LOCUS       NM_016472               2169 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GSK3B interacting protein (GSKIP), transcript variant
            2, mRNA.
ACCESSION   NM_016472
VERSION     NM_016472.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Cheng,Y.W., Chen,Y.Y., Lin,C.J., Lieu,A.S., Tsai,H.P. and Kwan,A.L.
  TITLE     High expression of GSKIP is associated with poor prognosis in
            meningioma
  JOURNAL   Medicine (Baltimore) 101 (50), e32209 (2022)
   PUBMED   36550871
  REMARK    GeneRIF: High expression of GSKIP is associated with poor prognosis
            in meningioma.
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Sakai,S.S., Hasegawa,A., Ishimura,R., Tamura,N., Kageyama,S.,
            Komatsu-Hirota,S., Abe,M., Ling,Y., Okuda,S., Funayama,M.,
            Kikkawa,M., Miura,Y., Sakimura,K., Narita,I., Waguri,S., Shimizu,R.
            and Komatsu,M.
  TITLE     Loss of Atg2b and Gskip Impairs the Maintenance of the
            Hematopoietic Stem Cell Pool Size
  JOURNAL   Mol Cell Biol 42 (1), e0002421 (2022)
   PUBMED   34748402
  REMARK    GeneRIF: Loss of Atg2b and Gskip Impairs the Maintenance of the
            Hematopoietic Stem Cell Pool Size.
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Pegliasco,J., Hirsch,P., Marzac,C., Isnard,F., Meniane,J.C.,
            Deswarte,C., Pellet,P., Lemaitre,C., Leroy,G., Rabadan Moraes,G.,
            Guermouche,H., Schmaltz-Panneau,B., Pasquier,F., Colas,C.,
            Benusiglio,P.R., Bera,O., Bourhis,J.H., Brissot,E., Caron,O.,
            Chraibi,S., Cony-Makhoul,P., Delaunay-Darivon,C., Lapusan,S., de
            Fontbrune,F.S., Fuseau,P., Najman,A., Vainchenker,W.,
            Delhommeau,F., Micol,J.B., Plo,I. and Bellanne-Chantelot,C.
  TITLE     Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to
            early clonal hematopoiesis leading to myeloid neoplasms
  JOURNAL   Leukemia 36 (1), 126-137 (2022)
   PUBMED   34172895
  REMARK    GeneRIF: Germline ATG2B/GSKIP-containing 14q32 duplication
            predisposes to early clonal hematopoiesis leading to myeloid
            neoplasms.
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Pilot-Storck,F., Chopin,E., Rual,J.F., Baudot,A., Dobrokhotov,P.,
            Robinson-Rechavi,M., Brun,C., Cusick,M.E., Hill,D.E., Schaeffer,L.,
            Vidal,M. and Goillot,E.
  TITLE     Interactome mapping of the phosphatidylinositol 3-kinase-mammalian
            target of rapamycin pathway identifies deformed epidermal
            autoregulatory factor-1 as a new glycogen synthase kinase-3
            interactor
  JOURNAL   Mol Cell Proteomics 9 (7), 1578-1593 (2010)
   PUBMED   20368287
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Howng,S.L., Hwang,C.C., Hsu,C.Y., Hsu,M.Y., Teng,C.Y., Chou,C.H.,
            Lee,M.F., Wu,C.H., Chiou,S.J., Lieu,A.S., Loh,J.K., Yang,C.N.,
            Lin,C.S. and Hong,Y.R.
  TITLE     Involvement of the residues of GSKIP, AxinGID, and FRATtide in
            their binding with GSK3beta to unravel a novel C-terminal
            scaffold-binding region
  JOURNAL   Mol Cell Biochem 339 (1-2), 23-33 (2010)
   PUBMED   20043192
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Hundsrucker,C., Skroblin,P., Christian,F., Zenn,H.M., Popara,V.,
            Joshi,M., Eichhorst,J., Wiesner,B., Herberg,F.W., Reif,B.,
            Rosenthal,W. and Klussmann,E.
  TITLE     Glycogen synthase kinase 3beta interaction protein functions as an
            A-kinase anchoring protein
  JOURNAL   J Biol Chem 285 (8), 5507-5521 (2010)
   PUBMED   20007971
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   Lin,C.C., Chou,C.H., Howng,S.L., Hsu,C.Y., Hwang,C.C., Wang,C.,
            Hsu,C.M. and Hong,Y.R.
  TITLE     GSKIP, an inhibitor of GSK3beta, mediates the
            N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y
            cells
  JOURNAL   J Cell Biochem 108 (6), 1325-1336 (2009)
   PUBMED   19830702
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   Chou,H.Y., Howng,S.L., Cheng,T.S., Hsiao,Y.L., Lieu,A.S., Loh,J.K.,
            Hwang,S.L., Lin,C.C., Hsu,C.M., Wang,C., Lee,C.I., Lu,P.J.,
            Chou,C.K., Huang,C.Y. and Hong,Y.R.
  TITLE     GSKIP is homologous to the Axin GSK3beta interaction domain and
            functions as a negative regulator of GSK3beta
  JOURNAL   Biochemistry 45 (38), 11379-11389 (2006)
   PUBMED   16981698
  REMARK    GeneRIF: GSKIP is a naturally occurring protein that is homologous
            with the GSK3beta interaction domain of Axin and is able to
            negatively regulate GSK3beta of the Wnt signaling pathway.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359240.4.
            
            On Nov 23, 2018 this sequence version replaced NM_016472.4.
