LOCUS       NM_001376321           10350 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 35, mRNA.
ACCESSION   NM_001376321
VERSION     NM_001376321.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10350)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10350)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10350)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10350)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10350)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10350)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10350)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10350)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376321.1.
            
            Transcript Variant: This variant (35), as well as variants 2, 34,
            and 36-38, encodes isoform b.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1163658.229241.1, SRR18074967.2396550.1
                                    [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-156              AC009957.11        115523-115604       c
            157-221             AC009957.11        96797-96861         c
            222-423             AC009957.11        93885-94086         c
            424-591             AC009957.11        30854-31021         c
            592-765             AC009957.11        27164-27337         c
            766-1119            AC010681.16        8445-8798           c
            1120-1190           AC016910.6         117406-117476       c
            1191-1282           AC016910.6         116615-116706       c
            1283-10350          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10350
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..156
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            157..221
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            222..423
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1366
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform b is encoded by transcript variant 35;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     b"
                     /protein_id="NP_001363250.1"
                     /db_xref="CCDS:CCDS2185.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWLEAVYCGCYPLCPKDLVYPEIFPAEYLYSTPEQLSKRLQNFC
                     KRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTTEPREDL"
     exon            424..591
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            592..765
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1119
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1190
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1282
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..10350
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2404
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10317..10322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10350
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggagtggtat aatgtgttat agaggtggac aagcctgcag attgaagtgg
      121 ggatcgtcca gattgttccc ttccctggac catatgattg tgcttcaaga agaccatagg
      181 gaagaacgca ttttcatctt gctgcaaaag ttgcaataga agatctgaag gtttgaatgg
      241 gccaatgagt atcctcatca ttgaagcatt ctatggaggc tcccataaac agctggtgga
