LOCUS       NM_001376332            9976 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 46, mRNA.
ACCESSION   NM_001376332
VERSION     NM_001376332.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9976)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 9976)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 9976)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 9976)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 9976)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 9976)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9976)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 9976)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376332.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.19648.1,
                                           SRR3476690.949577.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-136              AC009957.11        120958-121019       c
            137-201             AC009957.11        96797-96861         c
            202-403             AC009957.11        93885-94086         c
            404-571             AC009957.11        30854-31021         c
            572-745             AC009957.11        27164-27337         c
            746-816             AC016910.6         117406-117476       c
            817-908             AC016910.6         116615-116706       c
            909-9976            AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..9976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..9976
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..136
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            137..201
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..992
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform n is encoded by transcript variant 46;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     n"
                     /protein_id="NP_001363261.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFCKR
                     PDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL"
     exon            404..571
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..745
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            746..816
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            817..908
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            909..9976
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2030
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      9943..9948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      9976
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggaggtatct ctgcattagc cagattggac atatgtaaag ggacatcagt
      121 atatctggat catcagattg tgcttcaaga agaccatagg gaagaacgca ttttcatctt
      181 gctgcaaaag ttgcaataga agatctgaag gtttgaatgg gccaatgagt atcctcatca
      241 ttgaagcatt ctatggaggc tcccataaac agctggtgga tcttcttcaa gaagagttag
      301 gagactgtgt cgtttatacc cttcctgcaa agaaatggca ttggagagcc cggacatctg
      361 ctttatattt ctctcagacc attcccatca gtgagcatta caggaccctc tttgcaagtt
