LOCUS       NM_001376002            4240 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens GTF2H2 family member C (GTF2H2C), transcript variant
            6, mRNA.
ACCESSION   NM_001376002
VERSION     NM_001376002.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4240)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4240)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4240)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4240)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 4240)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147575.1 and AC145102.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410571.126718.1,
                                           SRR14038193.3650494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC147575.1         1337-1388           c
            53-141              AC145102.2         178103-178191       c
            142-219             AC145102.2         177083-177160       c
            220-256             AC145102.2         176666-176702       c
            257-343             AC145102.2         176238-176324       c
            344-398             AC145102.2         175084-175138       c
            399-504             AC145102.2         170741-170846       c
            505-595             AC145102.2         164489-164579       c
            596-683             AC145102.2         164183-164270       c
            684-791             AC145102.2         163427-163534       c
            792-855             AC145102.2         160862-160925       c
            856-959             AC145102.2         157594-157697       c
            960-1062            AC145102.2         156935-157037       c
            1063-1102           AC145102.2         152924-152963       c
            1103-4240           AC145102.2         148075-151212       c
FEATURES             Location/Qualifiers
     source          1..4240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..4240
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="GTF2H2 family member C"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
     exon            1..52
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            53..141
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1222
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="isoform 2 is encoded by transcript variant 6;
                     general transcription factor IIH subunit 2-like protein;
                     general transcription factor IIH polypeptide 2-like
                     protein; general transcription factor IIH, polypeptide 2C"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 2-like
                     protein isoform 2"
                     /protein_id="NP_001362931.1"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
                     /translation="MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRK
                     RVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKIGIIVTKSKRAEKLTE
                     LSGNPRKHITSLKEAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTC
                     DPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHH
                     LSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQ
                     CRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGE
                     LKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV"
     exon            142..219
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..256
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..343
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..398
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..504
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..595
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..683
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..791
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..855
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..959
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1062
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1102
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..4240
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaggagt gtcgggctga gtttccggct gagagtcctt ctagcggcgc cgattattga
       61 ataataaaat acagttttga aaaaaatgga tgaagaacct gaaagaacta agcgatggga
      121 aggaggctat gaaagaacat gggagattct taaagaagat gaatctggat cacttaaagc
      181 tacaatagaa gacattctat tcaaggcaaa gagaaaaaga gtatttgagc accatggaca
      241 agttcgactt ggaatgatgc gccaccttta tgtggtagta gatggatcaa gaacaatgga
      301 agaccaagat ttaaagccta atagactgac gtgtacttta aagattggaa taattgtaac
      361 taagagtaaa agagctgaaa aattgactga actttcagga aacccaagaa aacatataac
      421 gtctttgaag gaagctgtgg atatgacctg ccatggagag ccatctcttt ataattccct
