LOCUS       NM_001376316           10582 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 30, mRNA.
ACCESSION   NM_001376316
VERSION     NM_001376316.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10582)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10582)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10582)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10582)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10582)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10582)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10582)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10582)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.121042.1,
                                           DRR138516.256493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-136              AC009957.11        120958-121019       c
            137-201             AC009957.11        96797-96861         c
            202-403             AC009957.11        93885-94086         c
            404-571             AC009957.11        30854-31021         c
            572-745             AC009957.11        27164-27337         c
            746-1096            AC010681.16        8448-8798           c
            1097-1206           AC016910.6         135286-135395       c
            1207-1351           AC016910.6         121828-121972       c
            1352-1422           AC016910.6         117406-117476       c
            1423-1514           AC016910.6         116615-116706       c
            1515-10582          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10582
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..136
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            137..201
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1598
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform k is encoded by transcript variant 30;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     k"
                     /protein_id="NP_001363245.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHREHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEAK
                     KALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDL
                     VYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLT
                     TEPREDL"
     exon            404..571
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..745
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1096
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1206
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1351
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1422
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1514
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..10582
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2636
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10549..10554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10582
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggaggtatct ctgcattagc cagattggac atatgtaaag ggacatcagt
      121 atatctggat catcagattg tgcttcaaga agaccatagg gaagaacgca ttttcatctt
      181 gctgcaaaag ttgcaataga agatctgaag gtttgaatgg gccaatgagt atcctcatca
      241 ttgaagcatt ctatggaggc tcccataaac agctggtgga tcttcttcaa gaagagttag
