LOCUS       NM_001278940            6410 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens general transcription factor IIA subunit 1 (GTF2A1),
            transcript variant 3, mRNA.
ACCESSION   NM_001278940 NR_048573
VERSION     NM_001278940.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6410)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6410)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6410)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6410)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6410)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6410)
  AUTHORS   DeJong,J., Bernstein,R. and Roeder,R.G.
  TITLE     Human general transcription factor TFIIA: characterization of a
            cDNA encoding the small subunit and requirement for basal and
            activated transcription
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3313-3317 (1995)
   PUBMED   7724559
REFERENCE   7  (bases 1 to 6410)
  AUTHORS   Ozer,J., Moore,P.A., Bolden,A.H., Lee,A., Rosen,C.A. and
            Lieberman,P.M.
  TITLE     Molecular cloning of the small (gamma) subunit of human TFIIA
            reveals functions critical for activated transcription
  JOURNAL   Genes Dev 8 (19), 2324-2335 (1994)
   PUBMED   7958899
REFERENCE   8  (bases 1 to 6410)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   9  (bases 1 to 6410)
  AUTHORS   Ha,I., Lane,W.S. and Reinberg,D.
  TITLE     Cloning of a human gene encoding the general transcription
            initiation factor IIB
  JOURNAL   Nature 352 (6337), 689-695 (1991)
   PUBMED   1876184
REFERENCE   10 (bases 1 to 6410)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136040.5, BC050703.1 and BC107156.1.
            
            On May 31, 2019 this sequence version replaced NM_001278940.1.
            
            Summary: Accurate transcription initiation on TATA-containing class
            II genes involves the ordered assembly of RNA polymerase II
            (POLR2A; MIM 180660) and several general initiation factors
            (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of
            these factors is TFIIA, which when purified from HeLa extracts
            consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul
            2010].
            
            Transcript Variant: This variant (3) includes an alternate exon and
            uses a downstream start codon compared to variant 1. It encodes
            isoform 3 which has a shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.9486.1,
                                           SRR14038193.595634.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL136040.5         100437-100443
            8-324               BC050703.1         1-317
            325-381             BC107156.1         54-110
            382-1684            BC050703.1         374-1676
            1685-6410           AL136040.5         141219-145944
FEATURES             Location/Qualifiers
     source          1..6410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.1"
     gene            1..6410
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /note="general transcription factor IIA subunit 1"
                     /db_xref="GeneID:2957"
                     /db_xref="HGNC:HGNC:4646"
                     /db_xref="MIM:600520"
     exon            1..471
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            472..573
