LOCUS       NM_000849               4122 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glutathione S-transferase mu 3 (GSTM3), transcript
            variant 1, mRNA.
ACCESSION   NM_000849
VERSION     NM_000849.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Chen,Y., Feng,Y., Lin,Y., Zhou,X., Wang,L., Zhou,Y., Lin,K. and
            Cai,L.
  TITLE     GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by
            promoting radiation-induced ferroptosis through USP14/FASN axis and
            GPX4
  JOURNAL   Br J Cancer 130 (5), 755-768 (2024)
   PUBMED   38228715
  REMARK    GeneRIF: GSTM3 enhances radiosensitivity of nasopharyngeal
            carcinoma by promoting radiation-induced ferroptosis through
            USP14/FASN axis and GPX4.
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Cheng,S.Y., Chen,N.F., Wen,Z.H., Yao,Z.K., Tsui,K.H., Kuo,H.M. and
            Chen,W.F.
  TITLE     Glutathione S-Transferase M3 Is Associated with Glycolysis in
            Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells
  JOURNAL   Int J Mol Sci 22 (13), 7080 (2021)
   PUBMED   34209254
  REMARK    GeneRIF: Glutathione S-Transferase M3 Is Associated with Glycolysis
            in Intrinsic Temozolomide-Resistant Glioblastoma Multiforme Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4122)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4122)
  AUTHORS   Gibbard,E., Cochrane,D.R., Pors,J., Negri,G.L., Colborne,S.,
            Cheng,A.S., Chow,C., Farnell,D., Tessier-Cloutier,B.,
            McAlpine,J.N., Morin,G.B., Schmidt,D., Kommoss,S., Kommoss,F.,
            Keul,J., Gilks,B., Huntsman,D.G. and Hoang,L.
  TITLE     Whole-proteome analysis of mesonephric-derived cancers describes
            new potential biomarkers
  JOURNAL   Hum Pathol 108, 1-11 (2021)
   PUBMED   33121982
  REMARK    GeneRIF: Whole-proteome analysis of mesonephric-derived cancers
            describes new potential biomarkers.
REFERENCE   5  (bases 1 to 4122)
  AUTHORS   Yang,F., Wen,J., Luo,K. and Fu,J.
  TITLE     Low GSTM3 expression is associated with poor disease-free survival
            in resected esophageal squamous cell carcinoma
  JOURNAL   Diagn Pathol 16 (1), 10 (2021)
   PUBMED   33482859
  REMARK    GeneRIF: Low GSTM3 expression is associated with poor disease-free
            survival in resected esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4122)
  AUTHORS   Anttila,S., Hirvonen,A., Vainio,H., Husgafvel-Pursiainen,K.,
            Hayes,J.D. and Ketterer,B.
  TITLE     Immunohistochemical localization of glutathione S-transferases in
            human lung
  JOURNAL   Cancer Res 53 (23), 5643-5648 (1993)
   PUBMED   8242618
REFERENCE   7  (bases 1 to 4122)
  AUTHORS   Hussey,A.J. and Hayes,J.D.
  TITLE     Human Mu-class glutathione S-transferases present in liver,
            skeletal muscle and testicular tissue
  JOURNAL   Biochim Biophys Acta 1203 (1), 131-141 (1993)
   PUBMED   8218382
REFERENCE   8  (bases 1 to 4122)
  AUTHORS   Ross,V.L. and Board,P.G.
  TITLE     Molecular cloning and heterologous expression of an alternatively
            spliced human Mu class glutathione S-transferase transcript
  JOURNAL   Biochem J 294 (Pt 2) (Pt 2), 373-380 (1993)
   PUBMED   8373352
REFERENCE   9  (bases 1 to 4122)
  AUTHORS   Bogaards,J.J., van Ommen,B. and van Bladeren,P.J.
  TITLE     Purification and characterization of eight glutathione
            S-transferase isoenzymes of hamster. Comparison of subunit
            composition of enzymes from liver, kidney, testis, pancreas and
            trachea
  JOURNAL   Biochem J 286 (Pt 2) (Pt 2), 383-388 (1992)
   PUBMED   1530570
REFERENCE   10 (bases 1 to 4122)
  AUTHORS   Campbell,E., Takahashi,Y., Abramovitz,M., Peretz,M. and
            Listowsky,I.
  TITLE     A distinct human testis and brain mu-class glutathione
            S-transferase. Molecular cloning and characterization of a form
            present even in individuals lacking hepatic type mu isoenzymes
  JOURNAL   J Biol Chem 265 (16), 9188-9193 (1990)
   PUBMED   2345169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008790.2, AL158847.22 and
            BC030253.1.
