LOCUS       NM_000852                741 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens glutathione S-transferase pi 1 (GSTP1), mRNA.
ACCESSION   NM_000852
VERSION     NM_000852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 741)
  AUTHORS   Jalalian,E.J., Taravati,A. and Seyedalipour,B.
  TITLE     GSTP1-A313G genetic polymorphism and the risk of preeclampsia in
            pregnant women: A study in the northern population of Iran
  JOURNAL   Pregnancy Hypertens 37, 101144 (2024)
   PUBMED   39111192
  REMARK    GeneRIF: GSTP1-A313G genetic polymorphism and the risk of
            preeclampsia in pregnant women: A study in the northern population
            of Iran.
REFERENCE   2  (bases 1 to 741)
  AUTHORS   Juras,A., Crkvenac Gornik,K., Held,M., Sestan,M., Turudic,D.,
            Sapina,M., Srsen,S., Huljev Frkovic,S., Frkovic,M., Gagro,A. and
            Jelusic,M.
  TITLE     Association of Glutathione Transferase M1, T1, P1 and A1 Gene
            Polymorphism and Susceptibility to IgA Vasculitis
  JOURNAL   Int J Mol Sci 25 (14), 7777 (2024)
   PUBMED   39063019
  REMARK    GeneRIF: Association of Glutathione Transferase M1, T1, P1 and A1
            Gene Polymorphism and Susceptibility to IgA Vasculitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 741)
  AUTHORS   Gudur,R.A., Bhosale,S.J., Gudur,A.K. and Datkhile,K.D.
  TITLE     Genetic Polymorphisms in Glutathione S-Transferase (GST) Gene and
            Their Correlation with Toxicity of Chemotherapy in Breast Cancer
            Patients
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2271-2282 (2024)
   PUBMED   39068558
  REMARK    GeneRIF: Genetic Polymorphisms in Glutathione S-Transferase (GST)
            Gene and Their Correlation with Toxicity of Chemotherapy in Breast
            Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 741)
  AUTHORS   Bartolini,D., Stabile,A.M., Migni,A., Gurrado,F., Lioci,G., De
            Franco,F., Mandarano,M., Svegliati-Baroni,G., Di Cristina,M.,
            Bellezza,G., Rende,M. and Galli,F.
  TITLE     Subcellular distribution and Nrf2/Keap1-interacting properties of
            Glutathione S-transferase P in hepatocellular carcinoma
  JOURNAL   Arch Biochem Biophys 757, 110043 (2024)
   PUBMED   38789086
  REMARK    GeneRIF: Subcellular distribution and Nrf2/Keap1-interacting
            properties of Glutathione S-transferase P in hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 741)
  AUTHORS   Aykanli,E., Arisan,S., Arisan,E.D. and Yavuzsan,A.H.
  TITLE     Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum
            of Prostate Cancer Patients
  JOURNAL   Urol J 21 (3), 182-188 (2024)
   PUBMED   38493315
  REMARK    GeneRIF: Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation
            in Serum of Prostate Cancer Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 741)
  AUTHORS   Reinemer,P., Dirr,H.W., Ladenstein,R., Huber,R., Lo Bello,M.,
            Federici,G. and Parker,M.W.
  TITLE     Three-dimensional structure of class pi glutathione S-transferase
            from human placenta in complex with S-hexylglutathione at 2.8 A
            resolution
  JOURNAL   J Mol Biol 227 (1), 214-226 (1992)
   PUBMED   1522586
REFERENCE   7  (bases 1 to 741)
  AUTHORS   Kong,K.H., Nishida,M., Inoue,H. and Takahashi,K.
  TITLE     Tyrosine-7 is an essential residue for the catalytic activity of
            human class PI glutathione S-transferase: chemical modification and
            site-directed mutagenesis studies
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1122-1129 (1992)
   PUBMED   1540159
REFERENCE   8  (bases 1 to 741)
  AUTHORS   Bora,P.S., Bora,N.S., Wu,X.L. and Lange,L.G.
  TITLE     Molecular cloning, sequencing, and expression of human myocardial
            fatty acid ethyl ester synthase-III cDNA
  JOURNAL   J Biol Chem 266 (25), 16774-16777 (1991)
   PUBMED   1885604
REFERENCE   9  (bases 1 to 741)
  AUTHORS   Yamamuro,W., Saiki,H. and Sugimoto,M.
