LOCUS       NM_015917               1032 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens glutathione S-transferase kappa 1 (GSTK1), transcript
            variant 1, mRNA.
ACCESSION   NM_015917
VERSION     NM_015917.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Li,S., Wan,J., Peng,Z., Huang,Q. and He,B.
  TITLE     New insights of DsbA-L in the pathogenesis of metabolic diseases
  JOURNAL   Mol Cell Biochem 479 (12), 3293-3303 (2024)
   PUBMED   38430301
  REMARK    GeneRIF: New insights of DsbA-L in the pathogenesis of metabolic
            diseases.
            Review article
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Oniki,K.
  TITLE     [Multifaceted Clinical Research on Obesity-related Disease
            Prevention Focusing on the DsbA-L Gene]
  JOURNAL   Yakugaku Zasshi 142 (11), 1177-1183 (2022)
   PUBMED   36328447
  REMARK    GeneRIF: [Multifaceted Clinical Research on Obesity-related Disease
            Prevention Focusing on the DsbA-L Gene].
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Zhou,H. and Liu,F.
  TITLE     T cell metabolism in obesity and beyond: comments on 'DsbA-L
            deficiency in T cells promotes diet-induced thermogenesis through
            suppressing IFN-gamma production'
  JOURNAL   J Mol Cell Biol 13 (5), 389-391 (2021)
   PUBMED   33538302
  REMARK    GeneRIF: T cell metabolism in obesity and beyond: comments on
            'DsbA-L deficiency in T cells promotes diet-induced thermogenesis
            through suppressing IFN-gamma production'.
REFERENCE   5  (bases 1 to 1032)
  AUTHORS   Zhou,X., Li,J.Q., Wei,L.J., He,M.Z., Jia,J., Zhang,J.Y., Wang,S.S.
            and Feng,L.
  TITLE     Silencing of DsbA-L gene impairs the PPARgamma agonist function of
            improving insulin resistance in a high-glucose cell model
  JOURNAL   J Zhejiang Univ Sci B 21 (12), 990-998 (2020)
   PUBMED   33843164
  REMARK    GeneRIF: Silencing of DsbA-L gene impairs the PPARgamma agonist
            function of improving insulin resistance in a high-glucose cell
            model.
REFERENCE   6  (bases 1 to 1032)
  AUTHORS   Nebert,D.W. and Vasiliou,V.
  TITLE     Analysis of the glutathione S-transferase (GST) gene family
  JOURNAL   Hum Genomics 1 (6), 460-464 (2004)
   PUBMED   15607001
REFERENCE   7  (bases 1 to 1032)
  AUTHORS   Robinson,A., Huttley,G.A., Booth,H.S. and Board,P.G.
  TITLE     Modelling and bioinformatics studies of the human Kappa-class
            glutathione transferase predict a novel third glutathione
            transferase family with similarity to prokaryotic
            2-hydroxychromene-2-carboxylate isomerases
  JOURNAL   Biochem J 379 (Pt 3), 541-552 (2004)
   PUBMED   14709161
  REMARK    GeneRIF: structure and function characterization of a GST from
            human breast
REFERENCE   8  (bases 1 to 1032)
  AUTHORS   Morel,F., Rauch,C., Petit,E., Piton,A., Theret,N., Coles,B. and
            Guillouzo,A.
  TITLE     Gene and protein characterization of the human glutathione
            S-transferase kappa and evidence for a peroxisomal localization
  JOURNAL   J Biol Chem 279 (16), 16246-16253 (2004)
   PUBMED   14742434
  REMARK    GeneRIF: Gene and protein characterization; its subcellular
            localization in peroxisomes, suggesting a new function for this
            family of enzymes [glutathione S-transferase kappa (hGSTK1)]
            GeneRIF: Presence of hGSTK1 in both peroxisomes and mitochondria.
            The C-terminus of hGSTK1 is essential for localization of the
            protein to peroxisomes, and the C-terminal sequence Ala-Arg-Leu
            represents a peroxisome targeting signal 1 (PTS1).
REFERENCE   9  (bases 1 to 1032)
  AUTHORS   Jowsey,I.R., Thomson,R.E., Orton,T.C., Elcombe,C.R. and Hayes,J.D.