            
            On May 17, 2019 this sequence version replaced NM_000849.4.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Mutations of
            this class mu gene have been linked with a slight increase in a
            number of cancers, likely due to exposure with environmental
            toxins. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008790.2, SRR1660809.80016.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361066.7/ ENSP00000354357.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               BC008790.2         1-247
            248-248             AL158847.22        28365-28365         c
            249-979             BC008790.2         249-979
            980-3820            AL158847.22        22254-25094         c
            3821-4122           BC030253.1         671-972
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4122
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /note="glutathione S-transferase mu 3"
                     /db_xref="GeneID:2947"
                     /db_xref="HGNC:HGNC:4635"
                     /db_xref="MIM:138390"
     exon            1..86
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            87..358
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..988
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /EC_number="2.5.1.18"
                     /note="glutathione S-transferase M3 (brain); glutathione
                     S-transferase, Mu-3; brain GST; glutathione
                     S-alkyltransferase M3; glutathione S-aryltransferase M3;
                     S-(hydroxyalkyl)glutathione lyase M3; glutathione
                     S-aralkyltransferase M3; GST class-mu 3; glutathione
                     S-transferase mu 3 (brain); brain type mu-glutathione
                     S-transferase; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 3"
                     /protein_id="NP_000840.2"
                     /db_xref="CCDS:CCDS812.1"
                     /db_xref="GeneID:2947"
                     /db_xref="HGNC:HGNC:4635"
                     /db_xref="MIM:138390"
                     /translation="MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPD
                     YDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVD
                     IIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFV
                     DFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQ
                     WGNKPVC"
     exon            359..434
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..499
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..581
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..682
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..778
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..889
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..4122
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1065..1070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /note="hexamer: AATGAA"
     polyA_site      1084
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /note="major polyA site"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /note="hexamer: ATTAAA"
     polyA_site      1557
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="GSTM3"
                     /gene_synonym="GST5; GSTB; GSTM3-3; GSTM3TV2; GTM3;
                     hGSTM3-3"
ORIGIN      
        1 ggttggttct gagaaggctt caaggaatag gcagacattt cagcaaggct gctgaggaag
       61 gataggctgt ggaaattagg atgcagcact cctgcccggg tcccgcctcg gggtcgccag
      121 gccctgaacc ccaacgccgg cattagtcgc gcctgcgcac ggccctgtgg agccgcggag
      181 gcaagggacg gagaacgggg cggaggcgga gtcagggcgc ccgcgcgtgg gccccgcccc
      241 cttatgtcgg gtataaagcc cctcccgctc acagtttccc tagtcctcga aggctcggaa
      301 gcccgtcacc atgtcgtgcg agtcgtctat ggttctcggg tactgggata ttcgtgggct
      361 ggcgcacgcc atccgcctgc tcctggagtt cacggatacc tcttatgagg agaaacggta
      421 cacgtgcggg gaagctcctg actatgatcg aagccaatgg ctggatgtga aattcaagct
      481 agacctggac tttcctaatc tgccctacct cctggatggg aagaacaaga tcacccagag
      541 caatgccatc ttgcgctaca tcgctcgcaa gcacaacatg tgtggtgaga ctgaagaaga
      601 aaagattcga gtggacatca tagagaacca agtaatggat ttccgcacac aactgataag
      661 gctctgttac agctctgacc acgaaaaact gaagcctcag tacttggaag agctacctgg