      301 gagactgtgt cgtttatacc cttcctgcaa agaaatggca ttggagagcc cggacatctg
      361 ctttatattt ctctcagacc attcccatca gtgagcatta caggaccctc tttgcaagtt
      421 cagtgcttaa cctgaccgaa ctggctgccc ttcggcctga ccttgggaaa ctgaaaaaga
      481 ttctgtattt tcacgagaac cagttgatat atcctgtcaa gaaatgtcag gagagggatt
      541 tccaatatgg atacaaccaa attctttcat gcctggtggc tgatgtggtt gtattcaact
      601 cagtttttaa tatggaatca tttctcactt ccatgggaaa atttatgaag ctgattcctg
      661 atcacagacc caaggatctg gaaagcatca tcagacccaa gtgccaagtt atttactttc
      721 ccatcaggtt tcctgatgtg agcagattca tgcccaagca caaaacaacc catttaaaga
      781 agatgctcgg ccttaaagga aatggcggtg cggttctgtc catggccctt ccttttcagc
      841 cagagcagag agattcagag gatttattga agaattttaa ttcagagtgt gatacacact
      901 gtggccttga tactgcacga caagaatatt tgggtaactc attaagacag gaatcagact
      961 tgaaaaaatc cacctcgtca gataattcaa gctctcatca tggtgaaaat aaacaaaatc
     1021 tgactgttga tccctgtgac attttgggtg gagttgataa tcagcaaaga ctgctacaca
     1081 ttgtctggcc tcacagggag catgataaag atccagaaag cttttttaag gtattaatgc
     1141 atcttaaaga cttaggactc aatttccacg tgtctgtact tggagaaacc ttcacagatg
     1201 tcccagatat tttttcagag gccaaaaagg cattgggatc ttctgtctta cactggggct
     1261 acttacccag caaagatgac tatttccaag tactgtgcat ggctgatgtt gtcatctcaa
     1321 cagctaagca tgaattcttt ggagtggcaa tgttggaagc tgtgtactgt gggtgttacc
     1381 cactttgtcc taaagatttg gtttatcccg aaatatttcc agctgaatat ctgtattcta
     1441 cacctgaaca gctttcaaaa aggctccaga atttctgcaa gagaccagat attataagaa
     1501 aacatctcta taagggtgaa atcgctccgt tttcttgggc agccctacat ggtaaattca
     1561 ggtctctgct tacaacagaa cctagggaag atttgtgaca gatggggcta agtcacaaac
     1621 ttgcagccta aggcagaatc tgaagaactt tccagagtgt gcccatattt acctgatcag
     1681 agagaaaaga aaatctgcag aggaagctga gcctggctgc ttgtcatagc tgacacagag
     1741 ccatctgcca caaacctgtg gcggcttcag atctccaatc cctgccacca ccccaactca
     1801 aattaaatac agattcctag agacgttatg atggttacac atgtcctcgg catcacatgt
     1861 aggagactgt tcaaaaaaaa tatgtggcct gttgtataac cgcactcatg tatcccatat
     1921 gtggtgccac attgaatttc cggttgaatc cgtttttatc ctttgtactg gatgacatgg
     1981 tgcctgaatt ctttcttttc gccgacacga tggcagccaa actgcagctt caaacgctca
     2041 cacttggctg ggtttctacc taggttgcca ggttatcatc ggagccttct tgtgtcctca
     2101 aagggccacg aggcctgaaa ggaggatcag aatgctttgg gattaattgg gcagccatcg
     2161 cagaattgtt tgtgggcaaa gggctgcttt agcacttttc ttttagcaaa ttaatgactc
     2221 tcaggcacag ggggttttaa gtgaaggtat taataagagg tctggcaggt attcccatga
     2281 ttcacagagt tacatttgca tttaattaat cttaaagttg caagataaac agctgtaatt
     2341 cggacaaaca tgacaaacac agtgaagcca actatcccat aaaatgaaca ctgacatact
     2401 tgttttaatt tttttcccag cgtaaaaata gaaaaatcaa aatactccta acaaaaccag
     2461 tgattttgat agaaatattt ctccaatata cttgcatcca cctacaaata taaccttttc
     2521 aagataaatc gcttatgatt tcaatagtca aactgctgtg tttgttgatg taaagatgtt
     2581 ttgaatggct agatggtaaa ataaattctt aataaagtac ccactgcaat ttttaattag
     2641 catattcatt tacatataga tgtatacatc tacctatgtg tttctcactg aacgttttcc
     2701 ttgtgacaga gacaacaaat acaattgttt cttttccgga tgaacaagga tctgttttgc
     2761 aaatgtttgt aagatattat gacatttcca agattttctt tgcattctgg aaagcaggag
     2821 gtaaacattt gtagtcatta aggtaaagtc tgttgataaa ccatcttctg tttactgaca
