LOCUS       NM_001354354           10681 bp    mRNA    linear   PRI 12-MAY-2024
DEFINITION  Homo sapiens glycosyltransferase like domain containing 1 (GTDC1),
            transcript variant 12, mRNA.
ACCESSION   NM_001354354 XM_017004927
VERSION     NM_001354354.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10681)
  AUTHORS   Zhao,X., Ma,D., Ishiguro,K., Saito,H., Akichika,S., Matsuzawa,I.,
            Mito,M., Irie,T., Ishibashi,K., Wakabayashi,K., Sakaguchi,Y.,
            Yokoyama,T., Mishima,Y., Shirouzu,M., Iwasaki,S., Suzuki,T. and
            Suzuki,T.
  TITLE     Glycosylated queuosines in tRNAs optimize translational rate and
            post-embryonic growth
  JOURNAL   Cell 186 (25), 5517-5535 (2023)
   PUBMED   37992713
REFERENCE   2  (bases 1 to 10681)
  AUTHORS   Igo,R.P. Jr., Hall,N.B., Malone,L.L., Hall,J.B., Truitt,B., Qiu,F.,
            Tao,L., Mupere,E., Schnell,A., Hawn,T.R., Bush,W.S., Joloba,M.,
            Boom,W.H. and Stein,C.M.
  TITLE     Fine-mapping analysis of a chromosome 2 region linked to resistance
            to Mycobacterium tuberculosis infection in Uganda reveals potential
            regulatory variants
  JOURNAL   Genes Immun 20 (6), 473-483 (2019)
   PUBMED   30100616
  REMARK    GeneRIF: Genomewide linkage scan by a targeted, high-density
            association scan for genetic variants enhancing persistently
            negative tuberculin skin test (PTST) in two independent Ugandan
            tuberculosis household cohorts. Association found with SNPs in
            neighboring genes ZEB2 and GTDC1 supported by both samples.
            Bioinformatic analysis suggests these variants may affect PTST- by
            regulating the histone deacetylase pathway.
REFERENCE   3  (bases 1 to 10681)
  AUTHORS   Aksoy,I., Utami,K.H., Winata,C.L., Hillmer,A.M., Rouam,S.L.,
            Briault,S., Davila,S., Stanton,L.W. and Cacheux,V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: By deriving iPSCs from this patient and differentiating
            them into neural progenitor cells (NPCs) and neurons we dissected
            the disease process at the cellular level and observed defects in
            both NPCs and neuronal cells. We also showed that disruption of
            GTDC1 expression in wild type human NPCs and neurons showed a
            similar phenotype as patient's iPSCs
REFERENCE   4  (bases 1 to 10681)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 10681)
  AUTHORS   Shimono,N., Nishimura,Y., Kamiguchi,H. and Nishikawa,Y.
  TITLE     Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a
            human mannosyltransferase-like gene, that is homologous to
            drosophila gene GC15914
  JOURNAL   Biosci Biotechnol Biochem 75 (8), 1451-1455 (2011)
   PUBMED   21821951
  REMARK    GeneRIF: The elevated expression of the Hmat-Xa gene (GTDC1) might
            serve as a candidate marker for colon adenocarcinoma.
REFERENCE   6  (bases 1 to 10681)
  AUTHORS   Akbari,M.R., Malekzadeh,R., Shakeri,R., Nasrollahzadeh,D.,
            Foumani,M., Sun,Y., Pourshams,A., Sadjadi,A., Jafari,E.,
            Sotoudeh,M., Kamangar,F., Boffetta,P., Dawsey,S.M., Ghadirian,P.
            and Narod,S.A.
  TITLE     Candidate gene association study of esophageal squamous cell
            carcinoma in a high-risk region in Iran
  JOURNAL   Cancer Res 69 (20), 7994-8000 (2009)
   PUBMED   19826048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10681)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   8  (bases 1 to 10681)
  AUTHORS   Zhao,E., Li,Y., Fu,X., Zhang,J.Y., Zeng,H., Zeng,L., Lin,Y.,
            Chen,J., Yin,G., Qian,J., Ying,K., Xie,Y., Zhao,R.C. and Mao,Y.M.
