LOCUS       NM_001358664             964 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens glutathione S-transferase theta 4 (GSTT4), transcript
            variant 1, mRNA.
ACCESSION   NM_001358664
VERSION     NM_001358664.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   2  (bases 1 to 964)
  AUTHORS   To-Figueras,J., Gene,M., Gomez-Catalan,J., Pique,E., Borrego,N.,
            Carrasco,J.L., Ramon,J. and Corbella,J.
  TITLE     Genetic polymorphism of glutathione S-transferase P1 gene and lung
            cancer risk
  JOURNAL   Cancer Causes Control 10 (1), 65-70 (1999)
   PUBMED   10334644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC253536.1.
            
            On Aug 6, 2019 this sequence version replaced NM_001358664.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000621179.6/
                                                ENSP00000492273.1
            RefSeq Select criteria           :: based on conservation, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC253536.1         49213-49421         c
            210-297             AC253536.1         47728-47815         c
            298-448             AC253536.1         45143-45293         c
            449-625             AC253536.1         44043-44219         c
            626-964             AC253536.1         42369-42707         c
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..964
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /note="glutathione S-transferase theta 4"
                     /db_xref="GeneID:25774"
                     /db_xref="HGNC:HGNC:26930"
     exon            1..209
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..823
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /note="GST class-theta-4; glutathione S-transferase theta
                     pseudogene 1"
                     /codon_start=1
                     /product="glutathione S-transferase theta-4"
                     /protein_id="NP_001345593.1"
                     /db_xref="CCDS:CCDS87011.1"
                     /db_xref="GeneID:25774"
                     /db_xref="HGNC:HGNC:26930"
                     /translation="MALELYMDLLSAPCRAVYIFSKKHDIQFNFQFVDLLKGHHHSKG
                     YIDINPLRKLPSLKDGKFILSESAAILYYLCRKYSAPSHWCPPDPHARARVDEFVAWQ
                     HTAFQLPMKKIVWLKLLIPKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITG
                     NQISLADLVAVVEMMQPMAANYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLA
                     DWDFSTLDSMVKENISELLKKSR"
     exon            210..297
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /inference="alignment:Splign:2.1.0"
     exon            298..448
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /inference="alignment:Splign:2.1.0"
     exon            449..625
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /inference="alignment:Splign:2.1.0"
     exon            626..964
                     /gene="GSTT4"
                     /gene_synonym="GSTTP1; HS322B1A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcggaga gggcacaggg ccagggactc tggccagaca taggcccagg tctgtggctg
       61 gccaactgcg gctgtggggc ctggcatgtg tctcaacatg gcactggagc tctacatgga
      121 cctgctgtca gcaccctgcc gtgccgtcta catcttctcg aagaagcatg acatccagtt
      181 caactttcag tttgtggatc tgctgaaagg tcaccaccac agcaaaggat acattgacat
      241 caaccccctc aggaagctgc ccagcctcaa agatgggaaa tttatcttaa gtgaaagcgc
      301 ggccatcctt tactacctgt gccgcaagta cagcgcacca tcgcactggt gcccgccaga
      361 cccgcacgca cgtgcccgtg tggatgagtt cgtggcttgg caacacacgg cctttcagct
      421 gcccatgaag aagatagtct ggctcaagtt gctgatccca aagataacag gggaggaagt
      481 ttcagctgag aagatggagc atgcagtgga agaggtgaag aacagcctgc agctctttga
      541 ggagtatttt ctgcaggata agatgttcat caccgggaac caaatctcac tggctgacct
      601 ggtggccgtg gtggagatga tgcagcccat ggcagccaac tataatgtct tcctcaacag
      661 ctccaagcta gctgagtggc gtatgcaggt ggagctgaat attggctctg gcctctttag
      721 ggaggcccat gatcgactaa tgcagttggc cgactgggac ttttcaacat tggattcaat
      781 ggtcaaggag aatatttctg agttgctgaa gaagagcagg tgaccctagg cgcagcctgt
      841 cccgcagggc ctggctggct tagcaatctg agccaccttc cttaaaggaa atgttaaaaa
      901 aaaaaaaaca aaaaaacaaa aaaacaactg ttctttgcct aataaagaac tggaacaacc
      961 atca
//
