LOCUS       NM_001354362           10659 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 19, mRNA.
ACCESSION   NM_001354362 XM_017004952
VERSION     NM_001354362.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10659)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10659)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10659)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10659)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10659)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10659)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10659)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10659)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001354362.2.
            
            Transcript Variant: This variant (19), as well as variants 10 and
            39-42, encodes isoform h.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.24979.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AC010130.12        27896-28397         c
            503-564             AC009957.11        120958-121019       c
            565-629             AC009957.11        96797-96861         c
            630-831             AC009957.11        93885-94086         c
            832-999             AC009957.11        30854-31021         c
            1000-1173           AC009957.11        27164-27337         c
            1174-1283           AC016910.6         135286-135395       c
            1284-1428           AC016910.6         121828-121972       c
            1429-1499           AC016910.6         117406-117476       c
            1500-1591           AC016910.6         116615-116706       c
            1592-10659          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10659
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..502
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            503..564
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            565..629
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            630..831
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..1675
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform h is encoded by transcript variant 19;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     h"
                     /protein_id="NP_001341291.1"
                     /db_xref="CCDS:CCDS86884.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSREHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEAKK
                     ALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKDLV
                     YPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLLTT
                     EPREDL"
     exon            832..999
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1173
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1283
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1428
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1499
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1591
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..10659
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2696
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2713
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10626..10631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10659
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acgcgctgcg ctccctgcgc cgccgtccgc accgcgctcg gaatggggcg tcacgccgtg
