LOCUS       NM_001376308           10703 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 22, mRNA.
ACCESSION   NM_001376308
VERSION     NM_001376308.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10703)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10703)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10703)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10703)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10703)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10703)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10703)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10703)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001376308.1.
            
            Transcript Variant: This variant (22), as well as variants 1, 3,
            12, 18, 21, and 23-29, encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.102629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC010130.12        29041-29232         c
            193-254             AC009957.11        120958-121019       c
            255-319             AC009957.11        96797-96861         c
            320-521             AC009957.11        93885-94086         c
            522-689             AC009957.11        30854-31021         c
            690-863             AC009957.11        27164-27337         c
            864-1217            AC010681.16        8445-8798           c
            1218-1327           AC016910.6         135286-135395       c
            1328-1472           AC016910.6         121828-121972       c
            1473-1543           AC016910.6         117406-117476       c
            1544-1635           AC016910.6         116615-116706       c
            1636-10703          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10703
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..192
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            193..254
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            255..319
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            320..521
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1719
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform a is encoded by transcript variant 22;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     a"
                     /protein_id="NP_001363237.1"
                     /db_xref="CCDS:CCDS33300.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEA
                     KKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKD
                     LVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLL
                     TTEPREDL"
     exon            522..689
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            690..863
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1217
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1327
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1472
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1543
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1635
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..10703
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2740
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2757
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10670..10675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10703
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 tggaggagct ccgggctgca gagcaggtag aggtgtcggc aagggagcca ggaacccgca
