LOCUS       NM_004832                813 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens glutathione S-transferase omega 1 (GSTO1), transcript
            variant 1, mRNA.
ACCESSION   NM_004832
VERSION     NM_004832.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 813)
  AUTHORS   Pan,Y.C., Chu,P.Y., Lin,C.C., Hsieh,C.Y., Hsu,W.Y., Shyur,L.F.,
            Yang,J.C., Chang,W.C. and Wu,Y.C.
  TITLE     Glutathione S-transferase omega class 1 (GSTO1)-associated large
            extracellular vesicles are involved in tumor-associated
            macrophage-mediated cisplatin resistance in bladder cancer
  JOURNAL   Mol Oncol 18 (8), 1866-1884 (2024)
   PUBMED   38750006
  REMARK    GeneRIF: Glutathione S-transferase omega class 1 (GSTO1)-associated
            large extracellular vesicles are involved in tumor-associated
            macrophage-mediated cisplatin resistance in bladder cancer.
REFERENCE   2  (bases 1 to 813)
  AUTHORS   Paul,S., Bhardwaj,M. and Kang,S.C.
  TITLE     GSTO1 confers drug resistance in HCT-116 colon cancer cells through
            an interaction with TNFalphaIP3/A20
  JOURNAL   Int J Oncol 61 (5) (2022)
   PUBMED   36129143
  REMARK    GeneRIF: GSTO1 confers drug resistance in HCT116 colon cancer cells
            through an interaction with TNFalphaIP3/A20.
REFERENCE   3  (bases 1 to 813)
  AUTHORS   Sun,D., Lin,R. and Ouyang,Y.
  TITLE     The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in
            the Pathogenesis of Chronic Obstructive Pulmonary Disease
  JOURNAL   Can Respir J 2022, 6810745 (2022)
   PUBMED   36051533
  REMARK    GeneRIF: The Role of CD40, CD86, and Glutathione S-Transferase
            Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary
            Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 813)
  AUTHORS   Oakley,A.J.
  TITLE     Proposed mechanism for monomethylarsonate reductase activity of
            human omega-class glutathione transferase GSTO1-1
  JOURNAL   Biochem Biophys Res Commun 590, 7-13 (2022)
   PUBMED   34959192
  REMARK    GeneRIF: Proposed mechanism for monomethylarsonate reductase
            activity of human omega-class glutathione transferase GSTO1-1.
REFERENCE   5  (bases 1 to 813)
  AUTHORS   Sobot,V., Stamenkovic,M., Simic,T., Jerotic,D., Djokic,M.,
            Jaksic,V., Bozic,M., Milic,J., Savic-Radojevic,A. and Djukic,T.
  TITLE     Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with
            primary open angle glaucoma
  JOURNAL   Exp Eye Res 214, 108863 (2022)
   PUBMED   34826418
  REMARK    GeneRIF: Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2
            polymorphism with primary open angle glaucoma.
REFERENCE   6  (bases 1 to 813)
  AUTHORS   Dulhunty,A., Gage,P., Curtis,S., Chelvanayagam,G. and Board,P.
  TITLE     The glutathione transferase structural family includes a nuclear
            chloride channel and a ryanodine receptor calcium release channel
            modulator
  JOURNAL   J Biol Chem 276 (5), 3319-3323 (2001)
   PUBMED   11035031
REFERENCE   7  (bases 1 to 813)
  AUTHORS   Board,P.G., Coggan,M., Chelvanayagam,G., Easteal,S., Jermiin,L.S.,
            Schulte,G.K., Danley,D.E., Hoth,L.R., Griffor,M.C., Kamath,A.V.,
            Rosner,M.H., Chrunyk,B.A., Perregaux,D.E., Gabel,C.A.,
            Geoghegan,K.F. and Pandit,J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J Biol Chem 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   8  (bases 1 to 813)
  AUTHORS   Kodym,R., Calkins,P. and Story,M.
  TITLE     The cloning and characterization of a new stress response protein.