       61 gcattttgtg ccttctgcaa actggtcgtg ttcgaattgc gtttttttgg tgcctacatg
      121 tcgtgcgtgc tggttttctg cggcccggcg ctccgcttct tcctcgcgca ggctgagagg
      181 acgggtgggg gcacgtcgcc ctcgcgcggg agaagggagg ccgggcgtcc gggttggcct
      241 gagttggctg gggtgcttcg ccgaccacca ggctgcccgg cgcttggccc cttgcagtgc
      301 gagccccagg ccttcctgac ggaaagcttc gcttctggct cctagtcgcc ctcagttacc
      361 agacctcccc agcgccccac tcctctctgc cagccgagtg tgaagaccct cactgtgccc
      421 cccaccccgg aatccctcgt ctgaggatta agcacataac ttcccatttt catcgggatc
      481 cagacaatcc cattctgtcc aggtatctct gcattagcca gattggacat atgtaaaggg
      541 acatcagtat atctggatca tcagattgtg cttcaagaag accataggga agaacgcatt
      601 ttcatcttgc tgcaaaagtt gcaatagaag atctgaaggt ttgaatgggc caatgagtat
      661 cctcatcatt gaagcattct atggaggctc ccataaacag ctggtggatc ttcttcaaga
      721 agagttagga gactgtgtcg tttataccct tcctgcaaag aaatggcatt ggagagcccg
      781 gacatctgct ttatatttct ctcagaccat tcccatcagt gagcattaca ggaccctctt
      841 tgcaagttca gtgcttaacc tgaccgaact ggctgccctt cggcctgacc ttgggaaact
      901 gaaaaagatt ctgtattttc acgagaacca gttgatatat cctgtcaaga aatgtcagga
      961 gagggatttc caatatggat acaaccaaat tctttcatgc ctggtggctg atgtggttgt
     1021 attcaactca gtttttaata tggaatcatt tctcacttcc atgggaaaat ttatgaagct
     1081 gattcctgat cacagaccca aggatctgga aagcatcatc agacccaagt gccaagttat
     1141 ttactttccc atcaggtttc ctgatgtgag cagggagcat gataaagatc cagaaagctt
     1201 ttttaaggta ttaatgcatc ttaaagactt aggactcaat ttccacgtgt ctgtacttgg
     1261 agaaaccttc acagatgtcc cagatatttt ttcagaggcc aaaaaggcat tgggatcttc
     1321 tgtcttacac tggggctact tacccagcaa agatgactat ttccaagtac tgtgcatggc
     1381 tgatgttgtc atctcaacag ctaagcatga attctttgga gtggcaatgt tggaagctgt
     1441 gtactgtggg tgttacccac tttgtcctaa agatttggtt tatcccgaaa tatttccagc
     1501 tgaatatctg tattctacac ctgaacagct ttcaaaaagg ctccagaatt tctgcaagag
     1561 accagatatt ataagaaaac atctctataa gggtgaaatc gctccgtttt cttgggcagc
     1621 cctacatggt aaattcaggt ctctgcttac aacagaacct agggaagatt tgtgacagat
     1681 ggggctaagt cacaaacttg cagcctaagg cagaatctga agaactttcc agagtgtgcc
     1741 catatttacc tgatcagaga gaaaagaaaa tctgcagagg aagctgagcc tggctgcttg
     1801 tcatagctga cacagagcca tctgccacaa acctgtggcg gcttcagatc tccaatccct
     1861 gccaccaccc caactcaaat taaatacaga ttcctagaga cgttatgatg gttacacatg
     1921 tcctcggcat cacatgtagg agactgttca aaaaaaatat gtggcctgtt gtataaccgc
     1981 actcatgtat cccatatgtg gtgccacatt gaatttccgg ttgaatccgt ttttatcctt
     2041 tgtactggat gacatggtgc ctgaattctt tcttttcgcc gacacgatgg cagccaaact
     2101 gcagcttcaa acgctcacac ttggctgggt ttctacctag gttgccaggt tatcatcgga
     2161 gccttcttgt gtcctcaaag ggccacgagg cctgaaagga ggatcagaat gctttgggat
     2221 taattgggca gccatcgcag aattgtttgt gggcaaaggg ctgctttagc acttttcttt
     2281 tagcaaatta atgactctca ggcacagggg gttttaagtg aaggtattaa taagaggtct
     2341 ggcaggtatt cccatgattc acagagttac atttgcattt aattaatctt aaagttgcaa
     2401 gataaacagc tgtaattcgg acaaacatga caaacacagt gaagccaact atcccataaa
     2461 atgaacactg acatacttgt tttaattttt ttcccagcgt aaaaatagaa aaatcaaaat
     2521 actcctaaca aaaccagtga ttttgataga aatatttctc caatatactt gcatccacct
     2581 acaaatataa ccttttcaag ataaatcgct tatgatttca atagtcaaac tgctgtgttt
     2641 gttgatgtaa agatgttttg aatggctaga tggtaaaata aattcttaat aaagtaccca