  TITLE     Biochemical and genetic characterization of a murine class Kappa
            glutathione S-transferase
  JOURNAL   Biochem J 373 (Pt 2), 559-569 (2003)
   PUBMED   12720545
REFERENCE   10 (bases 1 to 1032)
  AUTHORS   Pemble,S.E., Wardle,A.F. and Taylor,J.B.
  TITLE     Glutathione S-transferase class Kappa: characterization by the
            cloning of rat mitochondrial GST and identification of a human
            homologue
  JOURNAL   Biochem J 319 (Pt 3) (Pt 3), 749-754 (1996)
   PUBMED   8920976
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ436828.1 and AL136938.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015917.2.
            
            Summary: This gene encodes a member of the kappa class of the
            glutathione transferase superfamily of enzymes that function in
            cellular detoxification. The encoded protein is localized to the
            peroxisome and catalyzes the conjugation of glutathione to a wide
            range of hydrophobic substates facilitating the removal of these
            compounds from cells. Alternative splicing results in multiple
            transcript variants.[provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY520571.1, BC001231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000358406.10/
                                                  ENSP00000351181.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BQ436828.1         13-14
            3-1032              AL136938.1         1-1030
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1032
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /note="glutathione S-transferase kappa 1"
                     /db_xref="GeneID:373156"
                     /db_xref="HGNC:HGNC:16906"
                     /db_xref="MIM:602321"
     exon            1..145
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..754
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /EC_number="2.5.1.18"
                     /note="isoform a is encoded by transcript variant 1;
                     glutathione S-transferase subunit 13 homolog; GST
                     class-kappa; glutathione S-transferase k1"
                     /codon_start=1
                     /product="glutathione S-transferase kappa 1 isoform a"
                     /protein_id="NP_057001.1"
                     /db_xref="CCDS:CCDS5877.1"
                     /db_xref="GeneID:373156"
                     /db_xref="HGNC:HGNC:16906"
                     /db_xref="MIM:602321"
                     /translation="MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLI
                     TGIMKDSGNKPPGLLPRKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRF
                     LTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIA
                     TPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPI
                     PPAVNARL"
     exon            146..227
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..356
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..457
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..493
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..610
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..704
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1032
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /note="hexamer: AATAAA"
     polyA_site      1032
                     /gene="GSTK1"
                     /gene_synonym="GST; GST 13-13; GST13; GST13-13; GSTK1-1;
                     hGSTK1"
                     /note="major polyA site"
ORIGIN      
        1 agaagctggg cagcctctgc cgggttccgg gaaaaggagc tcctgctgcc actgctcttc
       61 cggagcctgc agcatggggc ccctgccgcg caccgtggag ctcttctatg acgtgctgtc
      121 cccctactcc tggctgggct tcgagatcct gtgccggtat cagaatatct ggaacatcaa
      181 cctgcagttg cggcccagcc tcataacagg gatcatgaaa gacagtggaa acaagcctcc
      241 aggtctgctt ccccgcaaag gactatacat ggcaaatgac ttaaagctcc tgagacacca
      301 tctccagatt cccatccact tccccaagga tttcttgtct gtgatgcttg aaaaaggaag
      361 tttgtctgcc atgcgtttcc tcaccgccgt gaacttggag catccagaga tgctggagaa
      421 agcgtcccgg gagctgtgga tgcgcgtctg gtcaaggaat gaagacatca ccgagccgca
      481 gagcatcctg gcggctgcag agaaggctgg tatgtctgca gaacaagccc agggacttct
      541 ggaaaagatc gcaacgccaa aggtgaagaa ccagctcaag gagaccactg aggcagcctg
      601 cagatacgga gcctttgggc tgcccatcac cgtggcccat gtggatggcc aaacccacat
      661 gttatttggc tctgaccgga tggagctgct ggcgcacctg ctgggagaga agtggatggg
      721 ccctatacct ccagccgtga atgccagact ttaagattgc ccggaggaag caaactcttc
      781 gtataaaaaa agcaggccat ctgcttaacc cttggctcca ccataaggca ctgggactcg
      841 gatttctcta tctgatagag gtattttctg tggccctggg agctgtctgt ctttccccta
      901 cccccaagga tgccaggaag acgtccacca ttagccatgt ggcaaccttt acttctatgc
      961 ctcacaagtg cctttcagag agccccaatt ctgctttccc acaaaataaa cctaatgcca
     1021 tcaggcaaaa ca
//
