LOCUS       NM_002095               1747 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIE subunit 2 (GTF2E2),
            transcript variant 1, mRNA.
ACCESSION   NM_002095
VERSION     NM_002095.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Qiao,X., Chen,Y., Wang,Z., Peng,N., Niu,W., Hou,S., Wu,J., Ji,Y.,
            Niu,C. and Cheng,C.
  TITLE     GTF2E2 downregulated by miR-340-5p inhibits the malignant
            progression of glioblastoma
  JOURNAL   Cancer Gene Ther 30 (12), 1702-1714 (2023)
   PUBMED   37845349
  REMARK    GeneRIF: GTF2E2 downregulated by miR-340-5p inhibits the malignant
            progression of glioblastoma.
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Zhang,Y., Zhang,Y., Ai,B., Gong,J., Li,Y., Yu,S., Cai,X. and
            Zhang,L.
  TITLE     GTF2E2 is a novel biomarker for recurrence after surgery and
            promotes progression of esophageal squamous cell carcinoma via
            miR-139-5p/GTF2E2/FUS axis
  JOURNAL   Oncogene 41 (6), 782-796 (2022)
   PUBMED   34853466
  REMARK    GeneRIF: GTF2E2 is a novel biomarker for recurrence after surgery
            and promotes progression of esophageal squamous cell carcinoma via
            miR-139-5p/GTF2E2/FUS axis.
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Ishida,R., Cole,J., Lopez-Orozco,J., Fayad,N., Felix-Lopez,A.,
            Elaish,M., Luo,S.Y., Julien,O., Kumar,A. and Hobman,T.C.
  TITLE     Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of
            Interferon in Part by Depleting Host Transcription Initiation
            Factor IIE Subunit 2
  JOURNAL   Cells 10 (12), 3510 (2021)
   PUBMED   34944018
  REMARK    GeneRIF: Mayaro Virus Non-Structural Protein 2 Circumvents the
            Induction of Interferon in Part by Depleting Host Transcription
            Initiation Factor IIE Subunit 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Phan,T., Maity,P., Ludwig,C., Streit,L., Michaelis,J.,
            Tsesmelis,M., Scharffetter-Kochanek,K. and Iben,S.
  TITLE     Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance
  JOURNAL   Nucleic Acids Res 49 (19), 11197-11210 (2021)
   PUBMED   34581812
  REMARK    GeneRIF: Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance.
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Sumimoto,H., Ohkuma,Y., Sinn,E., Kato,H., Shimasaki,S.,
            Horikoshi,M. and Roeder,R.G.
  TITLE     Conserved sequence motifs in the small subunit of human general
            transcription factor TFIIE
  JOURNAL   Nature 354 (6352), 401-404 (1991)
   PUBMED   1956404
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Peterson,M.G., Inostroza,J., Maxon,M.E., Flores,O., Admon,A.,
            Reinberg,D. and Tjian,R.
  TITLE     Structure and functional properties of human general transcription
            factor IIE
  JOURNAL   Nature 354 (6352), 369-373 (1991)
   PUBMED   1956398
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Inostroza,J., Flores,O. and Reinberg,D.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II. Purification and functional analysis of general
            transcription factor IIE
  JOURNAL   J Biol Chem 266 (14), 9304-9308 (1991)
   PUBMED   2026628
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Ohkuma,Y., Sumimoto,H., Horikoshi,M. and Roeder,R.G.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II: purification and characterization of general
            transcription factor TFIIE
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9163-9167 (1990)
   PUBMED   2251258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX421791.2, BC030572.2 and
            AA483281.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002095.5.