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            574..640
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            641..845
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             659..1639
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /note="isoform 3 is encoded by transcript variant 3;
                     glucose regulated protein, 58kD pseudogene; general
                     transcription factor IIA, 1, 19/37kDa; TFIIA alpha/beta
                     subunits; transcription initiation factor IIA subunit 1;
                     general transcription factor IIA 1; transcription
                     initiation factor TFIIA 42 kDa subunit"
                     /codon_start=1
                     /product="transcription initiation factor IIA subunit 1
                     isoform 3"
                     /protein_id="NP_001265869.1"
                     /db_xref="GeneID:2957"
                     /db_xref="HGNC:HGNC:4646"
                     /db_xref="MIM:600520"
                     /translation="MQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQ
                     TVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATAATLALPAGVTPV
                     QQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLP
                     GGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQAQPAQTQAP
                     LVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQ
                     ELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW"
     exon            846..910
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            911..986
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1120
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1441
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1531
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..6410
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6381..6386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /note="hexamer: AATAAA"
     polyA_site      6410
                     /gene="GTF2A1"
                     /gene_synonym="TF2A1; TFIIA; TFIIA-42; TFIIAL"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcggc ggcggcggcg gcggcggtgg tggctcgcgc agcttgttgg ctcgctatat
       61 aaaggagaga agcgggcgga ccggacggct ggagctgcag ccggtggcgg cagcggcggc
      121 gcagggagcg gtgaccggtg gtggtttccc tccttggcgc ggggtgggga gcgggcaacg
      181 ccccccggac ccctgaaggg tcgtggcttt tttttttttt ttaaggcgat tctcgaggtt
      241 ttcagctgcg ggaggagtgc ccccctcctc ctcctctctc cgctctcccc tactccttca
      301 ggattgattt tgtttaaaat tttttcccca atcttgcggt gatttgggtc accctccggg
      361 tgttatagtt tttttttttt tggttttgtt tttatcttgt tttcttgggg ttgccccctc
      421 ttgtttgtgt tgtgtgtgga aatggcgaac tcggcaaata caaacaccgt gcctaaatta
      481 tacagatctg tgattgaaga tgtcattaat gatgtgagag acatctttct ggatgatgga
      541 gtggatgaac aagtactgat ggaactaaaa actatcctga ataagacagt tgctgcccag
      601 aagatgttca tactttggta gaaatggtag actttgtgtg ttatgggaaa acaaactaat
      661 gcagtccagg gcagtagatg gatttcattc agaagagcag cagcttctac tgcaagttca
      721 acagcagcat caaccccagc agcagcagca tcaccaccat caccatcatc agcaagctca
      781 gcctcagcag acagtacctc agcaagcgca gacccagcag gttcttattc ctgcatcaca
      841 gcaagccaca gcaccacaag ttattgttcc agattctaag ttgatacagc atatgaatgc
      901 atcaaacatg agtgctgctg ctacagctgc taccttagca ctccctgcag gtgtgactcc
      961 tgttcagcag atattaacaa attcaggcca gcttcttcag gtggtcagag cagccaatgg
