LOCUS       NM_001354360           10558 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 17, mRNA.
ACCESSION   NM_001354360
VERSION     NM_001354360.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10558)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10558)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10558)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10558)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10558)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10558)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10558)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10558)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001354360.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.60114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC010130.12        29041-29232         c
            193-254             AC009957.11        120958-121019       c
            255-319             AC009957.11        96797-96861         c
            320-521             AC009957.11        93885-94086         c
            522-689             AC009957.11        30854-31021         c
            690-863             AC009957.11        27164-27337         c
            864-1217            AC010681.16        8445-8798           c
            1218-1327           AC016910.6         135286-135395       c
            1328-1398           AC016910.6         117406-117476       c
            1399-1490           AC016910.6         116615-116706       c
            1491-10558          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10558
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..192
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            193..254
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            255..319
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            320..521
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1473
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform c is encoded by transcript variant 17;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     c"
                     /protein_id="NP_001341289.1"
                     /db_xref="CCDS:CCDS63029.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPGWKLCT
                     VGVTHFVLKIWFIPKYFQLNICILHLNSFQKGSRISARDQIL"
     exon            522..689
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            690..863
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1217
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1327
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1398
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1490
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..10558
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2595
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2612
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10525..10530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10558
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 tggaggagct ccgggctgca gagcaggtag aggtgtcggc aagggagcca ggaacccgca
       61 caggggccct gaggctctag taggccgggg agtggaccag gaaaggagat gcaacgggcc
      121 ggctggaaaa ctgcacgggg aatccgaggt cgacctaatg aacagcacag accttccaga
      181 aggaaagaga aggtatctct gcattagcca gattggacat atgtaaaggg acatcagtat
