LOCUS       NM_000851               1561 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glutathione S-transferase mu 5 (GSTM5), mRNA.
ACCESSION   NM_000851
VERSION     NM_000851.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Hao,X., Zhang,J., Chen,G., Cao,W., Chen,H. and Chen,S.
  TITLE     Aberrant expression of GSTM5 in lung adenocarcinoma is associated
            with DNA hypermethylation and poor prognosis
  JOURNAL   BMC Cancer 22 (1), 685 (2022)
   PUBMED   35729618
  REMARK    GeneRIF: Aberrant expression of GSTM5 in lung adenocarcinoma is
            associated with DNA hypermethylation and poor prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   Jou,Y.C., Wang,S.C., Dia,Y.C., Wang,S.T., Yu,M.H., Yang,H.Y.,
            Chen,L.C., Shen,C.H. and Liu,Y.W.
  TITLE     Anti-Cancer Effects and Tumor Marker Role of Glutathione
            S-Transferase Mu 5 in Human Bladder Cancer
  JOURNAL   Int J Mol Sci 22 (6), 3056 (2021)
   PUBMED   33802702
  REMARK    GeneRIF: Anti-Cancer Effects and Tumor Marker Role of Glutathione
            S-Transferase Mu 5 in Human Bladder Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1561)
  AUTHORS   Patskovsky,Y.V., Patskovska,L.N. and Listowsky,I.
  TITLE     An asparagine-phenylalanine substitution accounts for catalytic
            differences between hGSTM3-3 and other human class mu glutathione
            S-transferases
  JOURNAL   Biochemistry 38 (49), 16187-16194 (1999)
   PUBMED   10587441
REFERENCE   7  (bases 1 to 1561)
  AUTHORS   Xu,S., Wang,Y., Roe,B. and Pearson,W.R.
  TITLE     Characterization of the human class Mu glutathione S-transferase
            gene cluster and the GSTM1 deletion
  JOURNAL   J Biol Chem 273 (6), 3517-3527 (1998)
   PUBMED   9452477
REFERENCE   8  (bases 1 to 1561)
  AUTHORS   Rowe,J.D., Nieves,E. and Listowsky,I.
  TITLE     Subunit diversity and tissue distribution of human glutathione
            S-transferases: interpretations based on electrospray ionization-MS
            and peptide sequence-specific antisera
  JOURNAL   Biochem J 325 (Pt 2) (Pt 2), 481-486 (1997)
   PUBMED   9230131
REFERENCE   9  (bases 1 to 1561)
  AUTHORS   Pearson,W.R., Vorachek,W.R., Xu,S.J., Berger,R., Hart,I.,
            Vannais,D. and Patterson,D.
  TITLE     Identification of class-mu glutathione transferase genes
            GSTM1-GSTM5 on human chromosome 1p13
  JOURNAL   Am J Hum Genet 53 (1), 220-233 (1993)
   PUBMED   8317488
REFERENCE   10 (bases 1 to 1561)
  AUTHORS   Takahashi,Y., Campbell,E.A., Hirata,Y., Takayama,T. and
            Listowsky,I.
