LOCUS       NM_001376312           10585 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 26, mRNA.
ACCESSION   NM_001376312 XM_017004929
VERSION     NM_001376312.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10585)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10585)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10585)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10585)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10585)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10585)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10585)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10585)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376312.1.
            
            Transcript Variant: This variant (26), as well as variants 1, 3,
            12, 18, 21-25, and 27-29, encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.383133.1,
                                           SRR1803612.161782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682281.1/ ENSP00000507713.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-136              AC009957.11        120958-121019       c
            137-201             AC009957.11        96797-96861         c
            202-403             AC009957.11        93885-94086         c
            404-571             AC009957.11        30854-31021         c
            572-745             AC009957.11        27164-27337         c
            746-1099            AC010681.16        8445-8798           c
            1100-1209           AC016910.6         135286-135395       c
            1210-1354           AC016910.6         121828-121972       c
            1355-1425           AC016910.6         117406-117476       c
            1426-1517           AC016910.6         116615-116706       c
            1518-10585          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10585
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..136
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            137..201
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1601
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform a is encoded by transcript variant 26;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     a"
                     /protein_id="NP_001363241.1"
                     /db_xref="CCDS:CCDS33300.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEA
                     KKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKD
                     LVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLL
                     TTEPREDL"
     exon            404..571
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..745
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1099
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1209
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1354
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1425
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1517
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..10585
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2614..2619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2622
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2639
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10552..10557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10585