      241 atctggatca tcagattgtg cttcaagaag accataggga agaacgcatt ttcatcttgc
      301 tgcaaaagtt gcaatagaag atctgaaggt ttgaatgggc caatgagtat cctcatcatt
      361 gaagcattct atggaggctc ccataaacag ctggtggatc ttcttcaaga agagttagga
      421 gactgtgtcg tttataccct tcctgcaaag aaatggcatt ggagagcccg gacatctgct
      481 ttatatttct ctcagaccat tcccatcagt gagcattaca ggaccctctt tgcaagttca
      541 gtgcttaacc tgaccgaact ggctgccctt cggcctgacc ttgggaaact gaaaaagatt
      601 ctgtattttc acgagaacca gttgatatat cctgtcaaga aatgtcagga gagggatttc
      661 caatatggat acaaccaaat tctttcatgc ctggtggctg atgtggttgt attcaactca
      721 gtttttaata tggaatcatt tctcacttcc atgggaaaat ttatgaagct gattcctgat
      781 cacagaccca aggatctgga aagcatcatc agacccaagt gccaagttat ttactttccc
      841 atcaggtttc ctgatgtgag cagattcatg cccaagcaca aaacaaccca tttaaagaag
      901 atgctcggcc ttaaaggaaa tggcggtgcg gttctgtcca tggcccttcc ttttcagcca
      961 gagcagagag attcagagga tttattgaag aattttaatt cagagtgtga tacacactgt
     1021 ggccttgata ctgcacgaca agaatatttg ggtaactcat taagacagga atcagacttg
     1081 aaaaaatcca cctcgtcaga taattcaagc tctcatcatg gtgaaaataa acaaaatctg
     1141 actgttgatc cctgtgacat tttgggtgga gttgataatc agcaaagact gctacacatt
     1201 gtctggcctc acaggtggga gcatgataaa gatccagaaa gcttttttaa ggtattaatg
     1261 catcttaaag acttaggact caatttccac gtgtctgtac ttggagaaac cttcacagat
     1321 gtcccaggtt ggaagctgtg tactgtgggt gttacccact ttgtcctaaa gatttggttt
     1381 atcccgaaat atttccagct gaatatctgt attctacacc tgaacagctt tcaaaaaggc
     1441 tccagaattt ctgcaagaga ccagatatta taagaaaaca tctctataag ggtgaaatcg
     1501 ctccgttttc ttgggcagcc ctacatggta aattcaggtc tctgcttaca acagaaccta
     1561 gggaagattt gtgacagatg gggctaagtc acaaacttgc agcctaaggc agaatctgaa
     1621 gaactttcca gagtgtgccc atatttacct gatcagagag aaaagaaaat ctgcagagga
     1681 agctgagcct ggctgcttgt catagctgac acagagccat ctgccacaaa cctgtggcgg
     1741 cttcagatct ccaatccctg ccaccacccc aactcaaatt aaatacagat tcctagagac
     1801 gttatgatgg ttacacatgt cctcggcatc acatgtagga gactgttcaa aaaaaatatg
     1861 tggcctgttg tataaccgca ctcatgtatc ccatatgtgg tgccacattg aatttccggt
     1921 tgaatccgtt tttatccttt gtactggatg acatggtgcc tgaattcttt cttttcgccg
     1981 acacgatggc agccaaactg cagcttcaaa cgctcacact tggctgggtt tctacctagg
     2041 ttgccaggtt atcatcggag ccttcttgtg tcctcaaagg gccacgaggc ctgaaaggag
     2101 gatcagaatg ctttgggatt aattgggcag ccatcgcaga attgtttgtg ggcaaagggc
     2161 tgctttagca cttttctttt agcaaattaa tgactctcag gcacaggggg ttttaagtga
     2221 aggtattaat aagaggtctg gcaggtattc ccatgattca cagagttaca tttgcattta
     2281 attaatctta aagttgcaag ataaacagct gtaattcgga caaacatgac aaacacagtg
     2341 aagccaacta tcccataaaa tgaacactga catacttgtt ttaatttttt tcccagcgta
     2401 aaaatagaaa aatcaaaata ctcctaacaa aaccagtgat tttgatagaa atatttctcc
     2461 aatatacttg catccaccta caaatataac cttttcaaga taaatcgctt atgatttcaa
     2521 tagtcaaact gctgtgtttg ttgatgtaaa gatgttttga atggctagat ggtaaaataa
     2581 attcttaata aagtacccac tgcaattttt aattagcata ttcatttaca tatagatgta
     2641 tacatctacc tatgtgtttc tcactgaacg ttttccttgt gacagagaca acaaatacaa
     2701 ttgtttcttt tccggatgaa caaggatctg ttttgcaaat gtttgtaaga tattatgaca
     2761 tttccaagat tttctttgca ttctggaaag caggaggtaa acatttgtag tcattaaggt