     2701 ctgcaatttt taattagcat attcatttac atatagatgt atacatctac ctatgtgttt
     2761 ctcactgaac gttttccttg tgacagagac aacaaataca attgtttctt ttccggatga
     2821 acaaggatct gttttgcaaa tgtttgtaag atattatgac atttccaaga ttttctttgc
     2881 attctggaaa gcaggaggta aacatttgta gtcattaagg taaagtctgt tgataaacca
     2941 tcttctgttt actgacaggt aaattgtaac tttccctagc ttttgaaatg agtaacttct
     3001 atacaccaca aagtgaggca cagcctggga aaggtggcta gacaaggggc aagccaggct
     3061 ttctagcttc tggaaggatc gagtggccta gcaggcatct aagataaaga aagcaatgat
     3121 tcggaagtcc agtagggccc atttgaccgg tagcaaaatc gaaagcacga aatagatcaa
     3181 ggttagggag ccagacaaag cccttggaag agaggcagta ttgcagatcg aagcaagcag
     3241 ttcagagtct atgaggcctg ggaatttaaa agcaggaaga gtaagaagca gaaacaagaa
     3301 gctccatctg aacagactcc tctctccaac cttcatgaga cccacagtgt gtgatgggcc
     3361 accacagcac tggcttctag acttttacag ggaagccagt gaacaaatta cctcgtcacc
     3421 cagaaaacaa agagctcagg aactattttg gaagttcctt ccagtctaag actatggaac
     3481 tcagaatcta gcaggtgtgt tcctttggat agcaaaacta aagatataaa tatgaataag
     3541 aaattctttg ccacttctcc tgggcaaggt tatactttat gccatctact gagataaacc
     3601 agatgagtca gtttgcttct gtcagttgct gtgtcacaga tgacatcttc tcaaaataat
     3661 attatctcac agccaagaaa tagcgcttcg tttactgtgt ttttctatcc tgaaactaaa
     3721 tgggcttacg cttcatagtg gctaagatac tccacacaca actagtaccc atagatcttt
     3781 tctcactgat aggaaaaaaa aaaaaaaagc attaaacacc tttcagagag tacatctgaa
     3841 acatttacgt attttcctga tttaggcaaa tataatattg aaagttacct gtatgtgggc
     3901 atttttttct acactcataa atgcaaatca aattttgcca ttagctgtgg ccaacattcc
     3961 ttccaggaca aaagcttaca ttaggccggg tgcggtggcg cacgcctgta atcccagcac
     4021 tttgggaggc cgagacgggt ggatcatgag gtcaggagat cgagaccatc ctggctaaca
     4081 cggtgaaacc ccatctctac taaaaataca aaaaaaatta gccaggcatg gtggcgggtg
     4141 cctgtagtcc cagctactgg ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg
     4201 agcttgcagt gagccgagat cgtgccactg cactccagcc tgggcgacag agcgagactc
     4261 tgtctcaaaa aataaataaa taaataaatt taaaataaat tttaaaaaaa ttacattaaa
     4321 ggtgtcactt atttgcatga taccgagatt tggagtttaa agaaaaacct tataaagact
     4381 gtaatgtcag agttgctact agttcacata agcaataaaa agttttgtaa atgtgtaatt
     4441 cttaacattt aaaaatatgt aggagtgtgt gtgtgtgtgt gtgtgtgcac acgcacattc
     4501 atgcttctca acacccacga cctagtggaa tggagtgtta ttaaataagt taatcagtat
     4561 tttgttgaaa tctcagcaga taattagtac tacacgttga ctcattaatt cagtttccct
     4621 tatcaaccac ccccatcatt tattgttttg agtatgtttg atggaaaact tagtcttcct
     4681 cttttttttt aacactcgat tgtttttttc ttttaaaata aagtcaattt taattttaaa
     4741 tgtctttaaa agtccatcca ttatcaagac tttgacacag tgtcttgaaa tacagcttgc
     4801 cctaaactta atctatgctt ctggctaggt gtttctataa caaatatcag ggcacctggt
     4861 tcttaacctt ctcatttata ctgtgttgac agaaatagat gcaaatacct ttttaaaaat
     4921 gctcctggtt taataagcat ccttcaaata cagttaagtt taaatgccct gctcctgttc
     4981 tcagtccttc agacatcaat atggcaggca gaatccataa gtcaatggaa actcttagcc
     5041 atagagggct gcagagatta atttcaacac cttgaaatgc atctggaagc aaagatttca
     5101 ttttatgttg aaggtgttaa ttatatttga tatttttaaa agtaaaatct gtttttgaga
     5161 aagcatctgc tacccagaaa tattatgagc cacaaaagaa attttactga agtctcaaga
     5221 tactttctgt ggatgataga atcagttttc aaatgatagt ccatgctgtc ttttaatgct
     5281 gacatacact gtgggtctta ttcttctatt gactattgac ccaactgcct ttctttttca
