LOCUS       NM_004128               2228 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens general transcription factor IIF subunit 2 (GTF2F2),
            mRNA.
ACCESSION   NM_004128
VERSION     NM_004128.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   Choi,S.G., Olivet,J., Cassonnet,P., Vidalain,P.O., Luck,K.,
            Lambourne,L., Spirohn,K., Lemmens,I., Dos Santos,M., Demeret,C.,
            Jones,L., Rangarajan,S., Bian,W., Coutant,E.P., Janin,Y.L., van der
            Werf,S., Trepte,P., Wanker,E.E., De Las Rivas,J., Tavernier,J.,
            Twizere,J.C., Hao,T., Hill,D.E., Vidal,M., Calderwood,M.A. and
            Jacob,Y.
  TITLE     Maximizing binary interactome mapping with a minimal number of
            assays
  JOURNAL   Nat Commun 10 (1), 3907 (2019)
   PUBMED   31467278
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   Cabart,P., Ujvari,A., Pal,M. and Luse,D.S.
  TITLE     Transcription factor TFIIF is not required for initiation by RNA
            polymerase II, but it is essential to stabilize transcription
            factor TFIIB in early elongation complexes
  JOURNAL   Proc Natl Acad Sci U S A 108 (38), 15786-15791 (2011)
   PUBMED   21896726
  REMARK    GeneRIF: Data show that TFIIF has an important role in stabilizing
            TFIIB within the PIC and after transcription initiates.
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Horikoshi,M., Fujita,H., Wang,J., Takada,R. and Roeder,R.G.
  TITLE     Nucleotide and amino acid sequence of RAP30
  JOURNAL   Nucleic Acids Res 19 (19), 5436 (1991)
   PUBMED   1840667
REFERENCE   9  (bases 1 to 2228)
  AUTHORS   Sopta,M., Burton,Z.F. and Greenblatt,J.
  TITLE     Structure and associated DNA-helicase activity of a general
            transcription initiation factor that binds to RNA polymerase II
  JOURNAL   Nature 341 (6241), 410-414 (1989)
   PUBMED   2477704
REFERENCE   10 (bases 1 to 2228)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB124466.1, BC001771.1, DB252856.1, AK291545.1, CA429230.1 and
            AL138963.20.
            
            On Nov 23, 2018 this sequence version replaced NM_004128.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.39599.1,
                                           SRR1803616.117917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340473.8/ ENSP00000340823.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CB124466.1         15-39
            26-247              BC001771.1         1-222
            248-581             DB252856.1         254-587
            582-1020            AK291545.1         589-1027
            1021-1288           BC001771.1         996-1263
            1289-1440           CA429230.1         16-167              c
            1441-2228           AL138963.20        89887-90674
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.12-q14.13"
     gene            1..2228
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /note="general transcription factor IIF subunit 2"
                     /db_xref="GeneID:2963"
                     /db_xref="HGNC:HGNC:4653"
                     /db_xref="MIM:189969"
     exon            1..212
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..896
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /EC_number="3.6.4.12"
                     /note="general transcription factor IIF 30 kDa subunit;
                     transcription initiation factor IIF subunit beta;
                     TFIIF-beta; ATP-dependent helicase GTF2F2; transcription
                     initiation factor RAP30; general transcription factor IIF,
                     polypeptide 2, 30kDa"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 2"
                     /protein_id="NP_004119.1"
                     /db_xref="CCDS:CCDS9395.1"
                     /db_xref="GeneID:2963"
                     /db_xref="HGNC:HGNC:4653"
                     /db_xref="MIM:189969"
