LOCUS       NM_145870               1186 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glutathione S-transferase zeta 1 (GSTZ1), transcript
            variant 1, mRNA.
ACCESSION   NM_145870
VERSION     NM_145870.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Stacpoole,P.W.
  TITLE     Clinical physiology and pharmacology of GSTZ1/MAAI
  JOURNAL   Biochem Pharmacol 217, 115818 (2023)
   PUBMED   37742772
  REMARK    GeneRIF: Clinical physiology and pharmacology of GSTZ1/MAAI.
            Review article
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Zhu,H., Chen,Q., Zhang,Y. and Zhao,L.
  TITLE     Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to
            drive ferroptosis in bladder cancer cells
  JOURNAL   Hum Exp Toxicol 42, 9603271231161606 (2023)
   PUBMED   36905252
  REMARK    GeneRIF: Glutathione S-transferase zeta 1 alters the HMGB1/GPX4
            axis to drive ferroptosis in bladder cancer cells.
REFERENCE   3  (bases 1 to 1186)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1186)
  AUTHORS   Wang,Q., Bin,C., Xue,Q., Gao,Q., Huang,A., Wang,K. and Tang,N.
  TITLE     GSTZ1 sensitizes hepatocellular carcinoma cells to
            sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis
  JOURNAL   Cell Death Dis 12 (5), 426 (2021)
   PUBMED   33931597
  REMARK    GeneRIF: GSTZ1 sensitizes hepatocellular carcinoma cells to
            sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1186)
  AUTHORS   Jahn,S.C., Gay,L.A., Weaver,C.J., Renne,R., Langaee,T.Y.,
            Stacpoole,P.W. and James,M.O.
  TITLE     Age-Related Changes in miRNA Expression Influence GSTZ1 and Other
            Drug Metabolizing Enzymes
  JOURNAL   Drug Metab Dispos 48 (7), 563-569 (2020)
   PUBMED   32357971
  REMARK    GeneRIF: Age-Related Changes in miRNA Expression Influence GSTZ1
            and Other Drug Metabolizing Enzymes.
REFERENCE   6  (bases 1 to 1186)
  AUTHORS   Tong,Z., Board,P.G. and Anders,M.W.
  TITLE     Glutathione transferase zeta-catalyzed biotransformation of
            dichloroacetic acid and other alpha-haloacids
  JOURNAL   Chem Res Toxicol 11 (11), 1332-1338 (1998)
   PUBMED   9815194
REFERENCE   7  (bases 1 to 1186)
  AUTHORS   Tong,Z., Board,P.G. and Anders,M.W.
  TITLE     Glutathione transferase zeta catalyses the oxygenation of the
            carcinogen dichloroacetic acid to glyoxylic acid
  JOURNAL   Biochem J 331 (Pt 2) (Pt 2), 371-374 (1998)
   PUBMED   9531472
REFERENCE   8  (bases 1 to 1186)
  AUTHORS   Fernandez-Canon,J.M. and Penalva,M.A.
  TITLE     Characterization of a fungal maleylacetoacetate isomerase gene and
            identification of its human homologue
  JOURNAL   J Biol Chem 273 (1), 329-337 (1998)
   PUBMED   9417084
REFERENCE   9  (bases 1 to 1186)
  AUTHORS   Blackburn,A.C., Woollatt,E., Sutherland,G.R. and Board,P.G.
  TITLE     Characterization and chromosome location of the gene GSTZ1 encoding
            the human Zeta class glutathione transferase and maleylacetoacetate
            isomerase
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 109-114 (1998)
   PUBMED   9925947
REFERENCE   10 (bases 1 to 1186)
  AUTHORS   Board,P.G., Baker,R.T., Chelvanayagam,G. and Jermiin,L.S.
  TITLE     Zeta, a novel class of glutathione transferases in a range of
            species from plants to humans
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 929-935 (1997)
   PUBMED   9396740
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001453.1 and AJ001838.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145870.2.