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggaggtatct ctgcattagc cagattggac atatgtaaag ggacatcagt
      121 atatctggat catcagattg tgcttcaaga agaccatagg gaagaacgca ttttcatctt
      181 gctgcaaaag ttgcaataga agatctgaag gtttgaatgg gccaatgagt atcctcatca
      241 ttgaagcatt ctatggaggc tcccataaac agctggtgga tcttcttcaa gaagagttag
      301 gagactgtgt cgtttatacc cttcctgcaa agaaatggca ttggagagcc cggacatctg
      361 ctttatattt ctctcagacc attcccatca gtgagcatta caggaccctc tttgcaagtt
      421 cagtgcttaa cctgaccgaa ctggctgccc ttcggcctga ccttgggaaa ctgaaaaaga
      481 ttctgtattt tcacgagaac cagttgatat atcctgtcaa gaaatgtcag gagagggatt
      541 tccaatatgg atacaaccaa attctttcat gcctggtggc tgatgtggtt gtattcaact
      601 cagtttttaa tatggaatca tttctcactt ccatgggaaa atttatgaag ctgattcctg
      661 atcacagacc caaggatctg gaaagcatca tcagacccaa gtgccaagtt atttactttc
      721 ccatcaggtt tcctgatgtg agcagattca tgcccaagca caaaacaacc catttaaaga
      781 agatgctcgg ccttaaagga aatggcggtg cggttctgtc catggccctt ccttttcagc
      841 cagagcagag agattcagag gatttattga agaattttaa ttcagagtgt gatacacact
      901 gtggccttga tactgcacga caagaatatt tgggtaactc attaagacag gaatcagact
      961 tgaaaaaatc cacctcgtca gataattcaa gctctcatca tggtgaaaat aaacaaaatc
     1021 tgactgttga tccctgtgac attttgggtg gagttgataa tcagcaaaga ctgctacaca
     1081 ttgtctggcc tcacaggtgg gagcatgata aagatccaga aagctttttt aaggtattaa
     1141 tgcatcttaa agacttagga ctcaatttcc acgtgtctgt acttggagaa accttcacag
     1201 atgtcccaga tattttttca gaggccaaaa aggcattggg atcttctgtc ttacactggg
     1261 gctacttacc cagcaaagat gactatttcc aagtactgtg catggctgat gttgtcatct
     1321 caacagctaa gcatgaattc tttggagtgg caatgttgga agctgtgtac tgtgggtgtt
     1381 acccactttg tcctaaagat ttggtttatc ccgaaatatt tccagctgaa tatctgtatt
     1441 ctacacctga acagctttca aaaaggctcc agaatttctg caagagacca gatattataa
     1501 gaaaacatct ctataagggt gaaatcgctc cgttttcttg ggcagcccta catggtaaat
     1561 tcaggtctct gcttacaaca gaacctaggg aagatttgtg acagatgggg ctaagtcaca
     1621 aacttgcagc ctaaggcaga atctgaagaa ctttccagag tgtgcccata tttacctgat
     1681 cagagagaaa agaaaatctg cagaggaagc tgagcctggc tgcttgtcat agctgacaca
     1741 gagccatctg ccacaaacct gtggcggctt cagatctcca atccctgcca ccaccccaac
     1801 tcaaattaaa tacagattcc tagagacgtt atgatggtta cacatgtcct cggcatcaca
     1861 tgtaggagac tgttcaaaaa aaatatgtgg cctgttgtat aaccgcactc atgtatccca
     1921 tatgtggtgc cacattgaat ttccggttga atccgttttt atcctttgta ctggatgaca
     1981 tggtgcctga attctttctt ttcgccgaca cgatggcagc caaactgcag cttcaaacgc
     2041 tcacacttgg ctgggtttct acctaggttg ccaggttatc atcggagcct tcttgtgtcc
     2101 tcaaagggcc acgaggcctg aaaggaggat cagaatgctt tgggattaat tgggcagcca
     2161 tcgcagaatt gtttgtgggc aaagggctgc tttagcactt ttcttttagc aaattaatga
     2221 ctctcaggca cagggggttt taagtgaagg tattaataag aggtctggca ggtattccca
     2281 tgattcacag agttacattt gcatttaatt aatcttaaag ttgcaagata aacagctgta
     2341 attcggacaa acatgacaaa cacagtgaag ccaactatcc cataaaatga acactgacat
     2401 acttgtttta atttttttcc cagcgtaaaa atagaaaaat caaaatactc ctaacaaaac
     2461 cagtgatttt gatagaaata tttctccaat atacttgcat ccacctacaa atataacctt
     2521 ttcaagataa atcgcttatg atttcaatag tcaaactgct gtgtttgttg atgtaaagat
     2581 gttttgaatg gctagatggt aaaataaatt cttaataaag tacccactgc aatttttaat
     2641 tagcatattc atttacatat agatgtatac atctacctat gtgtttctca ctgaacgttt
