LOCUS       NM_001376311           10717 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 25, mRNA.
ACCESSION   NM_001376311
VERSION     NM_001376311.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10717)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10717)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10717)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10717)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10717)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10717)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10717)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10717)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376311.1.
            
            Transcript Variant: This variant (25), as well as variants 1, 3,
            12, 18, 21-24, and 26-29, encodes isoform a.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR18074969.976815.1, SRR1660805.156012.1
                                    [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-268              AC009957.11        182977-183170       c
            269-333             AC009957.11        96797-96861         c
            334-535             AC009957.11        93885-94086         c
            536-703             AC009957.11        30854-31021         c
            704-877             AC009957.11        27164-27337         c
            878-1231            AC010681.16        8445-8798           c
            1232-1341           AC016910.6         135286-135395       c
            1342-1486           AC016910.6         121828-121972       c
            1487-1557           AC016910.6         117406-117476       c
            1558-1649           AC016910.6         116615-116706       c
            1650-10717          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10717
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..268
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            269..333
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            334..535
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1733
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform a is encoded by transcript variant 25;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     a"
                     /protein_id="NP_001363240.1"
                     /db_xref="CCDS:CCDS33300.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEA
                     KKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKD
                     LVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLL
                     TTEPREDL"
     exon            536..703
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            704..877
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1231
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1341
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1486
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1557
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1649
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..10717
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2771
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10684..10689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10717
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggagatggaa tccagcccgg cactgtggct cacacctgta atcccagcac