       61 caggggccct gaggctctag taggccgggg agtggaccag gaaaggagat gcaacgggcc
      121 ggctggaaaa ctgcacgggg aatccgaggt cgacctaatg aacagcacag accttccaga
      181 aggaaagaga aggtatctct gcattagcca gattggacat atgtaaaggg acatcagtat
      241 atctggatca tcagattgtg cttcaagaag accataggga agaacgcatt ttcatcttgc
      301 tgcaaaagtt gcaatagaag atctgaaggt ttgaatgggc caatgagtat cctcatcatt
      361 gaagcattct atggaggctc ccataaacag ctggtggatc ttcttcaaga agagttagga
      421 gactgtgtcg tttataccct tcctgcaaag aaatggcatt ggagagcccg gacatctgct
      481 ttatatttct ctcagaccat tcccatcagt gagcattaca ggaccctctt tgcaagttca
      541 gtgcttaacc tgaccgaact ggctgccctt cggcctgacc ttgggaaact gaaaaagatt
      601 ctgtattttc acgagaacca gttgatatat cctgtcaaga aatgtcagga gagggatttc
      661 caatatggat acaaccaaat tctttcatgc ctggtggctg atgtggttgt attcaactca
      721 gtttttaata tggaatcatt tctcacttcc atgggaaaat ttatgaagct gattcctgat
      781 cacagaccca aggatctgga aagcatcatc agacccaagt gccaagttat ttactttccc
      841 atcaggtttc ctgatgtgag cagattcatg cccaagcaca aaacaaccca tttaaagaag
      901 atgctcggcc ttaaaggaaa tggcggtgcg gttctgtcca tggcccttcc ttttcagcca
      961 gagcagagag attcagagga tttattgaag aattttaatt cagagtgtga tacacactgt
     1021 ggccttgata ctgcacgaca agaatatttg ggtaactcat taagacagga atcagacttg
     1081 aaaaaatcca cctcgtcaga taattcaagc tctcatcatg gtgaaaataa acaaaatctg
     1141 actgttgatc cctgtgacat tttgggtgga gttgataatc agcaaagact gctacacatt
     1201 gtctggcctc acaggtggga gcatgataaa gatccagaaa gcttttttaa ggtattaatg
     1261 catcttaaag acttaggact caatttccac gtgtctgtac ttggagaaac cttcacagat
     1321 gtcccagata ttttttcaga ggccaaaaag gcattgggat cttctgtctt acactggggc
     1381 tacttaccca gcaaagatga ctatttccaa gtactgtgca tggctgatgt tgtcatctca
     1441 acagctaagc atgaattctt tggagtggca atgttggaag ctgtgtactg tgggtgttac
     1501 ccactttgtc ctaaagattt ggtttatccc gaaatatttc cagctgaata tctgtattct
     1561 acacctgaac agctttcaaa aaggctccag aatttctgca agagaccaga tattataaga
     1621 aaacatctct ataagggtga aatcgctccg ttttcttggg cagccctaca tggtaaattc
     1681 aggtctctgc ttacaacaga acctagggaa gatttgtgac agatggggct aagtcacaaa
     1741 cttgcagcct aaggcagaat ctgaagaact ttccagagtg tgcccatatt tacctgatca
     1801 gagagaaaag aaaatctgca gaggaagctg agcctggctg cttgtcatag ctgacacaga
     1861 gccatctgcc acaaacctgt ggcggcttca gatctccaat ccctgccacc accccaactc
     1921 aaattaaata cagattccta gagacgttat gatggttaca catgtcctcg gcatcacatg
     1981 taggagactg ttcaaaaaaa atatgtggcc tgttgtataa ccgcactcat gtatcccata
     2041 tgtggtgcca cattgaattt ccggttgaat ccgtttttat cctttgtact ggatgacatg
     2101 gtgcctgaat tctttctttt cgccgacacg atggcagcca aactgcagct tcaaacgctc
     2161 acacttggct gggtttctac ctaggttgcc aggttatcat cggagccttc ttgtgtcctc
     2221 aaagggccac gaggcctgaa aggaggatca gaatgctttg ggattaattg ggcagccatc
     2281 gcagaattgt ttgtgggcaa agggctgctt tagcactttt cttttagcaa attaatgact
     2341 ctcaggcaca gggggtttta agtgaaggta ttaataagag gtctggcagg tattcccatg
     2401 attcacagag ttacatttgc atttaattaa tcttaaagtt gcaagataaa cagctgtaat
     2461 tcggacaaac atgacaaaca cagtgaagcc aactatccca taaaatgaac actgacatac
     2521 ttgttttaat ttttttccca gcgtaaaaat agaaaaatca aaatactcct aacaaaacca
     2581 gtgattttga tagaaatatt tctccaatat acttgcatcc acctacaaat ataacctttt
     2641 caagataaat cgcttatgat ttcaatagtc aaactgctgt gtttgttgat gtaaagatgt
