LOCUS       NM_001375998            4326 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens GTF2H2 family member C (GTF2H2C), transcript variant
            2, mRNA.
ACCESSION   NM_001375998
VERSION     NM_001375998.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147575.1 and AC145102.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.961789.1,
                                           SRR14038193.110012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC147575.1         1302-1388           c
            88-176              AC145102.2         178103-178191       c
            177-254             AC145102.2         177083-177160       c
            255-291             AC145102.2         176666-176702       c
            292-378             AC145102.2         176238-176324       c
            379-429             AC145102.2         175514-175564       c
            430-484             AC145102.2         175084-175138       c
            485-590             AC145102.2         170741-170846       c
            591-681             AC145102.2         164489-164579       c
            682-769             AC145102.2         164183-164270       c
            770-877             AC145102.2         163427-163534       c
            878-941             AC145102.2         160862-160925       c
            942-1045            AC145102.2         157594-157697       c
            1046-1148           AC145102.2         156935-157037       c
            1149-1188           AC145102.2         152924-152963       c
            1189-4326           AC145102.2         148075-151212       c
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..4326
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="GTF2H2 family member C"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
     exon            1..87
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            88..176
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1308
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     general transcription factor IIH subunit 2-like protein;
                     general transcription factor IIH polypeptide 2-like
                     protein; general transcription factor IIH, polypeptide 2C"
                     /codon_start=1
                     /product="general transcription factor IIH subunit 2-like
                     protein isoform 1"
                     /protein_id="NP_001362927.1"
                     /db_xref="CCDS:CCDS43325.1"
                     /db_xref="GeneID:728340"
                     /db_xref="HGNC:HGNC:31394"
                     /translation="MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRK
                     RVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPIS
                     QIGIIVTKSKRAEKLTELSGNPRKHITSLKEAVDMTCHGEPSLYNSLSMAMQTLKHMP
                     GHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGT
                     YHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHL
                     DGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEI
                     PLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAP
                     SGV"
     exon            177..254
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..291
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..378
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..429
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..484
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..590
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..681
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..769
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..877
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..941
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1045
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1148
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1188
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..4326
                     /gene="GTF2H2C"
                     /gene_synonym="GTF2H2C_2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaggagt gtcgggctga gtttccggct gagagtcctt ctagcggcgc cggtgagtcc
       61 gcgtgtggaa gtctgtgagg cgcagagatt attgaataat aaaatacagt tttgaaaaaa
      121 atggatgaag aacctgaaag aactaagcga tgggaaggag gctatgaaag aacatgggag
      181 attcttaaag aagatgaatc tggatcactt aaagctacaa tagaagacat tctattcaag
      241 gcaaagagaa aaagagtatt tgagcaccat ggacaagttc gacttggaat gatgcgccac
      301 ctttatgtgg tagtagatgg atcaagaaca atggaagacc aagatttaaa gcctaataga
      361 ctgacgtgta ctttaaagtt gttggaatac tttgtagagg aatattttga tcaaaatcct
      421 attagtcaga ttggaataat tgtaactaag agtaaaagag ctgaaaaatt gactgaactt
      481 tcaggaaacc caagaaaaca tataacgtct ttgaaggaag ctgtggatat gacctgccat