  TITLE     Cloning and expression of human GTDC1 gene
            (glycosyltransferase-like domain containing 1) from human fetal
            library
  JOURNAL   DNA Cell Biol 23 (3), 183-187 (2004)
   PUBMED   15068588
  REMARK    GeneRIF: relatively high expression level in the adult lung,
            spleen, testis, and peripheral blood leukocyte.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010130.12, AC009957.11, AC010681.16 and AC016910.6.
            
            On May 20, 2020 this sequence version replaced NM_001354354.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.262259.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC010130.12        28602-28675         c
            75-170              AC009957.11        122526-122621       c
            171-232             AC009957.11        120958-121019       c
            233-297             AC009957.11        96797-96861         c
            298-499             AC009957.11        93885-94086         c
            500-667             AC009957.11        30854-31021         c
            668-841             AC009957.11        27164-27337         c
            842-1195            AC010681.16        8445-8798           c
            1196-1305           AC016910.6         135286-135395       c
            1306-1450           AC016910.6         121828-121972       c
            1451-1521           AC016910.6         117406-117476       c
            1522-1613           AC016910.6         116615-116706       c
            1614-10681          AC016910.6         102701-111768       c
FEATURES             Location/Qualifiers
     source          1..10681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.3"
     gene            1..10681
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="glycosyltransferase like domain containing 1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
     exon            1..74
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            75..170
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            171..232
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            233..297
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            298..499
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1697
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /EC_number="2.4.1.110"
                     /note="isoform a is encoded by transcript variant 12;
                     glycosyltransferase-like domain-containing protein 1;
                     glycosyltransferase-like 1; mannosyltransferase candidate;
                     mannosyltransferase-like protein Xa; tRNA-queuosine
                     alpha-mannosyltransferase"
                     /codon_start=1
                     /product="tRNA-queuosine alpha-mannosyltransferase isoform
                     a"
                     /protein_id="NP_001341283.1"
                     /db_xref="CCDS:CCDS33300.1"
                     /db_xref="GeneID:79712"
                     /db_xref="HGNC:HGNC:20887"