     2701 tccttgtgac agagacaaca aatacaattg tttcttttcc ggatgaacaa ggatctgttt
     2761 tgcaaatgtt tgtaagatat tatgacattt ccaagatttt ctttgcattc tggaaagcag
     2821 gaggtaaaca tttgtagtca ttaaggtaaa gtctgttgat aaaccatctt ctgtttactg
     2881 acaggtaaat tgtaactttc cctagctttt gaaatgagta acttctatac accacaaagt
     2941 gaggcacagc ctgggaaagg tggctagaca aggggcaagc caggctttct agcttctgga
     3001 aggatcgagt ggcctagcag gcatctaaga taaagaaagc aatgattcgg aagtccagta
     3061 gggcccattt gaccggtagc aaaatcgaaa gcacgaaata gatcaaggtt agggagccag
     3121 acaaagccct tggaagagag gcagtattgc agatcgaagc aagcagttca gagtctatga
     3181 ggcctgggaa tttaaaagca ggaagagtaa gaagcagaaa caagaagctc catctgaaca
     3241 gactcctctc tccaaccttc atgagaccca cagtgtgtga tgggccacca cagcactggc
     3301 ttctagactt ttacagggaa gccagtgaac aaattacctc gtcacccaga aaacaaagag
     3361 ctcaggaact attttggaag ttccttccag tctaagacta tggaactcag aatctagcag
     3421 gtgtgttcct ttggatagca aaactaaaga tataaatatg aataagaaat tctttgccac
     3481 ttctcctggg caaggttata ctttatgcca tctactgaga taaaccagat gagtcagttt
     3541 gcttctgtca gttgctgtgt cacagatgac atcttctcaa aataatatta tctcacagcc
     3601 aagaaatagc gcttcgttta ctgtgttttt ctatcctgaa actaaatggg cttacgcttc
     3661 atagtggcta agatactcca cacacaacta gtacccatag atcttttctc actgatagga
     3721 aaaaaaaaaa aaaagcatta aacacctttc agagagtaca tctgaaacat ttacgtattt
     3781 tcctgattta ggcaaatata atattgaaag ttacctgtat gtgggcattt ttttctacac
     3841 tcataaatgc aaatcaaatt ttgccattag ctgtggccaa cattccttcc aggacaaaag
     3901 cttacattag gccgggtgcg gtggcgcacg cctgtaatcc cagcactttg ggaggccgag
     3961 acgggtggat catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccat
     4021 ctctactaaa aatacaaaaa aaattagcca ggcatggtgg cgggtgcctg tagtcccagc
     4081 tactggggag gctgaggcag gagaatggcg tgaacccagg aggcggagct tgcagtgagc
     4141 cgagatcgtg ccactgcact ccagcctggg cgacagagcg agactctgtc tcaaaaaata
     4201 aataaataaa taaatttaaa ataaatttta aaaaaattac attaaaggtg tcacttattt
     4261 gcatgatacc gagatttgga gtttaaagaa aaaccttata aagactgtaa tgtcagagtt
     4321 gctactagtt cacataagca ataaaaagtt ttgtaaatgt gtaattctta acatttaaaa
     4381 atatgtagga gtgtgtgtgt gtgtgtgtgt gtgcacacgc acattcatgc ttctcaacac
     4441 ccacgaccta gtggaatgga gtgttattaa ataagttaat cagtattttg ttgaaatctc
     4501 agcagataat tagtactaca cgttgactca ttaattcagt ttcccttatc aaccaccccc
     4561 atcatttatt gttttgagta tgtttgatgg aaaacttagt cttcctcttt ttttttaaca
     4621 ctcgattgtt tttttctttt aaaataaagt caattttaat tttaaatgtc tttaaaagtc
     4681 catccattat caagactttg acacagtgtc ttgaaataca gcttgcccta aacttaatct
     4741 atgcttctgg ctaggtgttt ctataacaaa tatcagggca cctggttctt aaccttctca
     4801 tttatactgt gttgacagaa atagatgcaa ataccttttt aaaaatgctc ctggtttaat
     4861 aagcatcctt caaatacagt taagtttaaa tgccctgctc ctgttctcag tccttcagac
     4921 atcaatatgg caggcagaat ccataagtca atggaaactc ttagccatag agggctgcag
     4981 agattaattt caacaccttg aaatgcatct ggaagcaaag atttcatttt atgttgaagg
     5041 tgttaattat atttgatatt tttaaaagta aaatctgttt ttgagaaagc atctgctacc
     5101 cagaaatatt atgagccaca aaagaaattt tactgaagtc tcaagatact ttctgtggat
     5161 gatagaatca gttttcaaat gatagtccat gctgtctttt aatgctgaca tacactgtgg
     5221 gtcttattct tctattgact attgacccaa ctgcctttct ttttcagtgg aaaatttggg
     5281 actatttaat attagatctt atgtttaaca atgaagagag tatattataa accactgact
