LOCUS       NM_001376000            4555 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens GTF2H2 family member C (GTF2H2C), transcript variant
            4, mRNA.
ACCESSION   NM_001376000
VERSION     NM_001376000.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4555)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4555)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4555)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4555)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 4555)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147575.1 and AC145102.2.
            
            On Dec 13, 2019 this sequence version replaced NM_001376000.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.25921.1,
                                           SRR14038194.1163700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380729.8/ ENSP00000370105.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC147575.1         1176-1388           c
            214-311             AC145102.2         180521-180618       c
            312-400             AC145102.2         178103-178191       c
            401-478             AC145102.2         177083-177160       c
            479-515             AC145102.2         176666-176702       c
            516-602             AC145102.2         176238-176324       c
            603-653             AC145102.2         175514-175564       c
            654-708             AC145102.2         175084-175138       c
            709-814             AC145102.2         170741-170846       c
            815-905             AC145102.2         164489-164579       c
            906-993             AC145102.2         164183-164270       c
            994-1101            AC145102.2         163427-163534       c
            1102-1165           AC145102.2         160862-160925       c
            1166-1269           AC145102.2         157594-157697       c
            1270-1372           AC145102.2         156935-157037       c
            1373-1412           AC145102.2         152924-152963       c
            1413-4555           AC145102.2         148070-151212       c
FEATURES             Location/Qualifiers
     source          1..4555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..4555
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="GTF2H2 family member C"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
     exon            1..213
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..311
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..400
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1532
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     general transcription factor IIH subunit 2-like protein;
                     general transcription factor IIH polypeptide 2-like
                     protein; general transcription factor IIH, polypeptide 2C"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 2-like
                     protein isoform 1"
                     /protein_id="NP_001362929.1"
                     /db_xref="CCDS:CCDS43325.1"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
                     /translation="MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRK
                     RVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPIS
                     QIGIIVTKSKRAEKLTELSGNPRKHITSLKEAVDMTCHGEPSLYNSLSMAMQTLKHMP
                     GHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGT
                     YHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHL
                     DGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEI
                     PLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAP
                     SGV"
     exon            401..478
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..515
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..602
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..653
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..708
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..814
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..905
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..993
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1101
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1165
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1269
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1372
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1412
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..4555
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaggagt gtcgggctga gtttccggct gagagtcctt ctagcggcgc cggtgagtcc
       61 gcgtgtggaa gtctgtgagg cgcagaggtg gggcaggccg tctgactagc taggcggctg
      121 ggagcgtttt cgtggcgggg aacggaggtt gaattgccct gcctgggctc atagggaagg
      181 aggatgtgaa ggagcttgtg aaggcagagg aaggctggag tgcagtggca caaccttggc
      241 tcgctccagt gtctacctcc caggttcaag tgattctcct gcctcagcct cccgagtagc
      301 tgggattaca gattattgaa taataaaata cagttttgaa aaaaatggat gaagaacctg
      361 aaagaactaa gcgatgggaa ggaggctatg aaagaacatg ggagattctt aaagaagatg
      421 aatctggatc acttaaagct acaatagaag acattctatt caaggcaaag agaaaaagag