                     /db_xref="MIM:610165"
                     /translation="MSILIIEAFYGGSHKQLVDLLQEELGDCVVYTLPAKKWHWRART
                     SALYFSQTIPISEHYRTLFASSVLNLTELAALRPDLGKLKKILYFHENQLIYPVKKCQ
                     ERDFQYGYNQILSCLVADVVVFNSVFNMESFLTSMGKFMKLIPDHRPKDLESIIRPKC
                     QVIYFPIRFPDVSRFMPKHKTTHLKKMLGLKGNGGAVLSMALPFQPEQRDSEDLLKNF
                     NSECDTHCGLDTARQEYLGNSLRQESDLKKSTSSDNSSSHHGENKQNLTVDPCDILGG
                     VDNQQRLLHIVWPHRWEHDKDPESFFKVLMHLKDLGLNFHVSVLGETFTDVPDIFSEA
                     KKALGSSVLHWGYLPSKDDYFQVLCMADVVISTAKHEFFGVAMLEAVYCGCYPLCPKD
                     LVYPEIFPAEYLYSTPEQLSKRLQNFCKRPDIIRKHLYKGEIAPFSWAALHGKFRSLL
                     TTEPREDL"
     exon            500..667
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            668..841
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1195
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1305
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1450
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1521
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1613
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..10681
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     regulatory      2710..2715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     polyA_site      2735
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
     regulatory      10648..10653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="hexamer: AATAAA"
     polyA_site      10681
                     /gene="GTDC1"
                     /gene_synonym="Hmat-Xa; mat-Xa; QTMAN"
                     /note="major polyA site"
ORIGIN      
        1 acggcgtcag cgcgtcgccg gctgggccgc gccggtggcc aggagggaga gacaaggagg
       61 aggaggagga ggaggtctgg ctagctgtcc ctaacgtcat ttcctggtct caactcttta
      121 agaccctgac atactctgag attggagtga agatttctgt gacatgctgg gtatctctgc
      181 attagccaga ttggacatat gtaaagggac atcagtatat ctggatcatc agattgtgct
      241 tcaagaagac catagggaag aacgcatttt catcttgctg caaaagttgc aatagaagat
      301 ctgaaggttt gaatgggcca atgagtatcc tcatcattga agcattctat ggaggctccc
      361 ataaacagct ggtggatctt cttcaagaag agttaggaga ctgtgtcgtt tatacccttc
      421 ctgcaaagaa atggcattgg agagcccgga catctgcttt atatttctct cagaccattc
      481 ccatcagtga gcattacagg accctctttg caagttcagt gcttaacctg accgaactgg
      541 ctgcccttcg gcctgacctt gggaaactga aaaagattct gtattttcac gagaaccagt
      601 tgatatatcc tgtcaagaaa tgtcaggaga gggatttcca atatggatac aaccaaattc
      661 tttcatgcct ggtggctgat gtggttgtat tcaactcagt ttttaatatg gaatcatttc
      721 tcacttccat gggaaaattt atgaagctga ttcctgatca cagacccaag gatctggaaa
      781 gcatcatcag acccaagtgc caagttattt actttcccat caggtttcct gatgtgagca
      841 gattcatgcc caagcacaaa acaacccatt taaagaagat gctcggcctt aaaggaaatg
      901 gcggtgcggt tctgtccatg gcccttcctt ttcagccaga gcagagagat tcagaggatt
      961 tattgaagaa ttttaattca gagtgtgata cacactgtgg ccttgatact gcacgacaag
     1021 aatatttggg taactcatta agacaggaat cagacttgaa aaaatccacc tcgtcagata
