LOCUS       NM_145657               1823 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GS homeobox 1 (GSX1), mRNA.
ACCESSION   NM_145657
VERSION     NM_145657.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   Uzumcu,A., Karaman,B., Toksoy,G., Uyguner,Z.O., Candan,S., Eris,H.,
            Tatli,B., Geckinli,B., Yuksel,A., Kayserili,H. and Basaran,S.
  TITLE     Molecular genetic screening of MBS1 locus on chromosome 13 for
            microdeletions and exclusion of FGF9, GSH1 and CDX2 as causative
            genes in patients with Moebius syndrome
  JOURNAL   Eur J Med Genet 52 (5), 315-320 (2009)
   PUBMED   19460469
  REMARK    GeneRIF: the study ruled out microdeletions on the critical region
            as a common cause of Moebius syndrome and excluded GSH1 gene
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   8  (bases 1 to 1823)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   9  (bases 1 to 1823)
  AUTHORS   Mutsuga,N., Iwasaki,Y., Morishita,M., Nomura,A., Yamamori,E.,
            Yoshida,M., Asai,M., Ozaki,N., Kambe,F., Seo,H., Oiso,Y. and
            Saito,H.
  TITLE     Homeobox protein Gsh-1-dependent regulation of the rat GHRH gene
            promoter
  JOURNAL   Mol Endocrinol 15 (12), 2149-2156 (2001)
   PUBMED   11731616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390738.4 and AB044157.1.
            
            On May 17, 2019 this sequence version replaced NM_145657.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB044157.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302945.3/ ENSP00000304331.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL390738.4         79818-79977
            161-441             AB044157.1         1-281
            442-442             AL390738.4         80259-80259
            443-1007            AB044157.1         283-847
            1008-1823           AL390738.4         81288-82103
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.2"
     gene            1..1823
                     /gene="GSX1"
                     /gene_synonym="Gsh-1; GSH1"
                     /note="GS homeobox 1"
                     /db_xref="GeneID:219409"
                     /db_xref="HGNC:HGNC:20374"
                     /db_xref="MIM:616542"
     exon            1..620
                     /gene="GSX1"
                     /gene_synonym="Gsh-1; GSH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1003
                     /gene="GSX1"
                     /gene_synonym="Gsh-1; GSH1"
                     /note="homeobox protein Gsh-1; GS homeo box protein 1;
                     genomic screened homeo box 1"
                     /codon_start=1
                     /product="GS homeobox 1"
                     /protein_id="NP_663632.1"
                     /db_xref="CCDS:CCDS9326.1"
                     /db_xref="GeneID:219409"
                     /db_xref="HGNC:HGNC:20374"
                     /db_xref="MIM:616542"
                     /translation="MPRSFLVDSLVLREAGEKKAPEGSPPPLFPYAVPPPHALHGLSP
                     GACHARKAGLLCVCPLCVTASQLHGPPGPPALPLLKASFPPFGSQYCHAPLGRQHSAV
                     SPGVAHGPAAAAAAAALYQTSYPLPDPRQFHCISVDSSSNQLPSSKRMRTAFTSTQLL
                     ELEREFASNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGSNHRGGGGGG
                     AGGGGSAPQGCKCASLSSAKCSEDDDELPMSPSSSGKDDRDLTVTP"
     exon            621..1823
                     /gene="GSX1"
                     /gene_synonym="Gsh-1; GSH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accactagcg ctggccagca ccccgcgctc tttgggcggt gcccacggca gcagaggcta
       61 ctgtttcagc ctaggtctca gccgcgcgtt cagcctcctg ggcagaggca gctgcgggat
      121 accgcggcca gggaaagcgc gtggagagcc gaaaggtgcg gtgggcgcag agggcgggct
      181 ggctgcgggg cgaccgcgcg ccggggccat gccgcgctcc ttcctggtgg actcgctagt
      241 gctgcgcgag gcgggcgaga agaaggcgcc cgagggcagc ccgccgccgc tcttccccta
      301 cgctgtgccc ccgccgcacg cgctgcacgg tctctcgcct ggcgcctgcc acgcgcgcaa
      361 ggctgggctg ctgtgcgtgt gcccgctctg cgtcaccgcc tcgcagctgc atgggccccc
      421 cgggccgccc gcgctgcctc tactcaaggc ttccttccca cccttcggct cgcagtactg
      481 ccacgcgccc ctgggccgcc agcactctgc tgtgtcgccc ggggtcgctc acggcccggc
      541 cgccgctgct gctgccgccg cgctctacca gacctcctac ccgctgcctg accccaggca
      601 gttccactgc atctctgtgg acagcagctc taaccagctg cccagcagca agaggatgcg
      661 cacggctttc accagcacgc agctgctaga gctggagcgc gagttcgctt ctaatatgta
      721 cctgtcccgc ctacgtcgca tcgagatcgc gacctacctg aatctgtccg agaagcaggt
      781 gaagatctgg tttcagaacc gccgagtgaa gcacaagaag gagggcaagg gcagcaacca
      841 tcgtggcggc ggcggcgggg gtgccggtgg tggcgggagc gcaccgcaag gctgcaagtg
      901 cgcatcgctc tcctcagcca agtgctccga ggatgacgac gaattgccca tgtctccgtc
      961 ctcctcaggg aaggacgacc gggatcttac ggtcactccc taggcgcgtg tctccctagg
     1021 tcgcccaccc caagacctcc ctgcgcctcg gagactagtc ctgggactca gcgctgattc
     1081 ccaggcaccc gcagccaaac cactgcctgg catggatttg gcactgcttt gcagaggtcc
     1141 cgggcctggg cagggctgag agcttggcag agactggacc atggcgtccc cgccccaggg
     1201 ctcgctcgtg tccaaagcca actccaagct gtgaacactg taagcgctcg agtcctcctg
     1261 ggcagtgcag caccgcggcc cccgcccgca agcctgcttg gcgcagcgcc ttgctggcag
     1321 ccggcgcctc ctagcccgcc ctctctgggc tggcttgggc ttcctcgctt actctactct
     1381 cctccgctct cggtcaaggt cggcggcctt ggatgctcgt tcgcttctct ttttaaaatg
     1441 tctttttgtc cctccccacc tctttcctgt gatcatttat tcactcggcc cccgcccgcc
     1501 aacacacaca tttatgaacc cccacttttt ttttccttct ccttttccct tcccctcctc
     1561 agggagcctc ctccttcagt cagtccattt gtcccttgat ctggccttgc tgtcctcagt
     1621 ccccacggct cctctcacag atgataaatt tcgcccgtag tatccatatt ggggaaacag
     1681 atttgctctg tttccaacac gctcttcctt cctctaaaca taggaccccg ctctgcgccg
     1741 ctggcgaccc cactcttccc cctccagact ctggcccgcc ccagcctagc tgtgtaattg
     1801 tacggcctct gcaatgccag aag
//
