LOCUS       NM_001376317           10587 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 31, mRNA.
ACCESSION   NM_001376317
VERSION     NM_001376317.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10587)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10587)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10587)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10587)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10587)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10587)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10587)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10587)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376317.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1936030.1,
                                           SRR1803615.263338.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-136              AC009957.11        120958-121019       c
            137-201             AC009957.11        96797-96861         c
            202-403             AC009957.11        93885-94086         c
            404-571             AC009957.11        30854-31021         c
            572-745             AC009957.11        27164-27337         c
            746-892             AC010681.16        12931-13077         c
            893-1246            AC010681.16        8445-8798           c
            1247-1356           AC016910.6         135286-135395       c
            1357-1427           AC016910.6         117406-117476       c
            1428-1519           AC016910.6         116615-116706       c
            1520-10587          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10587
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..136
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            137..201
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1502
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform l is encoded by transcript variant 31;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     l"
                     /protein_id="NP_001363246.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSSTSTRVGTGKEKGSVQTCAYLHSHVIELMPGQHKHSVQFYRKASF
                     TPSVRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNFNSECDTHCG
                     LDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGGVDNQQRLLH
                     IVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPGWKLCTVGVTHFVLK
                     IWFIPKYFQLNICILHLNSFQKGSRISARDQIL"
     exon            404..571
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..745
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            746..892
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1246
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1356
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1427
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1519
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..10587
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2605..2610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2624
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2641
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10554..10559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10587
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggaggtatct ctgcattagc cagattggac atatgtaaag ggacatcagt