     2701 tttgaatggc tagatggtaa aataaattct taataaagta cccactgcaa tttttaatta
     2761 gcatattcat ttacatatag atgtatacat ctacctatgt gtttctcact gaacgttttc
     2821 cttgtgacag agacaacaaa tacaattgtt tcttttccgg atgaacaagg atctgttttg
     2881 caaatgtttg taagatatta tgacatttcc aagattttct ttgcattctg gaaagcagga
     2941 ggtaaacatt tgtagtcatt aaggtaaagt ctgttgataa accatcttct gtttactgac
     3001 aggtaaattg taactttccc tagcttttga aatgagtaac ttctatacac cacaaagtga
     3061 ggcacagcct gggaaaggtg gctagacaag gggcaagcca ggctttctag cttctggaag
     3121 gatcgagtgg cctagcaggc atctaagata aagaaagcaa tgattcggaa gtccagtagg
     3181 gcccatttga ccggtagcaa aatcgaaagc acgaaataga tcaaggttag ggagccagac
     3241 aaagcccttg gaagagaggc agtattgcag atcgaagcaa gcagttcaga gtctatgagg
     3301 cctgggaatt taaaagcagg aagagtaaga agcagaaaca agaagctcca tctgaacaga
     3361 ctcctctctc caaccttcat gagacccaca gtgtgtgatg ggccaccaca gcactggctt
     3421 ctagactttt acagggaagc cagtgaacaa attacctcgt cacccagaaa acaaagagct
     3481 caggaactat tttggaagtt ccttccagtc taagactatg gaactcagaa tctagcaggt
     3541 gtgttccttt ggatagcaaa actaaagata taaatatgaa taagaaattc tttgccactt
     3601 ctcctgggca aggttatact ttatgccatc tactgagata aaccagatga gtcagtttgc
     3661 ttctgtcagt tgctgtgtca cagatgacat cttctcaaaa taatattatc tcacagccaa
     3721 gaaatagcgc ttcgtttact gtgtttttct atcctgaaac taaatgggct tacgcttcat
     3781 agtggctaag atactccaca cacaactagt acccatagat cttttctcac tgataggaaa
     3841 aaaaaaaaaa aagcattaaa cacctttcag agagtacatc tgaaacattt acgtattttc
     3901 ctgatttagg caaatataat attgaaagtt acctgtatgt gggcattttt ttctacactc
     3961 ataaatgcaa atcaaatttt gccattagct gtggccaaca ttccttccag gacaaaagct
     4021 tacattaggc cgggtgcggt ggcgcacgcc tgtaatccca gcactttggg aggccgagac
     4081 gggtggatca tgaggtcagg agatcgagac catcctggct aacacggtga aaccccatct
     4141 ctactaaaaa tacaaaaaaa attagccagg catggtggcg ggtgcctgta gtcccagcta
     4201 ctggggaggc tgaggcagga gaatggcgtg aacccaggag gcggagcttg cagtgagccg
     4261 agatcgtgcc actgcactcc agcctgggcg acagagcgag actctgtctc aaaaaataaa
     4321 taaataaata aatttaaaat aaattttaaa aaaattacat taaaggtgtc acttatttgc
     4381 atgataccga gatttggagt ttaaagaaaa accttataaa gactgtaatg tcagagttgc
     4441 tactagttca cataagcaat aaaaagtttt gtaaatgtgt aattcttaac atttaaaaat
     4501 atgtaggagt gtgtgtgtgt gtgtgtgtgt gcacacgcac attcatgctt ctcaacaccc
     4561 acgacctagt ggaatggagt gttattaaat aagttaatca gtattttgtt gaaatctcag
     4621 cagataatta gtactacacg ttgactcatt aattcagttt cccttatcaa ccacccccat
     4681 catttattgt tttgagtatg tttgatggaa aacttagtct tcctcttttt ttttaacact
     4741 cgattgtttt tttcttttaa aataaagtca attttaattt taaatgtctt taaaagtcca
     4801 tccattatca agactttgac acagtgtctt gaaatacagc ttgccctaaa cttaatctat
     4861 gcttctggct aggtgtttct ataacaaata tcagggcacc tggttcttaa ccttctcatt
     4921 tatactgtgt tgacagaaat agatgcaaat acctttttaa aaatgctcct ggtttaataa
     4981 gcatccttca aatacagtta agtttaaatg ccctgctcct gttctcagtc cttcagacat
     5041 caatatggca ggcagaatcc ataagtcaat ggaaactctt agccatagag ggctgcagag
     5101 attaatttca acaccttgaa atgcatctgg aagcaaagat ttcattttat gttgaaggtg
     5161 ttaattatat ttgatatttt taaaagtaaa atctgttttt gagaaagcat ctgctaccca
     5221 gaaatattat gagccacaaa agaaatttta ctgaagtctc aagatacttt ctgtggatga
     5281 tagaatcagt tttcaaatga tagtccatgc tgtcttttaa tgctgacata cactgtgggt