      301 tcttcttcaa gaagagttag gagactgtgt cgtttatacc cttcctgcaa agaaatggca
      361 ttggagagcc cggacatctg ctttatattt ctctcagacc attcccatca gtgagcatta
      421 caggaccctc tttgcaagtt cagtgcttaa cctgaccgaa ctggctgccc ttcggcctga
      481 ccttgggaaa ctgaaaaaga ttctgtattt tcacgagaac cagttgatat atcctgtcaa
      541 gaaatgtcag gagagggatt tccaatatgg atacaaccaa attctttcat gcctggtggc
      601 tgatgtggtt gtattcaact cagtttttaa tatggaatca tttctcactt ccatgggaaa
      661 atttatgaag ctgattcctg atcacagacc caaggatctg gaaagcatca tcagacccaa
      721 gtgccaagtt atttactttc ccatcaggtt tcctgatgtg agcagattca tgcccaagca
      781 caaaacaacc catttaaaga agatgctcgg ccttaaagga aatggcggtg cggttctgtc
      841 catggccctt ccttttcagc cagagcagag agattcagag gatttattga agaattttaa
      901 ttcagagtgt gatacacact gtggccttga tactgcacga caagaatatt tgggtaactc
      961 attaagacag gaatcagact tgaaaaaatc cacctcgtca gataattcaa gctctcatca
     1021 tggtgaaaat aaacaaaatc tgactgttga tccctgtgac attttgggtg gagttgataa
     1081 tcagcaaaga ctgctacaca ttgtctggcc tcacaggtgg ttggaagctg tgtactgtgg
     1141 gtgttaccca ctttgtccta aagatttggt ttatcccgaa atatttccag ctgaatatct
     1201 gtattctaca cctgaacagc tttcaaaaag gctccagaat ttctgcaaga gaccagatat
     1261 tataagaaaa catctctata agggtgaaat cgctccgttt tcttgggcag ccctacatgg
     1321 taaattcagg tctctgctta caacagaacc tagggaagat ttgtgacaga tggggctaag
     1381 tcacaaactt gcagcctaag gcagaatctg aagaactttc cagagtgtgc ccatatttac
     1441 ctgatcagag agaaaagaaa atctgcagag gaagctgagc ctggctgctt gtcatagctg
     1501 acacagagcc atctgccaca aacctgtggc ggcttcagat ctccaatccc tgccaccacc
     1561 ccaactcaaa ttaaatacag attcctagag acgttatgat ggttacacat gtcctcggca
     1621 tcacatgtag gagactgttc aaaaaaaata tgtggcctgt tgtataaccg cactcatgta
     1681 tcccatatgt ggtgccacat tgaatttccg gttgaatccg tttttatcct ttgtactgga
     1741 tgacatggtg cctgaattct ttcttttcgc cgacacgatg gcagccaaac tgcagcttca
     1801 aacgctcaca cttggctggg tttctaccta ggttgccagg ttatcatcgg agccttcttg
     1861 tgtcctcaaa gggccacgag gcctgaaagg aggatcagaa tgctttggga ttaattgggc
     1921 agccatcgca gaattgtttg tgggcaaagg gctgctttag cacttttctt ttagcaaatt
     1981 aatgactctc aggcacaggg ggttttaagt gaaggtatta ataagaggtc tggcaggtat
     2041 tcccatgatt cacagagtta catttgcatt taattaatct taaagttgca agataaacag
     2101 ctgtaattcg gacaaacatg acaaacacag tgaagccaac tatcccataa aatgaacact
     2161 gacatacttg ttttaatttt tttcccagcg taaaaataga aaaatcaaaa tactcctaac
     2221 aaaaccagtg attttgatag aaatatttct ccaatatact tgcatccacc tacaaatata
     2281 accttttcaa gataaatcgc ttatgatttc aatagtcaaa ctgctgtgtt tgttgatgta
     2341 aagatgtttt gaatggctag atggtaaaat aaattcttaa taaagtaccc actgcaattt
     2401 ttaattagca tattcattta catatagatg tatacatcta cctatgtgtt tctcactgaa
     2461 cgttttcctt gtgacagaga caacaaatac aattgtttct tttccggatg aacaaggatc
     2521 tgttttgcaa atgtttgtaa gatattatga catttccaag attttctttg cattctggaa
     2581 agcaggaggt aaacatttgt agtcattaag gtaaagtctg ttgataaacc atcttctgtt
     2641 tactgacagg taaattgtaa ctttccctag cttttgaaat gagtaacttc tatacaccac
     2701 aaagtgaggc acagcctggg aaaggtggct agacaagggg caagccaggc tttctagctt
     2761 ctggaaggat cgagtggcct agcaggcatc taagataaag aaagcaatga ttcggaagtc