      121 atatctggat catcagattg tgcttcaaga agaccatagg gaagaacgca ttttcatctt
      181 gctgcaaaag ttgcaataga agatctgaag gtttgaatgg gccaatgagt atcctcatca
      241 ttgaagcatt ctatggaggc tcccataaac agctggtgga tcttcttcaa gaagagttag
      301 gagactgtgt cgtttatacc cttcctgcaa agaaatggca ttggagagcc cggacatctg
      361 ctttatattt ctctcagacc attcccatca gtgagcatta caggaccctc tttgcaagtt
      421 cagtgcttaa cctgaccgaa ctggctgccc ttcggcctga ccttgggaaa ctgaaaaaga
      481 ttctgtattt tcacgagaac cagttgatat atcctgtcaa gaaatgtcag gagagggatt
      541 tccaatatgg atacaaccaa attctttcat gcctggtggc tgatgtggtt gtattcaact
      601 cagtttttaa tatggaatca tttctcactt ccatgggaaa atttatgaag ctgattcctg
      661 atcacagacc caaggatctg gaaagcatca tcagacccaa gtgccaagtt atttactttc
      721 ccatcaggtt tcctgatgtg agcagcacct ccaccagagt tggaactggg aaagagaaag
      781 gaagtgttca gacatgtgcc tatttgcata gtcacgtcat tgaattaatg ccaggacagc
      841 acaaacattc tgtccagttc tatagaaaag ccagtttcac cccatcagta agattcatgc
      901 ccaagcacaa aacaacccat ttaaagaaga tgctcggcct taaaggaaat ggcggtgcgg
      961 ttctgtccat ggcccttcct tttcagccag agcagagaga ttcagaggat ttattgaaga
     1021 attttaattc agagtgtgat acacactgtg gccttgatac tgcacgacaa gaatatttgg
     1081 gtaactcatt aagacaggaa tcagacttga aaaaatccac ctcgtcagat aattcaagct
     1141 ctcatcatgg tgaaaataaa caaaatctga ctgttgatcc ctgtgacatt ttgggtggag
     1201 ttgataatca gcaaagactg ctacacattg tctggcctca caggtgggag catgataaag
     1261 atccagaaag cttttttaag gtattaatgc atcttaaaga cttaggactc aatttccacg
     1321 tgtctgtact tggagaaacc ttcacagatg tcccaggttg gaagctgtgt actgtgggtg
     1381 ttacccactt tgtcctaaag atttggttta tcccgaaata tttccagctg aatatctgta
     1441 ttctacacct gaacagcttt caaaaaggct ccagaatttc tgcaagagac cagatattat
     1501 aagaaaacat ctctataagg gtgaaatcgc tccgttttct tgggcagccc tacatggtaa
     1561 attcaggtct ctgcttacaa cagaacctag ggaagatttg tgacagatgg ggctaagtca
     1621 caaacttgca gcctaaggca gaatctgaag aactttccag agtgtgccca tatttacctg
     1681 atcagagaga aaagaaaatc tgcagaggaa gctgagcctg gctgcttgtc atagctgaca
     1741 cagagccatc tgccacaaac ctgtggcggc ttcagatctc caatccctgc caccacccca
     1801 actcaaatta aatacagatt cctagagacg ttatgatggt tacacatgtc ctcggcatca
     1861 catgtaggag actgttcaaa aaaaatatgt ggcctgttgt ataaccgcac tcatgtatcc
     1921 catatgtggt gccacattga atttccggtt gaatccgttt ttatcctttg tactggatga
     1981 catggtgcct gaattctttc ttttcgccga cacgatggca gccaaactgc agcttcaaac
     2041 gctcacactt ggctgggttt ctacctaggt tgccaggtta tcatcggagc cttcttgtgt
     2101 cctcaaaggg ccacgaggcc tgaaaggagg atcagaatgc tttgggatta attgggcagc
     2161 catcgcagaa ttgtttgtgg gcaaagggct gctttagcac ttttctttta gcaaattaat
     2221 gactctcagg cacagggggt tttaagtgaa ggtattaata agaggtctgg caggtattcc
     2281 catgattcac agagttacat ttgcatttaa ttaatcttaa agttgcaaga taaacagctg
     2341 taattcggac aaacatgaca aacacagtga agccaactat cccataaaat gaacactgac
     2401 atacttgttt taattttttt cccagcgtaa aaatagaaaa atcaaaatac tcctaacaaa
     2461 accagtgatt ttgatagaaa tatttctcca atatacttgc atccacctac aaatataacc
     2521 ttttcaagat aaatcgctta tgatttcaat agtcaaactg ctgtgtttgt tgatgtaaag
     2581 atgttttgaa tggctagatg gtaaaataaa ttcttaataa agtacccact gcaattttta
     2641 attagcatat tcatttacat atagatgtat acatctacct atgtgtttct cactgaacgt
