LOCUS       NM_002096               2432 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens general transcription factor IIF subunit 1 (GTF2F1),
            mRNA.
ACCESSION   NM_002096
VERSION     NM_002096.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Hamilton,K., Morrow,K., Markantoni,E. and Harvey,J.
  TITLE     Leptin prevents aberrant targeting of tau to hippocampal synapses
            via PI 3 kinase driven inhibition of GSK3beta
  JOURNAL   J Neurochem 167 (4), 520-537 (2023)
   PUBMED   37822142
  REMARK    GeneRIF: Leptin prevents aberrant targeting of tau to hippocampal
            synapses via PI 3 kinase driven inhibition of GSK3beta.
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Choi,S.G., Olivet,J., Cassonnet,P., Vidalain,P.O., Luck,K.,
            Lambourne,L., Spirohn,K., Lemmens,I., Dos Santos,M., Demeret,C.,
            Jones,L., Rangarajan,S., Bian,W., Coutant,E.P., Janin,Y.L., van der
            Werf,S., Trepte,P., Wanker,E.E., De Las Rivas,J., Tavernier,J.,
            Twizere,J.C., Hao,T., Hill,D.E., Vidal,M., Calderwood,M.A. and
            Jacob,Y.
  TITLE     Maximizing binary interactome mapping with a minimal number of
            assays
  JOURNAL   Nat Commun 10 (1), 3907 (2019)
   PUBMED   31467278
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   De Mol,E., Szulc,E., Di Sanza,C., Martinez-Cristobal,P.,
            Bertoncini,C.W., Fenwick,R.B., Frigole-Vivas,M., Masin,M.,
            Hunter,I., Buzon,V., Brun-Heath,I., Garcia,J., De Fabritiis,G.,
            Estebanez-Perpina,E., McEwan,I.J., Nebreda,A.R. and Salvatella,X.
  TITLE     Regulation of Androgen Receptor Activity by Transient Interactions
            of Its Transactivation Domain with General Transcription Regulators
  JOURNAL   Structure 26 (1), 145-152 (2018)
   PUBMED   29225078
  REMARK    GeneRIF: An AR motif of the transactivation domain has been
            identified that contributes to transcriptional activity by
            recruiting the C-terminal domain of subunit 1 of the general
            transcription regulator TFIIF.
REFERENCE   5  (bases 1 to 2432)
  AUTHORS   He,Y., Yan,C., Fang,J., Inouye,C., Tjian,R., Ivanov,I. and
            Nogales,E.
  TITLE     Near-atomic resolution visualization of human transcription
            promoter opening
  JOURNAL   Nature 533 (7603), 359-365 (2016)
   PUBMED   27193682
REFERENCE   6  (bases 1 to 2432)
  AUTHORS   Kato,H., Sumimoto,H., Pognonec,P., Chen,C.H., Rosen,C.A. and
            Roeder,R.G.
  TITLE     HIV-1 Tat acts as a processivity factor in vitro in conjunction
            with cellular elongation factors
  JOURNAL   Genes Dev 6 (4), 655-666 (1992)
   PUBMED   1559613
REFERENCE   7  (bases 1 to 2432)
  AUTHORS   Finkelstein,A., Kostrub,C.F., Li,J., Chavez,D.P., Wang,B.Q.,
            Fang,S.M., Greenblatt,J. and Burton,Z.F.
  TITLE     A cDNA encoding RAP74, a general initiation factor for
            transcription by RNA polymerase II
  JOURNAL   Nature 355 (6359), 464-467 (1992)
   PUBMED   1734284
REFERENCE   8  (bases 1 to 2432)
  AUTHORS   Aso,T., Vasavada,H.A., Kawaguchi,T., Germino,F.J., Ganguly,S.,
            Kitajima,S., Weissman,S.M. and Yasukochi,Y.
