LOCUS       NM_001146156            7743 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript
            variant 2, mRNA.
ACCESSION   NM_001146156
VERSION     NM_001146156.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7743)
  AUTHORS   Chen,F., Li,Y., Zhao,L., Lin,C., Zhou,Y., Ye,W., Wan,W., Zou,H. and
            Xue,Y.
  TITLE     Anti-inflammatory effects of MerTK by inducing M2 macrophage
            polarization via PI3K/Akt/GSK-3beta pathway in gout
  JOURNAL   Int Immunopharmacol 142 (Pt A), 112942 (2024)
   PUBMED   39217874
  REMARK    GeneRIF: Anti-inflammatory effects of MerTK by inducing M2
            macrophage polarization via PI3K/Akt/GSK-3beta pathway in gout.
REFERENCE   2  (bases 1 to 7743)
  AUTHORS   Toral-Rios,D., Pichardo-Rojas,P., Ruiz-Sanchez,E.,
            Rosas-Carrasco,O., Carvajal-Garcia,R., Galvez-Coutino,D.C.,
            Martinez-Rodriguez,N.L., Rubio-Chavez,A.D., Alcantara-Flores,M.,
            Lopez-Ramirez,A., Martinez-Rosas,A.R., Ruiz-Chow,A.A.,
            Alonso-Vanegas,M. and Campos-Pena,V.
  TITLE     Synergistic Effect between the APOE epsilon4 Allele with Genetic
            Variants of GSK3B and MAPT: Differential Profile between Refractory
            Epilepsy and Alzheimer Disease
  JOURNAL   Int J Mol Sci 25 (18), 10228 (2024)
   PUBMED   39337715
  REMARK    GeneRIF: Synergistic Effect between the APOE epsilon4 Allele with
            Genetic Variants of GSK3B and MAPT: Differential Profile between
            Refractory Epilepsy and Alzheimer Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7743)
  AUTHORS   Enos,M.D., Gavagan,M., Jameson,N., Zalatan,J.G. and Weis,W.I.
  TITLE     Structural and functional effects of phosphopriming and scaffolding
            in the kinase GSK-3beta
  JOURNAL   Sci Signal 17 (852), eado0881 (2024)
   PUBMED   39226374
  REMARK    GeneRIF: Structural and functional effects of phosphopriming and
            scaffolding in the kinase GSK-3beta.
REFERENCE   4  (bases 1 to 7743)
  AUTHORS   Zhao,J., Wei,M., Guo,M., Wang,M., Niu,H., Xu,T. and Zhou,Y.
  TITLE     GSK3: A potential target and pending issues for treatment of
            Alzheimer's disease
  JOURNAL   CNS Neurosci Ther 30 (7), e14818 (2024)
   PUBMED   38946682
  REMARK    GeneRIF: GSK3: A potential target and pending issues for treatment
            of Alzheimer's disease.
            Review article
REFERENCE   5  (bases 1 to 7743)
  AUTHORS   El Hajjar,L., Page,A., Bridot,C., Cantrelle,F.X., Landrieu,I. and
            Smet-Nocca,C.
  TITLE     Regulation of Glycogen Synthase Kinase-3beta by Phosphorylation and
            O-beta-Linked N-Acetylglucosaminylation: Implications on Tau
            Protein Phosphorylation
  JOURNAL   Biochemistry 63 (12), 1513-1533 (2024)
   PUBMED   38788673
  REMARK    GeneRIF: Regulation of Glycogen Synthase Kinase-3beta by
            Phosphorylation and O-beta-Linked N-Acetylglucosaminylation:
            Implications on Tau Protein Phosphorylation.
REFERENCE   6  (bases 1 to 7743)
  AUTHORS   Plyte,S.E., Hughes,K., Nikolakaki,E., Pulverer,B.J. and
            Woodgett,J.R.
  TITLE     Glycogen synthase kinase-3: functions in oncogenesis and
            development
  JOURNAL   Biochim Biophys Acta 1114 (2-3), 147-162 (1992)
   PUBMED   1333807
  REMARK    Review article
REFERENCE   7  (bases 1 to 7743)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 7743)
  AUTHORS   Goode,N., Hughes,K., Woodgett,J.R. and Parker,P.J.
  TITLE     Differential regulation of glycogen synthase kinase-3 beta by
            protein kinase C isotypes
  JOURNAL   J Biol Chem 267 (24), 16878-16882 (1992)
   PUBMED   1324914
REFERENCE   9  (bases 1 to 7743)
  AUTHORS   Rylatt,D.B., Aitken,A., Bilham,T., Condon,G.D., Embi,N. and
            Cohen,P.
  TITLE     Glycogen synthase from rabbit skeletal muscle. Amino acid sequence
            at the sites phosphorylated by glycogen synthase kinase-3, and
            extension of the N-terminal sequence containing the site
            phosphorylated by phosphorylase kinase
  JOURNAL   Eur J Biochem 107 (2), 529-537 (1980)
   PUBMED   6772446
REFERENCE   10 (bases 1 to 7743)
  AUTHORS   Ameli,N.O., Teymoorian,G.A., Saleh,H. and Slamdoost,A.
  TITLE     Proceedings: Aneurysmal bone cysts of the spine
  JOURNAL   Acta Neurochir (Wien) 31 (3-4), 273 (1975)
   PUBMED   1181841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092910.9, BC012760.2,
            DA477189.1, AC069444.17 and CA312249.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001146156.1.