     2701 tttccttgtg acagagacaa caaatacaat tgtttctttt ccggatgaac aaggatctgt
     2761 tttgcaaatg tttgtaagat attatgacat ttccaagatt ttctttgcat tctggaaagc
     2821 aggaggtaaa catttgtagt cattaaggta aagtctgttg ataaaccatc ttctgtttac
     2881 tgacaggtaa attgtaactt tccctagctt ttgaaatgag taacttctat acaccacaaa
     2941 gtgaggcaca gcctgggaaa ggtggctaga caaggggcaa gccaggcttt ctagcttctg
     3001 gaaggatcga gtggcctagc aggcatctaa gataaagaaa gcaatgattc ggaagtccag
     3061 tagggcccat ttgaccggta gcaaaatcga aagcacgaaa tagatcaagg ttagggagcc
     3121 agacaaagcc cttggaagag aggcagtatt gcagatcgaa gcaagcagtt cagagtctat
     3181 gaggcctggg aatttaaaag caggaagagt aagaagcaga aacaagaagc tccatctgaa
     3241 cagactcctc tctccaacct tcatgagacc cacagtgtgt gatgggccac cacagcactg
     3301 gcttctagac ttttacaggg aagccagtga acaaattacc tcgtcaccca gaaaacaaag
     3361 agctcaggaa ctattttgga agttccttcc agtctaagac tatggaactc agaatctagc
     3421 aggtgtgttc ctttggatag caaaactaaa gatataaata tgaataagaa attctttgcc
     3481 acttctcctg ggcaaggtta tactttatgc catctactga gataaaccag atgagtcagt
     3541 ttgcttctgt cagttgctgt gtcacagatg acatcttctc aaaataatat tatctcacag
     3601 ccaagaaata gcgcttcgtt tactgtgttt ttctatcctg aaactaaatg ggcttacgct
     3661 tcatagtggc taagatactc cacacacaac tagtacccat agatcttttc tcactgatag
     3721 gaaaaaaaaa aaaaaagcat taaacacctt tcagagagta catctgaaac atttacgtat
     3781 tttcctgatt taggcaaata taatattgaa agttacctgt atgtgggcat ttttttctac
     3841 actcataaat gcaaatcaaa ttttgccatt agctgtggcc aacattcctt ccaggacaaa
     3901 agcttacatt aggccgggtg cggtggcgca cgcctgtaat cccagcactt tgggaggccg
     3961 agacgggtgg atcatgaggt caggagatcg agaccatcct ggctaacacg gtgaaacccc
     4021 atctctacta aaaatacaaa aaaaattagc caggcatggt ggcgggtgcc tgtagtccca
     4081 gctactgggg aggctgaggc aggagaatgg cgtgaaccca ggaggcggag cttgcagtga
     4141 gccgagatcg tgccactgca ctccagcctg ggcgacagag cgagactctg tctcaaaaaa
     4201 taaataaata aataaattta aaataaattt taaaaaaatt acattaaagg tgtcacttat
     4261 ttgcatgata ccgagatttg gagtttaaag aaaaacctta taaagactgt aatgtcagag
     4321 ttgctactag ttcacataag caataaaaag ttttgtaaat gtgtaattct taacatttaa
     4381 aaatatgtag gagtgtgtgt gtgtgtgtgt gtgtgcacac gcacattcat gcttctcaac
     4441 acccacgacc tagtggaatg gagtgttatt aaataagtta atcagtattt tgttgaaatc
     4501 tcagcagata attagtacta cacgttgact cattaattca gtttccctta tcaaccaccc
     4561 ccatcattta ttgttttgag tatgtttgat ggaaaactta gtcttcctct ttttttttaa
     4621 cactcgattg tttttttctt ttaaaataaa gtcaatttta attttaaatg tctttaaaag
     4681 tccatccatt atcaagactt tgacacagtg tcttgaaata cagcttgccc taaacttaat
     4741 ctatgcttct ggctaggtgt ttctataaca aatatcaggg cacctggttc ttaaccttct
     4801 catttatact gtgttgacag aaatagatgc aaataccttt ttaaaaatgc tcctggttta
     4861 ataagcatcc ttcaaataca gttaagttta aatgccctgc tcctgttctc agtccttcag
     4921 acatcaatat ggcaggcaga atccataagt caatggaaac tcttagccat agagggctgc
     4981 agagattaat ttcaacacct tgaaatgcat ctggaagcaa agatttcatt ttatgttgaa
     5041 ggtgttaatt atatttgata tttttaaaag taaaatctgt ttttgagaaa gcatctgcta
     5101 cccagaaata ttatgagcca caaaagaaat tttactgaag tctcaagata ctttctgtgg
     5161 atgatagaat cagttttcaa atgatagtcc atgctgtctt ttaatgctga catacactgt
     5221 gggtcttatt cttctattga ctattgaccc aactgccttt ctttttcagt ggaaaatttg
     5281 ggactattta atattagatc ttatgtttaa caatgaagag agtatattat aaaccactga