      481 tatttgagca ccatggacaa gttcgacttg gaatgatgcg ccacctttat gtggtagtag
      541 atggatcaag aacaatggaa gaccaagatt taaagcctaa tagactgacg tgtactttaa
      601 agttgttgga atactttgta gaggaatatt ttgatcaaaa tcctattagt cagattggaa
      661 taattgtaac taagagtaaa agagctgaaa aattgactga actttcagga aacccaagaa
      721 aacatataac gtctttgaag gaagctgtgg atatgacctg ccatggagag ccatctcttt
      781 ataattccct aagcatggct atgcagactc taaaacacat gcctggacat acaagtcgag
      841 aagtactaat catctttagc agccttacaa cttgcgatcc atctaatatt tatgatctaa
      901 tcaagaccct aaaggcagct aaaattagag tatctgttat tggattgtct gcagaagttc
      961 gcgtttgcac tgtacttgct cgtgaaactg gtggcacgta ccatgttatt ttagatgaaa
     1021 gccattacaa agagttgctc acacatcatc ttagtcctcc tcctgctagc tcaagttctg
     1081 aatgctcact tattcgtatg ggatttcctc agcacaccat tgcttcttta tctgaccagg
     1141 atgcaaaacc ctctttcagc atggcgcatt tggatggcaa tactgagcca gggcttacat
     1201 taggaggcta tttctgccca cagtgtcggg caaagtactg tgagctacct gttgaatgta
     1261 aaatctgtgg tcttactttg gtgtctgctc cccacttggc acggtcttac catcatttgt
     1321 ttcctttgga tgcttttcaa gaaattcccc tagaagaata taatggagaa agattttgtt
     1381 atggatgtca gggggaattg aaagaccaac atgtttatgt ttgtgctgtg tgccaaaatg
     1441 ttttctgtgt ggactgtgat gtttttgttc atgattctct acactgttgc cctggctgta
     1501 ttcataagat tccagctcct tcaggtgttt gattccagca tgtagtatac attgtatgtg
     1561 ttaaaaagaa atttgcaact gtgaataaaa ggacttcttt agaagaagct tcatttaaaa
     1621 catgaaagga taatctgact taagaaactt tttgctaaga aaaggtaata ttttattaaa
     1681 ttttaaattt gtgttgtcac agaaatacct gaaattcagt agtacttcat tcaattaatt
     1741 ttgttttcta ttattttgag ttatactgtt ttcaaagtca ttatgcagta tgtataaact
     1801 tataagaatt aaattgatgt gataatttta tgtttttata attaaatata gaatctttat
     1861 gatttatgtt aattcattaa tttagtgtaa gaagaaagtt aagtctgaat gtaaattcag
     1921 tgtaagatga aaatttatca atacttatga aattaggctg ggcgctgtgg ctcacacctg
     1981 taatcccaac actttgggag gctgaggtgg gcagatcact tgaggtcagg agttcgagac
     2041 cagcctggcc aacatggtga aaccccgtca ctactaaaaa tacaaaaaat aattagccgg
     2101 gcatggtggt tcacgcctgg agtcccagct acttgggagg ctgaggcagg agaatcgctt
     2161 gaacccagga ggcggaggtt gcagtgagcc gagattgtgc cactgcactc caccctagag
     2221 taagactccc tctcaaaaaa aaaaaaagtt atgaaattaa tacatatgaa atgatgtact
     2281 gctacatcca ccagagaggt ctttttaggt ttaaccaaac atctggaata tgtttatcaa
     2341 gttagtacat ctgaaattat ttgtggctat gaccaacaga agtcacttta cattaaacat
     2401 tcaaactcac aagactgcca tggccatact tggtacccgc ttactcagaa ggatattaaa
     2461 cagaaacaac agcctgccag cacagcatca agcagtcctc attagcagtg gaagtccttg
     2521 tagcagtcca ctagtacaat ttgggtgcaa ggagataaga tcctccacag gcatcaagga
     2581 accaatatct cttaacaatt ccataaacac agcttccagg tatccacaag ggatgtgtca
     2641 atttcaagag tcactacact caggaaagcc taaagcttga agactccatt tatttatagt
     2701 gcatcccaat ccagatacgt aacaattaac gagttatttt tactataagc aaagttgcct
     2761 aaaatcatag ttgatactaa ccatggttaa cagagctcta aagtttgaca gaaagtgaga
     2821 ttcaaatcct ttcactctca tatgctaaac cttttgcctt actctgggtc atcagagaaa
     2881 tttaggtgag aatgtatgat gaagtctgtg ttttagattc aatgcagata tatcattgtg
     2941 ggcagaactc tttctggtta tatccagtta agagtaaatc aggctttcag ccgggcgcgg
     3001 tggctcacgc ctgtaatcct agcactttgg gaggccgagg cgggcagatc acgaggtcag
     3061 gagatcgaga ccatcctggc taacacggtg aaaccccgtc tctactaaac atacaaaaaa
     3121 ttagctgggc ctggtggcgg gcgcctgtag tcccagctat tcggaaggct ggggcaggag
     3181 aatggtgtga acccaggagg cggagcttgc agtgaaccga gatcgctcca ctgcactcca
     3241 gcctgggcga cagagctaga ctctgtctca agaaaaaaaa aaaaaaaaaa aaaaaaaaga
     3301 gtaaatcagg ctttcatagc aaaggtatgt ctattttatg tatataaact tcaggtactc
     3361 taacttgagt ttcactatga aatttgtgat tttttttttt ttttttttga gatggagtct
     3421 tgctccatcg cccaggctgg agtgcagtgg cctgctgttg gctcactgca acctccgcct
     3481 cccaggctca agccattctc ctgtctcagc ctcctgagta gctgggacta caggcgcctg
     3541 ccaccacgcc tggctaattt ttgcattttt ggtagagacg gggtttcacc ttgttgatca
     3601 ggctgatctc caactcctga cctcaggtca tccacccacc tccgccaccg tgcccggccg
     3661 aaatttgtga ttttataact aagaattttt agttaagaac attatcagta aagacaacgt
     3721 aatcccaccc tggagagttt attgggagcc caggaatatt catttttaat acacacacac
     3781 acacacacac acacacacac acacacacac actgatcaga gtaacgggag tttctctcag
     3841 gagtcatact ccatgagcct ggacccagtg gttctttatg tggaaacaaa tttcacctat
     3901 aggtaacctg gtaactgcta ttttcttctg tgtgctctgt caacaaaggt atcagtggct
     3961 tgcaggagat gcctttaata ctcagagcat tctatctccc cctatctggt ttagaaggaa
     4021 ggccttcatt agttaccttt tgagaagtta ctagaactct ctattagaga cttaccctcc
     4081 tgacctgata aaaagggata cccatgtctc tattaacagc tttatctctt tctacagttt
     4141 tgggtatttg ataaggttaa ggcaaaattt tagttatgct taaggaggag ttcttttttc
     4201 acaattacag agaaaatttt ggtttgttga agattgcaga aacagcaatg gtaatgtaag
     4261 acagttttgg cctttaattt ttttcttgaa actctacagt atactacaat agtgaaggaa
     4321 actattatca tgagagatcc ttctgaatag gatgtctttc tgagttccac tattcagtta
     4381 caaaactcct taatgcttaa aattcattat gaaaattaga tttattttaa atactttcaa
     4441 gtgtatacat ttttatttca taatttttat tgtcttttaa ctaaagcatt tagttcattt
     4501 atatttactg tgtacctttt atatttaata aatatattta cttattaaaa gatta
//