      721 acaactgaaa caattctcca tgtttctggg gaaattctca tggtttgccg gggaaaagct
      781 cacctttgtg gattttctca cctatgatat cttggatcag aaccgtatat ttgaccccaa
      841 gtgcctggat gagttcccaa acctgaaggc tttcatgtgc cgttttgagg ctttggagaa
      901 aatcgctgcc tacttacagt ctgatcagtt ctgcaagatg cccatcaaca acaagatggc
      961 ccagtggggc aacaagcctg tatgctgagc aggaggcaga cttgcagagc ttgttttgtt
     1021 tcatcctgtc cgtaaggggt cagcgctctt gctttgctct tttcaatgaa tagcacttat
     1081 gttactggtg tccagctgag tttctcttgg gtataaaggc taaaagggaa aaaggatatg
     1141 tggagaatca tcaagatatg aattgaatcg ctgcgatact ggcatttccc tactccccaa
     1201 ctgagttcaa gggctgtagg ttcatgccca agccctgaga gtgggtacta gaaaaaacga
     1261 gattgcacag ttggagagag caggtgtgtt aaatgggact ggagtccctg tgaagactgg
     1321 gtgaggataa cacaagtaaa actgtggtac tgatggactt aaccggagtt cggaaaccgt
     1381 cctgtgtaca catgggagtt tagtgtgata aaggcagtat ttcagactgg tgggctagcc
     1441 aatagagttg ggacaattgc ttactcatta aaaataatag agccccactt gacactattc
     1501 actaaaatta atctggaatt taaggcccaa cattaaacac aaagctgttg aaatattgat
     1561 gaaaatgtaa gaatttttgt gaccacgggg taggagaagt ttctttaaag acgtaaaaag
     1621 aaaaaaacca taggctgctc tgcctgtgga gtagccattc tttattcttt tactttttaa
     1681 aataataaca atcacaaagg aaagatttgc caattgaata ggatcaaatt ctacaacttt
     1741 tcctaaggca cccacaaata aatgacaagt gagacaaaaa gcactagtat aaagattata
     1801 taaagaccta taaatcatta agacaactga gtttttaaaa atggacaaaa tccatgaaca
     1861 atttataaaa tagaaatata gccaaaaatg tctaaaagat gtttatgatg taaggaatta
     1921 tcaattacaa cagtgagaaa ccatatttcc ttctatccga tgagtaaaaa gtttctaaag
     1981 tgttggcaag gcttaggaaa gtgatatgca tttcctgctg gtcaagttgt aaattagtat
     2041 agctactttg gaggacaatt gtaaaattta aatcatatcc tatgacccag caattccatg
     2101 ctataaaaac tcatccatgg ccgggcttgg tggctcacgc ctgtaatccc agcactttgg
     2161 gaggctgagg tgggcagatc acgaggtcaa gagatcgaga ccatcctggc caacatgatg
     2221 aaaccccgtt tctactaaaa atacaaaaat tagctgggca tggtggcatg tgcctatagt
     2281 cccagctact caggaggctg aggcaggaga attgcttgaa cctgggaggc agaggttgca
     2341 gtgagccgag atcacgccac tgcactccag cctggctaca gggcgagact ctgtctcaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaacattc aaagagacat atactaagat gttcactgtg
     2461 gcattgtctg taatgacaaa taagtggaaa ccgtgtaaat acctgtcaat actatggagt
     2521 accatgtggc aacggaagaa tgagactgaa ctgtgtgaac taacatgcaa agatccccaa
     2581 aacaggccag gtgtggttgc tcacagctgt aataacaaca ccttcagagg ctgaggtgag
     2641 aggatcagtt gaggccagga gtttaagacc agcctgggca acatagtgag acccctgtct
     2701 cccaaaaatt ttttttaatt agctgtgcgc aattgctcat gcatagtccc agctacccag
     2761 gaggctgagg tgggaggatc acttgagccc aggaatttga agctgcagtg agctgtgttc
     2821 ttgccactgc actccaatct gggtgactga gcaagaccct gtctcttaaa aaaataaaaa
     2881 agatctccaa gcatagagaa gagtctggag ggaaacacca aactcataac agtcttactg
     2941 caggcaagtg ggataaaggc ccagactcca tggtggaagt taaagggcat ttccaagtta
     3001 aggctaagac ttgcttttct aactaagaga atgtgctcat gcattgcttg tgtagtagaa
     3061 actagttttt agaaaagaaa gcaaacttaa gaaacactga ctcctgtgga gatgacttgg
     3121 caccactctc ctttcacaga gcagagtctg aatagtcttc agagataggc ctgtgggcca
     3181 gattgccatc ccctatggac cagaagccaa ggatctctct agtgatggtc agagggccca
     3241 aatggcaggg atacccagtg atgtcaggag gaatagtaca gacagaaggt gctaagcaga
     3301 caattcaact gccatgtttt gccaccccct gtgagcaggg attaggtgtt caggccagta
     3361 tcttgggcat gggggagcct ttggccagaa gaggtataaa gctcagaagt ttttcagtct
     3421 gataactatt gatataattt ccatagtgtg agggagcggt atgctctacc cttgtgtatt
     3481 taaggcagga cagagaaatt gaggatgccc ctggggctag atcgatgata tgaccagaaa
     3541 tcaaaaaggg aatgcattat ttattgctgt gtaacactgt taagagagga ggtagttaag
     3601 ggatggatag gcacatagag agggaaggtc tcaggagaag ggatagaaag gaactatgtt
     3661 cacaagaaca acggcaagac agtgcctata ctgcctctac agttaatagg aaaaacggaa
     3721 gaagttaccc ttaagctagg atgttgctca gaagtgacca tcccaacttt ggtgcgggca
     3781 caataaatca gcctaaatgt ccctaattta acccagctca ttataatgtc attaaacatg
     3841 acattagcat tgtggtttta gcacccccat gggttttgct taggcactca tgggtaataa
     3901 ccaagatgga gtccctttgg caaaacttag gcatgcacag ctgtagtacc ccaagaagaa
     3961 aatgttactt ctctcatctg ggcaaaaccc acagaagact tcccagcttc tgccacataa
     4021 aagacacaga acacagacgc cttactggca acctgctttc aagacccctg tctttgctga
     4081 gagctttcct ttttcccaat aaattctact ctgccctact ca
//
