LOCUS       NM_000561               1164 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens glutathione S-transferase mu 1 (GSTM1), transcript
            variant 1, mRNA.
ACCESSION   NM_000561
VERSION     NM_000561.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Zhang,T., Zhang,S., Zhang,C., Liu,H., Liu,M., Zhang,G.H., Duan,G.,
            Chen,S. and Ren,J.
  TITLE     The moderation effect of GSTM1/GSTT1 gene polymorphisms on the
            association of sperm mitochondrial DNA copy number and sperm
            mobility
  JOURNAL   Sci Rep 14 (1), 24790 (2024)
   PUBMED   39433861
  REMARK    GeneRIF: The moderation effect of GSTM1/GSTT1 gene polymorphisms on
            the association of sperm mitochondrial DNA copy number and sperm
            mobility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Yang,F., Chen,F., Shay,C., Chen,G.Z., Saba,N.F. and Teng,Y.
  TITLE     Exploring the impact of GSTM1 as a novel molecular determinant of
            survival in head and neck cancer patients of African descent
  JOURNAL   J Exp Clin Cancer Res 43 (1), 203 (2024)
   PUBMED   39044272
  REMARK    GeneRIF: Exploring the impact of GSTM1 as a novel molecular
            determinant of survival in head and neck cancer patients of African
            descent.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Juras,A., Crkvenac Gornik,K., Held,M., Sestan,M., Turudic,D.,
            Sapina,M., Srsen,S., Huljev Frkovic,S., Frkovic,M., Gagro,A. and
            Jelusic,M.
  TITLE     Association of Glutathione Transferase M1, T1, P1 and A1 Gene
            Polymorphism and Susceptibility to IgA Vasculitis
  JOURNAL   Int J Mol Sci 25 (14), 7777 (2024)
   PUBMED   39063019
  REMARK    GeneRIF: Association of Glutathione Transferase M1, T1, P1 and A1
            Gene Polymorphism and Susceptibility to IgA Vasculitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Gudur,R.A., Bhosale,S.J., Gudur,A.K. and Datkhile,K.D.
  TITLE     Genetic Polymorphisms in Glutathione S-Transferase (GST) Gene and
            Their Correlation with Toxicity of Chemotherapy in Breast Cancer
            Patients
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2271-2282 (2024)
   PUBMED   39068558
  REMARK    GeneRIF: Genetic Polymorphisms in Glutathione S-Transferase (GST)
            Gene and Their Correlation with Toxicity of Chemotherapy in Breast
            Cancer Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Ji,F., Zhang,J., Ding,X., Rong,L., Liu,X., Yan,T. and Li,J.
  TITLE     Associations of GST Gene Polymorphisms and GST Enzyme Activity with
            the Development of Noise-Induced Hearing Loss in Chinese Han Males
  JOURNAL   Public Health Genomics 27 (1), 168-176 (2024)
   PUBMED   39476807
  REMARK    GeneRIF: Associations of GST Gene Polymorphisms and GST Enzyme
            Activity with the Development of Noise-Induced Hearing Loss in
            Chinese Han Males.
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Zhong,S., Wolf,C.R. and Spurr,N.K.
  TITLE     Chromosomal assignment and linkage analysis of the human
            glutathione S-transferase mu gene (GSTM1) using intron specific
            polymerase chain reaction
  JOURNAL   Hum Genet 90 (4), 435-439 (1992)
   PUBMED   1483702
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Singhal,S.S., Saxena,M., Awasthi,S., Ahmad,H., Sharma,R. and
            Awasthi,Y.C.
  TITLE     Gender related differences in the expression and characteristics of
            glutathione S-transferases of human colon
  JOURNAL   Biochim Biophys Acta 1171 (1), 19-26 (1992)
   PUBMED   1420361
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Bogaards,J.J., van Ommen,B. and van Bladeren,P.J.
  TITLE     Purification and characterization of eight glutathione
            S-transferase isoenzymes of hamster. Comparison of subunit
            composition of enzymes from liver, kidney, testis, pancreas and
            trachea
  JOURNAL   Biochem J 286 (Pt 2) (Pt 2), 383-388 (1992)
   PUBMED   1530570
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Strange,R.C., Fryer,A.A., Matharoo,B., Zhao,L., Broome,J.,
            Campbell,D.A., Jones,P., Pastor,I.C. and Singh,R.V.
  TITLE     The human glutathione S-transferases: comparison of isoenzyme
            expression in normal and astrocytoma brain
  JOURNAL   Biochim Biophys Acta 1139 (3), 222-228 (1992)
   PUBMED   1627661
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   Singhal,S.S., Ahmad,H., Sharma,R., Gupta,S., Haque,A.K. and
            Awasthi,Y.C.
