LOCUS       NM_005513               3000 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIE subunit 1 (GTF2E1),
            mRNA.
ACCESSION   NM_005513
VERSION     NM_005513.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Phan,T., Maity,P., Ludwig,C., Streit,L., Michaelis,J.,
            Tsesmelis,M., Scharffetter-Kochanek,K. and Iben,S.
  TITLE     Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance
  JOURNAL   Nucleic Acids Res 49 (19), 11197-11210 (2021)
   PUBMED   34581812
  REMARK    GeneRIF: Nucleolar TFIIE plays a role in ribosomal biogenesis and
            performance.
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Su Mo,J. and Cheon Chae,S.
  TITLE     MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells
  JOURNAL   J Genet 100 (2021)
   PUBMED   34553694
  REMARK    GeneRIF: MicroRNA 452 regulates GTF2E1 expression in colorectal
            cancer cells.
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Ayoubi,L.E., Dumay-Odelot,H., Chernev,A., Boissier,F.,
            Minvielle-Sebastia,L., Urlaub,H., Fribourg,S. and Teichmann,M.
  TITLE     The hRPC62 subunit of human RNA polymerase III displays helicase
            activity
  JOURNAL   Nucleic Acids Res 47 (19), 10313-10326 (2019)
   PUBMED   31529052
  REMARK    GeneRIF: the eWH domain of hTFIIEalpha can replace the first eWH
            (eWH1) domain of hRPC62 in ATPase and DNA unwinding assays. Our
            results identify intrinsic enzymatic activities in hRPC62 and
            hTFIIEalpha.
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Ohkuma,Y., Hashimoto,S., Roeder,R.G. and Horikoshi,M.
  TITLE     Identification of two large subdomains in TFIIE-alpha on the basis
            of homology between Xenopus and human sequences
  JOURNAL   Nucleic Acids Res 20 (21), 5838 (1992)
   PUBMED   1454543
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Ohkuma,Y., Sumimoto,H., Hoffmann,A., Shimasaki,S., Horikoshi,M. and
            Roeder,R.G.
  TITLE     Structural motifs and potential sigma homologies in the large
            subunit of human general transcription factor TFIIE
  JOURNAL   Nature 354 (6352), 398-401 (1991)
   PUBMED   1956403
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Peterson,M.G., Inostroza,J., Maxon,M.E., Flores,O., Admon,A.,
            Reinberg,D. and Tjian,R.
  TITLE     Structure and functional properties of human general transcription
            factor IIE
  JOURNAL   Nature 354 (6352), 369-373 (1991)
   PUBMED   1956398
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Inostroza,J., Flores,O. and Reinberg,D.
  TITLE     Factors involved in specific transcription by mammalian RNA
            polymerase II. Purification and functional analysis of general
            transcription factor IIE
  JOURNAL   J Biol Chem 266 (14), 9304-9308 (1991)
   PUBMED   2026628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA498425.1, S67859.1 and AC117472.3.
            
            On Nov 22, 2018 this sequence version replaced NM_005513.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.1917.1,
                                           SRR1803611.158154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283875.6/ ENSP00000283875.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA498425.1         34-51
            19-1549             S67859.1           1-1531
            1550-3000           AC117472.3         45060-46510         c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..3000
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /note="general transcription factor IIE subunit 1"
                     /db_xref="GeneID:2960"
                     /db_xref="HGNC:HGNC:4650"
                     /db_xref="MIM:189962"
     exon            1..51
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            52..529
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1401
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /note="TFIIE-alpha; general transcription factor IIE 56
                     kDa subunit; transcription initiation factor IIE subunit
                     alpha; general transcription factor IIE, polypeptide 1,
                     alpha 56kDa; TFIIE alpha subunit"
                     /codon_start=1
                     /product="general transcription factor IIE subunit 1"
                     /protein_id="NP_005504.2"
                     /db_xref="CCDS:CCDS3002.1"
                     /db_xref="GeneID:2960"
                     /db_xref="HGNC:HGNC:4650"
                     /db_xref="MIM:189962"
                     /translation="MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNSCVK
                     EEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNV
                     VKYKLDHMRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHTE
                     VEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSK
                     DHAATTAGAASLAGGHHREAWATKGPSYEDLYTQNVVINMDDQEDLHRASLEGKSAKE
                     RPIWLRESTVQGAYGSEDMKEGGIDMDAFQEREEGHAGPDDNEEVMRALLIHEKKTSS
                     AMAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAVAVHKREEDEEEDDEFEEVAD
                     DPIVMVAGRPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE"
     exon            530..731
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            732..973
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            974..3000
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="GTF2E1"
                     /gene_synonym="FE; TF2E1; TFIIE-A"
                     /note="major polyA site"
ORIGIN      
        1 agttgaagcg ctgggggcag ctgtagtggg agtgttccag gattcgcctt gtatatttaa
       61 agttggagtt cgttgctaaa gatggcagac ccagatgtcc tcactgaagt tccagcagca
      121 ttgaagcggt tagccaagta tgtgatccgg ggattttatg gcattgagca tgccttggcc
      181 ttggacatct tgatcaggaa ctcctgtgtg aaagaggagg atatgctgga gctgctcaag
      241 tttgatcgga agcaacttcg atcagttttg aataatttaa agggagacaa gtttatcaaa
      301 tgcagaatga gggtagagac tgctgcagac gggaaaacca ctcgccataa ctactacttc
      361 atcaattatc gtactcttgt taatgtggta aaatataaac tggaccacat gagaagaaga
      421 attgagaccg atgagagaga ttcgaccaac cgggcttcct tcaaatgtcc tgtctgtagt
      481 agtactttca cagacttaga agctaatcag ctctttgatc ctatgacagg aactttccgc
      541 tgtacttttt gccatacaga ggtagaagag gatgaatcag caatgcccaa aaaagatgca
      601 cgcacacttt tggcaaggtt taatgaacaa attgagccca tttatgcatt gcttcgggag
      661 acagaggatg tgaacttggc ctatgaaata cttgagccag aacccacaga aatcccagcc
      721 ctgaaacaga gcaaggacca tgcagcaact actgctggag ctgctagcct agcaggtggg
      781 caccaccggg aagcatgggc caccaaaggt ccttcctatg aagacttata cactcagaat
      841 gttgtcatta acatggatga ccaagaagat cttcatcgag cctcactgga agggaaatct
      901 gccaaagaga ggcctatttg gttgagagaa agcactgtcc aaggggcata tggttctgaa
      961 gatatgaaag aagggggcat agatatggac gcatttcagg agcgtgagga aggccatgct
     1021 gggcctgatg acaacgaaga ggtcatgcga gcactgctca ttcacgagaa aaagacttcc
     1081 tctgccatgg ctggttcagt gggggcagct gctccagtga ccgctgccaa tggcagtgac
     1141 tcagaaagcg agaccagtga gtcagatgat gattctccac cccgtccggc agctgtggct
     1201 gtgcataaac gagaagagga tgaagaggaa gatgacgagt ttgaagaagt agcagatgac
     1261 cccattgtca tggtggctgg ccgtccgttc tcctacagtg aagtgagcca acggccagag
     1321 ctagtggccc agatgacacc agaagaaaag gaagcatata tagcaatggg acaacgcatg
     1381 tttgaggacc tctttgagtg agctttccct aattctttct cctttctcta atgctcagtt
     1441 caaaaaggaa tgtctcatct ttgaagaaaa gtatttaagt ggctttctgc ccctcttgat
     1501 gtaagcaact gtccatcctt gtgcaaagat tgatggtaga gagtttgact tttatgccag
     1561 aaactttccc agcaaggtag ggtgctgaga atcctaccct tccttgctgt cactacagta
     1621 ttaatatttt actgtatttt cttttctttt tttttttttt ttggagatga agtctcactc
     1681 ttgtacccca ggctggagtg caatggcgtg atctcggctc actgcaacct ctgcctcctg
     1741 ggttcaagcg attctcctgc ctcagcctcc cgagtagctg ggattacagg tgcctgccac
     1801 catgcctggc taatttttgt atttttagta gaggcagggt ttcaccatgt tagccaggat
     1861 gatctcgatc tcctgacctc atgatccacc cgcctcggcc tcccaaagtg ctgtattttc
     1921 ttatctgatt tttttcttgc cttattaaga cataattttc tcccttctga aatgagtgag
     1981 ggaagttcat aaggtaaatc cttcccatcc atctgtttac tacaataggt tacaataatt
     2041 cactgatcac atccatttta tctgttctag ccaggcattc caaacaattt cttatactgc
     2101 tgcccaccaa agcagcttgc caacagtcaa atcactgatt gggggaaaaa atcctgaaat
     2161 tttgcttaga atttgagcat ttcctcaaaa ttgagatgga tcaatatgta aggggaggtg
     2221 ggagcgtgtg tggaaggggg agagatatac ttgagtctta tgattaatgt ctaaaccaga
     2281 atttgtgtct ttagaactga ccagactggt agattttatt gtattgctta atgtcttttg
     2341 gtttggattt aggatgatag aaaacagaag tataattggt aaacccttag gaagaaatta
     2401 gaaaaacatg gacgtaagac aagaagtctc tgtgaagggt tgaagagtga caagcattgg
     2461 taacagtgcc ttagaactgt gtcagttagt ctgatttgga aatcctttat gtaaagctga
     2521 gactggtcct ggttttgttc cctttgggta cagacctctt gtcagtgcta taaattgttt
     2581 aatgaggcca ttccagcaga aatcaacaga ataattgatt actcttctct ctctctgtca
     2641 ctctccctct ttctaaacat cattgaaggc tgtctctctt ttaatttttg tcagacacag
     2701 tattttaggg tgcatccagt ataccattga gcattgtaac ctcaggaaac agtttatttt
     2761 gggttctgat atgtagcatg gtattttccc taaggcagaa ctttaaaaat aaagaacttt
     2821 cacacaaggg tctgtaacaa ttgtatatct tacaatattt ttccttgcat tgtaattttt
     2881 aagtatttat cattttatag tacacatgta aagaatatat gagccttgta tggagtgatg
     2941 tttcatttac ctgggttgtg ttaatgactg aatgttgaca ataaatctgt tttatactga
//