     2881 ggtaaattgt aactttccct agcttttgaa atgagtaact tctatacacc acaaagtgag
     2941 gcacagcctg ggaaaggtgg ctagacaagg ggcaagccag gctttctagc ttctggaagg
     3001 atcgagtggc ctagcaggca tctaagataa agaaagcaat gattcggaag tccagtaggg
     3061 cccatttgac cggtagcaaa atcgaaagca cgaaatagat caaggttagg gagccagaca
     3121 aagcccttgg aagagaggca gtattgcaga tcgaagcaag cagttcagag tctatgaggc
     3181 ctgggaattt aaaagcagga agagtaagaa gcagaaacaa gaagctccat ctgaacagac
     3241 tcctctctcc aaccttcatg agacccacag tgtgtgatgg gccaccacag cactggcttc
     3301 tagactttta cagggaagcc agtgaacaaa ttacctcgtc acccagaaaa caaagagctc
     3361 aggaactatt ttggaagttc cttccagtct aagactatgg aactcagaat ctagcaggtg
     3421 tgttcctttg gatagcaaaa ctaaagatat aaatatgaat aagaaattct ttgccacttc
     3481 tcctgggcaa ggttatactt tatgccatct actgagataa accagatgag tcagtttgct
     3541 tctgtcagtt gctgtgtcac agatgacatc ttctcaaaat aatattatct cacagccaag
     3601 aaatagcgct tcgtttactg tgtttttcta tcctgaaact aaatgggctt acgcttcata
     3661 gtggctaaga tactccacac acaactagta cccatagatc ttttctcact gataggaaaa
     3721 aaaaaaaaaa agcattaaac acctttcaga gagtacatct gaaacattta cgtattttcc
     3781 tgatttaggc aaatataata ttgaaagtta cctgtatgtg ggcatttttt tctacactca
     3841 taaatgcaaa tcaaattttg ccattagctg tggccaacat tccttccagg acaaaagctt
     3901 acattaggcc gggtgcggtg gcgcacgcct gtaatcccag cactttggga ggccgagacg
     3961 ggtggatcat gaggtcagga gatcgagacc atcctggcta acacggtgaa accccatctc
     4021 tactaaaaat acaaaaaaaa ttagccaggc atggtggcgg gtgcctgtag tcccagctac
     4081 tggggaggct gaggcaggag aatggcgtga acccaggagg cggagcttgc agtgagccga
     4141 gatcgtgcca ctgcactcca gcctgggcga cagagcgaga ctctgtctca aaaaataaat
     4201 aaataaataa atttaaaata aattttaaaa aaattacatt aaaggtgtca cttatttgca
     4261 tgataccgag atttggagtt taaagaaaaa ccttataaag actgtaatgt cagagttgct
     4321 actagttcac ataagcaata aaaagttttg taaatgtgta attcttaaca tttaaaaata
     4381 tgtaggagtg tgtgtgtgtg tgtgtgtgtg cacacgcaca ttcatgcttc tcaacaccca
     4441 cgacctagtg gaatggagtg ttattaaata agttaatcag tattttgttg aaatctcagc
     4501 agataattag tactacacgt tgactcatta attcagtttc ccttatcaac cacccccatc
     4561 atttattgtt ttgagtatgt ttgatggaaa acttagtctt cctctttttt tttaacactc
     4621 gattgttttt ttcttttaaa ataaagtcaa ttttaatttt aaatgtcttt aaaagtccat
     4681 ccattatcaa gactttgaca cagtgtcttg aaatacagct tgccctaaac ttaatctatg
     4741 cttctggcta ggtgtttcta taacaaatat cagggcacct ggttcttaac cttctcattt
     4801 atactgtgtt gacagaaata gatgcaaata cctttttaaa aatgctcctg gtttaataag
     4861 catccttcaa atacagttaa gtttaaatgc cctgctcctg ttctcagtcc ttcagacatc
     4921 aatatggcag gcagaatcca taagtcaatg gaaactctta gccatagagg gctgcagaga
     4981 ttaatttcaa caccttgaaa tgcatctgga agcaaagatt tcattttatg ttgaaggtgt
     5041 taattatatt tgatattttt aaaagtaaaa tctgtttttg agaaagcatc tgctacccag
     5101 aaatattatg agccacaaaa gaaattttac tgaagtctca agatactttc tgtggatgat
     5161 agaatcagtt ttcaaatgat agtccatgct gtcttttaat gctgacatac actgtgggtc
     5221 ttattcttct attgactatt gacccaactg cctttctttt tcagtggaaa atttgggact
     5281 atttaatatt agatcttatg tttaacaatg aagagagtat attataaacc actgacttga
     5341 acatgtttca ttttaaaatt tgagttgtga tacagacaac taatgctcct atcctatgcc
     5401 ctctcttcaa agctattcat taaaatataa ctggggaagt ttgaaaaaca tgcgagcaat