                     /translation="MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLR
                     IAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSD
                     KLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQ
                     YNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILK
                     EIGVQNVKGIHKNTWELKPEYRHYQGEEKSD"
     exon            213..286
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            287..305
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            306..450
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            451..532
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            533..632
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            633..776
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2228
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /note="major polyA site"
     regulatory      2207..2212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /note="hexamer: AATAAA"
     polyA_site      2228
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
ORIGIN      
        1 ctcggttccc agtgttctgg caggtaagga acgccggctc ttcgcctctc agcgcggctt
       61 gtcctttgtt ccggacgccc gctcctcagc cctgcggctc ctggggtcgc tgctgcatcc
      121 cgcacgcctc caccggctgc agacccatgg ccgagcgcgg ggaactcgac ttgaccggcg
      181 ccaaacagaa cacaggagtg tggctagtca aggttcctaa atatttgtca cagcaatggg
      241 ctaaagcctc tggaagaggt gaagttggga aactgcggat tgccaagact caaggaagga
      301 ctgaggtgtc atttactttg aatgaggatc ttgcaaatat tcatgatatt ggtggaaaac
      361 cagcttcagt cagtgctcct agagaacatc catttgtctt gcaaagtgtt ggaggacaga
      421 cattaacagt atttactgag agctcatcag ataagctgtc attggaagga atagtggtac
      481 aaagagctga atgccgacca gctgccagtg aaaactacat gcgattaaaa agattgcaaa
      541 tagaagagtc ttccaaacca gtgaggctat cacaacagct ggacaaagtt gtaacaacca
      601 attacaaacc tgttgctaat catcaataca atatcgaata tgaaaggaaa aagaaagaag
      661 acggaaagcg agctcgagct gataaacaac atgttttaga catgctattt tcagcctttg
      721 agaaacatca atactataat cttaaggact tggtggacat cacaaagcaa cctgtggtgt
      781 acctgaagga aatcttaaaa gaaattggtg ttcagaatgt aaaagggatc cacaaaaaca
      841 catgggagct gaagccagag tacagacact atcaaggaga agaaaagagt gactaagaag
      901 actcctagcc agcatgctag tgaaacgact agcagcgatg ctatgcaaaa ggcgctgata
      961 ctggaaggct tgaacaccgt atgttaatag gggttaagtg acagtacttt gatttctctc
     1021 ggtaaatttt ttaaacctgt aattcttgta aagtttctta actgtttttt tgaggagaaa
     1081 gaacagattt atttatagac ttaacttgta ttaaaccaga ttattcacag taggaatagg
     1141 ggttggagga ttaagagggt ttttcttaaa tattagcttt taatgtgtac aattaggaaa
     1201 tttttttaag tgaggactct ctacccttgc cgtatctaag gagctgaggt aatacagatc
     1261 caaggagaat tgtatagcaa gaaaaaaaca gtcaactaca gaaactctta aaaggaataa
     1321 aaacccaaag ttccttattt tgaaattgtc aaagaacaaa gcggtgtttt tcttttaaac
     1381 aggtgatcac gtttcgtgtt catactcaac gttaataaaa ggagagagtt tgtagtgaaa
     1441 tggcagtgtt catcattggc ttattttacc gtagtgatgc tgagatgaga aatgtgcagg
     1501 atcatggtca gttgatgttt cttttatttg cttttaagat aattagaaat taaatatctt
     1561 tccaaaattt gaagatatgt ctcccccagt cagattataa gcttctcaaa actggcttgc
     1621 ccccagaatt ttactgctta cccagcagac atgtattgac catcacatgg caaatgatat
     1681 cagcaaatca aaagatgggc gtaggggtcc agccgagaca gaaaacgtta gtttcaattc
     1741 ctggggcatt aaaatgttgc ttttctcttt ctctttaatt aatttttaaa tgaaaacaat
     1801 acatgtatat gttagttttt tctagcacaa cacaatatta tatattaagc gatccaaaat
     1861 catactgtca agaccatcaa acaaaacaaa gaagcttaag tgaactaagc acagggaaaa
     1921 gttgtttttt cactcgttca ttttgtcatc tgcttctaga tgctgcaatc aagaagtagc
     1981 aaatgcccaa gttgccatag tgtttgcagg aaaaaaagag aaaaaataat aaaaataagg
     2041 aaggagcaat gccaaaaatt gaagaaaata ttatataatt aaagcaagaa gatatctatc
     2101 cattgagaaa aacaattttt atattatttg cttttagcag caaagcatta gaattctgag
     2161 attgttatag cactaagaag atttttattc tgtgtacaca ctgaaaaata aaattctgag
     2221 taaagaaa
//