     5341 cttgaacatg tttcatttta aaatttgagt tgtgatacag acaactaatg ctcctatcct
     5401 atgccctctc ttcaaagcta ttcattaaaa tataactggg gaagtttgaa aaacatgcga
     5461 gcaattctac atgctgctca aagatacaga catgtgtgat taaagtacag tattacagaa
     5521 aacctgggaa ttaaccaaac ttacaataat ggttatgtca gaggggccat ggtagagaaa
     5581 aaaaaggaca tagaagtagg gaaaggtgca ttcgttgcat gatgagaagt ctgtttctta
     5641 agctgagtcg tgatacacaa aggcttcttg ccactctttg tgacatttca tgtgtcttca
     5701 gtgtatttat tgcatatatc ttttgatagg agatataaat acttcaggaa gcatgttact
     5761 agttttgcta tcaggctatc cttaacattt cttggttttc tcaattattg attgagtcag
     5821 aaaactgctt gcctcagaca gtgatacaaa ctactctact gccaatgttg cttgagaaga
     5881 ctttcctctg cttaacagga gccaggggct tcacctcaac cctcatgctg tggagaaagt
     5941 cagactcaac tggccacagg ttcctgtttc ttggggctgc taatcaccat ttctaacaga
     6001 tgcctgtggc attgcaaaca caagatggaa aactatagct ctaaactccc ttctgaaggg
     6061 taaggaaagg aagaggaagg cagatgttaa atgagcccag tctttctcat ctcaaaaaat
     6121 tcagagctgc ctgttagagc acaagagctc tcagagctcc caaccacact gcccactccc
     6181 catagtgttg cctctcccct ttcctcttta agacgcagga gcgaatcgtg gtctttgtgc
     6241 tttcactgca atctatccca ggggaagagt tctcccgggt atctgtggga tgcccttgct
     6301 gcatgtgagg cacaaatggc ttcagggacc aggatcctca ctcactctgc agtccatttt
     6361 tctaaattgg aatttgcgat cggtttcttc aggtgtccca ccatcatcta tcattatctg
     6421 agttattcct tatcctctcc caaccccaag gagaggatct taattgtttt tataaactga
     6481 cagaaggaat tggtgattct tggaagataa ttttaaatgg ttatattact ttcctattac
     6541 tgcatttact gcatttaaat agcaggtcta aggtggggtg cgagaagatg tgacccctag
     6601 gaatattggt atgacctttc tcaagcaatt tgaagtcctt tagatctgaa aatttaatgt
     6661 cttcaatatc atttcacaga tgagaaaatt aaggcacata tagtgacata tttaggagct
     6721 gaagtgtgtt acagaaacaa agtttttttg tataagcctt tccctacatg ggatgttatc
     6781 attgtcacct atgtgccttt caggaagcac caagtgcagt atgcgtgact cagttggacc
     6841 cctagttccc ttctatttct ccagctggca ggagacagca aaggacagtg gaggtggtta
     6901 ttttgtggcc cacatttctg ccattaaaag ggacataaga gactatgtag tgtggccaat
     6961 tttttttttt ttttttttga gagagagagt ctggctctgt cgcccaggct ggagtgcagt
     7021 ggcaccatct cggctcactg caagctccac ctcccgggtt cacgccattc tcctgcctca
     7081 gcctcccgag tagctgggac tacaggtgcc caccaccacg cccggctaat ttttttgtat
     7141 ttttagtaga gacggggttt caccatgtta gccagggtgg tctcaatctc ctgacctcgt
     7201 gatccacctg tctcggcctc ccaaagtgct gggattacag gtgtaagcca ccatgcccgg
     7261 aatatggcca ttattttaag tgtttttatt attgctctgg ttctcccttt agggaggcat
     7321 tcagtgagta taccccatct gtcacaggcc cccaccactc cctgtggtct tacactctgc
     7381 tgaattcata catttaggta acttccctgg ccctcctgag aatcacttat ttttgtaacc
     7441 tcctgtattt gagatgtagg aaactggggc ctgaggagaa gttgacttgc cttgggtccc
     7501 acagtggtac aggcagatct agaactcaga ttttccaggg ctctttcagt aggctgtggt
     7561 tgagcagtag tcaagaccac ctcttcaaga agggaaaaac atttgtcttc tctttctcct
     7621 ctttcttcct tctgcctctc actgtaagaa gaaacgtgtt aataagttgc taatacctta
     7681 ctctaggtgt atttcatgtt acaccagcca gtgcttgtat tctcaatgac cataaggaga
     7741 ggaatgcgga agaattgatt tctgtactaa aagttcagac tctgtggcac ttgtgatatt
     7801 tctggacaac tgactcttct ctattgcctt tcgaatcata cagtggcaaa gctgctcacc
     7861 catgtgtgta taaagctgac ccttcatcag aaaggcagcc cccagtgtct ccccacacag
     7921 ggcagaagag cagagggagc aggtggcaat gtggcagcac cttgaactgt gcatcactgg
