LOCUS       NM_001080843            1108 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutathione S-transferase theta 2B (GSTT2B),
            transcript variant 1, mRNA.
ACCESSION   NM_001080843 XM_001131290 XM_928923
VERSION     NM_001080843.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Iorio,A., Polimanti,R., Calandro,M., Graziano,M.E., Piacentini,S.,
            Bucossi,S., Squitti,R., Lazzarin,N., Scano,G., Limbruno,G.M.,
            Manfellotto,D. and Fuciarelli,M.
  TITLE     Explorative genetic association study of GSTT2B copy number variant
            in complex disease risks
  JOURNAL   Ann Hum Biol 43 (3), 279-284 (2016)
   PUBMED   26207597
  REMARK    GeneRIF: The data highlights that GSTT2B copy number variant is not
            associated with the investigated complex diseases in Italian
            patients.
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Bustamante,M., Danileviciute,A., Espinosa,A., Gonzalez,J.R.,
            Subirana,I., Cordier,S., Chevrier,C., Chatzi,L., Grazuleviciene,R.,
            Sunyer,J., Ibarluzea,J., Ballester,F., Villanueva,C.M.,
            Nieuwenhuijsen,M., Estivill,X. and Kogevinas,M.
  TITLE     Influence of fetal glutathione S-transferase copy number variants
            on adverse reproductive outcomes
  JOURNAL   BJOG 119 (9), 1141-1146 (2012)
   PUBMED   22676722
  REMARK    GeneRIF: Results GSTT2B insertion allele was associated with an
            increased risk of being small for gestational age indicate that
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Chambers,J.C., Zhang,W., Sehmi,J., Li,X., Wass,M.N., Van der
            Harst,P., Holm,H., Sanna,S., Kavousi,M., Baumeister,S.E.,
            Coin,L.J., Deng,G., Gieger,C., Heard-Costa,N.L., Hottenga,J.J.,
            Kuhnel,B., Kumar,V., Lagou,V., Liang,L., Luan,J., Vidal,P.M., Mateo
            Leach,I., O'Reilly,P.F., Peden,J.F., Rahmioglu,N., Soininen,P.,
            Speliotes,E.K., Yuan,X., Thorleifsson,G., Alizadeh,B.Z.,
            Atwood,L.D., Borecki,I.B., Brown,M.J., Charoen,P., Cucca,F.,
            Das,D., de Geus,E.J., Dixon,A.L., Doring,A., Ehret,G.,
            Eyjolfsson,G.I., Farrall,M., Forouhi,N.G., Friedrich,N.,
            Goessling,W., Gudbjartsson,D.F., Harris,T.B., Hartikainen,A.L.,
            Heath,S., Hirschfield,G.M., Hofman,A., Homuth,G., Hypponen,E.,
            Janssen,H.L., Johnson,T., Kangas,A.J., Kema,I.P., Kuhn,J.P.,
            Lai,S., Lathrop,M., Lerch,M.M., Li,Y., Liang,T.J., Lin,J.P.,
            Loos,R.J., Martin,N.G., Moffatt,M.F., Montgomery,G.W., Munroe,P.B.,
            Musunuru,K., Nakamura,Y., O'Donnell,C.J., Olafsson,I.,
            Penninx,B.W., Pouta,A., Prins,B.P., Prokopenko,I., Puls,R.,
            Ruokonen,A., Savolainen,M.J., Schlessinger,D., Schouten,J.N.,
            Seedorf,U., Sen-Chowdhry,S., Siminovitch,K.A., Smit,J.H.,
            Spector,T.D., Tan,W., Teslovich,T.M., Tukiainen,T.,
            Uitterlinden,A.G., Van der Klauw,M.M., Vasan,R.S., Wallace,C.,
            Wallaschofski,H., Wichmann,H.E., Willemsen,G., Wurtz,P., Xu,C.,
            Yerges-Armstrong,L.M., Abecasis,G.R., Ahmadi,K.R., Boomsma,D.I.,
            Caulfield,M., Cookson,W.O., van Duijn,C.M., Froguel,P., Matsuda,K.,
            McCarthy,M.I., Meisinger,C., Mooser,V., Pietilainen,K.H.,
            Schumann,G., Snieder,H., Sternberg,M.J., Stolk,R.P., Thomas,H.C.,
            Thorsteinsdottir,U., Uda,M., Waeber,G., Wareham,N.J.,
            Waterworth,D.M., Watkins,H., Whitfield,J.B., Witteman,J.C.,
            Wolffenbuttel,B.H., Fox,C.S., Ala-Korpela,M., Stefansson,K.,
            Vollenweider,P., Volzke,H., Schadt,E.E., Scott,J., Jarvelin,M.R.,
            Elliott,P. and Kooner,J.S.
  CONSRTM   Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes
            Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic
            Investigation of Anthropometric Traits (GIANT) Consortium; Global
            Lipids Genetics Consortium; Genetics of Liver Disease (GOLD)
            Consortium; International Consortium for Blood Pressure
            (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits
            Consortium (MAGIC)
  TITLE     Genome-wide association study identifies loci influencing
            concentrations of liver enzymes in plasma
  JOURNAL   Nat Genet 43 (11), 1131-1138 (2011)
   PUBMED   22001757
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Matejcic,M., Li,D., Prescott,N.J., Lewis,C.M., Mathew,C.G. and
            Parker,M.I.
  TITLE     Association of a deletion of GSTT2B with an altered risk of
            oesophageal squamous cell carcinoma in a South African population:
            a case-control study
  JOURNAL   PLoS One 6 (12), e29366 (2011)
   PUBMED   22216261
  REMARK    GeneRIF: results suggest that the presence of the recently
            described GSTT2B deletion may have a protective effect on the risk
            of OSCC in the Mixed Ancestry South African population
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Zhao,Y., Marotta,M., Eichler,E.E., Eng,C. and Tanaka,H.