  TITLE     A basis for differentiating among the multiple human Mu-glutathione
            S-transferases and molecular cloning of brain GSTM5
  JOURNAL   J Biol Chem 268 (12), 8893-8898 (1993)
   PUBMED   8473333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB089682.1, BC058881.1,
            AC000032.7 and BX281326.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000851.3.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Diversification
            of these genes has occurred in regions encoding substrate-binding
            domains, as well as in tissue expression patterns, to accommodate
            an increasing number of foreign compounds. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.68655.1,
                                           SRR3476690.576038.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256593.8/ ENSP00000256593.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB089682.1         10-23
            15-260              BC058881.1         1-246
            261-261             AC000032.7         477-477             c
            262-1531            BC058881.1         248-1517
            1532-1561           BX281326.1         316-345
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1561
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /note="glutathione S-transferase mu 5"
                     /db_xref="GeneID:2949"
                     /db_xref="HGNC:HGNC:4637"
                     /db_xref="MIM:138385"
     exon            1..98
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..719
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase M5; glutathione
                     S-alkyltransferase M5; glutathione S-aryltransferase M5;
                     S-(hydroxyalkyl)glutathione lyase M5; glutathione
                     S-aralkyltransferase M5; GST class-mu 5; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 5"
                     /protein_id="NP_000842.2"
                     /db_xref="CCDS:CCDS811.1"
                     /db_xref="GeneID:2949"
                     /db_xref="HGNC:HGNC:4637"
                     /db_xref="MIM:138385"
                     /translation="MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILEN
                     QVMDNHMELVRLCYDPDFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLA
                     YDVLDMKRIFEPKCLDAFLNLKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK
                     "
     exon            99..174
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            175..239
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            240..321
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            322..422
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            423..518
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..629
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1561
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1114..1119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /note="hexamer: AGTAAA"
     polyA_site      1133
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /note="major polyA site"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
                     /note="hexamer: AATAAA"
     polyA_site      1561
                     /gene="GSTM5"
                     /gene_synonym="GSTM5-5; GTM5"
ORIGIN      
        1 ctctcaaagt ctgagccccg ctccgctgat gcctgtctgc agaatccgca ccaaccagca
       61 ccatgcccat gactctgggg tactgggaca tccgtgggct ggcccacgcc atccgcttgc
      121 tcctggaata cacagactca agctatgtgg aaaagaagta cacgctgggg gacgctcctg
      181 actatgacag aagccagtgg ctgaatgaaa aattcaagct gggcctggac tttcccaatc
      241 tgccctactt gattgatggg gctcacaaga tcacccagag caatgccatc ctgcgctaca
      301 ttgcccgcaa gcacaacctg tgtggggaga cagaagagga gaagattcgt gtggacattt
      361 tggagaacca ggttatggat aaccacatgg agctggtcag actgtgctat gacccagatt
      421 ttgagaaact gaagccaaaa tacttggagg aactccctga aaagctaaag ctctactcag
      481 agtttctggg gaagcggcca tggtttgcag gagacaagat cacctttgtg gatttccttg
      541 cctatgatgt ccttgacatg aagcgtatat ttgagcccaa gtgcttggac gccttcctaa
      601 acttgaagga cttcatctcc cgctttgagg gtttgaagaa gatctctgcc tacatgaagt
      661 ccagccaatt cctccgaggt cttttgtttg gaaagtcagc tacatggaac agcaaatagg
      721 gcccagtgat gccagaagat gggagggagg agccaacctt gctgcctgcg accctggagg
      781 acagcctgac tccctggacc tgccttcttc ctttttcctt ctttctactc tcttctcttc
      841 cccaaggcct cattggcttc ctttcttcta acatcatccc tccccgcatc gaggctcttt
      901 aaagcttcag ctccccactg tcctccatca aagtccccct cctaacgtct tcctttccct
      961 gcactaacgc caacctgact gcttttcctg tcagtgcttt tctcttcttt gagaagccag
     1021 actgatctct gagctcccta gcactgtcct caaagaccat ctgtatgccc tgctcccttt
     1081 gctgggtccc taccccagct ccgtgtgatg cccagtaaag cctgaaccat gcctgccatg
     1141 tcttgtctta ttccctgagg ctcccttgac tcaggactgt gctcgaattg tgggtggttt
     1201 tttgtcttct gttgtccaca gccagagctt agtggatggg tgtgtgtgtg tgtgtgttgg
     1261 gggtggtgat caggcaggtt cataaatttc cttggtcatt tctgccctct agccacatcc
     1321 ctctgttcct cactgtgggg attactacag aaaggtgctc tgtgccaagt tcctcactca
     1381 ttcgcgctcc tgtaggccgt ctagaactgg catggttcaa agaggggcta ggctgatggg
     1441 gaagggggct gagcagctcc caggcagact gccttctttc accctgtcct gatagacttc
     1501 cctgatctag atatccttcg tcatgacact tctcaataaa acgtatccca ccgtattgta
     1561 a
//
