LOCUS       NM_001348353            1425 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIE subunit 2 (GTF2E2),
            transcript variant 2, mRNA.
ACCESSION   NM_001348353
VERSION     NM_001348353.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Qiao,X., Chen,Y., Wang,Z., Peng,N., Niu,W., Hou,S., Wu,J., Ji,Y.,
            Niu,C. and Cheng,C.
  TITLE     GTF2E2 downregulated by miR-340-5p inhibits the malignant
            progression of glioblastoma
  JOURNAL   Cancer Gene Ther 30 (12), 1702-1714 (2023)
   PUBMED   37845349
  REMARK    GeneRIF: GTF2E2 downregulated by miR-340-5p inhibits the malignant
            progression of glioblastoma.
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Zhang,Y., Zhang,Y., Ai,B., Gong,J., Li,Y., Yu,S., Cai,X. and
            Zhang,L.
  TITLE     GTF2E2 is a novel biomarker for recurrence after surgery and
            promotes progression of esophageal squamous cell carcinoma via
            miR-139-5p/GTF2E2/FUS axis
  JOURNAL   Oncogene 41 (6), 782-796 (2022)
   PUBMED   34853466
  REMARK    GeneRIF: GTF2E2 is a novel biomarker for recurrence after surgery
            and promotes progression of esophageal squamous cell carcinoma via
            miR-139-5p/GTF2E2/FUS axis.
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Ishida,R., Cole,J., Lopez-Orozco,J., Fayad,N., Felix-Lopez,A.,
            Elaish,M., Luo,S.Y., Julien,O., Kumar,A. and Hobman,T.C.
  TITLE     Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of
            Interferon in Part by Depleting Host Transcription Initiation
            Factor IIE Subunit 2
  JOURNAL   Cells 10 (12), 3510 (2021)
   PUBMED   34944018
  REMARK    GeneRIF: Mayaro Virus Non-Structural Protein 2 Circumvents the
            Induction of Interferon in Part by Depleting Host Transcription
            Initiation Factor IIE Subunit 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Phan,T., Maity,P., Ludwig,C., Streit,L., Michaelis,J.,
            Tsesmelis,M., Scharffetter-Kochanek,K. and Iben,S.
  TITLE     Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance
  JOURNAL   Nucleic Acids Res 49 (19), 11197-11210 (2021)
   PUBMED   34581812
  REMARK    GeneRIF: Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance.
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Sumimoto,H., Ohkuma,Y., Sinn,E., Kato,H., Shimasaki,S.,
            Horikoshi,M. and Roeder,R.G.
  TITLE     Conserved sequence motifs in the small subunit of human general
            transcription factor TFIIE
  JOURNAL   Nature 354 (6352), 401-404 (1991)
   PUBMED   1956404
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Peterson,M.G., Inostroza,J., Maxon,M.E., Flores,O., Admon,A.,
            Reinberg,D. and Tjian,R.
  TITLE     Structure and functional properties of human general transcription
            factor IIE
  JOURNAL   Nature 354 (6352), 369-373 (1991)
   PUBMED   1956398
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Inostroza,J., Flores,O. and Reinberg,D.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II. Purification and functional analysis of general
            transcription factor IIE
  JOURNAL   J Biol Chem 266 (14), 9304-9308 (1991)
   PUBMED   2026628
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Ohkuma,Y., Sumimoto,H., Horikoshi,M. and Roeder,R.G.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II: purification and characterization of general
            transcription factor TFIIE
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9163-9167 (1990)
   PUBMED   2251258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103959.18 and AC102945.2.