            
            Summary: The general transcription factor IIE (TFIIE) is part of
            the RNA polymerase II transcription initiation complex, recruiting
            TFIIH and being essential for promoter clearance by RNA polymerase
            II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha
            and beta subunits. The protein encoded by this gene represents the
            beta subunit of TFIIE. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.176763.1,
                                           SRR3476690.184229.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355904.9/ ENSP00000348168.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BX421791.2         6-26
            22-1549             BC030572.2         1-1528
            1550-1747           AA483281.1         7-204               c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1747
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="general transcription factor IIE subunit 2"
                     /db_xref="GeneID:2961"
                     /db_xref="HGNC:HGNC:4651"
                     /db_xref="MIM:189964"
     exon            1..264
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            265..434
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1144
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription initiation factor IIE subunit beta;
                     TFIIE-beta; general transcription factor IIE, polypeptide
                     2, beta 34kDa; TFIIE beta subunit"
                     /codon_start=1
                     /product="transcription initiation factor IIE subunit beta
                     isoform 1"
                     /protein_id="NP_002086.1"
                     /db_xref="CCDS:CCDS6078.1"
                     /db_xref="GeneID:2961"
                     /db_xref="HGNC:HGNC:4651"
                     /db_xref="MIM:189964"
                     /translation="MDPSLLRERELFKKRALSTPVVEKRSASSESSSSSSKKKKTKVE
                     HGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEI
                     LDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNVRDKKALLRLLDQHDQ
                     RGLGGILLEDIEEALPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQK
                     LWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVAPIQRRKKPASQKKRRFKTHNEH
                     LAGVLKDYSDITSSK"
     exon            435..526
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            527..634
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            635..817
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            818..911
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1027
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1747
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="major polyA site"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
ORIGIN      
        1 actgagctcc tagcacccga tcgggaagtg gcgggcggag tcccgggtcc agtcgccgcc
       61 tcagctaccg ccgctgccgc cgccgccgcc gccaccgcca gtggtgagac cccgacctgg
      121 cgggtcagcg ctgggcgtgc gtgcgggcag gcgggggcgc tgacgagaag caggaagagg
      181 gtgcagtgcc ggcgtgggcg gccggccgag gcggaggcgc aggaaggggg cggcgagtcg
      241 tgcgaggctg cccttctcac tcagcattat ggatccaagc ctgttgagag aaagggagct
      301 gttcaaaaaa cgagctcttt ctactcctgt agtagaaaaa cgttcagcat cttctgagtc
      361 atcatcatca tcgtcaaaga agaagaaaac aaaggtagaa catggaggat cgtcaggctc
      421 taaacaaaat tctgatcata gcaatggatc atttaacttg aaagctttgt caggaagctc
      481 tggatataag tttggtgttc ttgctaagat tgtgaattac atgaagacac ggcatcagcg
      541 aggagatacg catcctctaa ccttagatga aattttggat gaaacacaac atttagatat
      601 tggactcaag cagaaacaat ggctaatgac tgaggcttta gtcaacaatc ccaaaattga
      661 agtaatagat gggaagtatg ctttcaagcc caagtacaac gtgagagata agaaggccct
      721 acttaggctc ttagatcagc atgaccagcg aggattagga ggaattcttt tagaagacat
      781 agaagaagca ctgcccaatt cccagaaagc tgtcaaggct ttgggggacc agatactatt
      841 tgtaaatcgt cccgataaga agaaaatact tttcttcaat gataagagct gtcagttttc
      901 tgtggatgaa gaatttcaga aactgtggag gagtgtcact gtagattcca tggacgagga
      961 gaaaattgaa gaatatctga agcgacaggg tatttcttcc atgcaggaat ctggaccaaa
     1021 gaaagtggcc cctattcaga gaaggaaaaa gcctgcttca cagaaaaagc gacgctttaa
     1081 gactcataac gaacacttgg ctggagtgct gaaggattac tctgacatta cttccagcaa
     1141 atagggaaca gttttgccct ggaacagagt tacagataca caatcaagag tgttcttgct
     1201 gatgctcggg gtctgaagac tgtcttccta tctgcttctt gcggctgagg agaggagcag
     1261 ttcagtttac aaaacaagtg caaattacca aactcaaagc ttatttgagt agaatgggct
     1321 catgggcaat gtgatgttcc ctgttaacct tctgttactc cctgggagaa aggcgctgag
     1381 cgtggcatgc aggtgtcttt gctgtgtttt tctccacttc taaatggttc ctggttcctt
     1441 tcttcctcgt ttgttacttt agagcaagtt tgcccatagt cttgaatgca atatttgttt
     1501 attccaaaag aacatattta taataaaatc actgtagaag gatttttaag atgttagtga
     1561 attctgtttc ttttcattct cggaaatggc aggaagcagc tccagtctct gatttccatg
     1621 ggtcacgtgc tggggatgtg atgaagcctg cagtctgcac tgtgttgctg agcacatgga
     1681 tttcaccact ggaacacagg tgtgctgctt gttagcaagc agagcaataa agatgtgctg
     1741 gatgtca
//