     5461 tctacatgct gctcaaagat acagacatgt gtgattaaag tacagtatta cagaaaacct
     5521 gggaattaac caaacttaca ataatggtta tgtcagaggg gccatggtag agaaaaaaaa
     5581 ggacatagaa gtagggaaag gtgcattcgt tgcatgatga gaagtctgtt tcttaagctg
     5641 agtcgtgata cacaaaggct tcttgccact ctttgtgaca tttcatgtgt cttcagtgta
     5701 tttattgcat atatcttttg ataggagata taaatacttc aggaagcatg ttactagttt
     5761 tgctatcagg ctatccttaa catttcttgg ttttctcaat tattgattga gtcagaaaac
     5821 tgcttgcctc agacagtgat acaaactact ctactgccaa tgttgcttga gaagactttc
     5881 ctctgcttaa caggagccag gggcttcacc tcaaccctca tgctgtggag aaagtcagac
     5941 tcaactggcc acaggttcct gtttcttggg gctgctaatc accatttcta acagatgcct
     6001 gtggcattgc aaacacaaga tggaaaacta tagctctaaa ctcccttctg aagggtaagg
     6061 aaaggaagag gaaggcagat gttaaatgag cccagtcttt ctcatctcaa aaaattcaga
     6121 gctgcctgtt agagcacaag agctctcaga gctcccaacc acactgccca ctccccatag
     6181 tgttgcctct cccctttcct ctttaagacg caggagcgaa tcgtggtctt tgtgctttca
     6241 ctgcaatcta tcccagggga agagttctcc cgggtatctg tgggatgccc ttgctgcatg
     6301 tgaggcacaa atggcttcag ggaccaggat cctcactcac tctgcagtcc atttttctaa
     6361 attggaattt gcgatcggtt tcttcaggtg tcccaccatc atctatcatt atctgagtta
     6421 ttccttatcc tctcccaacc ccaaggagag gatcttaatt gtttttataa actgacagaa
     6481 ggaattggtg attcttggaa gataatttta aatggttata ttactttcct attactgcat
     6541 ttactgcatt taaatagcag gtctaaggtg gggtgcgaga agatgtgacc cctaggaata
     6601 ttggtatgac ctttctcaag caatttgaag tcctttagat ctgaaaattt aatgtcttca
     6661 atatcatttc acagatgaga aaattaaggc acatatagtg acatatttag gagctgaagt
     6721 gtgttacaga aacaaagttt ttttgtataa gcctttccct acatgggatg ttatcattgt
     6781 cacctatgtg cctttcagga agcaccaagt gcagtatgcg tgactcagtt ggacccctag
     6841 ttcccttcta tttctccagc tggcaggaga cagcaaagga cagtggaggt ggttattttg
     6901 tggcccacat ttctgccatt aaaagggaca taagagacta tgtagtgtgg ccaatttttt
     6961 tttttttttt tttgagagag agagtctggc tctgtcgccc aggctggagt gcagtggcac
     7021 catctcggct cactgcaagc tccacctccc gggttcacgc cattctcctg cctcagcctc
     7081 ccgagtagct gggactacag gtgcccacca ccacgcccgg ctaatttttt tgtattttta
     7141 gtagagacgg ggtttcacca tgttagccag ggtggtctca atctcctgac ctcgtgatcc
     7201 acctgtctcg gcctcccaaa gtgctgggat tacaggtgta agccaccatg cccggaatat
     7261 ggccattatt ttaagtgttt ttattattgc tctggttctc cctttaggga ggcattcagt
     7321 gagtataccc catctgtcac aggcccccac cactccctgt ggtcttacac tctgctgaat
     7381 tcatacattt aggtaacttc cctggccctc ctgagaatca cttatttttg taacctcctg
     7441 tatttgagat gtaggaaact ggggcctgag gagaagttga cttgccttgg gtcccacagt
     7501 ggtacaggca gatctagaac tcagattttc cagggctctt tcagtaggct gtggttgagc
     7561 agtagtcaag accacctctt caagaaggga aaaacatttg tcttctcttt ctcctctttc
     7621 ttccttctgc ctctcactgt aagaagaaac gtgttaataa gttgctaata ccttactcta
     7681 ggtgtatttc atgttacacc agccagtgct tgtattctca atgaccataa ggagaggaat
     7741 gcggaagaat tgatttctgt actaaaagtt cagactctgt ggcacttgtg atatttctgg
     7801 acaactgact cttctctatt gcctttcgaa tcatacagtg gcaaagctgc tcacccatgt
     7861 gtgtataaag ctgacccttc atcagaaagg cagcccccag tgtctcccca cacagggcag
     7921 aagagcagag ggagcaggtg gcaatgtggc agcaccttga actgtgcatc actgggcctg
     7981 ctccccctca tcccaaagca ataacccaga aattacatcc tgagacttac ttcctcagaa