     5341 cttattcttc tattgactat tgacccaact gcctttcttt ttcagtggaa aatttgggac
     5401 tatttaatat tagatcttat gtttaacaat gaagagagta tattataaac cactgacttg
     5461 aacatgtttc attttaaaat ttgagttgtg atacagacaa ctaatgctcc tatcctatgc
     5521 cctctcttca aagctattca ttaaaatata actggggaag tttgaaaaac atgcgagcaa
     5581 ttctacatgc tgctcaaaga tacagacatg tgtgattaaa gtacagtatt acagaaaacc
     5641 tgggaattaa ccaaacttac aataatggtt atgtcagagg ggccatggta gagaaaaaaa
     5701 aggacataga agtagggaaa ggtgcattcg ttgcatgatg agaagtctgt ttcttaagct
     5761 gagtcgtgat acacaaaggc ttcttgccac tctttgtgac atttcatgtg tcttcagtgt
     5821 atttattgca tatatctttt gataggagat ataaatactt caggaagcat gttactagtt
     5881 ttgctatcag gctatcctta acatttcttg gttttctcaa ttattgattg agtcagaaaa
     5941 ctgcttgcct cagacagtga tacaaactac tctactgcca atgttgcttg agaagacttt
     6001 cctctgctta acaggagcca ggggcttcac ctcaaccctc atgctgtgga gaaagtcaga
     6061 ctcaactggc cacaggttcc tgtttcttgg ggctgctaat caccatttct aacagatgcc
     6121 tgtggcattg caaacacaag atggaaaact atagctctaa actcccttct gaagggtaag
     6181 gaaaggaaga ggaaggcaga tgttaaatga gcccagtctt tctcatctca aaaaattcag
     6241 agctgcctgt tagagcacaa gagctctcag agctcccaac cacactgccc actccccata
     6301 gtgttgcctc tcccctttcc tctttaagac gcaggagcga atcgtggtct ttgtgctttc
     6361 actgcaatct atcccagggg aagagttctc ccgggtatct gtgggatgcc cttgctgcat
     6421 gtgaggcaca aatggcttca gggaccagga tcctcactca ctctgcagtc catttttcta
     6481 aattggaatt tgcgatcggt ttcttcaggt gtcccaccat catctatcat tatctgagtt
     6541 attccttatc ctctcccaac cccaaggaga ggatcttaat tgtttttata aactgacaga
     6601 aggaattggt gattcttgga agataatttt aaatggttat attactttcc tattactgca
     6661 tttactgcat ttaaatagca ggtctaaggt ggggtgcgag aagatgtgac ccctaggaat
     6721 attggtatga cctttctcaa gcaatttgaa gtcctttaga tctgaaaatt taatgtcttc
     6781 aatatcattt cacagatgag aaaattaagg cacatatagt gacatattta ggagctgaag
     6841 tgtgttacag aaacaaagtt tttttgtata agcctttccc tacatgggat gttatcattg
     6901 tcacctatgt gcctttcagg aagcaccaag tgcagtatgc gtgactcagt tggaccccta
     6961 gttcccttct atttctccag ctggcaggag acagcaaagg acagtggagg tggttatttt
     7021 gtggcccaca tttctgccat taaaagggac ataagagact atgtagtgtg gccaattttt
     7081 tttttttttt ttttgagaga gagagtctgg ctctgtcgcc caggctggag tgcagtggca
     7141 ccatctcggc tcactgcaag ctccacctcc cgggttcacg ccattctcct gcctcagcct
     7201 cccgagtagc tgggactaca ggtgcccacc accacgcccg gctaattttt ttgtattttt
     7261 agtagagacg gggtttcacc atgttagcca gggtggtctc aatctcctga cctcgtgatc
     7321 cacctgtctc ggcctcccaa agtgctggga ttacaggtgt aagccaccat gcccggaata
     7381 tggccattat tttaagtgtt tttattattg ctctggttct ccctttaggg aggcattcag
     7441 tgagtatacc ccatctgtca caggccccca ccactccctg tggtcttaca ctctgctgaa
     7501 ttcatacatt taggtaactt ccctggccct cctgagaatc acttattttt gtaacctcct
     7561 gtatttgaga tgtaggaaac tggggcctga ggagaagttg acttgccttg ggtcccacag
     7621 tggtacaggc agatctagaa ctcagatttt ccagggctct ttcagtaggc tgtggttgag
     7681 cagtagtcaa gaccacctct tcaagaaggg aaaaacattt gtcttctctt tctcctcttt
     7741 cttccttctg cctctcactg taagaagaaa cgtgttaata agttgctaat accttactct
     7801 aggtgtattt catgttacac cagccagtgc ttgtattctc aatgaccata aggagaggaa
     7861 tgcggaagaa ttgatttctg tactaaaagt tcagactctg tggcacttgt gatatttctg
     7921 gacaactgac tcttctctat tgcctttcga atcatacagt ggcaaagctg ctcacccatg
     7981 tgtgtataaa gctgaccctt catcagaaag gcagccccca gtgtctcccc acacagggca