     5341 tgaacatgtt tcattttaaa atttgagttg tgatacagac aactaatgct cctatcctat
     5401 gccctctctt caaagctatt cattaaaata taactgggga agtttgaaaa acatgcgagc
     5461 aattctacat gctgctcaaa gatacagaca tgtgtgatta aagtacagta ttacagaaaa
     5521 cctgggaatt aaccaaactt acaataatgg ttatgtcaga ggggccatgg tagagaaaaa
     5581 aaaggacata gaagtaggga aaggtgcatt cgttgcatga tgagaagtct gtttcttaag
     5641 ctgagtcgtg atacacaaag gcttcttgcc actctttgtg acatttcatg tgtcttcagt
     5701 gtatttattg catatatctt ttgataggag atataaatac ttcaggaagc atgttactag
     5761 ttttgctatc aggctatcct taacatttct tggttttctc aattattgat tgagtcagaa
     5821 aactgcttgc ctcagacagt gatacaaact actctactgc caatgttgct tgagaagact
     5881 ttcctctgct taacaggagc caggggcttc acctcaaccc tcatgctgtg gagaaagtca
     5941 gactcaactg gccacaggtt cctgtttctt ggggctgcta atcaccattt ctaacagatg
     6001 cctgtggcat tgcaaacaca agatggaaaa ctatagctct aaactccctt ctgaagggta
     6061 aggaaaggaa gaggaaggca gatgttaaat gagcccagtc tttctcatct caaaaaattc
     6121 agagctgcct gttagagcac aagagctctc agagctccca accacactgc ccactcccca
     6181 tagtgttgcc tctccccttt cctctttaag acgcaggagc gaatcgtggt ctttgtgctt
     6241 tcactgcaat ctatcccagg ggaagagttc tcccgggtat ctgtgggatg cccttgctgc
     6301 atgtgaggca caaatggctt cagggaccag gatcctcact cactctgcag tccatttttc
     6361 taaattggaa tttgcgatcg gtttcttcag gtgtcccacc atcatctatc attatctgag
     6421 ttattcctta tcctctccca accccaagga gaggatctta attgttttta taaactgaca
     6481 gaaggaattg gtgattcttg gaagataatt ttaaatggtt atattacttt cctattactg
     6541 catttactgc atttaaatag caggtctaag gtggggtgcg agaagatgtg acccctagga
     6601 atattggtat gacctttctc aagcaatttg aagtccttta gatctgaaaa tttaatgtct
     6661 tcaatatcat ttcacagatg agaaaattaa ggcacatata gtgacatatt taggagctga
     6721 agtgtgttac agaaacaaag tttttttgta taagcctttc cctacatggg atgttatcat
     6781 tgtcacctat gtgcctttca ggaagcacca agtgcagtat gcgtgactca gttggacccc
     6841 tagttccctt ctatttctcc agctggcagg agacagcaaa ggacagtgga ggtggttatt
     6901 ttgtggccca catttctgcc attaaaaggg acataagaga ctatgtagtg tggccaattt
     6961 tttttttttt ttttttgaga gagagagtct ggctctgtcg cccaggctgg agtgcagtgg
     7021 caccatctcg gctcactgca agctccacct cccgggttca cgccattctc ctgcctcagc
     7081 ctcccgagta gctgggacta caggtgccca ccaccacgcc cggctaattt ttttgtattt
     7141 ttagtagaga cggggtttca ccatgttagc cagggtggtc tcaatctcct gacctcgtga
     7201 tccacctgtc tcggcctccc aaagtgctgg gattacaggt gtaagccacc atgcccggaa
     7261 tatggccatt attttaagtg tttttattat tgctctggtt ctccctttag ggaggcattc
     7321 agtgagtata ccccatctgt cacaggcccc caccactccc tgtggtctta cactctgctg
     7381 aattcataca tttaggtaac ttccctggcc ctcctgagaa tcacttattt ttgtaacctc
     7441 ctgtatttga gatgtaggaa actggggcct gaggagaagt tgacttgcct tgggtcccac
     7501 agtggtacag gcagatctag aactcagatt ttccagggct ctttcagtag gctgtggttg
     7561 agcagtagtc aagaccacct cttcaagaag ggaaaaacat ttgtcttctc tttctcctct
     7621 ttcttccttc tgcctctcac tgtaagaaga aacgtgttaa taagttgcta ataccttact
     7681 ctaggtgtat ttcatgttac accagccagt gcttgtattc tcaatgacca taaggagagg
     7741 aatgcggaag aattgatttc tgtactaaaa gttcagactc tgtggcactt gtgatatttc
     7801 tggacaactg actcttctct attgcctttc gaatcataca gtggcaaagc tgctcaccca
     7861 tgtgtgtata aagctgaccc ttcatcagaa aggcagcccc cagtgtctcc ccacacaggg
     7921 cagaagagca gagggagcag gtggcaatgt ggcagcacct tgaactgtgc atcactgggc