      421 cagtgcttaa cctgaccgaa ctggctgccc ttcggcctga ccttgggaaa ctgaaaaaga
      481 ttctgtattt tcacgagaac cagttgatat atcctgtcaa gaaatgtcag gagagggatt
      541 tccaatatgg atacaaccaa attctttcat gcctggtggc tgatgtggtt gtattcaact
      601 cagtttttaa tatggaatca tttctcactt ccatgggaaa atttatgaag ctgattcctg
      661 atcacagacc caaggatctg gaaagcatca tcagacccaa gtgccaagtt atttactttc
      721 ccatcaggtt tcctgatgtg agcaggttgg aagctgtgta ctgtgggtgt tacccacttt
      781 gtcctaaaga tttggtttat cccgaaatat ttccagctga atatctgtat tctacacctg
      841 aacagctttc aaaaaggctc cagaatttct gcaagagacc agatattata agaaaacatc
      901 tctataaggg tgaaatcgct ccgttttctt gggcagccct acatggtaaa ttcaggtctc
      961 tgcttacaac agaacctagg gaagatttgt gacagatggg gctaagtcac aaacttgcag
     1021 cctaaggcag aatctgaaga actttccaga gtgtgcccat atttacctga tcagagagaa
     1081 aagaaaatct gcagaggaag ctgagcctgg ctgcttgtca tagctgacac agagccatct
     1141 gccacaaacc tgtggcggct tcagatctcc aatccctgcc accaccccaa ctcaaattaa
     1201 atacagattc ctagagacgt tatgatggtt acacatgtcc tcggcatcac atgtaggaga
     1261 ctgttcaaaa aaaatatgtg gcctgttgta taaccgcact catgtatccc atatgtggtg
     1321 ccacattgaa tttccggttg aatccgtttt tatcctttgt actggatgac atggtgcctg
     1381 aattctttct tttcgccgac acgatggcag ccaaactgca gcttcaaacg ctcacacttg
     1441 gctgggtttc tacctaggtt gccaggttat catcggagcc ttcttgtgtc ctcaaagggc
     1501 cacgaggcct gaaaggagga tcagaatgct ttgggattaa ttgggcagcc atcgcagaat
     1561 tgtttgtggg caaagggctg ctttagcact tttcttttag caaattaatg actctcaggc
     1621 acagggggtt ttaagtgaag gtattaataa gaggtctggc aggtattccc atgattcaca
     1681 gagttacatt tgcatttaat taatcttaaa gttgcaagat aaacagctgt aattcggaca
     1741 aacatgacaa acacagtgaa gccaactatc ccataaaatg aacactgaca tacttgtttt
     1801 aatttttttc ccagcgtaaa aatagaaaaa tcaaaatact cctaacaaaa ccagtgattt
     1861 tgatagaaat atttctccaa tatacttgca tccacctaca aatataacct tttcaagata
     1921 aatcgcttat gatttcaata gtcaaactgc tgtgtttgtt gatgtaaaga tgttttgaat
     1981 ggctagatgg taaaataaat tcttaataaa gtacccactg caatttttaa ttagcatatt
     2041 catttacata tagatgtata catctaccta tgtgtttctc actgaacgtt ttccttgtga
     2101 cagagacaac aaatacaatt gtttcttttc cggatgaaca aggatctgtt ttgcaaatgt
     2161 ttgtaagata ttatgacatt tccaagattt tctttgcatt ctggaaagca ggaggtaaac
     2221 atttgtagtc attaaggtaa agtctgttga taaaccatct tctgtttact gacaggtaaa
     2281 ttgtaacttt ccctagcttt tgaaatgagt aacttctata caccacaaag tgaggcacag
     2341 cctgggaaag gtggctagac aaggggcaag ccaggctttc tagcttctgg aaggatcgag
     2401 tggcctagca ggcatctaag ataaagaaag caatgattcg gaagtccagt agggcccatt
     2461 tgaccggtag caaaatcgaa agcacgaaat agatcaaggt tagggagcca gacaaagccc
     2521 ttggaagaga ggcagtattg cagatcgaag caagcagttc agagtctatg aggcctggga
     2581 atttaaaagc aggaagagta agaagcagaa acaagaagct ccatctgaac agactcctct
     2641 ctccaacctt catgagaccc acagtgtgtg atgggccacc acagcactgg cttctagact
     2701 tttacaggga agccagtgaa caaattacct cgtcacccag aaaacaaaga gctcaggaac
     2761 tattttggaa gttccttcca gtctaagact atggaactca gaatctagca ggtgtgttcc