            
            Summary: The general transcription factor IIE (TFIIE) is part of
            the RNA polymerase II transcription initiation complex, recruiting
            TFIIH and being essential for promoter clearance by RNA polymerase
            II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha
            and beta subunits. The protein encoded by this gene represents the
            beta subunit of TFIIE. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR,
            and 3' coding sequence compared to variant 1. The resulting isoform
            (2) has a shorter and distinct C-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.636943.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC103959.18        74144-74187         c
            45-214              AC103959.18        70002-70171         c
            215-306             AC102945.2         118102-118193       c
            307-414             AC102945.2         97678-97785         c
            415-597             AC102945.2         95369-95551         c
            598-691             AC102945.2         90127-90220         c
            692-1425            AC102945.2         67495-68228         c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1425
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="general transcription factor IIE subunit 2"
                     /db_xref="GeneID:2961"
                     /db_xref="HGNC:HGNC:4651"
                     /db_xref="MIM:189964"
     exon            1..44
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            45..214
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..711
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription initiation factor IIE subunit beta;
                     TFIIE-beta; general transcription factor IIE, polypeptide
                     2, beta 34kDa; TFIIE beta subunit"
                     /codon_start=1
                     /product="transcription initiation factor IIE subunit beta
                     isoform 2"
                     /protein_id="NP_001335282.1"
                     /db_xref="GeneID:2961"
                     /db_xref="HGNC:HGNC:4651"
                     /db_xref="MIM:189964"
                     /translation="MDPSLLRERELFKKRALSTPVVEKRSASSESSSSSSKKKKTKVE
                     HGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEI
                     LDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNVRDKKALLRLLDQHDQ
                     RGLGGILLEDIEEALPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEGWSA
                     MA"
     exon            215..306
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            307..414
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            415..597
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            598..691
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1425
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="GTF2E2"
                     /gene_synonym="FE; TF2E2; TFIIE-B; TTD6"
                     /note="major polyA site"
ORIGIN      
        1 tgctcatacg cggactgctt tctaggctac cttttggaga tttgcattat ggatccaagc
       61 ctgttgagag aaagggagct gttcaaaaaa cgagctcttt ctactcctgt agtagaaaaa
      121 cgttcagcat cttctgagtc atcatcatca tcgtcaaaga agaagaaaac aaaggtagaa
      181 catggaggat cgtcaggctc taaacaaaat tctgatcata gcaatggatc atttaacttg
      241 aaagctttgt caggaagctc tggatataag tttggtgttc ttgctaagat tgtgaattac
      301 atgaagacac ggcatcagcg aggagatacg catcctctaa ccttagatga aattttggat
      361 gaaacacaac atttagatat tggactcaag cagaaacaat ggctaatgac tgaggcttta
      421 gtcaacaatc ccaaaattga agtaatagat gggaagtatg ctttcaagcc caagtacaac
      481 gtgagagata agaaggccct acttaggctc ttagatcagc atgaccagcg aggattagga
      541 ggaattcttt tagaagacat agaagaagca ctgcccaatt cccagaaagc tgtcaaggct
      601 ttgggggacc agatactatt tgtaaatcgt cccgataaga agaaaatact tttcttcaat
      661 gataagagct gtcagttttc tgtggatgaa ggctggagtg caatggcgtg atctcggctc
      721 accgcaacct ctgccttccg gactcaagcg attctccttc ctcagcctcc caagtagctg
      781 ggactacagg catgtgccac cacgcctggc taattttgta tttttaatag agatggggtt
      841 tctccatgtt ggtcaggctg gtctcgaact cccgacctca ggtgatccgc ctgccttggc
      901 ctcctaaagt gcttggatta cagagccacc acgctcggcg aggcaggtat tattattatc
      961 ctcactttac agatgaagaa atggaggcag aaaaattaag atgtttgcac cactttgtgc
     1021 aggaaatgtg gtaactgagg tcacagccag gccatctggc tctgaggcct gcaccacact
     1081 gttgtgctac ttttgcattt acgggaaagg gctaagcaca gacaaaatgt gagtgcgtta
     1141 tttgggaatt ttaagcaaag cctcattggt aagttggctc attttcttcc cttctatggc
     1201 agttacacag ttttttattc ttaactcatg tgggacaagg aagggtcttt tgaaatgaaa
     1261 ggatcaaatc tgagctttta aattctagtc tgttttctcc tcttttctgc taagagagta
     1321 gatttctaaa tcagttctga ttttatttac ccttacggtt tagagtgtgc ctgactttca
     1381 tgatacttgg ctgtcttctg ccataataaa gtgtctgcct ttaaa
//