      121 tttgggaggc cgaggtgggt ggatcacgag gtcaggagat ggagaccatc ctggctaaca
      181 tggtgaaacc ccatctatac taaaaataca aaaaattagc caggtgtggt ggcacgcacc
      241 tgtagtccca gctacttagg aggctgagat tgtgcttcaa gaagaccata gggaagaacg
      301 cattttcatc ttgctgcaaa agttgcaata gaagatctga aggtttgaat gggccaatga
      361 gtatcctcat cattgaagca ttctatggag gctcccataa acagctggtg gatcttcttc
      421 aagaagagtt aggagactgt gtcgtttata cccttcctgc aaagaaatgg cattggagag
      481 cccggacatc tgctttatat ttctctcaga ccattcccat cagtgagcat tacaggaccc
      541 tctttgcaag ttcagtgctt aacctgaccg aactggctgc ccttcggcct gaccttggga
      601 aactgaaaaa gattctgtat tttcacgaga accagttgat atatcctgtc aagaaatgtc
      661 aggagaggga tttccaatat ggatacaacc aaattctttc atgcctggtg gctgatgtgg
      721 ttgtattcaa ctcagttttt aatatggaat catttctcac ttccatggga aaatttatga
      781 agctgattcc tgatcacaga cccaaggatc tggaaagcat catcagaccc aagtgccaag
      841 ttatttactt tcccatcagg tttcctgatg tgagcagatt catgcccaag cacaaaacaa
      901 cccatttaaa gaagatgctc ggccttaaag gaaatggcgg tgcggttctg tccatggccc
      961 ttccttttca gccagagcag agagattcag aggatttatt gaagaatttt aattcagagt
     1021 gtgatacaca ctgtggcctt gatactgcac gacaagaata tttgggtaac tcattaagac
     1081 aggaatcaga cttgaaaaaa tccacctcgt cagataattc aagctctcat catggtgaaa
     1141 ataaacaaaa tctgactgtt gatccctgtg acattttggg tggagttgat aatcagcaaa
     1201 gactgctaca cattgtctgg cctcacaggt gggagcatga taaagatcca gaaagctttt
     1261 ttaaggtatt aatgcatctt aaagacttag gactcaattt ccacgtgtct gtacttggag
     1321 aaaccttcac agatgtccca gatatttttt cagaggccaa aaaggcattg ggatcttctg
     1381 tcttacactg gggctactta cccagcaaag atgactattt ccaagtactg tgcatggctg
     1441 atgttgtcat ctcaacagct aagcatgaat tctttggagt ggcaatgttg gaagctgtgt
     1501 actgtgggtg ttacccactt tgtcctaaag atttggttta tcccgaaata tttccagctg
     1561 aatatctgta ttctacacct gaacagcttt caaaaaggct ccagaatttc tgcaagagac
     1621 cagatattat aagaaaacat ctctataagg gtgaaatcgc tccgttttct tgggcagccc
     1681 tacatggtaa attcaggtct ctgcttacaa cagaacctag ggaagatttg tgacagatgg
     1741 ggctaagtca caaacttgca gcctaaggca gaatctgaag aactttccag agtgtgccca
     1801 tatttacctg atcagagaga aaagaaaatc tgcagaggaa gctgagcctg gctgcttgtc
     1861 atagctgaca cagagccatc tgccacaaac ctgtggcggc ttcagatctc caatccctgc
     1921 caccacccca actcaaatta aatacagatt cctagagacg ttatgatggt tacacatgtc
     1981 ctcggcatca catgtaggag actgttcaaa aaaaatatgt ggcctgttgt ataaccgcac
     2041 tcatgtatcc catatgtggt gccacattga atttccggtt gaatccgttt ttatcctttg
     2101 tactggatga catggtgcct gaattctttc ttttcgccga cacgatggca gccaaactgc
     2161 agcttcaaac gctcacactt ggctgggttt ctacctaggt tgccaggtta tcatcggagc
     2221 cttcttgtgt cctcaaaggg ccacgaggcc tgaaaggagg atcagaatgc tttgggatta
     2281 attgggcagc catcgcagaa ttgtttgtgg gcaaagggct gctttagcac ttttctttta
     2341 gcaaattaat gactctcagg cacagggggt tttaagtgaa ggtattaata agaggtctgg
     2401 caggtattcc catgattcac agagttacat ttgcatttaa ttaatcttaa agttgcaaga
     2461 taaacagctg taattcggac aaacatgaca aacacagtga agccaactat cccataaaat
     2521 gaacactgac atacttgttt taattttttt cccagcgtaa aaatagaaaa atcaaaatac
     2581 tcctaacaaa accagtgatt ttgatagaaa tatttctcca atatacttgc atccacctac
     2641 aaatataacc ttttcaagat aaatcgctta tgatttcaat agtcaaactg ctgtgtttgt
     2701 tgatgtaaag atgttttgaa tggctagatg gtaaaataaa ttcttaataa agtacccact
