LOCUS       NM_018094               2791 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G1 to S phase transition 2 (GSPT2), mRNA.
ACCESSION   NM_018094
VERSION     NM_018094.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 2791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2791)
  AUTHORS   Xu,Z., Li,T., Li,M., Yang,L., Xiao,R., Liu,L., Chi,X. and Liu,D.
  TITLE     eRF3b-37 inhibits the TGF-beta1-induced activation of hepatic
            stellate cells by regulating cell proliferation, G0/G1 arrest,
            apoptosis and migration
  JOURNAL   Int J Mol Med 42 (6), 3602-3612 (2018)
   PUBMED   30272252
  REMARK    GeneRIF: eRF3b37 is thought to serve a role in hepatic stellate
            cells by inhibiting TGFbeta signaling.
REFERENCE   4  (bases 1 to 2791)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2791)
  AUTHORS   Grau,C., Starkovich,M., Azamian,M.S., Xia,F., Cheung,S.W.,
            Evans,P., Henderson,A., Lalani,S.R. and Scott,D.A.
  TITLE     Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2
            as a cause of syndromic X-linked intellectual disability
  JOURNAL   PLoS One 12 (4), e0175962 (2017)
   PUBMED   28414775
  REMARK    GeneRIF: Loss of GSPT2 and/or MAGED1 function may contribute to the
            intellectual disability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2791)
  AUTHORS   Chauvin,C., Salhi,S., Le Goff,C., Viranaicken,W., Diop,D. and
            Jean-Jean,O.
  TITLE     Involvement of human release factors eRF3a and eRF3b in translation
            termination and regulation of the termination complex formation
  JOURNAL   Mol Cell Biol 25 (14), 5801-5811 (2005)
   PUBMED   15987998
  REMARK    GeneRIF: eRF3b can substitute for eRF3a in its translation
            termination function.
REFERENCE   7  (bases 1 to 2791)
  AUTHORS   Kozlov,G., De Crescenzo,G., Lim,N.S., Siddiqui,N., Fantus,D.,
            Kahvejian,A., Trempe,J.F., Elias,D., Ekiel,I., Sonenberg,N.,
            O'Connor-McCourt,M. and Gehring,K.
  TITLE     Structural basis of ligand recognition by PABC, a highly specific
            peptide-binding domain found in poly(A)-binding protein and a HECT
            ubiquitin ligase
  JOURNAL   EMBO J 23 (2), 272-281 (2004)
   PUBMED   14685257
REFERENCE   8  (bases 1 to 2791)
  AUTHORS   Hoshino,S., Imai,M., Kobayashi,T., Uchida,N. and Katada,T.
  TITLE     The eukaryotic polypeptide chain releasing factor (eRF3/GSPT)
            carrying the translation termination signal to the 3'-Poly(A) tail
            of mRNA. Direct association of erf3/GSPT with polyadenylate-binding
            protein
  JOURNAL   J Biol Chem 274 (24), 16677-16680 (1999)
   PUBMED   10358005
REFERENCE   9  (bases 1 to 2791)
  AUTHORS   Hansen,L.L., Jakobsen,C.G. and Justesen,J.
  TITLE     Assignment of the human peptide chain release factor 3 (GSPT2) to
            Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation
            hybrid mapping
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 250-251 (1999)
   PUBMED   10575220
REFERENCE   10 (bases 1 to 2791)
  AUTHORS   Hoshino,S., Imai,M., Mizutani,M., Kikuchi,Y., Hanaoka,F., Ui,M. and
            Katada,T.
  TITLE     Molecular cloning of a novel member of the eukaryotic polypeptide
            chain-releasing factors (eRF). Its identification as eRF3
            interacting with eRF1
  JOURNAL   J Biol Chem 273 (35), 22254-22259 (1998)
   PUBMED   9712840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB173006.1, AJ251548.1,
            AK001303.1 and BF514488.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_018094.4.
            
            Summary: This gene encodes a GTPase that belongs to the GTP-binding
            elongation factor family. The encoded protein is a polypeptide
            release factor that complexes with eukaryotic peptide chain release
            factor 1 to mediate translation termination. This protein may also
            be involved in mRNA stability.[provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803615.204101.1,
                                        SRR1660805.209605.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340438.6/ ENSP00000341247.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                DB173006.1         58-122
            66-522              DB173006.1         124-580
            523-1516            AJ251548.1         338-1331
            1517-2486           AK001303.1         1512-2481
            2487-2791           BF514488.1         14-318              c
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..2791
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="G1 to S phase transition 2"
                     /db_xref="GeneID:23708"
                     /db_xref="HGNC:HGNC:4622"
                     /db_xref="MIM:300418"
     exon            1..2791
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2072
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="eukaryotic peptide chain release factor subunit 3b"
                     /codon_start=1
                     /product="eukaryotic peptide chain release factor
                     GTP-binding subunit ERF3B"