      481 aagcatggct atgcagactc taaaacacat gcctggacat acaagtcgag aagtactaat
      541 catctttagc agccttacaa cttgcgatcc atctaatatt tatgatctaa tcaagaccct
      601 aaaggcagct aaaattagag tatctgttat tggattgtct gcagaagttc gcgtttgcac
      661 tgtacttgct cgtgaaactg gtggcacgta ccatgttatt ttagatgaaa gccattacaa
      721 agagttgctc acacatcatc ttagtcctcc tcctgctagc tcaagttctg aatgctcact
      781 tattcgtatg ggatttcctc agcacaccat tgcttcttta tctgaccagg atgcaaaacc
      841 ctctttcagc atggcgcatt tggatggcaa tactgagcca gggcttacat taggaggcta
      901 tttctgccca cagtgtcggg caaagtactg tgagctacct gttgaatgta aaatctgtgg
      961 tcttactttg gtgtctgctc cccacttggc acggtcttac catcatttgt ttcctttgga
     1021 tgcttttcaa gaaattcccc tagaagaata taatggagaa agattttgtt atggatgtca
     1081 gggggaattg aaagaccaac atgtttatgt ttgtgctgtg tgccaaaatg ttttctgtgt
     1141 ggactgtgat gtttttgttc atgattctct acactgttgc cctggctgta ttcataagat
     1201 tccagctcct tcaggtgttt gattccagca tgtagtatac attgtatgtg ttaaaaagaa
     1261 atttgcaact gtgaataaaa ggacttcttt agaagaagct tcatttaaaa catgaaagga
     1321 taatctgact taagaaactt tttgctaaga aaaggtaata ttttattaaa ttttaaattt
     1381 gtgttgtcac agaaatacct gaaattcagt agtacttcat tcaattaatt ttgttttcta
     1441 ttattttgag ttatactgtt ttcaaagtca ttatgcagta tgtataaact tataagaatt
     1501 aaattgatgt gataatttta tgtttttata attaaatata gaatctttat gatttatgtt
     1561 aattcattaa tttagtgtaa gaagaaagtt aagtctgaat gtaaattcag tgtaagatga
     1621 aaatttatca atacttatga aattaggctg ggcgctgtgg ctcacacctg taatcccaac
     1681 actttgggag gctgaggtgg gcagatcact tgaggtcagg agttcgagac cagcctggcc
     1741 aacatggtga aaccccgtca ctactaaaaa tacaaaaaat aattagccgg gcatggtggt
     1801 tcacgcctgg agtcccagct acttgggagg ctgaggcagg agaatcgctt gaacccagga
     1861 ggcggaggtt gcagtgagcc gagattgtgc cactgcactc caccctagag taagactccc
     1921 tctcaaaaaa aaaaaaagtt atgaaattaa tacatatgaa atgatgtact gctacatcca
     1981 ccagagaggt ctttttaggt ttaaccaaac atctggaata tgtttatcaa gttagtacat
     2041 ctgaaattat ttgtggctat gaccaacaga agtcacttta cattaaacat tcaaactcac
     2101 aagactgcca tggccatact tggtacccgc ttactcagaa ggatattaaa cagaaacaac
     2161 agcctgccag cacagcatca agcagtcctc attagcagtg gaagtccttg tagcagtcca
     2221 ctagtacaat ttgggtgcaa ggagataaga tcctccacag gcatcaagga accaatatct
     2281 cttaacaatt ccataaacac agcttccagg tatccacaag ggatgtgtca atttcaagag
     2341 tcactacact caggaaagcc taaagcttga agactccatt tatttatagt gcatcccaat
     2401 ccagatacgt aacaattaac gagttatttt tactataagc aaagttgcct aaaatcatag
     2461 ttgatactaa ccatggttaa cagagctcta aagtttgaca gaaagtgaga ttcaaatcct
     2521 ttcactctca tatgctaaac cttttgcctt actctgggtc atcagagaaa tttaggtgag
     2581 aatgtatgat gaagtctgtg ttttagattc aatgcagata tatcattgtg ggcagaactc
     2641 tttctggtta tatccagtta agagtaaatc aggctttcag ccgggcgcgg tggctcacgc
     2701 ctgtaatcct agcactttgg gaggccgagg cgggcagatc acgaggtcag gagatcgaga
     2761 ccatcctggc taacacggtg aaaccccgtc tctactaaac atacaaaaaa ttagctgggc
     2821 ctggtggcgg gcgcctgtag tcccagctat tcggaaggct ggggcaggag aatggtgtga
     2881 acccaggagg cggagcttgc agtgaaccga gatcgctcca ctgcactcca gcctgggcga
     2941 cagagctaga ctctgtctca agaaaaaaaa aaaaaaaaaa aaaaaaaaga gtaaatcagg
     3001 ctttcatagc aaaggtatgt ctattttatg tatataaact tcaggtactc taacttgagt
     3061 ttcactatga aatttgtgat tttttttttt ttttttttga gatggagtct tgctccatcg
     3121 cccaggctgg agtgcagtgg cctgctgttg gctcactgca acctccgcct cccaggctca
     3181 agccattctc ctgtctcagc ctcctgagta gctgggacta caggcgcctg ccaccacgcc
     3241 tggctaattt ttgcattttt ggtagagacg gggtttcacc ttgttgatca ggctgatctc
     3301 caactcctga cctcaggtca tccacccacc tccgccaccg tgcccggccg aaatttgtga
     3361 ttttataact aagaattttt agttaagaac attatcagta aagacaacgt aatcccaccc
     3421 tggagagttt attgggagcc caggaatatt catttttaat acacacacac acacacacac
     3481 acacacacac acacacacac actgatcaga gtaacgggag tttctctcag gagtcatact
     3541 ccatgagcct ggacccagtg gttctttatg tggaaacaaa tttcacctat aggtaacctg
     3601 gtaactgcta ttttcttctg tgtgctctgt caacaaaggt atcagtggct tgcaggagat
     3661 gcctttaata ctcagagcat tctatctccc cctatctggt ttagaaggaa ggccttcatt
     3721 agttaccttt tgagaagtta ctagaactct ctattagaga cttaccctcc tgacctgata
     3781 aaaagggata cccatgtctc tattaacagc tttatctctt tctacagttt tgggtatttg
     3841 ataaggttaa ggcaaaattt tagttatgct taaggaggag ttcttttttc acaattacag
     3901 agaaaatttt ggtttgttga agattgcaga aacagcaatg gtaatgtaag acagttttgg
     3961 cctttaattt ttttcttgaa actctacagt atactacaat agtgaaggaa actattatca
     4021 tgagagatcc ttctgaatag gatgtctttc tgagttccac tattcagtta caaaactcct
     4081 taatgcttaa aattcattat gaaaattaga tttattttaa atactttcaa gtgtatacat
     4141 ttttatttca taatttttat tgtcttttaa ctaaagcatt tagttcattt atatttactg
     4201 tgtacctttt atatttaata aatatattta cttattaaaa
//