     2761 gcaattttta attagcatat tcatttacat atagatgtat acatctacct atgtgtttct
     2821 cactgaacgt tttccttgtg acagagacaa caaatacaat tgtttctttt ccggatgaac
     2881 aaggatctgt tttgcaaatg tttgtaagat attatgacat ttccaagatt ttctttgcat
     2941 tctggaaagc aggaggtaaa catttgtagt cattaaggta aagtctgttg ataaaccatc
     3001 ttctgtttac tgacaggtaa attgtaactt tccctagctt ttgaaatgag taacttctat
     3061 acaccacaaa gtgaggcaca gcctgggaaa ggtggctaga caaggggcaa gccaggcttt
     3121 ctagcttctg gaaggatcga gtggcctagc aggcatctaa gataaagaaa gcaatgattc
     3181 ggaagtccag tagggcccat ttgaccggta gcaaaatcga aagcacgaaa tagatcaagg
     3241 ttagggagcc agacaaagcc cttggaagag aggcagtatt gcagatcgaa gcaagcagtt
     3301 cagagtctat gaggcctggg aatttaaaag caggaagagt aagaagcaga aacaagaagc
     3361 tccatctgaa cagactcctc tctccaacct tcatgagacc cacagtgtgt gatgggccac
     3421 cacagcactg gcttctagac ttttacaggg aagccagtga acaaattacc tcgtcaccca
     3481 gaaaacaaag agctcaggaa ctattttgga agttccttcc agtctaagac tatggaactc
     3541 agaatctagc aggtgtgttc ctttggatag caaaactaaa gatataaata tgaataagaa
     3601 attctttgcc acttctcctg ggcaaggtta tactttatgc catctactga gataaaccag
     3661 atgagtcagt ttgcttctgt cagttgctgt gtcacagatg acatcttctc aaaataatat
     3721 tatctcacag ccaagaaata gcgcttcgtt tactgtgttt ttctatcctg aaactaaatg
     3781 ggcttacgct tcatagtggc taagatactc cacacacaac tagtacccat agatcttttc
     3841 tcactgatag gaaaaaaaaa aaaaaagcat taaacacctt tcagagagta catctgaaac
     3901 atttacgtat tttcctgatt taggcaaata taatattgaa agttacctgt atgtgggcat
     3961 ttttttctac actcataaat gcaaatcaaa ttttgccatt agctgtggcc aacattcctt
     4021 ccaggacaaa agcttacatt aggccgggtg cggtggcgca cgcctgtaat cccagcactt
     4081 tgggaggccg agacgggtgg atcatgaggt caggagatcg agaccatcct ggctaacacg
     4141 gtgaaacccc atctctacta aaaatacaaa aaaaattagc caggcatggt ggcgggtgcc
     4201 tgtagtccca gctactgggg aggctgaggc aggagaatgg cgtgaaccca ggaggcggag
     4261 cttgcagtga gccgagatcg tgccactgca ctccagcctg ggcgacagag cgagactctg
     4321 tctcaaaaaa taaataaata aataaattta aaataaattt taaaaaaatt acattaaagg
     4381 tgtcacttat ttgcatgata ccgagatttg gagtttaaag aaaaacctta taaagactgt
     4441 aatgtcagag ttgctactag ttcacataag caataaaaag ttttgtaaat gtgtaattct
     4501 taacatttaa aaatatgtag gagtgtgtgt gtgtgtgtgt gtgtgcacac gcacattcat
     4561 gcttctcaac acccacgacc tagtggaatg gagtgttatt aaataagtta atcagtattt
     4621 tgttgaaatc tcagcagata attagtacta cacgttgact cattaattca gtttccctta
     4681 tcaaccaccc ccatcattta ttgttttgag tatgtttgat ggaaaactta gtcttcctct
     4741 ttttttttaa cactcgattg tttttttctt ttaaaataaa gtcaatttta attttaaatg
     4801 tctttaaaag tccatccatt atcaagactt tgacacagtg tcttgaaata cagcttgccc
     4861 taaacttaat ctatgcttct ggctaggtgt ttctataaca aatatcaggg cacctggttc
     4921 ttaaccttct catttatact gtgttgacag aaatagatgc aaataccttt ttaaaaatgc
     4981 tcctggttta ataagcatcc ttcaaataca gttaagttta aatgccctgc tcctgttctc
     5041 agtccttcag acatcaatat ggcaggcaga atccataagt caatggaaac tcttagccat
     5101 agagggctgc agagattaat ttcaacacct tgaaatgcat ctggaagcaa agatttcatt
     5161 ttatgttgaa ggtgttaatt atatttgata tttttaaaag taaaatctgt ttttgagaaa
     5221 gcatctgcta cccagaaata ttatgagcca caaaagaaat tttactgaag tctcaagata
     5281 ctttctgtgg atgatagaat cagttttcaa atgatagtcc atgctgtctt ttaatgctga
     5341 catacactgt gggtcttatt cttctattga ctattgaccc aactgccttt ctttttcagt