            
            Summary: This gene is a member of the glutathione S-transferase
            (GSTs) super-family which encodes multifunctional enzymes important
            in the detoxification of electrophilic molecules, including
            carcinogens, mutagens, and several therapeutic drugs, by
            conjugation with glutathione. This enzyme catalyzes the conversion
            of maleylacetoacetate to fumarylacetoacatate, which is one of the
            steps in the phenylalanine/tyrosine degradation pathway. Deficiency
            of a similar gene in mouse causes oxidative stress. Several
            transcript variants of this gene encode multiple protein isoforms.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.79497.1,
                                           SRR5189652.13179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216465.10/ ENSP00000216465.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1082              BC001453.1         26-1107
            1083-1186           AJ001838.1         1053-1156
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1186
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /note="glutathione S-transferase zeta 1"
                     /db_xref="GeneID:2954"
                     /db_xref="HGNC:HGNC:4643"
                     /db_xref="MIM:603758"
     exon            1..148
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..784
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /EC_number="2.5.1.18"
                     /EC_number="5.2.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     maleylacetone isomerase; glutathione S-alkyltransferase;
                     glutathione S-aryltransferase; S-(hydroxyalkyl)glutathione
                     lyase; glutathione S-aralkyltransferase;
                     maleylacetoacetate isomerase; glutathione transferase zeta
                     1"
                     /codon_start=1
                     /product="maleylacetoacetate isomerase isoform 1"
                     /protein_id="NP_665877.1"
                     /db_xref="CCDS:CCDS9858.1"
                     /db_xref="GeneID:2954"
                     /db_xref="HGNC:HGNC:4643"
                     /db_xref="MIM:603758"
                     /translation="MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQ
                     QFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMI
                     SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVT
                     MADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA"
     exon            149..200
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            201..268
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            269..349
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            350..475
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            476..554
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            555..607
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            608..657
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1186
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /note="hexamer: ATTAAA"
     polyA_site      1082
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /note="major polyA site"
     regulatory      1163..1168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /note="hexamer: ATTAAA"
     polyA_site      1186
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
ORIGIN      
        1 ctagtccagc ccctcgcttt acccggacga aagacacggg cctgattcgt cgagtctcac
       61 tgagccttag tcgtcggcag gtcccaggcg cgaagtttct cggcctggag gagggggtcg
      121 cgcgaagtgc cagatgcagg cggggaagcc catcctctat tcctatttcc gaagctcctg
      181 ctcatggaga gttcgaattg ctctggcctt gaaaggcatc gactacgaga cggtgcccat
      241 caatctcata aaggatgggg gccaacagtt ttctaaggac ttccaggcac tgaatcctat
      301 gaagcaggtg ccaaccctga agattgatgg aatcaccatt caccagtcac tggccatcat
      361 tgagtatcta gaggagatgc gtcccactcc gcgacttctg cctcaggacc caaagaagag
      421 ggccagcgtg cgtatgattt ctgacctcat cgctggtggc atccagcccc tgcagaacct
      481 gtctgtcctg aagcaagtgg gagaggagat gcagctgacc tgggcccaga acgccatcac
      541 ttgtggcttt aacgccctgg agcagatcct acagagcaca gcgggcatat actgtgtagg
      601 agacgaggtg accatggctg atctgtgctt ggtgcctcag gtggcaaatg ctgaaagatt
      661 caaggtggat ctcaccccct accctaccat cagctccatc aacaagaggc tgctggtctt
      721 ggaggccttc caggtgtctc acccctgccg gcagccagat acacccactg agctgagggc
      781 ctagctccca aatcctgccc cgttggcaca gggccacagg agcagaagct gggtgggctg
      841 aagaggcctg gaaacgagag tcttaattga ggagatggga gactcgaact ctagccctgg
      901 atctgccttc ctgctgaaac ttgttccacc tcagtcccct catctgtcac acgcatgtgg
      961 ggtggagtag ggagatgcgg ggagcagggt gggcaggaat actgttatct atgtgacggg
     1021 gcagtcgtga ggctgagatg agaatgcgga ttaaaatgcc tggcgtgctc accgtaacac
     1081 cacggggaag gctgtgtgcc ttttctcatc cgcttttgtt gtgtgtgact ccaaagaatg
     1141 cccgcgctga aatttggcgt gaattaaact gaagcccagg cctcta
//