     1081 attcaagctc tcatcatggt gaaaataaac aaaatctgac tgttgatccc tgtgacattt
     1141 tgggtggagt tgataatcag caaagactgc tacacattgt ctggcctcac aggtgggagc
     1201 atgataaaga tccagaaagc ttttttaagg tattaatgca tcttaaagac ttaggactca
     1261 atttccacgt gtctgtactt ggagaaacct tcacagatgt cccagatatt ttttcagagg
     1321 ccaaaaaggc attgggatct tctgtcttac actggggcta cttacccagc aaagatgact
     1381 atttccaagt actgtgcatg gctgatgttg tcatctcaac agctaagcat gaattctttg
     1441 gagtggcaat gttggaagct gtgtactgtg ggtgttaccc actttgtcct aaagatttgg
     1501 tttatcccga aatatttcca gctgaatatc tgtattctac acctgaacag ctttcaaaaa
     1561 ggctccagaa tttctgcaag agaccagata ttataagaaa acatctctat aagggtgaaa
     1621 tcgctccgtt ttcttgggca gccctacatg gtaaattcag gtctctgctt acaacagaac
     1681 ctagggaaga tttgtgacag atggggctaa gtcacaaact tgcagcctaa ggcagaatct
     1741 gaagaacttt ccagagtgtg cccatattta cctgatcaga gagaaaagaa aatctgcaga
     1801 ggaagctgag cctggctgct tgtcatagct gacacagagc catctgccac aaacctgtgg
     1861 cggcttcaga tctccaatcc ctgccaccac cccaactcaa attaaataca gattcctaga
     1921 gacgttatga tggttacaca tgtcctcggc atcacatgta ggagactgtt caaaaaaaat
     1981 atgtggcctg ttgtataacc gcactcatgt atcccatatg tggtgccaca ttgaatttcc
     2041 ggttgaatcc gtttttatcc tttgtactgg atgacatggt gcctgaattc tttcttttcg
     2101 ccgacacgat ggcagccaaa ctgcagcttc aaacgctcac acttggctgg gtttctacct
     2161 aggttgccag gttatcatcg gagccttctt gtgtcctcaa agggccacga ggcctgaaag
     2221 gaggatcaga atgctttggg attaattggg cagccatcgc agaattgttt gtgggcaaag
     2281 ggctgcttta gcacttttct tttagcaaat taatgactct caggcacagg gggttttaag
     2341 tgaaggtatt aataagaggt ctggcaggta ttcccatgat tcacagagtt acatttgcat
     2401 ttaattaatc ttaaagttgc aagataaaca gctgtaattc ggacaaacat gacaaacaca
     2461 gtgaagccaa ctatcccata aaatgaacac tgacatactt gttttaattt ttttcccagc
     2521 gtaaaaatag aaaaatcaaa atactcctaa caaaaccagt gattttgata gaaatatttc
     2581 tccaatatac ttgcatccac ctacaaatat aaccttttca agataaatcg cttatgattt
     2641 caatagtcaa actgctgtgt ttgttgatgt aaagatgttt tgaatggcta gatggtaaaa
     2701 taaattctta ataaagtacc cactgcaatt tttaattagc atattcattt acatatagat
     2761 gtatacatct acctatgtgt ttctcactga acgttttcct tgtgacagag acaacaaata
     2821 caattgtttc ttttccggat gaacaaggat ctgttttgca aatgtttgta agatattatg
     2881 acatttccaa gattttcttt gcattctgga aagcaggagg taaacatttg tagtcattaa
     2941 ggtaaagtct gttgataaac catcttctgt ttactgacag gtaaattgta actttcccta
     3001 gcttttgaaa tgagtaactt ctatacacca caaagtgagg cacagcctgg gaaaggtggc
     3061 tagacaaggg gcaagccagg ctttctagct tctggaagga tcgagtggcc tagcaggcat
     3121 ctaagataaa gaaagcaatg attcggaagt ccagtagggc ccatttgacc ggtagcaaaa
     3181 tcgaaagcac gaaatagatc aaggttaggg agccagacaa agcccttgga agagaggcag
     3241 tattgcagat cgaagcaagc agttcagagt ctatgaggcc tgggaattta aaagcaggaa
     3301 gagtaagaag cagaaacaag aagctccatc tgaacagact cctctctcca accttcatga
     3361 gacccacagt gtgtgatggg ccaccacagc actggcttct agacttttac agggaagcca
     3421 gtgaacaaat tacctcgtca cccagaaaac aaagagctca ggaactattt tggaagttcc