     5401 ggaaaatttg ggactattta atattagatc ttatgtttaa caatgaagag agtatattat
     5461 aaaccactga cttgaacatg tttcatttta aaatttgagt tgtgatacag acaactaatg
     5521 ctcctatcct atgccctctc ttcaaagcta ttcattaaaa tataactggg gaagtttgaa
     5581 aaacatgcga gcaattctac atgctgctca aagatacaga catgtgtgat taaagtacag
     5641 tattacagaa aacctgggaa ttaaccaaac ttacaataat ggttatgtca gaggggccat
     5701 ggtagagaaa aaaaaggaca tagaagtagg gaaaggtgca ttcgttgcat gatgagaagt
     5761 ctgtttctta agctgagtcg tgatacacaa aggcttcttg ccactctttg tgacatttca
     5821 tgtgtcttca gtgtatttat tgcatatatc ttttgatagg agatataaat acttcaggaa
     5881 gcatgttact agttttgcta tcaggctatc cttaacattt cttggttttc tcaattattg
     5941 attgagtcag aaaactgctt gcctcagaca gtgatacaaa ctactctact gccaatgttg
     6001 cttgagaaga ctttcctctg cttaacagga gccaggggct tcacctcaac cctcatgctg
     6061 tggagaaagt cagactcaac tggccacagg ttcctgtttc ttggggctgc taatcaccat
     6121 ttctaacaga tgcctgtggc attgcaaaca caagatggaa aactatagct ctaaactccc
     6181 ttctgaaggg taaggaaagg aagaggaagg cagatgttaa atgagcccag tctttctcat
     6241 ctcaaaaaat tcagagctgc ctgttagagc acaagagctc tcagagctcc caaccacact
     6301 gcccactccc catagtgttg cctctcccct ttcctcttta agacgcagga gcgaatcgtg
     6361 gtctttgtgc tttcactgca atctatccca ggggaagagt tctcccgggt atctgtggga
     6421 tgcccttgct gcatgtgagg cacaaatggc ttcagggacc aggatcctca ctcactctgc
     6481 agtccatttt tctaaattgg aatttgcgat cggtttcttc aggtgtccca ccatcatcta
     6541 tcattatctg agttattcct tatcctctcc caaccccaag gagaggatct taattgtttt
     6601 tataaactga cagaaggaat tggtgattct tggaagataa ttttaaatgg ttatattact
     6661 ttcctattac tgcatttact gcatttaaat agcaggtcta aggtggggtg cgagaagatg
     6721 tgacccctag gaatattggt atgacctttc tcaagcaatt tgaagtcctt tagatctgaa
     6781 aatttaatgt cttcaatatc atttcacaga tgagaaaatt aaggcacata tagtgacata
     6841 tttaggagct gaagtgtgtt acagaaacaa agtttttttg tataagcctt tccctacatg
     6901 ggatgttatc attgtcacct atgtgccttt caggaagcac caagtgcagt atgcgtgact
     6961 cagttggacc cctagttccc ttctatttct ccagctggca ggagacagca aaggacagtg
     7021 gaggtggtta ttttgtggcc cacatttctg ccattaaaag ggacataaga gactatgtag
     7081 tgtggccaat tttttttttt ttttttttga gagagagagt ctggctctgt cgcccaggct
     7141 ggagtgcagt ggcaccatct cggctcactg caagctccac ctcccgggtt cacgccattc
     7201 tcctgcctca gcctcccgag tagctgggac tacaggtgcc caccaccacg cccggctaat
     7261 ttttttgtat ttttagtaga gacggggttt caccatgtta gccagggtgg tctcaatctc
     7321 ctgacctcgt gatccacctg tctcggcctc ccaaagtgct gggattacag gtgtaagcca
     7381 ccatgcccgg aatatggcca ttattttaag tgtttttatt attgctctgg ttctcccttt
     7441 agggaggcat tcagtgagta taccccatct gtcacaggcc cccaccactc cctgtggtct
     7501 tacactctgc tgaattcata catttaggta acttccctgg ccctcctgag aatcacttat
     7561 ttttgtaacc tcctgtattt gagatgtagg aaactggggc ctgaggagaa gttgacttgc
     7621 cttgggtccc acagtggtac aggcagatct agaactcaga ttttccaggg ctctttcagt
     7681 aggctgtggt tgagcagtag tcaagaccac ctcttcaaga agggaaaaac atttgtcttc
     7741 tctttctcct ctttcttcct tctgcctctc actgtaagaa gaaacgtgtt aataagttgc
     7801 taatacctta ctctaggtgt atttcatgtt acaccagcca gtgcttgtat tctcaatgac
     7861 cataaggaga ggaatgcgga agaattgatt tctgtactaa aagttcagac tctgtggcac
     7921 ttgtgatatt tctggacaac tgactcttct ctattgcctt tcgaatcata cagtggcaaa
     7981 gctgctcacc catgtgtgta taaagctgac ccttcatcag aaaggcagcc cccagtgtct
     8041 ccccacacag ggcagaagag cagagggagc aggtggcaat gtggcagcac cttgaactgt