  TITLE     Characterization of cDNA for the large subunit of the transcription
            initiation factor TFIIF
  JOURNAL   Nature 355 (6359), 461-464 (1992)
   PUBMED   1734283
REFERENCE   9  (bases 1 to 2432)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 2432)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X64037.1, BC013007.2 and X64002.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002096.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64002.1, X64037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394456.10/ ENSP00000377969.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                X64037.1           10-31
            23-23               BC013007.2         1-1
            24-1249             X64037.1           33-1258
            1250-2261           BC013007.2         1228-2239
            2262-2432           X64002.1           2156-2326
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2432
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="general transcription factor IIF subunit 1"
                     /db_xref="GeneID:2962"
                     /db_xref="HGNC:HGNC:4652"
                     /db_xref="MIM:189968"
     exon            1..181
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1723
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="TFIIF-alpha; transcription initiation factor RAP74;
                     general transcription factor IIF 74 kDa subunit;
                     transcription initiation factor IIF subunit alpha; general
                     transcription factor IIF, polypeptide 1, 74kDa"
                     /codon_start=1
                     /product="general transcription factor IIF subunit 1"
                     /protein_id="NP_002087.2"
                     /db_xref="CCDS:CCDS12165.1"
                     /db_xref="GeneID:2962"
                     /db_xref="HGNC:HGNC:4652"
                     /db_xref="MIM:189968"
                     /translation="MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQ
                     ARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRV
                     NGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEA
                     EEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSS
                     DASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSD
                     GSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQE
                     KKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSA
                     EGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSG
                     DVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMIN
                     DKMHFSLKE"
     exon            182..228
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            229..301
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            302..495
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            496..666
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            667..851
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1005
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1067
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1187
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1261
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1400
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1518
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2432
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="hexamer: AATACA"
     polyA_site      1757
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="major polyA site"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="hexamer: AATACA"
     polyA_site      1829
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="major polyA site"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="hexamer: AATAAA"
     polyA_site      2432
                     /gene="GTF2F1"
                     /gene_synonym="BTF4; RAP74; TF2F1; TFIIF"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccggt taccttttcc cagcgccaga ggcgcctagg gttggggtcc tcgctcaggc
       61 acagagaccc gacaccgagc ggcggcttcc ccgggatcga gggacgcgca cgccagagga
      121 gacgaaagga acccgggtcg gaccagatcg gaaccactga ccattgccca tggcggccct
      181 aggccctagc agccagaatg tcactgaata cgtcgttcga gttcctaaga atacaaccaa
      241 aaaatataac atcatggctt ttaatgcagc cgacaaagtc aactttgcta cgtggaatca
      301 ggctcggctg gagcgggact tgagcaacaa gaaaatctac caagaggagg agatgcccga
      361 atcgggcgcg ggcagtgagt tcaaccgcaa gcttcgggag gaggctcgga ggaagaagta
      421 cggcatcgtc ctcaaggagt tccggcccga ggaccagccc tggctgctcc gggtcaacgg
      481 caaatcaggc aggaagttca agggcatcaa gaagggaggc gtaacagaga acacgtccta
      541 ctacatcttc acccagtgcc ccgacggggc cttcgaggcc ttccccgtgc acaactggta
      601 caatttcaca ccgctggccc ggcatcgcac gctcactgcc gaggaggccg aggaggagtg
      661 ggagaggagg aacaaggtgc tgaaccactt cagcatcatg cagcagcggc ggctcaagga
      721 tcaggaccag gacgaggatg aggaggagaa ggagaaacgt ggccgcagga aggcgagcga
      781 gctgcgcatc cacgacctgg aggacgacct ggagatgtcg tccgatgcca gtgatgccag
      841 tggtgaggag gggggcagag tccccaaggc caagaagaag gcgccgctgg ccaagggcgg
      901 caggaaaaag aagaagaaga agggttcaga cgacgaggcc ttcgaggaca gcgatgatgg
      961 ggacttcgag ggccaagagg tggactacat gtcagacggc tccagtagct cccaagaaga
     1021 gcctgagagc aaggccaagg cgccgcagca ggaggagggg cccaagggtg tcgatgagca
     1081 gagcgacagt agtgaggaga gtgaggagga gaagccgcct gaggaggaca aggaggagga
     1141 ggaggagaag aaggcaccca ccccgcagga gaagaagcgc aggaaagaca gcagcgagga
     1201 gtcggacagc tcagaggaga gcgacattga cagcgaggcc tcctcagccc tcttcatggc
     1261 gaagaagaag acgccaccca agagagagcg gaagccgtcg ggagggagct caaggggcaa
     1321 cagccgccca ggcacgccca gcgcagaggg tggcagcacc tcctccaccc tgcgggcggc
     1381 tgccagcaaa ctcgagcaag ggaagcgggt gagcgagatg cctgcagcca agcggttgcg
     1441 gctggacacg ggaccccaga gcctgtctgg gaagtcgaca ccccagccac catcaggcaa
     1501 gacaacaccc aacagcggcg acgtgcaggt gactgaggat gccgtgcgcc gctacctgac
     1561 acggaagccc atgaccacta aggacctgct gaaaaagttc cagaccaaga agacagggct
     1621 gagcagcgag cagacagtga acgtgttggc ccagatcctc aagcgactca accccgagcg
     1681 caagatgatc aacgacaaaa tgcacttctc cctcaaggag tgaggcttgg tccaatacat
     1741 ggctctgccc cccagaactt aaggctctca ctgccccttc gccatcctag agtgaggctc
     1801 tgtccaatac atggctctgc cctccagaac ttcaggctct cagtgaccct tcgacatcct
     1861 gcttgctccc tgactcccag ggccccgtag ttagcaattc tggaaaagtt aagccatctc
     1921 ctcctctggc ccttccttct ggaatcttca gatgcctgtt aggccttctt attgtcctcc
     1981 tcctcctggc tcggcctccc tcacactgac caagggcctg tgctgcccac tgggtaactt
     2041 ctacagttct cccttccact tccctaagtc tctcttcagc tgtgacttat ccaccacata
     2101 gcccagtaag tcttcagttt tggctgggca tgatggtgag cgcctgcagt cccagctact
     2161 tgggaggcta agcccagttc aaggctgcag tgaactatga tggtgccact gcattccagc
     2221 ctgggtgaca gaatgaaatc ctggcacaaa aaaaaaaaaa aagtagccag gcatggtggc
     2281 gggagcctgt tgtcccagct gttccgtagg ctgaggcacg agattcactt gaacctggga
     2341 ggtggaggtt gctgtgagct gacaccacgc cactgcactc cagcctgggt gacagtgaga
     2401 ctctgtctca ataaataaaa aataataata aa
//