     3481 ttccagtcta agactatgga actcagaatc tagcaggtgt gttcctttgg atagcaaaac
     3541 taaagatata aatatgaata agaaattctt tgccacttct cctgggcaag gttatacttt
     3601 atgccatcta ctgagataaa ccagatgagt cagtttgctt ctgtcagttg ctgtgtcaca
     3661 gatgacatct tctcaaaata atattatctc acagccaaga aatagcgctt cgtttactgt
     3721 gtttttctat cctgaaacta aatgggctta cgcttcatag tggctaagat actccacaca
     3781 caactagtac ccatagatct tttctcactg ataggaaaaa aaaaaaaaaa gcattaaaca
     3841 cctttcagag agtacatctg aaacatttac gtattttcct gatttaggca aatataatat
     3901 tgaaagttac ctgtatgtgg gcattttttt ctacactcat aaatgcaaat caaattttgc
     3961 cattagctgt ggccaacatt ccttccagga caaaagctta cattaggccg ggtgcggtgg
     4021 cgcacgcctg taatcccagc actttgggag gccgagacgg gtggatcatg aggtcaggag
     4081 atcgagacca tcctggctaa cacggtgaaa ccccatctct actaaaaata caaaaaaaat
     4141 tagccaggca tggtggcggg tgcctgtagt cccagctact ggggaggctg aggcaggaga
     4201 atggcgtgaa cccaggaggc ggagcttgca gtgagccgag atcgtgccac tgcactccag
     4261 cctgggcgac agagcgagac tctgtctcaa aaaataaata aataaataaa tttaaaataa
     4321 attttaaaaa aattacatta aaggtgtcac ttatttgcat gataccgaga tttggagttt
     4381 aaagaaaaac cttataaaga ctgtaatgtc agagttgcta ctagttcaca taagcaataa
     4441 aaagttttgt aaatgtgtaa ttcttaacat ttaaaaatat gtaggagtgt gtgtgtgtgt
     4501 gtgtgtgtgc acacgcacat tcatgcttct caacacccac gacctagtgg aatggagtgt
     4561 tattaaataa gttaatcagt attttgttga aatctcagca gataattagt actacacgtt
     4621 gactcattaa ttcagtttcc cttatcaacc acccccatca tttattgttt tgagtatgtt
     4681 tgatggaaaa cttagtcttc ctcttttttt ttaacactcg attgtttttt tcttttaaaa
     4741 taaagtcaat tttaatttta aatgtcttta aaagtccatc cattatcaag actttgacac
     4801 agtgtcttga aatacagctt gccctaaact taatctatgc ttctggctag gtgtttctat
     4861 aacaaatatc agggcacctg gttcttaacc ttctcattta tactgtgttg acagaaatag
     4921 atgcaaatac ctttttaaaa atgctcctgg tttaataagc atccttcaaa tacagttaag
     4981 tttaaatgcc ctgctcctgt tctcagtcct tcagacatca atatggcagg cagaatccat
     5041 aagtcaatgg aaactcttag ccatagaggg ctgcagagat taatttcaac accttgaaat
     5101 gcatctggaa gcaaagattt cattttatgt tgaaggtgtt aattatattt gatattttta
     5161 aaagtaaaat ctgtttttga gaaagcatct gctacccaga aatattatga gccacaaaag
     5221 aaattttact gaagtctcaa gatactttct gtggatgata gaatcagttt tcaaatgata
     5281 gtccatgctg tcttttaatg ctgacataca ctgtgggtct tattcttcta ttgactattg
     5341 acccaactgc ctttcttttt cagtggaaaa tttgggacta tttaatatta gatcttatgt
     5401 ttaacaatga agagagtata ttataaacca ctgacttgaa catgtttcat tttaaaattt
     5461 gagttgtgat acagacaact aatgctccta tcctatgccc tctcttcaaa gctattcatt
     5521 aaaatataac tggggaagtt tgaaaaacat gcgagcaatt ctacatgctg ctcaaagata
     5581 cagacatgtg tgattaaagt acagtattac agaaaacctg ggaattaacc aaacttacaa
     5641 taatggttat gtcagagggg ccatggtaga gaaaaaaaag gacatagaag tagggaaagg
     5701 tgcattcgtt gcatgatgag aagtctgttt cttaagctga gtcgtgatac acaaaggctt
     5761 cttgccactc tttgtgacat ttcatgtgtc ttcagtgtat ttattgcata tatcttttga
     5821 taggagatat aaatacttca ggaagcatgt tactagtttt gctatcaggc tatccttaac