     8101 gcatcactgg gcctgctccc cctcatccca aagcaataac ccagaaatta catcctgaga
     8161 cttacttcct cagaaagaaa aggaagggga gggataactt aaaaaggaga aacttctaat
     8221 atggtattag actgtaattc atagggaaat ttatgcctga gatatgaatt tctgaaaata
     8281 aggggctttt ttggaaggga aacactgaca catccttaat tatagagtaa taaataccaa
     8341 tggtatatta tctttcgata tttccttaca cagatatcaa agcatgcagc tgtttttgaa
     8401 aactgataat caagtacaat ataagtatat tacatcttgc acttacaaca cacccttcaa
     8461 ctaagcagca tcatggagca cttaacggtg agaaacagag ctgctcatag tagaaaccta
     8521 actgaacaaa ttagctttga attgtaactt aagaatcgta gtcaaaccaa agcgtctgtc
     8581 cttgccagga aaggcattcc aaaggcagag agcatgccaa gtaaaaaggc tttgcttcag
     8641 gattatggag acagttctga aaagccagca taacttaatg atcaatcaga aaaatataga
     8701 gcagtaacta cacaactgaa ggatgcataa aaattgtaca aaacgttaat agtggaatgg
     8761 ggaggtagga tgggatttta cgggcaagta ttaagctctt ggaaagcttc atttgttgcc
     8821 ctcaatccac acagcagaaa gaaagagaaa gagacaaaca tggtcaaaga aaagtatgtg
     8881 gacaaatgtg gggggtagaa aaggaaatga aggttaagca aggccaatat aattcagaat
     8941 aaaagggagg gagggaagta taaggagcca gctgtaatta ctgaatgtta cattaagaag
     9001 agctgaaatt gagaggggga ggtcttgagt attttactaa gtggattaat gtcctcttcc
     9061 tcgggtgtct gaagttgcag attttaattt atttggtgca gggatttatt acagaattct
     9121 taatgggtgg ggagataaac agggacaatt ataagctctt aagaagaaga aaagaggacc
     9181 atataatact ttctataaat ttaactgtaa taaacagggt ttcaagctat ggacaaagat
     9241 agtcaaaaaa agcatttatt ccatgatata ggactaaaag ggaaataaga ggtgtgtcca
     9301 aaaaacttaa agaccaaaac aaagaaagaa aaacccacat agatgtgtga tgccaggatt
     9361 ttgaatgact tgggagctag ttattgccgc tctcctttct ccacccattt aaaaaaataa
     9421 atcataactc tggcatttaa aaacctactc atgaacatca tttattaata taaacttaat
     9481 cctgtgctat tctttggtgg gtggtaagaa catgaattaa caacaactgg actaaaacga
     9541 tggcaacagg atgatccact caaacacagg aaagctgtaa gaaaaagaaa aactcctaat
     9601 ctgctctttc accttactta ttttacagaa ggagaaagcc aaaaagggga gagcatgtgg
     9661 ctaaaccaca gaaagactag atgcctaaag gaaaaatttt aaagtgttcc taaataggta
     9721 ttagaagggg aagggggatg taaagcttat gtgatttaca tcattttgtt aatctgctaa
     9781 tctacttccc tggaaggtga gaaagagtgt tgtctgcctt ctgcaattga agagactagg
     9841 gcagaaactt aattatgttc ttaccctgtg tatacctggc tgtcatctgg ctggcaacta
     9901 gtccacaaac tattggttca ggcatttgcc tggcaataat gttagccatc atttaaattg
     9961 ttaaatatgg atcagaagat ctctaagaat tactgatatg cagctattaa tactggatgt
    10021 aaataatatt atttggggtg tgggtaaatc atttgactgg aaccacattt aaaaaaagga
    10081 cttggaaatt ttatttttga aatgctgttg gggagatggc attgatgaaa aaaaaaattg
    10141 aaaatggaaa aaaacatcat ctacaaagag atgggtaaaa atgactaagc aaagaagcct
    10201 tgtcaccttc gacctgatgc ttcattgtat cagaagaaag taaacagatt gctaacaaag
    10261 agaccacccc ttctaatttc caaaaccggc ccagcaacaa gagggagaaa atagagaaga
    10321 gtgcactgcg tggtggctca gggtgatcct ttaatttgag tgttaaaaat gagggcacag
    10381 acctagaggt ttttaatggt ccgcgggtgg acttcagatt ctgaacactc ctccaccttc
    10441 tgtggagaat tcgggacacg gtggagttta accagtatct taaatcccag ggacagggtg
    10501 gagattgctt tgtgatcctg attaattaaa aggaaagaaa tcaaagcaga catctctcct
    10561 ttttccattt gagccgcaga gccatggagg ggaacttgtg ctctctggtg cttgcagcta
    10621 tgttccctgg ctttcatcgt cttggctttt ccccttgtat ttctaatgct gtgataccag
    10681 gccaataaaa tggaatctac aaaactgcaa aacaaaa
//