            
            Summary: This gene encodes a protein that is involved as a negative
            regulator of GSK3-beta in the Wnt signaling pathway. The encoded
            protein may play a role in the retinoic acid signaling pathway by
            regulating the functional interactions between GSK3-beta,
            beta-catenin and cyclin D1, and it regulates the
            beta-catenin/N-cadherin pool. The encoded protein contains a
            GSK3-beta interacting domain (GID) in its C-terminus, which is
            similar to the GID of Axin. The protein also contains an
            evolutionarily conserved RII-binding domain, which facilitates
            binding with protein kinase-A and GSK3-beta, enabling its role as
            an A-kinase anchoring protein. Alternatively spliced transcript
            variants have been observed for this gene. [provided by RefSeq, Dec
            2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000796.1, SRR1660805.148365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555181.6/ ENSP00000450420.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL359240.4         68785-68827
            44-144              AL359240.4         84947-85047
            145-403             AL359240.4         87506-87764
            404-2169            AL359240.4         90782-92547
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..2169
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /note="GSK3B interacting protein"
                     /db_xref="GeneID:51527"
                     /db_xref="HGNC:HGNC:20343"
                     /db_xref="MIM:616605"
     exon            1..43
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /inference="alignment:Splign:2.1.0"
     exon            44..144
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /inference="alignment:Splign:2.1.0"
     exon            145..403
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..565
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /note="GSK3-beta interaction protein"
                     /codon_start=1
                     /product="GSK3B-interacting protein"
                     /protein_id="NP_057556.2"
                     /db_xref="CCDS:CCDS32153.1"
                     /db_xref="GeneID:51527"
                     /db_xref="HGNC:HGNC:20343"
                     /db_xref="MIM:616605"
                     /translation="METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDV
                     LFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTP
                     YHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS"
     exon            404..2169
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /note="hexamer: AATAAA"
     polyA_site      2112
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /note="hexamer: GATAAA"
     polyA_site      2169
                     /gene="GSKIP"
                     /gene_synonym="C14orf129; HSPC210"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcctcc ggaggaagga agaagaggac gccgggcgcg cagctcggtg ctgattatca
       61 caactgtttg gtgacctact tcactgacct gtgaggattc cttcccttca ggtactggat
      121 tcttgatctt tctgcatcat caagaatgga aacagactgt aatcccatgg agctaagcag
      181 tatgtcagga tttgaagaag gttcagagct gaacggtttt gaaggaactg acatgaaaga
      241 catgaggctc gaagctgaag cagttgtaaa tgatgttctc tttgctgtta acaacatgtt
      301 tgtctcgaaa agcctgcggt gtgcggatga tgtggcctat atcaatgtgg aaacaaagga
      361 aagaaacaga tattgcctag aactcactga agcagggctc aaggtggtag gctatgcttt
      421 tgaccaggta gatgatcatt tacagactcc ctaccatgaa acagtctact ccttgttgga
      481 tacactcagc cccgcctacc gagaagcatt tggaaacgca ctgcttcaaa gactggaagc
      541 tttgaaaaga gatggacagt catgactaca ctttttcctt tcagaggggc tggtgctggt
      601 acagaatgtt gatataaagc ttaaaattct tgcatatggt catagaaaat gcatctttgg
      661 ttttgtgttt ttatcacttg cttccaactt aggcttttgg ctcagaagat tattgaataa
      721 tgatttgtct tagtttctgt ttcagtaagg gaattctgag gccgttgcta tgataccatc
      781 attaagacat tcacatgtct tcatataata tctcttcatt tcaaatccta atcactattt
      841 catactatta cagggctttg atgctgccag cactgtcttt tacataggaa attctagatt
      901 tgcacagtaa tagaggaatt agaagtacct aactatacac tttgattcag cctgctaaat
      961 caggggttca atactagctt ggacaaactt tgtagtaatt aattgctacc agccttattg
     1021 gaaacaaatt atcaactagt ttcccctgca caaattttga aattcactgc ttcacttaat
     1081 ctatttatat tactaataat ggattaataa agatgaatta attatatatt acttaactag
     1141 tattaaatga aaaacaggga ctgaaatagt tctgtattcc gtgtttgcaa cagccagcca
     1201 actaagcaga ggataaaccg ttagcaaatg aatgtaataa ttactcattt ccaagatatc
     1261 taagcacata agcaaataca ggaacagact tcattctttt tcttaacaaa aaagcatctt
     1321 cagtgtgtga tttaaaagaa agaagattct ggtttcctag aaaacaatat tttggcctgt
     1381 gttgattctt attctgaatg tgtgtttaca taatgtacag tatatattca gaaagtattt
     1441 ttgcttcaac gtttactttc tatgatgtag tgctttggta ttcctacagc accccacctt
     1501 ccccaacaga tgtacagtgt tctgtctcca ttcgaaatct acaatgtaat atgagtgcat
     1561 tgtatgggtt tgaaaccaaa ggatgaatga agcattcaga gacttaatat ttgaaaaagg
     1621 aatagtcagt attttatatt ttattacagg tactgatatt tataaattta ataaactgta
     1681 ccatgctgct gcatgttttc aagtacatgt tgaacagtaa ggattgggga gttgtttttt
     1741 aatggtcacc taaagcagct gctatagaaa tgttgaacta aaattttgca tctggtcata
     1801 ccttcatgca tttatcattt gcagatattt ttccatcatt attaaaaaac aggaactttt
     1861 aggctctgaa gatcatgtgg accagagcaa attaaagttc agtttgtgtc acaattcatt
     1921 gccagacttc attggaatgc tttgtttgat gatgtatgtt cattctcagc tttattttca
     1981 gatgcttaac tgggcaacga agtctaactt caggttgaac tttctcatgt ttaatctcag
     2041 gctaaatgta aatgatattt gtaaagtttg aataaaattc tgtttactca ttttgagtta
     2101 gtatgaaaaa aagtgattgt atgtttaaga attgaaattg ttcattttgt gataaatgat
     2161 taattccaa
//