     8041 agaaaaggaa ggggagggat aacttaaaaa ggagaaactt ctaatatggt attagactgt
     8101 aattcatagg gaaatttatg cctgagatat gaatttctga aaataagggg cttttttgga
     8161 agggaaacac tgacacatcc ttaattatag agtaataaat accaatggta tattatcttt
     8221 cgatatttcc ttacacagat atcaaagcat gcagctgttt ttgaaaactg ataatcaagt
     8281 acaatataag tatattacat cttgcactta caacacaccc ttcaactaag cagcatcatg
     8341 gagcacttaa cggtgagaaa cagagctgct catagtagaa acctaactga acaaattagc
     8401 tttgaattgt aacttaagaa tcgtagtcaa accaaagcgt ctgtccttgc caggaaaggc
     8461 attccaaagg cagagagcat gccaagtaaa aaggctttgc ttcaggatta tggagacagt
     8521 tctgaaaagc cagcataact taatgatcaa tcagaaaaat atagagcagt aactacacaa
     8581 ctgaaggatg cataaaaatt gtacaaaacg ttaatagtgg aatggggagg taggatggga
     8641 ttttacgggc aagtattaag ctcttggaaa gcttcatttg ttgccctcaa tccacacagc
     8701 agaaagaaag agaaagagac aaacatggtc aaagaaaagt atgtggacaa atgtgggggg
     8761 tagaaaagga aatgaaggtt aagcaaggcc aatataattc agaataaaag ggagggaggg
     8821 aagtataagg agccagctgt aattactgaa tgttacatta agaagagctg aaattgagag
     8881 ggggaggtct tgagtatttt actaagtgga ttaatgtcct cttcctcggg tgtctgaagt
     8941 tgcagatttt aatttatttg gtgcagggat ttattacaga attcttaatg ggtggggaga
     9001 taaacaggga caattataag ctcttaagaa gaagaaaaga ggaccatata atactttcta
     9061 taaatttaac tgtaataaac agggtttcaa gctatggaca aagatagtca aaaaaagcat
     9121 ttattccatg atataggact aaaagggaaa taagaggtgt gtccaaaaaa cttaaagacc
     9181 aaaacaaaga aagaaaaacc cacatagatg tgtgatgcca ggattttgaa tgacttggga
     9241 gctagttatt gccgctctcc tttctccacc catttaaaaa aataaatcat aactctggca
     9301 tttaaaaacc tactcatgaa catcatttat taatataaac ttaatcctgt gctattcttt
     9361 ggtgggtggt aagaacatga attaacaaca actggactaa aacgatggca acaggatgat
     9421 ccactcaaac acaggaaagc tgtaagaaaa agaaaaactc ctaatctgct ctttcacctt
     9481 acttatttta cagaaggaga aagccaaaaa ggggagagca tgtggctaaa ccacagaaag
     9541 actagatgcc taaaggaaaa attttaaagt gttcctaaat aggtattaga aggggaaggg
     9601 ggatgtaaag cttatgtgat ttacatcatt ttgttaatct gctaatctac ttccctggaa
     9661 ggtgagaaag agtgttgtct gccttctgca attgaagaga ctagggcaga aacttaatta
     9721 tgttcttacc ctgtgtatac ctggctgtca tctggctggc aactagtcca caaactattg
     9781 gttcaggcat ttgcctggca ataatgttag ccatcattta aattgttaaa tatggatcag
     9841 aagatctcta agaattactg atatgcagct attaatactg gatgtaaata atattatttg
     9901 gggtgtgggt aaatcatttg actggaacca catttaaaaa aaggacttgg aaattttatt
     9961 tttgaaatgc tgttggggag atggcattga tgaaaaaaaa aattgaaaat ggaaaaaaac
    10021 atcatctaca aagagatggg taaaaatgac taagcaaaga agccttgtca ccttcgacct
    10081 gatgcttcat tgtatcagaa gaaagtaaac agattgctaa caaagagacc accccttcta
    10141 atttccaaaa ccggcccagc aacaagaggg agaaaataga gaagagtgca ctgcgtggtg
    10201 gctcagggtg atcctttaat ttgagtgtta aaaatgaggg cacagaccta gaggttttta
    10261 atggtccgcg ggtggacttc agattctgaa cactcctcca ccttctgtgg agaattcggg
    10321 acacggtgga gtttaaccag tatcttaaat cccagggaca gggtggagat tgctttgtga
    10381 tcctgattaa ttaaaaggaa agaaatcaaa gcagacatct ctcctttttc catttgagcc
    10441 gcagagccat ggaggggaac ttgtgctctc tggtgcttgc agctatgttc cctggctttc
    10501 atcgtcttgg cttttcccct tgtatttcta atgctgtgat accaggccaa taaaatggaa
    10561 tctacaaaac tgcaaaacaa aa
//