     2821 cagtagggcc catttgaccg gtagcaaaat cgaaagcacg aaatagatca aggttaggga
     2881 gccagacaaa gcccttggaa gagaggcagt attgcagatc gaagcaagca gttcagagtc
     2941 tatgaggcct gggaatttaa aagcaggaag agtaagaagc agaaacaaga agctccatct
     3001 gaacagactc ctctctccaa ccttcatgag acccacagtg tgtgatgggc caccacagca
     3061 ctggcttcta gacttttaca gggaagccag tgaacaaatt acctcgtcac ccagaaaaca
     3121 aagagctcag gaactatttt ggaagttcct tccagtctaa gactatggaa ctcagaatct
     3181 agcaggtgtg ttcctttgga tagcaaaact aaagatataa atatgaataa gaaattcttt
     3241 gccacttctc ctgggcaagg ttatacttta tgccatctac tgagataaac cagatgagtc
     3301 agtttgcttc tgtcagttgc tgtgtcacag atgacatctt ctcaaaataa tattatctca
     3361 cagccaagaa atagcgcttc gtttactgtg tttttctatc ctgaaactaa atgggcttac
     3421 gcttcatagt ggctaagata ctccacacac aactagtacc catagatctt ttctcactga
     3481 taggaaaaaa aaaaaaaaag cattaaacac ctttcagaga gtacatctga aacatttacg
     3541 tattttcctg atttaggcaa atataatatt gaaagttacc tgtatgtggg catttttttc
     3601 tacactcata aatgcaaatc aaattttgcc attagctgtg gccaacattc cttccaggac
     3661 aaaagcttac attaggccgg gtgcggtggc gcacgcctgt aatcccagca ctttgggagg
     3721 ccgagacggg tggatcatga ggtcaggaga tcgagaccat cctggctaac acggtgaaac
     3781 cccatctcta ctaaaaatac aaaaaaaatt agccaggcat ggtggcgggt gcctgtagtc
     3841 ccagctactg gggaggctga ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag
     3901 tgagccgaga tcgtgccact gcactccagc ctgggcgaca gagcgagact ctgtctcaaa
     3961 aaataaataa ataaataaat ttaaaataaa ttttaaaaaa attacattaa aggtgtcact
     4021 tatttgcatg ataccgagat ttggagttta aagaaaaacc ttataaagac tgtaatgtca
     4081 gagttgctac tagttcacat aagcaataaa aagttttgta aatgtgtaat tcttaacatt
     4141 taaaaatatg taggagtgtg tgtgtgtgtg tgtgtgtgca cacgcacatt catgcttctc
     4201 aacacccacg acctagtgga atggagtgtt attaaataag ttaatcagta ttttgttgaa
     4261 atctcagcag ataattagta ctacacgttg actcattaat tcagtttccc ttatcaacca
     4321 cccccatcat ttattgtttt gagtatgttt gatggaaaac ttagtcttcc tctttttttt
     4381 taacactcga ttgttttttt cttttaaaat aaagtcaatt ttaattttaa atgtctttaa
     4441 aagtccatcc attatcaaga ctttgacaca gtgtcttgaa atacagcttg ccctaaactt
     4501 aatctatgct tctggctagg tgtttctata acaaatatca gggcacctgg ttcttaacct
     4561 tctcatttat actgtgttga cagaaataga tgcaaatacc tttttaaaaa tgctcctggt
     4621 ttaataagca tccttcaaat acagttaagt ttaaatgccc tgctcctgtt ctcagtcctt
     4681 cagacatcaa tatggcaggc agaatccata agtcaatgga aactcttagc catagagggc
     4741 tgcagagatt aatttcaaca ccttgaaatg catctggaag caaagatttc attttatgtt
     4801 gaaggtgtta attatatttg atatttttaa aagtaaaatc tgtttttgag aaagcatctg
     4861 ctacccagaa atattatgag ccacaaaaga aattttactg aagtctcaag atactttctg
     4921 tggatgatag aatcagtttt caaatgatag tccatgctgt cttttaatgc tgacatacac
     4981 tgtgggtctt attcttctat tgactattga cccaactgcc tttctttttc agtggaaaat
     5041 ttgggactat ttaatattag atcttatgtt taacaatgaa gagagtatat tataaaccac
     5101 tgacttgaac atgtttcatt ttaaaatttg agttgtgata cagacaacta atgctcctat
     5161 cctatgccct ctcttcaaag ctattcatta aaatataact ggggaagttt gaaaaacatg
     5221 cgagcaattc tacatgctgc tcaaagatac agacatgtgt gattaaagta cagtattaca
     5281 gaaaacctgg gaattaacca aacttacaat aatggttatg tcagaggggc catggtagag
