LOCUS       NM_000850               1394 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glutathione S-transferase mu 4 (GSTM4), transcript
            variant 1, mRNA.
ACCESSION   NM_000850
VERSION     NM_000850.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Dalli,J., Vlasakov,I., Riley,I.R., Rodriguez,A.R., Spur,B.W.,
            Petasis,N.A., Chiang,N. and Serhan,C.N.
  TITLE     Maresin conjugates in tissue regeneration biosynthesis enzymes in
            human macrophages
  JOURNAL   Proc Natl Acad Sci U S A 113 (43), 12232-12237 (2016)
   PUBMED   27791009
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Comstock,K.E., Widersten,M., Hao,X.Y., Henner,W.D. and Mannervik,B.
  TITLE     A comparison of the enzymatic and physicochemical properties of
            human glutathione transferase M4-4 and three other human Mu class
            enzymes
  JOURNAL   Arch Biochem Biophys 311 (2), 487-495 (1994)
   PUBMED   8203914
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Ross,V.L., Board,P.G. and Webb,G.C.
  TITLE     Chromosomal mapping of the human Mu class glutathione
            S-transferases to 1p13
  JOURNAL   Genomics 18 (1), 87-91 (1993)
   PUBMED   8276420
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Bogaards,J.J., van Ommen,B. and van Bladeren,P.J.
  TITLE     Purification and characterization of eight glutathione
            S-transferase isoenzymes of hamster. Comparison of subunit
            composition of enzymes from liver, kidney, testis, pancreas and
            trachea
  JOURNAL   Biochem J 286 (Pt 2) (Pt 2), 383-388 (1992)
   PUBMED   1530570
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Taylor,J.B., Oliver,J., Sherrington,R. and Pemble,S.E.
  TITLE     Structure of human glutathione S-transferase class Mu genes
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 587-593 (1991)
   PUBMED   2006920
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   Seidegard,J., Vorachek,W.R., Pero,R.W. and Pearson,W.R.
  TITLE     Hereditary differences in the expression of the human glutathione
            transferase active on trans-stilbene oxide are due to a gene
            deletion
  JOURNAL   Proc Natl Acad Sci U S A 85 (19), 7293-7297 (1988)
   PUBMED   3174634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA895954.1, BC108729.1 and
            AC000031.6.
            
            On Nov 22, 2018 this sequence version replaced NM_000850.4.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Diversification
            of these genes has occurred in regions encoding substrate-binding
            domains, as well as in tissue expression patterns, to accommodate
            an increasing number of foreign compounds. Multiple transcript
            variants, each encoding a distinct protein isoform, have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.436427.1, HM005683.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369836.9/ ENSP00000358851.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DA895954.1         24-55
            33-195              BC108729.1         13-175
            196-196             AC000031.6         32273-32273         c
            197-824             BC108729.1         177-804
            825-825             AC000031.6         29490-29490         c
            826-1394            BC108729.1         806-1374
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1394
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /note="glutathione S-transferase mu 4"
                     /db_xref="GeneID:2948"
                     /db_xref="HGNC:HGNC:4636"
                     /db_xref="MIM:138333"
     exon            1..327
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..948
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /EC_number="2.5.1.18"
                     /EC_number="4.4.1.20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-alkyltransferase M4; leukotriene C4 synthase
                     GSTM4; glutathione S-transferase M4; glutathione
                     S-aryltransferase M4; S-(hydroxyalkyl)glutathione lyase
                     M4; glutathione S-aralkyltransferase M4; GTS-Mu2; GST
                     class-mu 4; GST-Mu2; testis tissue sperm-binding protein
                     Li 60n"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 4 isoform 1"
                     /protein_id="NP_000841.1"
                     /db_xref="CCDS:CCDS807.1"
                     /db_xref="GeneID:2948"
                     /db_xref="HGNC:HGNC:4636"
                     /db_xref="MIM:138333"
                     /translation="MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QAMDVSNQLARVCYSPDFEKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLA
                     YDVLDLHRIFEPNCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
                     "
     exon            328..403
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            404..468
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..550
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            551..651
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            652..747
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..858
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1394
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1377..1382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="GSTM4"
                     /gene_synonym="GSTM4-4; GTM4"
                     /note="major polyA site"
ORIGIN      
        1 ctagtgcttc cggaccttgc tccctgaaca ctcggaggtg gcggtggatc ttactccttc
       61 cagccagtga ggatccagca acctgctccg tgcctcccgc gcctgttggt tggaagtgac
      121 gaccttgaag atcggccggt tggaagtgac gaccttgaag atcggcgggc gcagcggggc
      181 cgagggggcg ggtctggcgc taggtccagc ccctgcgtgc cgggaacccc agaggaggtc
      241 gcagttcagc ccagctgagg cctgtctgca gaatcgacac caaccagcat catgtccatg
      301 acactggggt actgggacat ccgcgggctg gcccacgcca tccgcctgct cctggaatac
      361 acagactcaa gctacgagga aaagaagtat acgatggggg acgctcctga ctatgacaga
      421 agccagtggc tgaatgaaaa attcaagctg ggcctggact ttcccaatct gccctacttg
      481 attgatgggg ctcacaagat cacccagagc aacgccatcc tgtgctacat tgcccgcaag
      541 cacaacctgt gtggggagac agaagaggag aagattcgtg tggacatttt ggagaaccag
      601 gctatggacg tctccaatca gctggccaga gtctgctaca gccctgactt tgagaaactg
      661 aagccagaat acttggagga acttcctaca atgatgcagc acttctcaca gttcctgggg
      721 aagaggccat ggtttgttgg agacaagatc acctttgtag atttcctcgc ctatgatgtc
      781 cttgacctcc accgtatatt tgagcccaac tgcttggacg cctttccaaa tctgaaggac
      841 ttcatctccc gctttgaggg cttggagaag atctctgcct acatgaagtc cagccgcttc
      901 ctcccaaaac ctctgtacac aagggtggct gtctggggca acaagtaatg ccttgaaggc
      961 caggaggtgg gagtgaggag cccatactca gcctgctgcc caggctgtgc agcgcagctg
     1021 gactctgcat cccagcacct gcctcctcgt tcctttctcc tgtttattcc catctttacc
     1081 cccaagactt tattgggcct cttcacttcc cctaaacccc tgtcccatgc aggccctttg
     1141 aagcctcagc tacccacttt ccttcatgaa catccccctc ccaacactac ccttccctgc
     1201 actaaagcca gcctgacctt ccttcctgtt agtggttgta tctgctttga agggcctacc
     1261 tggcccctcg cctgtggagc tcagccctga gctgtccccg tgttgcatga cagcattgac
     1321 tggtttacag gccctgctcc tgcagcatgg cccctgcctt aggcctacct gatcaaaata
     1381 aagcctcagc caca
//