     5881 atttcttggt tttctcaatt attgattgag tcagaaaact gcttgcctca gacagtgata
     5941 caaactactc tactgccaat gttgcttgag aagactttcc tctgcttaac aggagccagg
     6001 ggcttcacct caaccctcat gctgtggaga aagtcagact caactggcca caggttcctg
     6061 tttcttgggg ctgctaatca ccatttctaa cagatgcctg tggcattgca aacacaagat
     6121 ggaaaactat agctctaaac tcccttctga agggtaagga aaggaagagg aaggcagatg
     6181 ttaaatgagc ccagtctttc tcatctcaaa aaattcagag ctgcctgtta gagcacaaga
     6241 gctctcagag ctcccaacca cactgcccac tccccatagt gttgcctctc ccctttcctc
     6301 tttaagacgc aggagcgaat cgtggtcttt gtgctttcac tgcaatctat cccaggggaa
     6361 gagttctccc gggtatctgt gggatgccct tgctgcatgt gaggcacaaa tggcttcagg
     6421 gaccaggatc ctcactcact ctgcagtcca tttttctaaa ttggaatttg cgatcggttt
     6481 cttcaggtgt cccaccatca tctatcatta tctgagttat tccttatcct ctcccaaccc
     6541 caaggagagg atcttaattg tttttataaa ctgacagaag gaattggtga ttcttggaag
     6601 ataattttaa atggttatat tactttccta ttactgcatt tactgcattt aaatagcagg
     6661 tctaaggtgg ggtgcgagaa gatgtgaccc ctaggaatat tggtatgacc tttctcaagc
     6721 aatttgaagt cctttagatc tgaaaattta atgtcttcaa tatcatttca cagatgagaa
     6781 aattaaggca catatagtga catatttagg agctgaagtg tgttacagaa acaaagtttt
     6841 tttgtataag cctttcccta catgggatgt tatcattgtc acctatgtgc ctttcaggaa
     6901 gcaccaagtg cagtatgcgt gactcagttg gacccctagt tcccttctat ttctccagct
     6961 ggcaggagac agcaaaggac agtggaggtg gttattttgt ggcccacatt tctgccatta
     7021 aaagggacat aagagactat gtagtgtggc caattttttt tttttttttt ttgagagaga
     7081 gagtctggct ctgtcgccca ggctggagtg cagtggcacc atctcggctc actgcaagct
     7141 ccacctcccg ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg
     7201 tgcccaccac cacgcccggc taattttttt gtatttttag tagagacggg gtttcaccat
     7261 gttagccagg gtggtctcaa tctcctgacc tcgtgatcca cctgtctcgg cctcccaaag
     7321 tgctgggatt acaggtgtaa gccaccatgc ccggaatatg gccattattt taagtgtttt
     7381 tattattgct ctggttctcc ctttagggag gcattcagtg agtatacccc atctgtcaca
     7441 ggcccccacc actccctgtg gtcttacact ctgctgaatt catacattta ggtaacttcc
     7501 ctggccctcc tgagaatcac ttatttttgt aacctcctgt atttgagatg taggaaactg
     7561 gggcctgagg agaagttgac ttgccttggg tcccacagtg gtacaggcag atctagaact
     7621 cagattttcc agggctcttt cagtaggctg tggttgagca gtagtcaaga ccacctcttc
     7681 aagaagggaa aaacatttgt cttctctttc tcctctttct tccttctgcc tctcactgta
     7741 agaagaaacg tgttaataag ttgctaatac cttactctag gtgtatttca tgttacacca
     7801 gccagtgctt gtattctcaa tgaccataag gagaggaatg cggaagaatt gatttctgta
     7861 ctaaaagttc agactctgtg gcacttgtga tatttctgga caactgactc ttctctattg
     7921 cctttcgaat catacagtgg caaagctgct cacccatgtg tgtataaagc tgacccttca
     7981 tcagaaaggc agcccccagt gtctccccac acagggcaga agagcagagg gagcaggtgg
     8041 caatgtggca gcaccttgaa ctgtgcatca ctgggcctgc tccccctcat cccaaagcaa
     8101 taacccagaa attacatcct gagacttact tcctcagaaa gaaaaggaag gggagggata
     8161 acttaaaaag gagaaacttc taatatggta ttagactgta attcataggg aaatttatgc
     8221 ctgagatatg aatttctgaa aataaggggc ttttttggaa gggaaacact gacacatcct