     2821 tttggatagc aaaactaaag atataaatat gaataagaaa ttctttgcca cttctcctgg
     2881 gcaaggttat actttatgcc atctactgag ataaaccaga tgagtcagtt tgcttctgtc
     2941 agttgctgtg tcacagatga catcttctca aaataatatt atctcacagc caagaaatag
     3001 cgcttcgttt actgtgtttt tctatcctga aactaaatgg gcttacgctt catagtggct
     3061 aagatactcc acacacaact agtacccata gatcttttct cactgatagg aaaaaaaaaa
     3121 aaaaagcatt aaacaccttt cagagagtac atctgaaaca tttacgtatt ttcctgattt
     3181 aggcaaatat aatattgaaa gttacctgta tgtgggcatt tttttctaca ctcataaatg
     3241 caaatcaaat tttgccatta gctgtggcca acattccttc caggacaaaa gcttacatta
     3301 ggccgggtgc ggtggcgcac gcctgtaatc ccagcacttt gggaggccga gacgggtgga
     3361 tcatgaggtc aggagatcga gaccatcctg gctaacacgg tgaaacccca tctctactaa
     3421 aaatacaaaa aaaattagcc aggcatggtg gcgggtgcct gtagtcccag ctactgggga
     3481 ggctgaggca ggagaatggc gtgaacccag gaggcggagc ttgcagtgag ccgagatcgt
     3541 gccactgcac tccagcctgg gcgacagagc gagactctgt ctcaaaaaat aaataaataa
     3601 ataaatttaa aataaatttt aaaaaaatta cattaaaggt gtcacttatt tgcatgatac
     3661 cgagatttgg agtttaaaga aaaaccttat aaagactgta atgtcagagt tgctactagt
     3721 tcacataagc aataaaaagt tttgtaaatg tgtaattctt aacatttaaa aatatgtagg
     3781 agtgtgtgtg tgtgtgtgtg tgtgcacacg cacattcatg cttctcaaca cccacgacct
     3841 agtggaatgg agtgttatta aataagttaa tcagtatttt gttgaaatct cagcagataa
     3901 ttagtactac acgttgactc attaattcag tttcccttat caaccacccc catcatttat
     3961 tgttttgagt atgtttgatg gaaaacttag tcttcctctt tttttttaac actcgattgt
     4021 ttttttcttt taaaataaag tcaattttaa ttttaaatgt ctttaaaagt ccatccatta
     4081 tcaagacttt gacacagtgt cttgaaatac agcttgccct aaacttaatc tatgcttctg
     4141 gctaggtgtt tctataacaa atatcagggc acctggttct taaccttctc atttatactg
     4201 tgttgacaga aatagatgca aatacctttt taaaaatgct cctggtttaa taagcatcct
     4261 tcaaatacag ttaagtttaa atgccctgct cctgttctca gtccttcaga catcaatatg
     4321 gcaggcagaa tccataagtc aatggaaact cttagccata gagggctgca gagattaatt
     4381 tcaacacctt gaaatgcatc tggaagcaaa gatttcattt tatgttgaag gtgttaatta
     4441 tatttgatat ttttaaaagt aaaatctgtt tttgagaaag catctgctac ccagaaatat
     4501 tatgagccac aaaagaaatt ttactgaagt ctcaagatac tttctgtgga tgatagaatc
     4561 agttttcaaa tgatagtcca tgctgtcttt taatgctgac atacactgtg ggtcttattc
     4621 ttctattgac tattgaccca actgcctttc tttttcagtg gaaaatttgg gactatttaa
     4681 tattagatct tatgtttaac aatgaagaga gtatattata aaccactgac ttgaacatgt
     4741 ttcattttaa aatttgagtt gtgatacaga caactaatgc tcctatccta tgccctctct
     4801 tcaaagctat tcattaaaat ataactgggg aagtttgaaa aacatgcgag caattctaca
     4861 tgctgctcaa agatacagac atgtgtgatt aaagtacagt attacagaaa acctgggaat
     4921 taaccaaact tacaataatg gttatgtcag aggggccatg gtagagaaaa aaaaggacat
     4981 agaagtaggg aaaggtgcat tcgttgcatg atgagaagtc tgtttcttaa gctgagtcgt
     5041 gatacacaaa ggcttcttgc cactctttgt gacatttcat gtgtcttcag tgtatttatt
     5101 gcatatatct tttgatagga gatataaata cttcaggaag catgttacta gttttgctat
     5161 caggctatcc ttaacatttc ttggttttct caattattga ttgagtcaga aaactgcttg
