaaaaactc tatagttgtc tgagtcgtta tgctcaaaat atccaataat atttcttttg
     5521 ctgagctgta aaataattat tttgcaaaca taaaagaaaa aaaaaagaat tgtaacagaa
     5581 acatggcttt accagtatga ccctcaagac aaaatacaaa acaatggcta ccaagaggtg
     5641 gaagtggccc agtcacagca agagcagatt gatcaagagc aaaggtcatg gtaacagttt
     5701 tttggatcct caagtcattt tgcttgttga ctttttggag ggccaaataa agatatcatc
     5761 tgcttattat gagagtgttt cgagagaaat ccaaagctta gcagagaaac gcctgggaaa
     5821 gcttcaccag agggtcttcc accgtgacag ttcccctgcg cattcctctc ataaagcaag
     5881 ggcagtttag ctagaatttc tatcaaaaat cattaggtat ccatctccca gtcctgattt
     5941 ggctccttct gacttctttt tgtttcccaa tcttaaaaaa atccctgaag ggcacctgtt
     6001 tttcttcagc taataaaaaa gacatggtta atttcccagg accctcagtt ctttagggat
     6061 agactgaatg gctggtatca ttgcttgaac ttaatggagc ttatgttgag aaataaaaga
     6121 aattatattt tatttttatc ttttaattct atttttccat gaactttttg aagtcccctc
     6181 agatataaag cagaacgtta tgaaactgag ttaccttgaa tctagaagag tacaatgata
     6241 aaggggaaga tagaaacaca cacatatgcg ttgttttccc cactttcaca atgccgtgca
     6301 gaaactaaca gatgaaggag gagaatccct aaaaacagag cattgggtag ctagtccacc
     6361 agcggtctga tgctttcatt gatctcaaaa ctgtctctga gtaactctac caggaaagtt
     6421 gtctggaggg ttaacatttc tgaaaccatt tttatctttg ccttcattct tgaatgataa
     6481 ttagtctcga atgtttggat cacaatccat tgaaagacta ggctattttt tcactgtcct
     6541 cagacattta ctgagtccag tttggacttt attttatttt attttttttg aaacaagatc
     6601 tcgctctgtt gctcaggctg aagtgcaata gcgcaaactc ggctcactgc aacctcccag
     6661 gttcaagcaa ttctcgtgcc tcagccatcc ctataggcat gcgccaccac actttgctaa
     6721 tcttgtattt ttggtagaga cggggtttgc accatgttgg ccaggctggt ctcgaactcc
     6781 caacctcaag taatctggcc tcccaaagtg gtgggattac aggcgtgagc cagcgcgccc
     6841 ggcctggact taacttctga agaactcttt ctgtttagat tgcaggagcg ttctctcggc
     6901 tcatctcttg ttttctcacc cagctgttct tcttctagtt ggccatcatt cttcatccct
     6961 ccctcccttt cctgcagtta attatttctt tgaaatttta aaacttctta atgttgcctg
     7021 gaatacatga gtcttcctga tctcttcaaa cggggtttgt tttgttttgc tttggggaga
     7081 attcttttga cgtttttgaa taagctgtta acaactttaa tacctgtctt gtttgttttc
     7141 ttcagaaatt tgttaattct ccatgattag cacctttatg tggttatctc attattttca
     7201 ttccttttta attctctgtt ttaggaatgc ttgtcaaatt cgtcactaaa attgatttac
     7261 tttcttgaaa acctgtttct gctgctccca acatgattta atcttggcta ctgagctttt
     7321 ggttacgttg cactcccttt aaaattactc cgtttaagta cagtgttcac tctttgggta
     7381 atgtgtacaa tagaagccca atccccacct atacccaata tatccatggg acaagcatgt
     7441 acatgcaccc cctgagtcta aaataaaaat tttaaaaaaa cta
//