     5341 gtggaaaatt tgggactatt taatattaga tcttatgttt aacaatgaag agagtatatt
     5401 ataaaccact gacttgaaca tgtttcattt taaaatttga gttgtgatac agacaactaa
     5461 tgctcctatc ctatgccctc tcttcaaagc tattcattaa aatataactg gggaagtttg
     5521 aaaaacatgc gagcaattct acatgctgct caaagataca gacatgtgtg attaaagtac
     5581 agtattacag aaaacctggg aattaaccaa acttacaata atggttatgt cagaggggcc
     5641 atggtagaga aaaaaaagga catagaagta gggaaaggtg cattcgttgc atgatgagaa
     5701 gtctgtttct taagctgagt cgtgatacac aaaggcttct tgccactctt tgtgacattt
     5761 catgtgtctt cagtgtattt attgcatata tcttttgata ggagatataa atacttcagg
     5821 aagcatgtta ctagttttgc tatcaggcta tccttaacat ttcttggttt tctcaattat
     5881 tgattgagtc agaaaactgc ttgcctcaga cagtgataca aactactcta ctgccaatgt
     5941 tgcttgagaa gactttcctc tgcttaacag gagccagggg cttcacctca accctcatgc
     6001 tgtggagaaa gtcagactca actggccaca ggttcctgtt tcttggggct gctaatcacc
     6061 atttctaaca gatgcctgtg gcattgcaaa cacaagatgg aaaactatag ctctaaactc
     6121 ccttctgaag ggtaaggaaa ggaagaggaa ggcagatgtt aaatgagccc agtctttctc
     6181 atctcaaaaa attcagagct gcctgttaga gcacaagagc tctcagagct cccaaccaca
     6241 ctgcccactc cccatagtgt tgcctctccc ctttcctctt taagacgcag gagcgaatcg
     6301 tggtctttgt gctttcactg caatctatcc caggggaaga gttctcccgg gtatctgtgg
     6361 gatgcccttg ctgcatgtga ggcacaaatg gcttcaggga ccaggatcct cactcactct
     6421 gcagtccatt tttctaaatt ggaatttgcg atcggtttct tcaggtgtcc caccatcatc
     6481 tatcattatc tgagttattc cttatcctct cccaacccca aggagaggat cttaattgtt
     6541 tttataaact gacagaagga attggtgatt cttggaagat aattttaaat ggttatatta
     6601 ctttcctatt actgcattta ctgcatttaa atagcaggtc taaggtgggg tgcgagaaga
     6661 tgtgacccct aggaatattg gtatgacctt tctcaagcaa tttgaagtcc tttagatctg
     6721 aaaatttaat gtcttcaata tcatttcaca gatgagaaaa ttaaggcaca tatagtgaca
     6781 tatttaggag ctgaagtgtg ttacagaaac aaagtttttt tgtataagcc tttccctaca
     6841 tgggatgtta tcattgtcac ctatgtgcct ttcaggaagc accaagtgca gtatgcgtga
     6901 ctcagttgga cccctagttc ccttctattt ctccagctgg caggagacag caaaggacag
     6961 tggaggtggt tattttgtgg cccacatttc tgccattaaa agggacataa gagactatgt
     7021 agtgtggcca attttttttt tttttttttt gagagagaga gtctggctct gtcgcccagg
     7081 ctggagtgca gtggcaccat ctcggctcac tgcaagctcc acctcccggg ttcacgccat
     7141 tctcctgcct cagcctcccg agtagctggg actacaggtg cccaccacca cgcccggcta
     7201 atttttttgt atttttagta gagacggggt ttcaccatgt tagccagggt ggtctcaatc
     7261 tcctgacctc gtgatccacc tgtctcggcc tcccaaagtg ctgggattac aggtgtaagc
     7321 caccatgccc ggaatatggc cattatttta agtgttttta ttattgctct ggttctccct
     7381 ttagggaggc attcagtgag tataccccat ctgtcacagg cccccaccac tccctgtggt
     7441 cttacactct gctgaattca tacatttagg taacttccct ggccctcctg agaatcactt
     7501 atttttgtaa cctcctgtat ttgagatgta ggaaactggg gcctgaggag aagttgactt
     7561 gccttgggtc ccacagtggt acaggcagat ctagaactca gattttccag ggctctttca
     7621 gtaggctgtg gttgagcagt agtcaagacc acctcttcaa gaagggaaaa acatttgtct
     7681 tctctttctc ctctttcttc cttctgcctc tcactgtaag aagaaacgtg ttaataagtt
     7741 gctaatacct tactctaggt gtatttcatg ttacaccagc cagtgcttgt attctcaatg
     7801 accataagga gaggaatgcg gaagaattga tttctgtact aaaagttcag actctgtggc
     7861 acttgtgata tttctggaca actgactctt ctctattgcc tttcgaatca tacagtggca
     7921 aagctgctca cccatgtgtg tataaagctg acccttcatc agaaaggcag cccccagtgt