     2821 aaagtctgtt gataaaccat cttctgttta ctgacaggta aattgtaact ttccctagct
     2881 tttgaaatga gtaacttcta tacaccacaa agtgaggcac agcctgggaa aggtggctag
     2941 acaaggggca agccaggctt tctagcttct ggaaggatcg agtggcctag caggcatcta
     3001 agataaagaa agcaatgatt cggaagtcca gtagggccca tttgaccggt agcaaaatcg
     3061 aaagcacgaa atagatcaag gttagggagc cagacaaagc ccttggaaga gaggcagtat
     3121 tgcagatcga agcaagcagt tcagagtcta tgaggcctgg gaatttaaaa gcaggaagag
     3181 taagaagcag aaacaagaag ctccatctga acagactcct ctctccaacc ttcatgagac
     3241 ccacagtgtg tgatgggcca ccacagcact ggcttctaga cttttacagg gaagccagtg
     3301 aacaaattac ctcgtcaccc agaaaacaaa gagctcagga actattttgg aagttccttc
     3361 cagtctaaga ctatggaact cagaatctag caggtgtgtt cctttggata gcaaaactaa
     3421 agatataaat atgaataaga aattctttgc cacttctcct gggcaaggtt atactttatg
     3481 ccatctactg agataaacca gatgagtcag tttgcttctg tcagttgctg tgtcacagat
     3541 gacatcttct caaaataata ttatctcaca gccaagaaat agcgcttcgt ttactgtgtt
     3601 tttctatcct gaaactaaat gggcttacgc ttcatagtgg ctaagatact ccacacacaa
     3661 ctagtaccca tagatctttt ctcactgata ggaaaaaaaa aaaaaaagca ttaaacacct
     3721 ttcagagagt acatctgaaa catttacgta ttttcctgat ttaggcaaat ataatattga
     3781 aagttacctg tatgtgggca tttttttcta cactcataaa tgcaaatcaa attttgccat
     3841 tagctgtggc caacattcct tccaggacaa aagcttacat taggccgggt gcggtggcgc
     3901 acgcctgtaa tcccagcact ttgggaggcc gagacgggtg gatcatgagg tcaggagatc
     3961 gagaccatcc tggctaacac ggtgaaaccc catctctact aaaaatacaa aaaaaattag
     4021 ccaggcatgg tggcgggtgc ctgtagtccc agctactggg gaggctgagg caggagaatg
     4081 gcgtgaaccc aggaggcgga gcttgcagtg agccgagatc gtgccactgc actccagcct
     4141 gggcgacaga gcgagactct gtctcaaaaa ataaataaat aaataaattt aaaataaatt
     4201 ttaaaaaaat tacattaaag gtgtcactta tttgcatgat accgagattt ggagtttaaa
     4261 gaaaaacctt ataaagactg taatgtcaga gttgctacta gttcacataa gcaataaaaa
     4321 gttttgtaaa tgtgtaattc ttaacattta aaaatatgta ggagtgtgtg tgtgtgtgtg
     4381 tgtgtgcaca cgcacattca tgcttctcaa cacccacgac ctagtggaat ggagtgttat
     4441 taaataagtt aatcagtatt ttgttgaaat ctcagcagat aattagtact acacgttgac
     4501 tcattaattc agtttccctt atcaaccacc cccatcattt attgttttga gtatgtttga
     4561 tggaaaactt agtcttcctc ttttttttta acactcgatt gtttttttct tttaaaataa
     4621 agtcaatttt aattttaaat gtctttaaaa gtccatccat tatcaagact ttgacacagt
     4681 gtcttgaaat acagcttgcc ctaaacttaa tctatgcttc tggctaggtg tttctataac
     4741 aaatatcagg gcacctggtt cttaaccttc tcatttatac tgtgttgaca gaaatagatg
     4801 caaatacctt tttaaaaatg ctcctggttt aataagcatc cttcaaatac agttaagttt
     4861 aaatgccctg ctcctgttct cagtccttca gacatcaata tggcaggcag aatccataag
     4921 tcaatggaaa ctcttagcca tagagggctg cagagattaa tttcaacacc ttgaaatgca
     4981 tctggaagca aagatttcat tttatgttga aggtgttaat tatatttgat atttttaaaa
     5041 gtaaaatctg tttttgagaa agcatctgct acccagaaat attatgagcc acaaaagaaa
     5101 ttttactgaa gtctcaagat actttctgtg gatgatagaa tcagttttca aatgatagtc
     5161 catgctgtct tttaatgctg acatacactg tgggtcttat tcttctattg actattgacc
     5221 caactgcctt tctttttcag tggaaaattt gggactattt aatattagat cttatgttta
     5281 acaatgaaga gagtatatta taaaccactg acttgaacat gtttcatttt aaaatttgag
     5341 ttgtgataca gacaactaat gctcctatcc tatgccctct cttcaaagct attcattaaa