     1021 tgcccaatat atctttcagc ctcagcagtc agtggttcta caacaacagg ttataccaca
     1081 aatgcagcct ggtggagtac aagctcctgt tatacagcag gtgctggctc ctcttcctgg
     1141 agggatttca ccacagacag gtgtcatcat ccagcctcag caaatcttat ttacaggaaa
     1201 taagactcaa gttataccta cgacagtggc agcacctaca ccagcccaag cacagataac
     1261 tgcaactggc cagcagcaac cgcaggccca gcctgctcaa acacaagctc cattggtctt
     1321 acaagttgat ggaactgggg atacatcatc tgaagaagat gaagatgaag aagaagacta
     1381 tgatgatgat gaggaggaag acaaagagaa agatggagct gaagatgggc aggtggaaga
     1441 agagcccctc aatagtgaag atgatgtgag tgatgaggaa ggacaggaac tctttgacac
     1501 agaaaatgtt gttgtatgcc aatatgataa gatacacaga agtaaaaaca aatggaaatt
     1561 tcatctcaag gatggcatta tgaatcttaa tggaagagat tatatatttt ccaaagccat
     1621 tggagatgca gaatggtgaa gagttgcttt ttttctttta taaataaaag aaacttaaaa
     1681 aaaatgtaaa gcggacagtt tgaaacttgg ggcatatgcc aaccaaaact tcgtttctgc
     1741 atgtcagaaa agtgcagtag aagcaaagct actggaacaa agatagacct tgacaacata
     1801 gacactactt actggcaagc catggaactg tagcacctag ggtttttggg tgggagggtt
     1861 ggggttttgt gtaggaaaac cataattgtt gattttaaat acaggtacct gccaccggta
     1921 attagcatgt aaagctttgt ctatattcct tcctccaact tgggttcaat cagaagatac
     1981 ttgttggaat gaactgaaga aacttccctt ttgatagatt gaactgaaac tgcttattgt
     2041 atgtggttat atttggtaaa agttgcgtgt gagcttttta caaaagggta agaattgtgt
     2101 tgaattttaa ttcacttgta taagaaaaca atttaaaact ctcataatag gtcttaaata
     2161 tttttacttg ctattctccc tcagtgatat atacctcttc ctttccagct ttatgaaaca
     2221 tctatttaag atttaaagtt atcagtgatc atagtttgga gataaaattt gacccaggaa
     2281 tgaatattta ttttaattag gttttcatac ttattaaatg taattaaaga cttgggtctt
     2341 gtctgagttc agtggaattg aaaccacaac tttaatttcc ttacagaaaa acttaatttg
     2401 tttcttttag tgccacacct taaaaagaaa ccccaaacta gctcctcagg aatatagttt
     2461 tattttgcaa gcataccatc tagctgaaat tgtatacaca tgaatatatg tagacttttc
     2521 ctgttgggct gaagtgtgtg cttataaatg tgtttagttt ttaagctaaa cattcagtta
     2581 acagtctgtg cattgattag catagggcag gtggtgagga cctggatttt tattaaacag
     2641 tttagtaatt ataaaagttt cttgtgttta ctagtaaaga attttaaaaa tctattctaa
     2701 ttcaacaagt ttttaaaatc aactttgtaa tttgagggga aaatttgggg ggaagaggtg
     2761 ggtgggccac taagttacct ctctttcatt tggtggccct tccaggccat tgaaaataaa
     2821 gacgttggct ccagtttgca cattgggaag aaagcataga aatttgactt gtatattaaa
     2881 aataatagaa atgtaatatg tatattaaga atgcataggt ctgtattctg taaggggctc
     2941 tgaagaacaa tatggcactg ctgtgttcag tgtgaattca ctgcctggga gaactgcagg
     3001 aatgcttgtc ttcaccattg tgttcttaca acgaattcaa ctttccatgg tttatcttga
     3061 caaaatttac atgtgtttag gttacttgta tattgatata tttttttaat cttcagtttt
     3121 tgtcttcctt ttgcctttgt gttttcagaa gtaacacatg aacacttttt aaagtacatt
     3181 acagagaaga aaactgtgag ctattatata gtgtttcttt tttaacacaa atcttttaac
     3241 tttaaaaaaa ggcaaaaatt ttttttttct acttcccacc cagcttacca ccttgatctc
     3301 tttaacttat gttctaaact ttggtgttaa tggtggtgtc tagcatgcta gtagttagat
     3361 tttatttaga tgccataact ggtaatacag cttttatttt gactatatta atttagtttt
     3421 ttgaggggaa gtttgtttat tctgtgactc tcaaagcaca cagaggtttt aaaatatata
     3481 ttattaagac tgagagaaga ggaaatggga gggagtaaca tcacagaagt gctgttgttc
     3541 aactgttctt caatatagtt gctagtaggt ttgtatttac tcagtaagga agtcagtgac
     3601 ctgaactacc tataaaaatt cagcagtgct gcagtgttgc ttaagtgaaa ccctttggct
     3661 atctagtagt ttttatgcta ctgaaacttg gattactgta tgatattcag cttgtcttgg