      541 ggagagccat ctctttataa ttccctaagc atggctatgc agactctaaa acacatgcct
      601 ggacatacaa gtcgagaagt actaatcatc tttagcagcc ttacaacttg cgatccatct
      661 aatatttatg atctaatcaa gaccctaaag gcagctaaaa ttagagtatc tgttattgga
      721 ttgtctgcag aagttcgcgt ttgcactgta cttgctcgtg aaactggtgg cacgtaccat
      781 gttattttag atgaaagcca ttacaaagag ttgctcacac atcatcttag tcctcctcct
      841 gctagctcaa gttctgaatg ctcacttatt cgtatgggat ttcctcagca caccattgct
      901 tctttatctg accaggatgc aaaaccctct ttcagcatgg cgcatttgga tggcaatact
      961 gagccagggc ttacattagg aggctatttc tgcccacagt gtcgggcaaa gtactgtgag
     1021 ctacctgttg aatgtaaaat ctgtggtctt actttggtgt ctgctcccca cttggcacgg
     1081 tcttaccatc atttgtttcc tttggatgct tttcaagaaa ttcccctaga agaatataat
     1141 ggagaaagat tttgttatgg atgtcagggg gaattgaaag accaacatgt ttatgtttgt
     1201 gctgtgtgcc aaaatgtttt ctgtgtggac tgtgatgttt ttgttcatga ttctctacac
     1261 tgttgccctg gctgtattca taagattcca gctccttcag gtgtttgatt ccagcatgta
     1321 gtatacattg tatgtgttaa aaagaaattt gcaactgtga ataaaaggac ttctttagaa
     1381 gaagcttcat ttaaaacatg aaaggataat ctgacttaag aaactttttg ctaagaaaag
     1441 gtaatatttt attaaatttt aaatttgtgt tgtcacagaa atacctgaaa ttcagtagta
     1501 cttcattcaa ttaattttgt tttctattat tttgagttat actgttttca aagtcattat
     1561 gcagtatgta taaacttata agaattaaat tgatgtgata attttatgtt tttataatta
     1621 aatatagaat ctttatgatt tatgttaatt cattaattta gtgtaagaag aaagttaagt
     1681 ctgaatgtaa attcagtgta agatgaaaat ttatcaatac ttatgaaatt aggctgggcg
     1741 ctgtggctca cacctgtaat cccaacactt tgggaggctg aggtgggcag atcacttgag
     1801 gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ccgtcactac taaaaataca
     1861 aaaaataatt agccgggcat ggtggttcac gcctggagtc ccagctactt gggaggctga
     1921 ggcaggagaa tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga ttgtgccact
     1981 gcactccacc ctagagtaag actccctctc aaaaaaaaaa aaagttatga aattaataca
     2041 tatgaaatga tgtactgcta catccaccag agaggtcttt ttaggtttaa ccaaacatct
     2101 ggaatatgtt tatcaagtta gtacatctga aattatttgt ggctatgacc aacagaagtc
     2161 actttacatt aaacattcaa actcacaaga ctgccatggc catacttggt acccgcttac
     2221 tcagaaggat attaaacaga aacaacagcc tgccagcaca gcatcaagca gtcctcatta
     2281 gcagtggaag tccttgtagc agtccactag tacaatttgg gtgcaaggag ataagatcct
     2341 ccacaggcat caaggaacca atatctctta acaattccat aaacacagct tccaggtatc
     2401 cacaagggat gtgtcaattt caagagtcac tacactcagg aaagcctaaa gcttgaagac
     2461 tccatttatt tatagtgcat cccaatccag atacgtaaca attaacgagt tatttttact
     2521 ataagcaaag ttgcctaaaa tcatagttga tactaaccat ggttaacaga gctctaaagt
     2581 ttgacagaaa gtgagattca aatcctttca ctctcatatg ctaaaccttt tgccttactc
     2641 tgggtcatca gagaaattta ggtgagaatg tatgatgaag tctgtgtttt agattcaatg
     2701 cagatatatc attgtgggca gaactctttc tggttatatc cagttaagag taaatcaggc
     2761 tttcagccgg gcgcggtggc tcacgcctgt aatcctagca ctttgggagg ccgaggcggg
     2821 cagatcacga ggtcaggaga tcgagaccat cctggctaac acggtgaaac cccgtctcta
     2881 ctaaacatac aaaaaattag ctgggcctgg tggcgggcgc ctgtagtccc agctattcgg
     2941 aaggctgggg caggagaatg gtgtgaaccc aggaggcgga gcttgcagtg aaccgagatc
     3001 gctccactgc actccagcct gggcgacaga gctagactct gtctcaagaa aaaaaaaaaa
     3061 aaaaaaaaaa aaaagagtaa atcaggcttt catagcaaag gtatgtctat tttatgtata
     3121 taaacttcag gtactctaac ttgagtttca ctatgaaatt tgtgattttt tttttttttt
     3181 ttttgagatg gagtcttgct ccatcgccca ggctggagtg cagtggcctg ctgttggctc
     3241 actgcaacct ccgcctccca ggctcaagcc attctcctgt ctcagcctcc tgagtagctg
     3301 ggactacagg cgcctgccac cacgcctggc taatttttgc atttttggta gagacggggt
     3361 ttcaccttgt tgatcaggct gatctccaac tcctgacctc aggtcatcca cccacctccg
     3421 ccaccgtgcc cggccgaaat ttgtgatttt ataactaaga atttttagtt aagaacatta
     3481 tcagtaaaga caacgtaatc ccaccctgga gagtttattg ggagcccagg aatattcatt
     3541 tttaatacac acacacacac acacacacac acacacacac acacacactg atcagagtaa
     3601 cgggagtttc tctcaggagt catactccat gagcctggac ccagtggttc tttatgtgga
     3661 aacaaatttc acctataggt aacctggtaa ctgctatttt cttctgtgtg ctctgtcaac
     3721 aaaggtatca gtggcttgca ggagatgcct ttaatactca gagcattcta tctcccccta
     3781 tctggtttag aaggaaggcc ttcattagtt accttttgag aagttactag aactctctat
     3841 tagagactta ccctcctgac ctgataaaaa gggataccca tgtctctatt aacagcttta
     3901 tctctttcta cagttttggg tatttgataa ggttaaggca aaattttagt tatgcttaag
     3961 gaggagttct tttttcacaa ttacagagaa aattttggtt tgttgaagat tgcagaaaca
     4021 gcaatggtaa tgtaagacag ttttggcctt taattttttt cttgaaactc tacagtatac
     4081 tacaatagtg aaggaaacta ttatcatgag agatccttct gaataggatg tctttctgag
     4141 ttccactatt cagttacaaa actccttaat gcttaaaatt cattatgaaa attagattta
     4201 ttttaaatac tttcaagtgt atacattttt atttcataat ttttattgtc ttttaactaa
     4261 agcatttagt tcatttatat ttactgtgta ccttttatat ttaataaata tatttactta
     4321 ttaaaa
//