     5401 atataactgg ggaagtttga aaaacatgcg agcaattcta catgctgctc aaagatacag
     5461 acatgtgtga ttaaagtaca gtattacaga aaacctggga attaaccaaa cttacaataa
     5521 tggttatgtc agaggggcca tggtagagaa aaaaaaggac atagaagtag ggaaaggtgc
     5581 attcgttgca tgatgagaag tctgtttctt aagctgagtc gtgatacaca aaggcttctt
     5641 gccactcttt gtgacatttc atgtgtcttc agtgtattta ttgcatatat cttttgatag
     5701 gagatataaa tacttcagga agcatgttac tagttttgct atcaggctat ccttaacatt
     5761 tcttggtttt ctcaattatt gattgagtca gaaaactgct tgcctcagac agtgatacaa
     5821 actactctac tgccaatgtt gcttgagaag actttcctct gcttaacagg agccaggggc
     5881 ttcacctcaa ccctcatgct gtggagaaag tcagactcaa ctggccacag gttcctgttt
     5941 cttggggctg ctaatcacca tttctaacag atgcctgtgg cattgcaaac acaagatgga
     6001 aaactatagc tctaaactcc cttctgaagg gtaaggaaag gaagaggaag gcagatgtta
     6061 aatgagccca gtctttctca tctcaaaaaa ttcagagctg cctgttagag cacaagagct
     6121 ctcagagctc ccaaccacac tgcccactcc ccatagtgtt gcctctcccc tttcctcttt
     6181 aagacgcagg agcgaatcgt ggtctttgtg ctttcactgc aatctatccc aggggaagag
     6241 ttctcccggg tatctgtggg atgcccttgc tgcatgtgag gcacaaatgg cttcagggac
     6301 caggatcctc actcactctg cagtccattt ttctaaattg gaatttgcga tcggtttctt
     6361 caggtgtccc accatcatct atcattatct gagttattcc ttatcctctc ccaaccccaa
     6421 ggagaggatc ttaattgttt ttataaactg acagaaggaa ttggtgattc ttggaagata
     6481 attttaaatg gttatattac tttcctatta ctgcatttac tgcatttaaa tagcaggtct
     6541 aaggtggggt gcgagaagat gtgaccccta ggaatattgg tatgaccttt ctcaagcaat
     6601 ttgaagtcct ttagatctga aaatttaatg tcttcaatat catttcacag atgagaaaat
     6661 taaggcacat atagtgacat atttaggagc tgaagtgtgt tacagaaaca aagttttttt
     6721 gtataagcct ttccctacat gggatgttat cattgtcacc tatgtgcctt tcaggaagca
     6781 ccaagtgcag tatgcgtgac tcagttggac ccctagttcc cttctatttc tccagctggc
     6841 aggagacagc aaaggacagt ggaggtggtt attttgtggc ccacatttct gccattaaaa
     6901 gggacataag agactatgta gtgtggccaa tttttttttt tttttttttg agagagagag
     6961 tctggctctg tcgcccaggc tggagtgcag tggcaccatc tcggctcact gcaagctcca
     7021 cctcccgggt tcacgccatt ctcctgcctc agcctcccga gtagctggga ctacaggtgc
     7081 ccaccaccac gcccggctaa tttttttgta tttttagtag agacggggtt tcaccatgtt
     7141 agccagggtg gtctcaatct cctgacctcg tgatccacct gtctcggcct cccaaagtgc
     7201 tgggattaca ggtgtaagcc accatgcccg gaatatggcc attattttaa gtgtttttat
     7261 tattgctctg gttctccctt tagggaggca ttcagtgagt ataccccatc tgtcacaggc
     7321 ccccaccact ccctgtggtc ttacactctg ctgaattcat acatttaggt aacttccctg
     7381 gccctcctga gaatcactta tttttgtaac ctcctgtatt tgagatgtag gaaactgggg
     7441 cctgaggaga agttgacttg ccttgggtcc cacagtggta caggcagatc tagaactcag
     7501 attttccagg gctctttcag taggctgtgg ttgagcagta gtcaagacca cctcttcaag
     7561 aagggaaaaa catttgtctt ctctttctcc tctttcttcc ttctgcctct cactgtaaga
     7621 agaaacgtgt taataagttg ctaatacctt actctaggtg tatttcatgt tacaccagcc
     7681 agtgcttgta ttctcaatga ccataaggag aggaatgcgg aagaattgat ttctgtacta
     7741 aaagttcaga ctctgtggca cttgtgatat ttctggacaa ctgactcttc tctattgcct
     7801 ttcgaatcat acagtggcaa agctgctcac ccatgtgtgt ataaagctga cccttcatca
     7861 gaaaggcagc ccccagtgtc tccccacaca gggcagaaga gcagagggag caggtggcaa
     7921 tgtggcagca ccttgaactg tgcatcactg ggcctgctcc ccctcatccc aaagcaataa