     3721 gccctctatg tagacaaaca ttcatattca tagtagtgtt gtatactggc ctgtttttat
     3781 aactttattt ttcaaatatt aacaaccact gctttcagag tggttatttt gttatttttg
     3841 aagcaggaaa taaccatttg tatttgcacc tgcgtattgc atatgaatta tggtatactt
     3901 ggcaaatgct tttcttttac ctgtgaaaat tctgaaagct ggtccaagct acattgcata
     3961 ccaaattgtg ctcttatata ttatttgcat cgtgtccttt ttaatcaaat agcatgtttt
     4021 agttttatta tagtagcttt tgctgtaaga atgtcacttg cttatctttt attgtacttg
     4081 aattcttaat catgctttta acattgtatt taacaaatca tttcgtatta ggttccatta
     4141 aaatgtcatt cctttgaaaa ggcaagggat ttccactttc agaatttgaa aatgaaagta
     4201 gcatgtttat ctaaaggcag aaaatagttc ggacttggta ttatgaaaat aagtaatggt
     4261 ttctggagag gatttgttta gatttgcaca gatggcgatg gcacctttta cttaaattaa
     4321 cattaatcaa cagtgctaag gaaaatttac acaaaattac aagataaaac atggaaatgt
     4381 gtgcctttca gtatacaaac tcttgcttgg tggccatttg ggtaatcaga ccatttgaat
     4441 gcctgagagc atgtttaatt tctgtggagt gccacatatg gctaaaacaa ctctttaatg
     4501 tgcaattaat ttctagagta aaatgtctgt tatgtgaggg ggatctttat gttgggcttt
     4561 tctatttttt aaatgttcac atttctttct gttaattaaa atgccatcat aatgtcacat
     4621 ttacactgtt gcctctttta aaagcaaagc cactttcttg ttctaagatt acatcaagac
     4681 ttgagcagtg tgtagtaatt aaaatgtgtg cttaatgagc ataatagatt ctggttttag
     4741 gaaataacat atagctttta tatgaatatt ttcttttgct ataatgaaag tcacagattt
     4801 tttttttcct ggcttttatg gaggaatgaa aagagttgtc tccctctaag agtatactat
     4861 ttttgattct catagcaata atgtcaccat tcttatcaga gggtaaatac cccttgtata
     4921 ggaaaacaga cataatttcc tcttgggagt tctctttatg acttagcatt ttcttctact
     4981 tgagaaaatt cctgtttttc cgattatttc atcttgaact ttcttttttt taagcttttg
     5041 tgcaatgtaa tagtttgttg atccatcttt gtacattttc attttatttc atgtctttct
     5101 ctcacctacc tgtcagaatc agctatagca gattttgaat tctttagtta aaaaatagtt
     5161 gctttacttg tttcctcatg agtttgttaa atagctttgc attttagtcc tctattatgc
     5221 tatgaaaatt attacgaagt ttatattgtt ccctttttaa gcctgcctta ctcttgtctt
     5281 ttgtcattgt ctatggttta atgaagaaca caccaaacta acatttttgt ttattttgag
     5341 gaacaaaaaa acttttctct tttaagggaa gttactacac attgagttag taactactct
     5401 ttcagtcaag gttccttaat cagtccagtc tacatcagga ctatgacttg gggggcgggg
     5461 ctaatccttt ttgctgttct gagctactat tgtcaactgc tgttgtacat actgttatgt
     5521 gtaatggcgt aaatatattt attatgtttg taaaattcat tgcagatcaa ggttgctctt
     5581 ctgtgatata tgggatatta tgttttaaag accatcttgg aatacaatta gagaacttag
     5641 tattttgatg tactaagacc tattttaagt ttaatattct actttgcaaa aactttaatt
     5701 aaagatgtta tttaaaaaaa aatgttgctt gctttgctta ctagtatatg gcattgttat
     5761 agataattga ataaaataca atttagaaag gaaaatgctt tacattgtta atgagaattc
     5821 catttaacaa caacaaaaag atgctaaatt ctgtacctta aagataagta gattgagatg
     5881 tcaatttgaa ttagtaaact gtgttacaaa tgattaatac tagcttttaa aaagttgtat
     5941 tttccaggca cacaggaatt taggttgggc gaattcacac taacaaatta taactaaaaa
     6001 ttggtataat taacattgtt tttcaaaata aagattactc cttgtgaaat attaataatt
     6061 aacatattgt attaaataag tatttctact ccaaagtata gattacttag gataaaaaca
     6121 ttgttatttc tctgtttagt caaaccactt cctcttagtt cagaggttat aaataattgc
     6181 atattaggag aattggatta ctgaggtttg tattgcgtat tgaatatatt ttgtgttatt
     6241 ttagaagata ataattagca ggtattttaa ttttatagtt aattcagctg aatcattaag
     6301 aagctcgcct ttttgtattt ttttatcctg ttaacagact atctagaaaa catgcaaatt
     6361 ttaactatta acataatcat aataaagata tcttatttat tgccagcaaa
//