  TITLE     Purification and characterization of human muscle glutathione
            S-transferases: evidence that glutathione S-transferase zeta
            corresponds to a locus distinct from GST1, GST2, and GST3
  JOURNAL   Arch Biochem Biophys 285 (1), 64-73 (1991)
   PUBMED   1846734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB459176.1, X08020.1 and
            BC036805.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000561.3.
            
            Summary: Cytosolic and membrane-bound forms of glutathione
            S-transferase are encoded by two distinct supergene families. At
            present, eight distinct classes of the soluble cytoplasmic
            mammalian glutathione S-transferases have been identified: alpha,
            kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
            glutathione S-transferase that belongs to the mu class. The mu
            class of enzymes functions in the detoxification of electrophilic
            compounds, including carcinogens, therapeutic drugs, environmental
            toxins and products of oxidative stress, by conjugation with
            glutathione. The genes encoding the mu class of enzymes are
            organized in a gene cluster on chromosome 1p13.3 and are known to
            be highly polymorphic. These genetic variations can change an
            individual's susceptibility to carcinogens and toxins as well as
            affect the toxicity and efficacy of certain drugs. Null mutations
            of this class mu gene have been linked with an increase in a number
            of cancers, likely due to an increased susceptibility to
            environmental toxins and carcinogens. Multiple protein isoforms are
            encoded by transcript variants of this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036805.1, X08020.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309851.10/ ENSP00000311469.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB459176.1         23-55
            34-726              X08020.1           1-693
            727-1164            BC036805.1         685-1122
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1164
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /note="glutathione S-transferase mu 1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:HGNC:4632"
                     /db_xref="MIM:138350"
     exon            1..93
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..714
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /EC_number="2.5.1.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutathione S-transferase M1; S-(hydroxyalkyl)glutathione
                     lyase; GST class-mu 1; glutathione S-alkyltransferase;
                     glutathione S-aryltransferase; glutathione
                     S-aralkyltransferase; HB subunit 4; GST HB subunit 4"
                     /codon_start=1
                     /product="glutathione S-transferase Mu 1 isoform 1"
                     /protein_id="NP_000552.2"
                     /db_xref="CCDS:CCDS809.1"
                     /db_xref="GeneID:2944"
                     /db_xref="HGNC:HGNC:4632"
                     /db_xref="MIM:138350"
                     /translation="MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRS
                     QWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILEN
                     QTMDNHMQLGMICYNPEFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLV
                     YDVLDLHRIFEPKCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
                     "
     exon            94..169
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..234
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..316
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..417
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..513
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..624
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1164
                     /gene="GSTM1"
                     /gene_synonym="GST1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4;
                     GTM1; H-B; MU; MU-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atactctgag ccctgctcgg tttaggcctg tctgcggaat ccgcaccaac cagcaccatg
       61 cccatgatac tggggtactg ggacatccgc gggctggccc acgccatccg cctgctcctg
      121 gaatacacag actcaagcta tgaggaaaag aagtacacga tgggggacgc tcctgattat
      181 gacagaagcc agtggctgaa tgaaaaattc aagctgggcc tggactttcc caatctgccc
      241 tacttgattg atggggctca caagatcacc cagagcaacg ccatcttgtg ctacattgcc
      301 cgcaagcaca acctgtgtgg ggagacagaa gaggagaaga ttcgtgtgga cattttggag
      361 aaccagacca tggacaacca tatgcagctg ggcatgatct gctacaatcc agaatttgag
      421 aaactgaagc caaagtactt ggaggaactc cctgaaaagc taaagctcta ctcagagttt
      481 ctggggaagc ggccatggtt tgcaggaaac aagatcactt ttgtagattt tctcgtctat
      541 gatgtccttg acctccaccg tatatttgag cccaagtgct tggacgcctt cccaaatctg
      601 aaggacttca tctcccgctt tgagggcttg gagaagatct ctgcctacat gaagtccagc
      661 cgcttcctcc caagacctgt gttctcaaag atggctgtct ggggcaacaa gtagggcctt
      721 gaaggccagg aggtgggagt gaggagccca tactcagcct gctgcccagg ctgtgcagcg
      781 cagctggact ctgcatccca gcacctgcct cctcgttcct ttctcctgtt tattcccatc
      841 tttactccca agacttcatt gtccctcttc actcccccta aacccctgtc ccatgcaggc
      901 cctttgaagc ctcagctacc cactatcctt cgtgaacatc ccctcccatc attacccttc
      961 cctgcactaa agccagcctg accttccttc ctgttagtgg ttgtgtctgc tttaaagggc
     1021 ctgcctggcc cctcgcctgt ggagctcagc cccgagctgt ccccgtgttg catgaaggag
     1081 cagcattgac tggtttacag gccctgctcc tgcagcatgg tccctgcctt aggcctacct
     1141 gatggaagta aagcctcaac caca
//