     5341 aaaaaaaagg acatagaagt agggaaaggt gcattcgttg catgatgaga agtctgtttc
     5401 ttaagctgag tcgtgataca caaaggcttc ttgccactct ttgtgacatt tcatgtgtct
     5461 tcagtgtatt tattgcatat atcttttgat aggagatata aatacttcag gaagcatgtt
     5521 actagttttg ctatcaggct atccttaaca tttcttggtt ttctcaatta ttgattgagt
     5581 cagaaaactg cttgcctcag acagtgatac aaactactct actgccaatg ttgcttgaga
     5641 agactttcct ctgcttaaca ggagccaggg gcttcacctc aaccctcatg ctgtggagaa
     5701 agtcagactc aactggccac aggttcctgt ttcttggggc tgctaatcac catttctaac
     5761 agatgcctgt ggcattgcaa acacaagatg gaaaactata gctctaaact cccttctgaa
     5821 gggtaaggaa aggaagagga aggcagatgt taaatgagcc cagtctttct catctcaaaa
     5881 aattcagagc tgcctgttag agcacaagag ctctcagagc tcccaaccac actgcccact
     5941 ccccatagtg ttgcctctcc cctttcctct ttaagacgca ggagcgaatc gtggtctttg
     6001 tgctttcact gcaatctatc ccaggggaag agttctcccg ggtatctgtg ggatgccctt
     6061 gctgcatgtg aggcacaaat ggcttcaggg accaggatcc tcactcactc tgcagtccat
     6121 ttttctaaat tggaatttgc gatcggtttc ttcaggtgtc ccaccatcat ctatcattat
     6181 ctgagttatt ccttatcctc tcccaacccc aaggagagga tcttaattgt ttttataaac
     6241 tgacagaagg aattggtgat tcttggaaga taattttaaa tggttatatt actttcctat
     6301 tactgcattt actgcattta aatagcaggt ctaaggtggg gtgcgagaag atgtgacccc
     6361 taggaatatt ggtatgacct ttctcaagca atttgaagtc ctttagatct gaaaatttaa
     6421 tgtcttcaat atcatttcac agatgagaaa attaaggcac atatagtgac atatttagga
     6481 gctgaagtgt gttacagaaa caaagttttt ttgtataagc ctttccctac atgggatgtt
     6541 atcattgtca cctatgtgcc tttcaggaag caccaagtgc agtatgcgtg actcagttgg
     6601 acccctagtt cccttctatt tctccagctg gcaggagaca gcaaaggaca gtggaggtgg
     6661 ttattttgtg gcccacattt ctgccattaa aagggacata agagactatg tagtgtggcc
     6721 aatttttttt tttttttttt tgagagagag agtctggctc tgtcgcccag gctggagtgc
     6781 agtggcacca tctcggctca ctgcaagctc cacctcccgg gttcacgcca ttctcctgcc
     6841 tcagcctccc gagtagctgg gactacaggt gcccaccacc acgcccggct aatttttttg
     6901 tatttttagt agagacgggg tttcaccatg ttagccaggg tggtctcaat ctcctgacct
     6961 cgtgatccac ctgtctcggc ctcccaaagt gctgggatta caggtgtaag ccaccatgcc
     7021 cggaatatgg ccattatttt aagtgttttt attattgctc tggttctccc tttagggagg
     7081 cattcagtga gtatacccca tctgtcacag gcccccacca ctccctgtgg tcttacactc
     7141 tgctgaattc atacatttag gtaacttccc tggccctcct gagaatcact tatttttgta
     7201 acctcctgta tttgagatgt aggaaactgg ggcctgagga gaagttgact tgccttgggt
     7261 cccacagtgg tacaggcaga tctagaactc agattttcca gggctctttc agtaggctgt
     7321 ggttgagcag tagtcaagac cacctcttca agaagggaaa aacatttgtc ttctctttct
     7381 cctctttctt ccttctgcct ctcactgtaa gaagaaacgt gttaataagt tgctaatacc
     7441 ttactctagg tgtatttcat gttacaccag ccagtgcttg tattctcaat gaccataagg
     7501 agaggaatgc ggaagaattg atttctgtac taaaagttca gactctgtgg cacttgtgat
     7561 atttctggac aactgactct tctctattgc ctttcgaatc atacagtggc aaagctgctc
     7621 acccatgtgt gtataaagct gacccttcat cagaaaggca gcccccagtg tctccccaca
     7681 cagggcagaa gagcagaggg agcaggtggc aatgtggcag caccttgaac tgtgcatcac
     7741 tgggcctgct ccccctcatc ccaaagcaat aacccagaaa ttacatcctg agacttactt
     7801 cctcagaaag aaaaggaagg ggagggataa cttaaaaagg agaaacttct aatatggtat