  TITLE     [Distribution of glutathione S-transferase isozymes in rat small
            intestinal mucosa]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 88 (5), 1184-1190 (1991)
   PUBMED   1880950
REFERENCE   10 (bases 1 to 741)
  AUTHORS   Hussey,A.J., Kerr,L.A., Cronshaw,A.D., Harrison,D.J. and Hayes,J.D.
  TITLE     Variation in the expression of Mu-class glutathione S-transferase
            isoenzymes from human skeletal muscle. Evidence for the existence
            of heterodimers
  JOURNAL   Biochem J 273(Pt 2) (Pt 2), 323-332 (1991)
   PUBMED   1991033
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010915.1 and X15480.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000852.3.
            
            Summary: Glutathione S-transferases (GSTs) are a family of enzymes
            that play an important role in detoxification by catalyzing the
            conjugation of many hydrophobic and electrophilic compounds with
            reduced glutathione. Based on their biochemical, immunologic, and
            structural properties, the soluble GSTs are categorized into 4 main
            classes: alpha, mu, pi, and theta. This GST family member is a
            polymorphic gene encoding active, functionally different GSTP1
            variant proteins that are thought to function in xenobiotic
            metabolism and play a role in susceptibility to cancer, and other
            diseases. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI598748.1, BM551510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398606.10/ ENSP00000381607.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               BC010915.1         5-348
            345-739             X15480.1           330-724
            740-741             BC010915.1         744-745
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..741
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /note="glutathione S-transferase pi 1"
                     /db_xref="GeneID:2950"
                     /db_xref="HGNC:HGNC:4638"
                     /db_xref="MIM:134660"
     exon            1..33
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..665
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /EC_number="2.5.1.18"
                     /note="fatty acid ethyl ester synthase III; deafness,
                     X-linked 7; GSTP1-1; GST class-pi; epididymis secretory
                     protein Li 22"
                     /codon_start=1
                     /product="glutathione S-transferase P"
                     /protein_id="NP_000843.1"
                     /db_xref="CCDS:CCDS41679.1"
                     /db_xref="GeneID:2950"
                     /db_xref="HGNC:HGNC:4638"
                     /db_xref="MIM:134660"
                     /translation="MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSL
                     KASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRC
                     KYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLL
                     LIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ"
     exon            34..69
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     exon            70..176
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     exon            177..264
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     exon            265..368
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     exon            369..476
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     exon            477..741
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      720..725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /note="hexamer: AATAAA"
     polyA_site      741
                     /gene="GSTP1"
                     /gene_synonym="DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI"
                     /note="major polyA site"
ORIGIN      
        1 gctggagttt cgccgccgca gtcttcgcca ccatgccgcc ctacaccgtg gtctatttcc
       61 cagttcgagg ccgctgcgcg gccctgcgca tgctgctggc agatcagggc cagagctgga
      121 aggaggaggt ggtgaccgtg gagacgtggc aggagggctc actcaaagcc tcctgcctat
      181 acgggcagct ccccaagttc caggacggag acctcaccct gtaccagtcc aataccatcc
      241 tgcgtcacct gggccgcacc cttgggctct atgggaagga ccagcaggag gcagccctgg
      301 tggacatggt gaatgacggc gtggaggacc tccgctgcaa atacatctcc ctcatctaca
      361 ccaactatga ggcgggcaag gatgactatg tgaaggcact gcccgggcaa ctgaagcctt
      421 ttgagaccct gctgtcccag aaccagggag gcaagacctt cattgtggga gaccagatct
      481 ccttcgctga ctacaacctg ctggacttgc tgctgatcca tgaggtccta gcccctggct
      541 gcctggatgc gttccccctg ctctcagcat atgtggggcg cctcagtgcc cggcccaagc
      601 tcaaggcctt cctggcctcc cctgagtacg tgaacctccc catcaatggc aacgggaaac
      661 agtgagggtt ggggggactc tgagcgggag gcagagtttg ccttcctttc tccaggacca
      721 ataaaatttc taagagagct a
//