     8041 gaagagcaga gggagcaggt ggcaatgtgg cagcaccttg aactgtgcat cactgggcct
     8101 gctccccctc atcccaaagc aataacccag aaattacatc ctgagactta cttcctcaga
     8161 aagaaaagga aggggaggga taacttaaaa aggagaaact tctaatatgg tattagactg
     8221 taattcatag ggaaatttat gcctgagata tgaatttctg aaaataaggg gcttttttgg
     8281 aagggaaaca ctgacacatc cttaattata gagtaataaa taccaatggt atattatctt
     8341 tcgatatttc cttacacaga tatcaaagca tgcagctgtt tttgaaaact gataatcaag
     8401 tacaatataa gtatattaca tcttgcactt acaacacacc cttcaactaa gcagcatcat
     8461 ggagcactta acggtgagaa acagagctgc tcatagtaga aacctaactg aacaaattag
     8521 ctttgaattg taacttaaga atcgtagtca aaccaaagcg tctgtccttg ccaggaaagg
     8581 cattccaaag gcagagagca tgccaagtaa aaaggctttg cttcaggatt atggagacag
     8641 ttctgaaaag ccagcataac ttaatgatca atcagaaaaa tatagagcag taactacaca
     8701 actgaaggat gcataaaaat tgtacaaaac gttaatagtg gaatggggag gtaggatggg
     8761 attttacggg caagtattaa gctcttggaa agcttcattt gttgccctca atccacacag
     8821 cagaaagaaa gagaaagaga caaacatggt caaagaaaag tatgtggaca aatgtggggg
     8881 gtagaaaagg aaatgaaggt taagcaaggc caatataatt cagaataaaa gggagggagg
     8941 gaagtataag gagccagctg taattactga atgttacatt aagaagagct gaaattgaga
     9001 gggggaggtc ttgagtattt tactaagtgg attaatgtcc tcttcctcgg gtgtctgaag
     9061 ttgcagattt taatttattt ggtgcaggga tttattacag aattcttaat gggtggggag
     9121 ataaacaggg acaattataa gctcttaaga agaagaaaag aggaccatat aatactttct
     9181 ataaatttaa ctgtaataaa cagggtttca agctatggac aaagatagtc aaaaaaagca
     9241 tttattccat gatataggac taaaagggaa ataagaggtg tgtccaaaaa acttaaagac
     9301 caaaacaaag aaagaaaaac ccacatagat gtgtgatgcc aggattttga atgacttggg
     9361 agctagttat tgccgctctc ctttctccac ccatttaaaa aaataaatca taactctggc
     9421 atttaaaaac ctactcatga acatcattta ttaatataaa cttaatcctg tgctattctt
     9481 tggtgggtgg taagaacatg aattaacaac aactggacta aaacgatggc aacaggatga
     9541 tccactcaaa cacaggaaag ctgtaagaaa aagaaaaact cctaatctgc tctttcacct
     9601 tacttatttt acagaaggag aaagccaaaa aggggagagc atgtggctaa accacagaaa
     9661 gactagatgc ctaaaggaaa aattttaaag tgttcctaaa taggtattag aaggggaagg
     9721 gggatgtaaa gcttatgtga tttacatcat tttgttaatc tgctaatcta cttccctgga
     9781 aggtgagaaa gagtgttgtc tgccttctgc aattgaagag actagggcag aaacttaatt
     9841 atgttcttac cctgtgtata cctggctgtc atctggctgg caactagtcc acaaactatt
     9901 ggttcaggca tttgcctggc aataatgtta gccatcattt aaattgttaa atatggatca
     9961 gaagatctct aagaattact gatatgcagc tattaatact ggatgtaaat aatattattt
    10021 ggggtgtggg taaatcattt gactggaacc acatttaaaa aaaggacttg gaaattttat
    10081 ttttgaaatg ctgttgggga gatggcattg atgaaaaaaa aaattgaaaa tggaaaaaaa
    10141 catcatctac aaagagatgg gtaaaaatga ctaagcaaag aagccttgtc accttcgacc
    10201 tgatgcttca ttgtatcaga agaaagtaaa cagattgcta acaaagagac caccccttct
    10261 aatttccaaa accggcccag caacaagagg gagaaaatag agaagagtgc actgcgtggt
    10321 ggctcagggt gatcctttaa tttgagtgtt aaaaatgagg gcacagacct agaggttttt
    10381 aatggtccgc gggtggactt cagattctga acactcctcc accttctgtg gagaattcgg
    10441 gacacggtgg agtttaacca gtatcttaaa tcccagggac agggtggaga ttgctttgtg
    10501 atcctgatta attaaaagga aagaaatcaa agcagacatc tctccttttt ccatttgagc
    10561 cgcagagcca tggaggggaa cttgtgctct ctggtgcttg cagctatgtt ccctggcttt
    10621 catcgtcttg gcttttcccc ttgtatttct aatgctgtga taccaggcca ataaaatgga
    10681 atctacaaaa ctgcaaaaca aaa
//