     7861 tagactgtaa ttcataggga aatttatgcc tgagatatga atttctgaaa ataaggggct
     7921 tttttggaag ggaaacactg acacatcctt aattatagag taataaatac caatggtata
     7981 ttatctttcg atatttcctt acacagatat caaagcatgc agctgttttt gaaaactgat
     8041 aatcaagtac aatataagta tattacatct tgcacttaca acacaccctt caactaagca
     8101 gcatcatgga gcacttaacg gtgagaaaca gagctgctca tagtagaaac ctaactgaac
     8161 aaattagctt tgaattgtaa cttaagaatc gtagtcaaac caaagcgtct gtccttgcca
     8221 ggaaaggcat tccaaaggca gagagcatgc caagtaaaaa ggctttgctt caggattatg
     8281 gagacagttc tgaaaagcca gcataactta atgatcaatc agaaaaatat agagcagtaa
     8341 ctacacaact gaaggatgca taaaaattgt acaaaacgtt aatagtggaa tggggaggta
     8401 ggatgggatt ttacgggcaa gtattaagct cttggaaagc ttcatttgtt gccctcaatc
     8461 cacacagcag aaagaaagag aaagagacaa acatggtcaa agaaaagtat gtggacaaat
     8521 gtggggggta gaaaaggaaa tgaaggttaa gcaaggccaa tataattcag aataaaaggg
     8581 agggagggaa gtataaggag ccagctgtaa ttactgaatg ttacattaag aagagctgaa
     8641 attgagaggg ggaggtcttg agtattttac taagtggatt aatgtcctct tcctcgggtg
     8701 tctgaagttg cagattttaa tttatttggt gcagggattt attacagaat tcttaatggg
     8761 tggggagata aacagggaca attataagct cttaagaaga agaaaagagg accatataat
     8821 actttctata aatttaactg taataaacag ggtttcaagc tatggacaaa gatagtcaaa
     8881 aaaagcattt attccatgat ataggactaa aagggaaata agaggtgtgt ccaaaaaact
     8941 taaagaccaa aacaaagaaa gaaaaaccca catagatgtg tgatgccagg attttgaatg
     9001 acttgggagc tagttattgc cgctctcctt tctccaccca tttaaaaaaa taaatcataa
     9061 ctctggcatt taaaaaccta ctcatgaaca tcatttatta atataaactt aatcctgtgc
     9121 tattctttgg tgggtggtaa gaacatgaat taacaacaac tggactaaaa cgatggcaac
     9181 aggatgatcc actcaaacac aggaaagctg taagaaaaag aaaaactcct aatctgctct
     9241 ttcaccttac ttattttaca gaaggagaaa gccaaaaagg ggagagcatg tggctaaacc
     9301 acagaaagac tagatgccta aaggaaaaat tttaaagtgt tcctaaatag gtattagaag
     9361 gggaaggggg atgtaaagct tatgtgattt acatcatttt gttaatctgc taatctactt
     9421 ccctggaagg tgagaaagag tgttgtctgc cttctgcaat tgaagagact agggcagaaa
     9481 cttaattatg ttcttaccct gtgtatacct ggctgtcatc tggctggcaa ctagtccaca
     9541 aactattggt tcaggcattt gcctggcaat aatgttagcc atcatttaaa ttgttaaata
     9601 tggatcagaa gatctctaag aattactgat atgcagctat taatactgga tgtaaataat
     9661 attatttggg gtgtgggtaa atcatttgac tggaaccaca tttaaaaaaa ggacttggaa
     9721 attttatttt tgaaatgctg ttggggagat ggcattgatg aaaaaaaaaa ttgaaaatgg
     9781 aaaaaaacat catctacaaa gagatgggta aaaatgacta agcaaagaag ccttgtcacc
     9841 ttcgacctga tgcttcattg tatcagaaga aagtaaacag attgctaaca aagagaccac
     9901 cccttctaat ttccaaaacc ggcccagcaa caagagggag aaaatagaga agagtgcact
     9961 gcgtggtggc tcagggtgat cctttaattt gagtgttaaa aatgagggca cagacctaga
    10021 ggtttttaat ggtccgcggg tggacttcag attctgaaca ctcctccacc ttctgtggag
    10081 aattcgggac acggtggagt ttaaccagta tcttaaatcc cagggacagg gtggagattg
    10141 ctttgtgatc ctgattaatt aaaaggaaag aaatcaaagc agacatctct cctttttcca
    10201 tttgagccgc agagccatgg aggggaactt gtgctctctg gtgcttgcag ctatgttccc
    10261 tggctttcat cgtcttggct tttccccttg tatttctaat gctgtgatac caggccaata
    10321 aaatggaatc tacaaaactg caaaacaaaa
//