     7981 ctccccacac agggcagaag agcagaggga gcaggtggca atgtggcagc accttgaact
     8041 gtgcatcact gggcctgctc cccctcatcc caaagcaata acccagaaat tacatcctga
     8101 gacttacttc ctcagaaaga aaaggaaggg gagggataac ttaaaaagga gaaacttcta
     8161 atatggtatt agactgtaat tcatagggaa atttatgcct gagatatgaa tttctgaaaa
     8221 taaggggctt ttttggaagg gaaacactga cacatcctta attatagagt aataaatacc
     8281 aatggtatat tatctttcga tatttcctta cacagatatc aaagcatgca gctgtttttg
     8341 aaaactgata atcaagtaca atataagtat attacatctt gcacttacaa cacacccttc
     8401 aactaagcag catcatggag cacttaacgg tgagaaacag agctgctcat agtagaaacc
     8461 taactgaaca aattagcttt gaattgtaac ttaagaatcg tagtcaaacc aaagcgtctg
     8521 tccttgccag gaaaggcatt ccaaaggcag agagcatgcc aagtaaaaag gctttgcttc
     8581 aggattatgg agacagttct gaaaagccag cataacttaa tgatcaatca gaaaaatata
     8641 gagcagtaac tacacaactg aaggatgcat aaaaattgta caaaacgtta atagtggaat
     8701 ggggaggtag gatgggattt tacgggcaag tattaagctc ttggaaagct tcatttgttg
     8761 ccctcaatcc acacagcaga aagaaagaga aagagacaaa catggtcaaa gaaaagtatg
     8821 tggacaaatg tggggggtag aaaaggaaat gaaggttaag caaggccaat ataattcaga
     8881 ataaaaggga gggagggaag tataaggagc cagctgtaat tactgaatgt tacattaaga
     8941 agagctgaaa ttgagagggg gaggtcttga gtattttact aagtggatta atgtcctctt
     9001 cctcgggtgt ctgaagttgc agattttaat ttatttggtg cagggattta ttacagaatt
     9061 cttaatgggt ggggagataa acagggacaa ttataagctc ttaagaagaa gaaaagagga
     9121 ccatataata ctttctataa atttaactgt aataaacagg gtttcaagct atggacaaag
     9181 atagtcaaaa aaagcattta ttccatgata taggactaaa agggaaataa gaggtgtgtc
     9241 caaaaaactt aaagaccaaa acaaagaaag aaaaacccac atagatgtgt gatgccagga
     9301 ttttgaatga cttgggagct agttattgcc gctctccttt ctccacccat ttaaaaaaat
     9361 aaatcataac tctggcattt aaaaacctac tcatgaacat catttattaa tataaactta
     9421 atcctgtgct attctttggt gggtggtaag aacatgaatt aacaacaact ggactaaaac
     9481 gatggcaaca ggatgatcca ctcaaacaca ggaaagctgt aagaaaaaga aaaactccta
     9541 atctgctctt tcaccttact tattttacag aaggagaaag ccaaaaaggg gagagcatgt
     9601 ggctaaacca cagaaagact agatgcctaa aggaaaaatt ttaaagtgtt cctaaatagg
     9661 tattagaagg ggaaggggga tgtaaagctt atgtgattta catcattttg ttaatctgct
     9721 aatctacttc cctggaaggt gagaaagagt gttgtctgcc ttctgcaatt gaagagacta
     9781 gggcagaaac ttaattatgt tcttaccctg tgtatacctg gctgtcatct ggctggcaac
     9841 tagtccacaa actattggtt caggcatttg cctggcaata atgttagcca tcatttaaat
     9901 tgttaaatat ggatcagaag atctctaaga attactgata tgcagctatt aatactggat
     9961 gtaaataata ttatttgggg tgtgggtaaa tcatttgact ggaaccacat ttaaaaaaag
    10021 gacttggaaa ttttattttt gaaatgctgt tggggagatg gcattgatga aaaaaaaaat
    10081 tgaaaatgga aaaaaacatc atctacaaag agatgggtaa aaatgactaa gcaaagaagc
    10141 cttgtcacct tcgacctgat gcttcattgt atcagaagaa agtaaacaga ttgctaacaa
    10201 agagaccacc ccttctaatt tccaaaaccg gcccagcaac aagagggaga aaatagagaa
    10261 gagtgcactg cgtggtggct cagggtgatc ctttaatttg agtgttaaaa atgagggcac
    10321 agacctagag gtttttaatg gtccgcgggt ggacttcaga ttctgaacac tcctccacct
    10381 tctgtggaga attcgggaca cggtggagtt taaccagtat cttaaatccc agggacaggg
    10441 tggagattgc tttgtgatcc tgattaatta aaaggaaaga aatcaaagca gacatctctc
    10501 ctttttccat ttgagccgca gagccatgga ggggaacttg tgctctctgg tgcttgcagc
    10561 tatgttccct ggctttcatc gtcttggctt ttccccttgt atttctaatg ctgtgatacc
    10621 aggccaataa aatggaatct acaaaactgc aaaacaaaa
//