     7981 cccagaaatt acatcctgag acttacttcc tcagaaagaa aaggaagggg agggataact
     8041 taaaaaggag aaacttctaa tatggtatta gactgtaatt catagggaaa tttatgcctg
     8101 agatatgaat ttctgaaaat aaggggcttt tttggaaggg aaacactgac acatccttaa
     8161 ttatagagta ataaatacca atggtatatt atctttcgat atttccttac acagatatca
     8221 aagcatgcag ctgtttttga aaactgataa tcaagtacaa tataagtata ttacatcttg
     8281 cacttacaac acacccttca actaagcagc atcatggagc acttaacggt gagaaacaga
     8341 gctgctcata gtagaaacct aactgaacaa attagctttg aattgtaact taagaatcgt
     8401 agtcaaacca aagcgtctgt ccttgccagg aaaggcattc caaaggcaga gagcatgcca
     8461 agtaaaaagg ctttgcttca ggattatgga gacagttctg aaaagccagc ataacttaat
     8521 gatcaatcag aaaaatatag agcagtaact acacaactga aggatgcata aaaattgtac
     8581 aaaacgttaa tagtggaatg gggaggtagg atgggatttt acgggcaagt attaagctct
     8641 tggaaagctt catttgttgc cctcaatcca cacagcagaa agaaagagaa agagacaaac
     8701 atggtcaaag aaaagtatgt ggacaaatgt ggggggtaga aaaggaaatg aaggttaagc
     8761 aaggccaata taattcagaa taaaagggag ggagggaagt ataaggagcc agctgtaatt
     8821 actgaatgtt acattaagaa gagctgaaat tgagaggggg aggtcttgag tattttacta
     8881 agtggattaa tgtcctcttc ctcgggtgtc tgaagttgca gattttaatt tatttggtgc
     8941 agggatttat tacagaattc ttaatgggtg gggagataaa cagggacaat tataagctct
     9001 taagaagaag aaaagaggac catataatac tttctataaa tttaactgta ataaacaggg
     9061 tttcaagcta tggacaaaga tagtcaaaaa aagcatttat tccatgatat aggactaaaa
     9121 gggaaataag aggtgtgtcc aaaaaactta aagaccaaaa caaagaaaga aaaacccaca
     9181 tagatgtgtg atgccaggat tttgaatgac ttgggagcta gttattgccg ctctcctttc
     9241 tccacccatt taaaaaaata aatcataact ctggcattta aaaacctact catgaacatc
     9301 atttattaat ataaacttaa tcctgtgcta ttctttggtg ggtggtaaga acatgaatta
     9361 acaacaactg gactaaaacg atggcaacag gatgatccac tcaaacacag gaaagctgta
     9421 agaaaaagaa aaactcctaa tctgctcttt caccttactt attttacaga aggagaaagc
     9481 caaaaagggg agagcatgtg gctaaaccac agaaagacta gatgcctaaa ggaaaaattt
     9541 taaagtgttc ctaaataggt attagaaggg gaagggggat gtaaagctta tgtgatttac
     9601 atcattttgt taatctgcta atctacttcc ctggaaggtg agaaagagtg ttgtctgcct
     9661 tctgcaattg aagagactag ggcagaaact taattatgtt cttaccctgt gtatacctgg
     9721 ctgtcatctg gctggcaact agtccacaaa ctattggttc aggcatttgc ctggcaataa
     9781 tgttagccat catttaaatt gttaaatatg gatcagaaga tctctaagaa ttactgatat
     9841 gcagctatta atactggatg taaataatat tatttggggt gtgggtaaat catttgactg
     9901 gaaccacatt taaaaaaagg acttggaaat tttatttttg aaatgctgtt ggggagatgg
     9961 cattgatgaa aaaaaaaatt gaaaatggaa aaaaacatca tctacaaaga gatgggtaaa
    10021 aatgactaag caaagaagcc ttgtcacctt cgacctgatg cttcattgta tcagaagaaa
    10081 gtaaacagat tgctaacaaa gagaccaccc cttctaattt ccaaaaccgg cccagcaaca
    10141 agagggagaa aatagagaag agtgcactgc gtggtggctc agggtgatcc tttaatttga
    10201 gtgttaaaaa tgagggcaca gacctagagg tttttaatgg tccgcgggtg gacttcagat
    10261 tctgaacact cctccacctt ctgtggagaa ttcgggacac ggtggagttt aaccagtatc
    10321 ttaaatccca gggacagggt ggagattgct ttgtgatcct gattaattaa aaggaaagaa
    10381 atcaaagcag acatctctcc tttttccatt tgagccgcag agccatggag gggaacttgt
    10441 gctctctggt gcttgcagct atgttccctg gctttcatcg tcttggcttt tccccttgta
    10501 tttctaatgc tgtgatacca ggccaataaa atggaatcta caaaactgca aaacaaaa
//