            A mammalian member of a family of theta class glutathione
            s-transferase-like proteins
  JOURNAL   J Biol Chem 274 (8), 5131-5137 (1999)
   PUBMED   9988762
REFERENCE   9  (bases 1 to 813)
  AUTHORS   Ishikawa,T., Casini,A.F. and Nishikimi,M.
  TITLE     Molecular cloning and functional expression of rat liver
            glutathione-dependent dehydroascorbate reductase
  JOURNAL   J Biol Chem 273 (44), 28708-28712 (1998)
   PUBMED   9786866
REFERENCE   10 (bases 1 to 813)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537431.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004832.2.
            
            Summary: The protein encoded by this gene is an omega class
            glutathione S-transferase (GST) with glutathione-dependent thiol
            transferase and dehydroascorbate reductase activities. GSTs are
            involved in the metabolism of xenobiotics and carcinogens. The
            encoded protein acts as a homodimer and is found in the cytoplasm.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.190562.1,
                                           SRR1163658.459091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369713.10/ ENSP00000358727.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               BX537431.1         111-923
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.1"
     gene            1..813
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /note="glutathione S-transferase omega 1"
                     /db_xref="GeneID:9446"
                     /db_xref="HGNC:HGNC:13312"
                     /db_xref="MIM:605482"
     exon            1..71
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..763
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /EC_number="2.5.1.18"
                     /EC_number="1.8.5.1"
                     /EC_number="1.20.4.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione-S-transferase like; glutathione S-transferase
                     omega 1-1; MMA(V) reductase; monomethylarsonic acid
                     reductase; S-(Phenacyl)glutathione reductase;
                     glutathione-dependent dehydroascorbate reductase;
                     epididymis secretory protein Li 21"
                     /codon_start=1
                     /product="glutathione S-transferase omega-1 isoform 1"
                     /protein_id="NP_004823.1"
                     /db_xref="CCDS:CCDS7555.1"
                     /db_xref="GeneID:9446"
                     /db_xref="HGNC:HGNC:13312"
                     /db_xref="MIM:605482"
                     /translation="MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKA
                     KGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKL
                     LPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNK
                     KTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTS
                     EKDWQGFLELYLQNSPEACDYGL"
     exon            72..180
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            181..403
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            404..502
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            503..609
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     exon            610..813
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      781..786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /note="hexamer: AATAAA"
     polyA_site      813
                     /gene="GSTO1"
                     /gene_synonym="GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R"
                     /note="major polyA site"
ORIGIN      
        1 gcaaacccca gaggagctcg gcctgcgctg cgccacgatg tccggggagt cagccaggag
       61 cttggggaag ggaagcgcgc ccccggggcc ggtcccggag ggctcgatcc gcatctacag
      121 catgaggttc tgcccgtttg ctgagaggac gcgtctagtc ctgaaggcca agggaatcag
      181 gcatgaagtc atcaatatca acctgaaaaa taagcctgag tggttcttta agaaaaatcc
      241 ctttggtctg gtgccagttc tggaaaacag tcagggtcag ctgatctacg agtctgccat
      301 cacctgtgag tacctggatg aagcataccc agggaagaag ctgttgccgg atgaccccta
      361 tgagaaagct tgccagaaga tgatcttaga gttgttttct aaggtgccat ccttggtagg
      421 aagctttatt agaagccaaa ataaagaaga ctatgctggc ctaaaagaag aatttcgtaa
      481 agaatttacc aagctagagg aggttctgac taataagaag acgaccttct ttggtggcaa
      541 ttctatctct atgattgatt acctcatctg gccctggttt gaacggctgg aagcaatgaa
      601 gttaaatgag tgtgtagacc acactccaaa actgaaactg tggatggcag ccatgaagga
      661 agatcccaca gtctcagccc tgcttactag tgagaaagac tggcaaggtt tcctagagct
      721 ctacttacag aacagccctg aggcctgtga ctatgggctc tgaagggggc aggagtcagc
      781 aataaagcta tgtctgatat tttccttcac taa
//