     7981 ctgctccccc tcatcccaaa gcaataaccc agaaattaca tcctgagact tacttcctca
     8041 gaaagaaaag gaaggggagg gataacttaa aaaggagaaa cttctaatat ggtattagac
     8101 tgtaattcat agggaaattt atgcctgaga tatgaatttc tgaaaataag gggctttttt
     8161 ggaagggaaa cactgacaca tccttaatta tagagtaata aataccaatg gtatattatc
     8221 tttcgatatt tccttacaca gatatcaaag catgcagctg tttttgaaaa ctgataatca
     8281 agtacaatat aagtatatta catcttgcac ttacaacaca cccttcaact aagcagcatc
     8341 atggagcact taacggtgag aaacagagct gctcatagta gaaacctaac tgaacaaatt
     8401 agctttgaat tgtaacttaa gaatcgtagt caaaccaaag cgtctgtcct tgccaggaaa
     8461 ggcattccaa aggcagagag catgccaagt aaaaaggctt tgcttcagga ttatggagac
     8521 agttctgaaa agccagcata acttaatgat caatcagaaa aatatagagc agtaactaca
     8581 caactgaagg atgcataaaa attgtacaaa acgttaatag tggaatgggg aggtaggatg
     8641 ggattttacg ggcaagtatt aagctcttgg aaagcttcat ttgttgccct caatccacac
     8701 agcagaaaga aagagaaaga gacaaacatg gtcaaagaaa agtatgtgga caaatgtggg
     8761 gggtagaaaa ggaaatgaag gttaagcaag gccaatataa ttcagaataa aagggaggga
     8821 gggaagtata aggagccagc tgtaattact gaatgttaca ttaagaagag ctgaaattga
     8881 gagggggagg tcttgagtat tttactaagt ggattaatgt cctcttcctc gggtgtctga
     8941 agttgcagat tttaatttat ttggtgcagg gatttattac agaattctta atgggtgggg
     9001 agataaacag ggacaattat aagctcttaa gaagaagaaa agaggaccat ataatacttt
     9061 ctataaattt aactgtaata aacagggttt caagctatgg acaaagatag tcaaaaaaag
     9121 catttattcc atgatatagg actaaaaggg aaataagagg tgtgtccaaa aaacttaaag
     9181 accaaaacaa agaaagaaaa acccacatag atgtgtgatg ccaggatttt gaatgacttg
     9241 ggagctagtt attgccgctc tcctttctcc acccatttaa aaaaataaat cataactctg
     9301 gcatttaaaa acctactcat gaacatcatt tattaatata aacttaatcc tgtgctattc
     9361 tttggtgggt ggtaagaaca tgaattaaca acaactggac taaaacgatg gcaacaggat
     9421 gatccactca aacacaggaa agctgtaaga aaaagaaaaa ctcctaatct gctctttcac
     9481 cttacttatt ttacagaagg agaaagccaa aaaggggaga gcatgtggct aaaccacaga
     9541 aagactagat gcctaaagga aaaattttaa agtgttccta aataggtatt agaaggggaa
     9601 gggggatgta aagcttatgt gatttacatc attttgttaa tctgctaatc tacttccctg
     9661 gaaggtgaga aagagtgttg tctgccttct gcaattgaag agactagggc agaaacttaa
     9721 ttatgttctt accctgtgta tacctggctg tcatctggct ggcaactagt ccacaaacta
     9781 ttggttcagg catttgcctg gcaataatgt tagccatcat ttaaattgtt aaatatggat
     9841 cagaagatct ctaagaatta ctgatatgca gctattaata ctggatgtaa ataatattat
     9901 ttggggtgtg ggtaaatcat ttgactggaa ccacatttaa aaaaaggact tggaaatttt
     9961 atttttgaaa tgctgttggg gagatggcat tgatgaaaaa aaaaattgaa aatggaaaaa
    10021 aacatcatct acaaagagat gggtaaaaat gactaagcaa agaagccttg tcaccttcga
    10081 cctgatgctt cattgtatca gaagaaagta aacagattgc taacaaagag accacccctt
    10141 ctaatttcca aaaccggccc agcaacaaga gggagaaaat agagaagagt gcactgcgtg
    10201 gtggctcagg gtgatccttt aatttgagtg ttaaaaatga gggcacagac ctagaggttt
    10261 ttaatggtcc gcgggtggac ttcagattct gaacactcct ccaccttctg tggagaattc
    10321 gggacacggt ggagtttaac cagtatctta aatcccaggg acagggtgga gattgctttg
    10381 tgatcctgat taattaaaag gaaagaaatc aaagcagaca tctctccttt ttccatttga
    10441 gccgcagagc catggagggg aacttgtgct ctctggtgct tgcagctatg ttccctggct
    10501 ttcatcgtct tggcttttcc ccttgtattt ctaatgctgt gataccaggc caataaaatg
    10561 gaatctacaa aactgcaaaa caaaa
//
