LOCUS       NM_153699                669 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens glutathione S-transferase alpha 5 (GSTA5), mRNA.
ACCESSION   NM_153699
VERSION     NM_153699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 669)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 669)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 669)
  AUTHORS   Moyer,A.M., Sun,Z., Batzler,A.J., Li,L., Schaid,D.J., Yang,P. and
            Weinshilboum,R.M.
  TITLE     Glutathione pathway genetic polymorphisms and lung cancer survival
            after platinum-based chemotherapy
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (3), 811-821 (2010)
   PUBMED   20200426
  REMARK    GeneRIF: We observed suggestive associations between survival and
            GSTT1 copy number and GSTA5, GSTM4, and ABCC4 single nucleotide
            polymorphisms
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 669)
  AUTHORS   Singh,S.P., Zimniak,L. and Zimniak,P.
  TITLE     The human hGSTA5 gene encodes an enzymatically active protein
  JOURNAL   Biochim Biophys Acta 1800 (1), 16-22 (2010)
   PUBMED   19664689
  REMARK    GeneRIF: Data show that hGSTA5 can be processed to a mature mRNA
            which is translation-competent, producing a catalytically active
            enzyme.
REFERENCE   6  (bases 1 to 669)
  AUTHORS   Morel,F., Rauch,C., Coles,B., Le Ferrec,E. and Guillouzo,A.
  TITLE     The human glutathione transferase alpha locus: genomic organization
            of the gene cluster and functional characterization of the genetic
            polymorphism in the hGSTA1 promoter
  JOURNAL   Pharmacogenetics 12 (4), 277-286 (2002)
   PUBMED   12042665
REFERENCE   7  (bases 1 to 669)
  AUTHORS   Coles,B.F., Anderson,K.E., Doerge,D.R., Churchwell,M.I., Lang,N.P.
            and Kadlubar,F.F.
  TITLE     Quantitative analysis of interindividual variation of glutathione
            S-transferase expression in human pancreas and the ambiguity of
            correlating genotype with phenotype
  JOURNAL   Cancer Res 60 (3), 573-579 (2000)
   PUBMED   10676639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590363.6.
            
            On Mar 2, 2023 this sequence version replaced NM_153699.2.
            
            Summary: The glutathione S-transferases (GST; EC 2.5.1.18) catalyze
            the conjugation of reduced glutathiones and a variety of
            electrophiles, including many known carcinogens and mutagens. The
            cytosolic GSTs belong to a large superfamily, with members located
            on different chromosomes. For additional information on GSTs, see
            GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA2144835
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370989.7/ ENSP00000360028.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL590363.6         54522-54608         c
            88-139              AL590363.6         51353-51404         c
            140-272             AL590363.6         50031-50163         c
            273-414             AL590363.6         47936-48077         c
            415-546             AL590363.6         46654-46785         c
            547-669             AL590363.6         45643-45765         c
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.2"
     gene            1..669
                     /gene="GSTA5"
                     /note="glutathione S-transferase alpha 5"
                     /db_xref="GeneID:221357"
                     /db_xref="HGNC:HGNC:19662"
                     /db_xref="MIM:607605"
     CDS             1..669
                     /gene="GSTA5"
                     /EC_number="2.5.1.18"
                     /note="GST class-alpha member 5; glutathione S-transferase
                     A5-5"
                     /codon_start=1
                     /product="glutathione S-transferase A5"
                     /protein_id="NP_714543.1"
                     /db_xref="CCDS:CCDS4946.1"
                     /db_xref="GeneID:221357"
                     /db_xref="HGNC:HGNC:19662"
                     /db_xref="MIM:607605"
                     /translation="MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKL
                     RNDGSLLFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDL
                     TEMILLLLICQPEERDAKTALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHL
                     VELFYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARK
                     IFRF"
     exon            1..87
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            88..139
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            140..272
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            273..414
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..546
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
     exon            547..669
                     /gene="GSTA5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcagaga agcccaagct ccactactcc aatgcacggg gcagtatgga gtccattcgg
       61 tggctcctgg ctgcagctgg agtagagttg gaagagaaat ttctagaatc tgcagaagat
      121 ttggacaagt taagaaatga tgggagtttg ctgttccagc aagtaccaat ggttgagatt
      181 gacgggatga agctggtgca gaccagagcc attcttaact acattgccag caaatacaac
      241 ctttatggga aagacatgaa ggagagagcc ctgattgata tgtacacaga aggtatagta
      301 gatttgactg aaatgatcct tcttctgctc atatgtcaac cagaggaaag agatgccaag
      361 actgccttgg tcaaagagaa aataaaaaat cgctacttcc ctgcctttga aaaagtctta
      421 aagagccaca gacaagacta ccttgttggc aacaagctga gctgggctga cattcacctg
      481 gtggaacttt tctactacgt ggaagagctt gactcgagtc ttatctccag cttccctctg
      541 ctgaaggccc tgaaaaccag aatcagcaac ctgcccacgg tgaagaagtt tctgcagcct
      601 ggcagccaga gaaagcctcc catggatgag aaatctttag aagaagcaag gaagattttc
      661 aggttttaa
//