     7981 gcctgctccc cctcatccca aagcaataac ccagaaatta catcctgaga cttacttcct
     8041 cagaaagaaa aggaagggga gggataactt aaaaaggaga aacttctaat atggtattag
     8101 actgtaattc atagggaaat ttatgcctga gatatgaatt tctgaaaata aggggctttt
     8161 ttggaaggga aacactgaca catccttaat tatagagtaa taaataccaa tggtatatta
     8221 tctttcgata tttccttaca cagatatcaa agcatgcagc tgtttttgaa aactgataat
     8281 caagtacaat ataagtatat tacatcttgc acttacaaca cacccttcaa ctaagcagca
     8341 tcatggagca cttaacggtg agaaacagag ctgctcatag tagaaaccta actgaacaaa
     8401 ttagctttga attgtaactt aagaatcgta gtcaaaccaa agcgtctgtc cttgccagga
     8461 aaggcattcc aaaggcagag agcatgccaa gtaaaaaggc tttgcttcag gattatggag
     8521 acagttctga aaagccagca taacttaatg atcaatcaga aaaatataga gcagtaacta
     8581 cacaactgaa ggatgcataa aaattgtaca aaacgttaat agtggaatgg ggaggtagga
     8641 tgggatttta cgggcaagta ttaagctctt ggaaagcttc atttgttgcc ctcaatccac
     8701 acagcagaaa gaaagagaaa gagacaaaca tggtcaaaga aaagtatgtg gacaaatgtg
     8761 gggggtagaa aaggaaatga aggttaagca aggccaatat aattcagaat aaaagggagg
     8821 gagggaagta taaggagcca gctgtaatta ctgaatgtta cattaagaag agctgaaatt
     8881 gagaggggga ggtcttgagt attttactaa gtggattaat gtcctcttcc tcgggtgtct
     8941 gaagttgcag attttaattt atttggtgca gggatttatt acagaattct taatgggtgg
     9001 ggagataaac agggacaatt ataagctctt aagaagaaga aaagaggacc atataatact
     9061 ttctataaat ttaactgtaa taaacagggt ttcaagctat ggacaaagat agtcaaaaaa
     9121 agcatttatt ccatgatata ggactaaaag ggaaataaga ggtgtgtcca aaaaacttaa
     9181 agaccaaaac aaagaaagaa aaacccacat agatgtgtga tgccaggatt ttgaatgact
     9241 tgggagctag ttattgccgc tctcctttct ccacccattt aaaaaaataa atcataactc
     9301 tggcatttaa aaacctactc atgaacatca tttattaata taaacttaat cctgtgctat
     9361 tctttggtgg gtggtaagaa catgaattaa caacaactgg actaaaacga tggcaacagg
     9421 atgatccact caaacacagg aaagctgtaa gaaaaagaaa aactcctaat ctgctctttc
     9481 accttactta ttttacagaa ggagaaagcc aaaaagggga gagcatgtgg ctaaaccaca
     9541 gaaagactag atgcctaaag gaaaaatttt aaagtgttcc taaataggta ttagaagggg
     9601 aagggggatg taaagcttat gtgatttaca tcattttgtt aatctgctaa tctacttccc
     9661 tggaaggtga gaaagagtgt tgtctgcctt ctgcaattga agagactagg gcagaaactt
     9721 aattatgttc ttaccctgtg tatacctggc tgtcatctgg ctggcaacta gtccacaaac
     9781 tattggttca ggcatttgcc tggcaataat gttagccatc atttaaattg ttaaatatgg
     9841 atcagaagat ctctaagaat tactgatatg cagctattaa tactggatgt aaataatatt
     9901 atttggggtg tgggtaaatc atttgactgg aaccacattt aaaaaaagga cttggaaatt
     9961 ttatttttga aatgctgttg gggagatggc attgatgaaa aaaaaaattg aaaatggaaa
    10021 aaaacatcat ctacaaagag atgggtaaaa atgactaagc aaagaagcct tgtcaccttc
    10081 gacctgatgc ttcattgtat cagaagaaag taaacagatt gctaacaaag agaccacccc
    10141 ttctaatttc caaaaccggc ccagcaacaa gagggagaaa atagagaaga gtgcactgcg
    10201 tggtggctca gggtgatcct ttaatttgag tgttaaaaat gagggcacag acctagaggt
    10261 ttttaatggt ccgcgggtgg acttcagatt ctgaacactc ctccaccttc tgtggagaat
    10321 tcgggacacg gtggagttta accagtatct taaatcccag ggacagggtg gagattgctt
    10381 tgtgatcctg attaattaaa aggaaagaaa tcaaagcaga catctctcct ttttccattt
    10441 gagccgcaga gccatggagg ggaacttgtg ctctctggtg cttgcagcta tgttccctgg
    10501 ctttcatcgt cttggctttt ccccttgtat ttctaatgct gtgataccag gccaataaaa
    10561 tggaatctac aaaactgcaa aacaaaa
//