  TITLE     Linkage disequilibrium between two high-frequency deletion
            polymorphisms: implications for association studies involving the
            glutathione-S transferase (GST) genes
  JOURNAL   PLoS Genet 5 (5), e1000472 (2009)
   PUBMED   19424424
  REMARK    GeneRIF: study describes a previously uncharacterized 38-kilo-base
            (kb) long deletion polymorphism of GSTT2B located within a 61-kb
            DNA inverted repeat
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Coggan,M., Whitbread,L., Whittington,A. and Board,P.
  TITLE     Structure and organization of the human theta-class glutathione
            S-transferase and D-dopachrome tautomerase gene complex
  JOURNAL   Biochem J 334 (Pt 3) (Pt 3), 617-623 (1998)
   PUBMED   9729470
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Tan,K.L., Webb,G.C., Baker,R.T. and Board,P.G.
  TITLE     Molecular cloning of a cDNA and chromosomal localization of a human
            theta-class glutathione S-transferase gene (GSTT2) to chromosome 22
  JOURNAL   Genomics 25 (2), 381-387 (1995)
   PUBMED   7789971
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Hussey,A.J. and Hayes,J.D.
  TITLE     Characterization of a human class-Theta glutathione S-transferase
            with activity towards 1-menaphthyl sulphate
  JOURNAL   Biochem J 286 (Pt 3) (Pt 3), 929-935 (1992)
   PUBMED   1417752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC253536.1.
            
            On Dec 31, 2019 this sequence version replaced NM_001080843.3.
            
            Summary: The protein encoded by this gene, glutathione
            S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily
            of proteins that catalyze the conjugation of reduced glutathione to
            a variety of electrophilic and hydrophobic compounds. Human GSTs
            can be divided into five main classes: alpha, mu, pi, theta, and
            zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and
            GSTT2B are nearly identical to each other, and share 55% amino acid
            identity with GSTT1. All three genes may play a role in human
            carcinogenesis. The GSTT2B gene is a pseudogene in some
            populations. [provided by RefSeq, Sep 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071700.1, BX376669.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290765.9/ ENSP00000290765.4
            polymorphic pseudogene :: PMID: 19424424
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC253536.1         4988-5163           c
            177-264             AC253536.1         4262-4349           c
            265-415             AC253536.1         2519-2669           c
            416-589             AC253536.1         2253-2426           c
            590-1108            AC253536.1         1382-1900           c
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..1108
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /note="glutathione S-transferase theta 2B"
                     /db_xref="GeneID:653689"
                     /db_xref="HGNC:HGNC:33437"
     exon            1..176
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..799
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /EC_number="2.5.1.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-transferase theta 2; GST class-theta-2"
                     /codon_start=1
                     /product="glutathione S-transferase theta-2B isoform 1"
                     /protein_id="NP_001074312.1"
                     /db_xref="CCDS:CCDS33617.1"
                     /db_xref="GeneID:653689"
                     /db_xref="HGNC:HGNC:33437"
                     /translation="MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKE
                     FLQINSLGKLPTLKDGDFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWH
                     ADCIRGTFGIPLWVQVLGPLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQ
                     QVTLADLMALEELMQPVALGYELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILE
                     QAAKKTLPTPSPEAYQAMLLRIARIP"
     exon            177..264
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            265..415
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            416..589
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /inference="alignment:Splign:2.1.0"
     exon            590..1108
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1078..1083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="GSTT2B"
                     /gene_synonym="GSTT2P"
                     /note="major polyA site"
ORIGIN      
        1 agctgctgcc cacaccgcgc tcagcgcctt cactgccatc cccgctgtcc ttgccgcccc
       61 cgccatgggc ctagagctgt ttcttgacct ggtgtcccag cccagccgcg ccgtctacat
      121 cttcgccaag aagaatggca tccccttaga gctgcgcacc gtggatttgg tcaaagggca
      181 gcacaagagc aaggagttct tgcagatcaa cagcctgggg aaactgccga cgctcaagga
      241 tggtgatttc atcttgaccg aaagctcggc catcctgatt tacctgagct gtaagtacca
      301 gacgccggac cactggtatc catctgacct gcaggctcgt gcccgtgttc atgagtacct
      361 gggctggcat gccgactgca tccgtggcac ctttggtata cccctgtggg tccaggtgtt
      421 ggggccactc attggggtcc aggtgcccga ggagaaggtg gaacgcaaca ggactgccat
      481 ggaccaggcc ctgcaatggc tggaggacaa gttcctgggg gacaggccct tcctcgctgg
      541 ccagcaggtg acactggctg atctcatggc cctggaggag ctgatgcagc cggtggctct
      601 cggctatgaa ctgtttgagg gacggccacg actggcagca tggcgtggac gagtggaggc
      661 tttcctgggt gctgagctat gccaggaggc ccacagcatc atcttgagca tcctggaaca
      721 ggcggccaag aaaaccctcc caacaccctc accagaggcc tatcaggcta tgctgcttcg
      781 aatcgccagg atcccctgaa gggtctggga tgggggccag gagattagca acaaggattc
      841 attctgttac ttacttgccc ctttttatct ttccctcttg ccccagtccc ttctctccag
      901 cttcatgtga agctctgcac agacaagaca ctcagtgtcc ttggcagtgc tgctactcct
      961 caggtgcagc atacataacc agtaagagac taaatctgca atatataaag agctcctaca
     1021 aatcagtaac atgaagaaca ctcaaaaatt ggcaaatgtc atcagtgttt taaacagaat
     1081 aaagattcca aacactttga atagagaa
//