                     /protein_id="NP_060564.2"
                     /db_xref="CCDS:CCDS14336.1"
                     /db_xref="GeneID:23708"
                     /db_xref="HGNC:HGNC:4622"
                     /db_xref="MIM:300418"
                     /translation="MDSGSSSSDSAPDCWDQVDMESPGSAPSGDGVSSAVAEAQREPL
                     SSAFSRKLNVNAKPFVPNVHAAEFVPSFLRGPTQPPTLPAGSGSNDETCTGAGYPQGK
                     RMGRGAPVEPSREEPLVSLEGSNSAVTMELSEPVVENGEVEMALEESWEHSKEVSEAE
                     PGGGSSGDSGPPEESGQEMMEEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKST
                     IGGQIMFLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYF
                     ETERKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAM
                     LAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCSG
                     LTGANIKEQSDFCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKL
                     ESGSIFKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFI
                     LCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSG
                     EKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLV
                     PEKD"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="hexamer: AATAAA"
     polyA_site      2492
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="major polyA site"
     regulatory      2751..2756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="hexamer: AATAAA"
     polyA_site      2791
                     /gene="GSPT2"
                     /gene_synonym="ERF3B; GST2"
                     /note="major polyA site"
ORIGIN      
        1 atatctgctg ctgccgccgc agttgcgaat gcagcatcgg cgcttagctg cctccgcggt
       61 gcagctaagg ttcgtgtcgc taccccttgg cccttcgctc ttgctgcctt aaccccgccg
      121 gcggagcccg ctcttctggc ctgttgagcc cgctccctca ctgccacaca gcaagttccg
      181 agaccatgga ttcgggcagc agcagcagcg actcggcgcc cgattgctgg gaccaggtgg
      241 acatggaatc cccggggtcg gccccgagcg gggatggagt ctcctctgcg gtggccgagg
      301 cccagcgcga gcccctcagc tcggctttca gccgtaagct caacgtcaac gccaagccct
      361 tcgtgcctaa cgtacacgcc gcggagttcg tgccgtcctt cctgcggggc ccgactcagc
      421 cgcccaccct cccggccggc tccggcagca acgatgaaac ctgcaccggc gcgggatacc
      481 ctcaaggtaa aaggatggga cggggggcac ctgtggaacc ttcccgagag gaaccgttag
      541 tgtcgcttga aggttccaat tcagccgtta ccatggaact ttcagaacct gttgtagaaa
      601 atggagaggt ggaaatggcc ctagaagaat catgggagca cagtaaagaa gtaagtgaag
      661 ccgagcctgg gggtggttcc tcgggagatt cagggccccc agaagaaagt ggccaggaaa
      721 tgatggagga aaaagaggaa ataagaaaat ccaaatctgt gatcgtaccc tcaggtgcac
      781 ctaagaaaga acacgtaaat gtagtattca ttggccatgt agacgctggc aagtcaacca
      841 tcggaggaca gataatgttt ttgactggaa tggttgacaa aagaacactg gagaaatatg
      901 aaagagaagc taaggaaaaa aacagagaaa cctggtattt gtcctgggcc ttagatacaa
      961 atcaggagga acgagacaag ggtaaaacag tcgaagtggg tcgtgcctat tttgaaacag
     1021 aaaggaaaca tttcacaatt ttagatgccc ctggccacaa gagttttgtc ccaaatatga
     1081 ttggtggtgc ttctcaagct gatttggctg tgctggtcat ctctgccagg aaaggagagt
     1141 ttgaaactgg atttgaaaaa ggtggacaga caagagaaca tgcgatgttg gcaaaaacgg
     1201 caggggtaaa acatttaata gtgcttatta ataagatgga tgatcccaca gtaaattgga
     1261 gcatcgagag atatgaagaa tgtaaagaaa aactggtgcc ctttttgaaa aaagtaggct
     1321 tcagtccaaa aaaggacatt cactttatgc cctgctcagg actgaccgga gcaaatatta
     1381 aagagcagtc agatttctgc ccttggtaca ctggattacc atttattccg tatttggata
     1441 acttgccaaa cttcaacaga tcaattgatg gaccaataag actgccaatt gtggataagt
     1501 acaaagatat gggcactgtg gtcctgggaa agctggaatc cgggtccatt tttaaaggcc
     1561 agcagctcgt gatgatgcca aacaagcaca atgtagaagt tcttggaata ctttctgatg
     1621 atactgaaac tgattttgta gccccaggtg aaaacctcaa aatcagactg aagggaattg
     1681 aagaagaaga gattcttcca ggattcatac tttgtgatcc tagtaacctc tgccattctg
     1741 gacgcacgtt tgatgttcag atagtgatta ttgagcacaa atccatcatc tgcccaggtt
     1801 ataatgcggt gctgcacatt catacttgta ttgaggaagt tgagataaca gcgttaatct
     1861 ccttggtaga caaaaaatca ggagaaaaaa gtaagacacg accccgcttc gtgaaacaag
     1921 atcaagtatg cattgctcgt ttaaggacag caggaaccat ctgcctcgag acgttcaaag
     1981 attttcctca gatgggtcgt tttactttaa gagatgaggg taagaccatt gcaattggaa
     2041 aagttctgaa attggtccca gagaaggact aagcaatttt cttgatgcct ctgcaagata
     2101 ctgtgaggag aattgacagc aaaagttcac cacctactct tatttactgc ccattgattg
     2161 acttttcttc atattttgca aagagaaatt tcacagcaaa aattcatgtt ttgtcagctt
     2221 tctcatgttg agatctgtta tgtcactgat gaatttaccc tcaagtttcc ttcctctgta
     2281 ccactctgct tccttggaca atatcagtaa tagctttgta agtgatgtgg acgtaattgc
     2341 ctacagtaat gaaaaattaa tgtactttaa tttttcattt tcttttagga tatttagacc
     2401 acccttgttc cacgcaaacc agagtgtgtc agtgtttgtg tgtgtgttaa aatgataact
     2461 aacatgtgaa taaaatactc catttgaaac tcttcggtta tttgaaatgc ttttgaataa
     2521 tgtttaaatg tcattatgta atgctattca attagcttta ttactttctc aaatagttga
     2581 atatgttcta tcacttaaaa acttaaaaac tcttcaccac ttactgtttt aagtgaggaa
     2641 tttacaaaca atgcataagt gtgtattaaa ggaataattt taattttgag aaaaaaacgt
     2701 atgttaaggc tcttcccagt gggctttgtt ttctctgtcc aagtccagtc aataaaggag
     2761 ctcttctgct tccccacttg tgatttgaaa a
//