     5221 cctcagacag tgatacaaac tactctactg ccaatgttgc ttgagaagac tttcctctgc
     5281 ttaacaggag ccaggggctt cacctcaacc ctcatgctgt ggagaaagtc agactcaact
     5341 ggccacaggt tcctgtttct tggggctgct aatcaccatt tctaacagat gcctgtggca
     5401 ttgcaaacac aagatggaaa actatagctc taaactccct tctgaagggt aaggaaagga
     5461 agaggaaggc agatgttaaa tgagcccagt ctttctcatc tcaaaaaatt cagagctgcc
     5521 tgttagagca caagagctct cagagctccc aaccacactg cccactcccc atagtgttgc
     5581 ctctcccctt tcctctttaa gacgcaggag cgaatcgtgg tctttgtgct ttcactgcaa
     5641 tctatcccag gggaagagtt ctcccgggta tctgtgggat gcccttgctg catgtgaggc
     5701 acaaatggct tcagggacca ggatcctcac tcactctgca gtccattttt ctaaattgga
     5761 atttgcgatc ggtttcttca ggtgtcccac catcatctat cattatctga gttattcctt
     5821 atcctctccc aaccccaagg agaggatctt aattgttttt ataaactgac agaaggaatt
     5881 ggtgattctt ggaagataat tttaaatggt tatattactt tcctattact gcatttactg
     5941 catttaaata gcaggtctaa ggtggggtgc gagaagatgt gacccctagg aatattggta
     6001 tgacctttct caagcaattt gaagtccttt agatctgaaa atttaatgtc ttcaatatca
     6061 tttcacagat gagaaaatta aggcacatat agtgacatat ttaggagctg aagtgtgtta
     6121 cagaaacaaa gtttttttgt ataagccttt ccctacatgg gatgttatca ttgtcaccta
     6181 tgtgcctttc aggaagcacc aagtgcagta tgcgtgactc agttggaccc ctagttccct
     6241 tctatttctc cagctggcag gagacagcaa aggacagtgg aggtggttat tttgtggccc
     6301 acatttctgc cattaaaagg gacataagag actatgtagt gtggccaatt tttttttttt
     6361 tttttttgag agagagagtc tggctctgtc gcccaggctg gagtgcagtg gcaccatctc
     6421 ggctcactgc aagctccacc tcccgggttc acgccattct cctgcctcag cctcccgagt
     6481 agctgggact acaggtgccc accaccacgc ccggctaatt tttttgtatt tttagtagag
     6541 acggggtttc accatgttag ccagggtggt ctcaatctcc tgacctcgtg atccacctgt
     6601 ctcggcctcc caaagtgctg ggattacagg tgtaagccac catgcccgga atatggccat
     6661 tattttaagt gtttttatta ttgctctggt tctcccttta gggaggcatt cagtgagtat
     6721 accccatctg tcacaggccc ccaccactcc ctgtggtctt acactctgct gaattcatac
     6781 atttaggtaa cttccctggc cctcctgaga atcacttatt tttgtaacct cctgtatttg
     6841 agatgtagga aactggggcc tgaggagaag ttgacttgcc ttgggtccca cagtggtaca
     6901 ggcagatcta gaactcagat tttccagggc tctttcagta ggctgtggtt gagcagtagt
     6961 caagaccacc tcttcaagaa gggaaaaaca tttgtcttct ctttctcctc tttcttcctt
     7021 ctgcctctca ctgtaagaag aaacgtgtta ataagttgct aataccttac tctaggtgta
     7081 tttcatgtta caccagccag tgcttgtatt ctcaatgacc ataaggagag gaatgcggaa
     7141 gaattgattt ctgtactaaa agttcagact ctgtggcact tgtgatattt ctggacaact
     7201 gactcttctc tattgccttt cgaatcatac agtggcaaag ctgctcaccc atgtgtgtat
     7261 aaagctgacc cttcatcaga aaggcagccc ccagtgtctc cccacacagg gcagaagagc
     7321 agagggagca ggtggcaatg tggcagcacc ttgaactgtg catcactggg cctgctcccc
     7381 ctcatcccaa agcaataacc cagaaattac atcctgagac ttacttcctc agaaagaaaa
     7441 ggaaggggag ggataactta aaaaggagaa acttctaata tggtattaga ctgtaattca
     7501 tagggaaatt tatgcctgag atatgaattt ctgaaaataa ggggcttttt tggaagggaa
     7561 acactgacac atccttaatt atagagtaat aaataccaat ggtatattat ctttcgatat