     8281 taattataga gtaataaata ccaatggtat attatctttc gatatttcct tacacagata
     8341 tcaaagcatg cagctgtttt tgaaaactga taatcaagta caatataagt atattacatc
     8401 ttgcacttac aacacaccct tcaactaagc agcatcatgg agcacttaac ggtgagaaac
     8461 agagctgctc atagtagaaa cctaactgaa caaattagct ttgaattgta acttaagaat
     8521 cgtagtcaaa ccaaagcgtc tgtccttgcc aggaaaggca ttccaaaggc agagagcatg
     8581 ccaagtaaaa aggctttgct tcaggattat ggagacagtt ctgaaaagcc agcataactt
     8641 aatgatcaat cagaaaaata tagagcagta actacacaac tgaaggatgc ataaaaattg
     8701 tacaaaacgt taatagtgga atggggaggt aggatgggat tttacgggca agtattaagc
     8761 tcttggaaag cttcatttgt tgccctcaat ccacacagca gaaagaaaga gaaagagaca
     8821 aacatggtca aagaaaagta tgtggacaaa tgtggggggt agaaaaggaa atgaaggtta
     8881 agcaaggcca atataattca gaataaaagg gagggaggga agtataagga gccagctgta
     8941 attactgaat gttacattaa gaagagctga aattgagagg gggaggtctt gagtatttta
     9001 ctaagtggat taatgtcctc ttcctcgggt gtctgaagtt gcagatttta atttatttgg
     9061 tgcagggatt tattacagaa ttcttaatgg gtggggagat aaacagggac aattataagc
     9121 tcttaagaag aagaaaagag gaccatataa tactttctat aaatttaact gtaataaaca
     9181 gggtttcaag ctatggacaa agatagtcaa aaaaagcatt tattccatga tataggacta
     9241 aaagggaaat aagaggtgtg tccaaaaaac ttaaagacca aaacaaagaa agaaaaaccc
     9301 acatagatgt gtgatgccag gattttgaat gacttgggag ctagttattg ccgctctcct
     9361 ttctccaccc atttaaaaaa ataaatcata actctggcat ttaaaaacct actcatgaac
     9421 atcatttatt aatataaact taatcctgtg ctattctttg gtgggtggta agaacatgaa
     9481 ttaacaacaa ctggactaaa acgatggcaa caggatgatc cactcaaaca caggaaagct
     9541 gtaagaaaaa gaaaaactcc taatctgctc tttcacctta cttattttac agaaggagaa
     9601 agccaaaaag gggagagcat gtggctaaac cacagaaaga ctagatgcct aaaggaaaaa
     9661 ttttaaagtg ttcctaaata ggtattagaa ggggaagggg gatgtaaagc ttatgtgatt
     9721 tacatcattt tgttaatctg ctaatctact tccctggaag gtgagaaaga gtgttgtctg
     9781 ccttctgcaa ttgaagagac tagggcagaa acttaattat gttcttaccc tgtgtatacc
     9841 tggctgtcat ctggctggca actagtccac aaactattgg ttcaggcatt tgcctggcaa
     9901 taatgttagc catcatttaa attgttaaat atggatcaga agatctctaa gaattactga
     9961 tatgcagcta ttaatactgg atgtaaataa tattatttgg ggtgtgggta aatcatttga
    10021 ctggaaccac atttaaaaaa aggacttgga aattttattt ttgaaatgct gttggggaga
    10081 tggcattgat gaaaaaaaaa attgaaaatg gaaaaaaaca tcatctacaa agagatgggt
    10141 aaaaatgact aagcaaagaa gccttgtcac cttcgacctg atgcttcatt gtatcagaag
    10201 aaagtaaaca gattgctaac aaagagacca ccccttctaa tttccaaaac cggcccagca
    10261 acaagaggga gaaaatagag aagagtgcac tgcgtggtgg ctcagggtga tcctttaatt
    10321 tgagtgttaa aaatgagggc acagacctag aggtttttaa tggtccgcgg gtggacttca
    10381 gattctgaac actcctccac cttctgtgga gaattcggga cacggtggag tttaaccagt
    10441 atcttaaatc ccagggacag ggtggagatt gctttgtgat cctgattaat taaaaggaaa
    10501 gaaatcaaag cagacatctc tcctttttcc atttgagccg cagagccatg gaggggaact
    10561 tgtgctctct ggtgcttgca gctatgttcc ctggctttca tcgtcttggc ttttcccctt
    10621 gtatttctaa tgctgtgata ccaggccaat aaaatggaat ctacaaaact gcaaaacaaa
    10681 a
//