     7621 ttccttacac agatatcaaa gcatgcagct gtttttgaaa actgataatc aagtacaata
     7681 taagtatatt acatcttgca cttacaacac acccttcaac taagcagcat catggagcac
     7741 ttaacggtga gaaacagagc tgctcatagt agaaacctaa ctgaacaaat tagctttgaa
     7801 ttgtaactta agaatcgtag tcaaaccaaa gcgtctgtcc ttgccaggaa aggcattcca
     7861 aaggcagaga gcatgccaag taaaaaggct ttgcttcagg attatggaga cagttctgaa
     7921 aagccagcat aacttaatga tcaatcagaa aaatatagag cagtaactac acaactgaag
     7981 gatgcataaa aattgtacaa aacgttaata gtggaatggg gaggtaggat gggattttac
     8041 gggcaagtat taagctcttg gaaagcttca tttgttgccc tcaatccaca cagcagaaag
     8101 aaagagaaag agacaaacat ggtcaaagaa aagtatgtgg acaaatgtgg ggggtagaaa
     8161 aggaaatgaa ggttaagcaa ggccaatata attcagaata aaagggaggg agggaagtat
     8221 aaggagccag ctgtaattac tgaatgttac attaagaaga gctgaaattg agagggggag
     8281 gtcttgagta ttttactaag tggattaatg tcctcttcct cgggtgtctg aagttgcaga
     8341 ttttaattta tttggtgcag ggatttatta cagaattctt aatgggtggg gagataaaca
     8401 gggacaatta taagctctta agaagaagaa aagaggacca tataatactt tctataaatt
     8461 taactgtaat aaacagggtt tcaagctatg gacaaagata gtcaaaaaaa gcatttattc
     8521 catgatatag gactaaaagg gaaataagag gtgtgtccaa aaaacttaaa gaccaaaaca
     8581 aagaaagaaa aacccacata gatgtgtgat gccaggattt tgaatgactt gggagctagt
     8641 tattgccgct ctcctttctc cacccattta aaaaaataaa tcataactct ggcatttaaa
     8701 aacctactca tgaacatcat ttattaatat aaacttaatc ctgtgctatt ctttggtggg
     8761 tggtaagaac atgaattaac aacaactgga ctaaaacgat ggcaacagga tgatccactc
     8821 aaacacagga aagctgtaag aaaaagaaaa actcctaatc tgctctttca ccttacttat
     8881 tttacagaag gagaaagcca aaaaggggag agcatgtggc taaaccacag aaagactaga
     8941 tgcctaaagg aaaaatttta aagtgttcct aaataggtat tagaagggga agggggatgt
     9001 aaagcttatg tgatttacat cattttgtta atctgctaat ctacttccct ggaaggtgag
     9061 aaagagtgtt gtctgccttc tgcaattgaa gagactaggg cagaaactta attatgttct
     9121 taccctgtgt atacctggct gtcatctggc tggcaactag tccacaaact attggttcag
     9181 gcatttgcct ggcaataatg ttagccatca tttaaattgt taaatatgga tcagaagatc
     9241 tctaagaatt actgatatgc agctattaat actggatgta aataatatta tttggggtgt
     9301 gggtaaatca tttgactgga accacattta aaaaaaggac ttggaaattt tatttttgaa
     9361 atgctgttgg ggagatggca ttgatgaaaa aaaaaattga aaatggaaaa aaacatcatc
     9421 tacaaagaga tgggtaaaaa tgactaagca aagaagcctt gtcaccttcg acctgatgct
     9481 tcattgtatc agaagaaagt aaacagattg ctaacaaaga gaccacccct tctaatttcc
     9541 aaaaccggcc cagcaacaag agggagaaaa tagagaagag tgcactgcgt ggtggctcag
     9601 ggtgatcctt taatttgagt gttaaaaatg agggcacaga cctagaggtt tttaatggtc
     9661 cgcgggtgga cttcagattc tgaacactcc tccaccttct gtggagaatt cgggacacgg
     9721 tggagtttaa ccagtatctt aaatcccagg gacagggtgg agattgcttt gtgatcctga
     9781 ttaattaaaa ggaaagaaat caaagcagac atctctcctt tttccatttg agccgcagag
     9841 ccatggaggg gaacttgtgc tctctggtgc ttgcagctat gttccctggc tttcatcgtc
     9901 ttggcttttc cccttgtatt tctaatgctg tgataccagg ccaataaaat ggaatctaca
     9961 aaactgcaaa acaaaa
//