            
            Summary: The protein encoded by this gene is a serine-threonine
            kinase belonging to the glycogen synthase kinase subfamily. It is a
            negative regulator of glucose homeostasis and is involved in energy
            metabolism, inflammation, ER-stress, mitochondrial dysfunction, and
            apoptotic pathways. Defects in this gene have been associated with
            Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug
            2017].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.23476.1,
                                           SRR11853561.21068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264235.13/ ENSP00000264235.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC092910.9         147676-147705       c
            31-485              BC012760.2         1-455
            486-559             DA477189.1         484-557
            560-2387            BC012760.2         529-2356
            2388-6943           AC069444.17        63360-67915
            6944-7111           CA312249.1         15-182              c
            7112-7743           AC069444.17        68084-68715
FEATURES             Location/Qualifiers
     source          1..7743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..7743
                     /gene="GSK3B"
                     /note="glycogen synthase kinase 3 beta"
                     /db_xref="GeneID:2932"
                     /db_xref="HGNC:HGNC:4617"
                     /db_xref="MIM:605004"
     exon            1..1101
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             1014..2276
                     /gene="GSK3B"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 2 is encoded by transcript variant 2; GSK-3
                     beta; serine/threonine-protein kinase GSK3B"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 beta isoform 2"
                     /protein_id="NP_001139628.1"
                     /db_xref="CCDS:CCDS54628.1"
                     /db_xref="GeneID:2932"
                     /db_xref="HGNC:HGNC:4617"
                     /db_xref="MIM:605004"
                     /translation="MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATP
                     GQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMR
                     KLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKL
                     YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC
                     SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP
                     TREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA
                     CAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPT
                     NATAASDANTGDRGQTNNAASASASNST"
     exon            1102..1295
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1379
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1490
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1621
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1728
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1826
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1922
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2109
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2208
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..7743
                     /gene="GSK3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7076..7081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSK3B"
                     /note="hexamer: AATAAA"
     polyA_site      7111
                     /gene="GSK3B"
                     /note="major polyA site"
     regulatory      7721..7726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSK3B"
                     /note="hexamer: AATAAA"
     polyA_site      7743
                     /gene="GSK3B"
                     /note="major polyA site"
ORIGIN      
        1 acacagagca gctcctgacc cgggcgaatg cgggcttgtg ccgccgccgc cgccgccgcc
       61 gcccgggcca agtgacaaag gaaggaagga agcgaggagg agccggcccc gcagccgctg
      121 acagggctct gggctggggc aaagcgcgga cacttcctga gcgggcaccg agcagagccg
      181 aggggcggga gggcggccga gctgttgccg cggacggggg agggggcccc gagggacgga
      241 agcggttgcc gggttcccat gtccccggcg aatggggaac agtcgaggag ccgctgcctg
      301 gggtctgaag ggagctgcct ccgccaccgc catggccgct ggatccagcc gccgcctgca
      361 gctgctcctg gcgcaatgag gagaggagcc gccgccaccg ccaccgcccg cctctgactg
      421 actcgcgact ccgccgccct ctagttcgcc gggcccctgc cgtcagcccg ccggatcccg
      481 cggcttgccg gagctgcagc gtttcccgtc gcatctccga gccaccccct ccctccctct
      541 ccctccctcc tacccatccc cctttctctt caagcgtgag actcgtgatc cttccgccgc
      601 ttcccttctt cattgactcg gaaaaaaaat ccccgaggaa aatataatat tcgaagtact
      661 cattttcaat caagtatttg cccccgtttc acgtgataca tattttttta ggatttgccc
      721 tctcttttct ctcctcccag gaaagggagg ggaaagaatt gtattttttc ccaagtccta
      781 aatcatctat atgttaaata tccgtgccga tctgtcttga aggagaaata tatcgcttgt
      841 tttgtttttt atagtataca aaaggagtga aaagccaaga ggacgaagtc tttttctttt
      901 tcttctgtgg gagaacttaa tgctgcattt atcgttaacc taacacccca acataaagac
      961 aaaaggaaga aaaggaggaa ggaaggaaaa ggtgattcgc gaagagagtg atcatgtcag
     1021 ggcggcccag aaccacctcc tttgcggaga gctgcaagcc ggtgcagcag ccttcagctt
     1081 ttggcagcat gaaagttagc agagacaagg acggcagcaa ggtgacaaca gtggtggcaa
     1141 ctcctgggca gggtccagac aggccacaag aagtcagcta tacagacact aaagtgattg
     1201 gaaatggatc atttggtgtg gtatatcaag ccaaactttg tgattcagga gaactggtcg
     1261 ccatcaagaa agtattgcag gacaagagat ttaagaatcg agagctccag atcatgagaa
     1321 agctagatca ctgtaacata gtccgattgc gttatttctt ctactccagt ggtgagaaga
     1381 aagatgaggt ctatcttaat ctggtgctgg actatgttcc ggaaacagta tacagagttg
     1441 ccagacacta tagtcgagcc aaacagacgc tccctgtgat ttatgtcaag ttgtatatgt
     1501 atcagctgtt ccgaagttta gcctatatcc attcctttgg aatctgccat cgggatatta
     1561 aaccgcagaa cctcttgttg gatcctgata ctgctgtatt aaaactctgt gactttggaa
     1621 gtgcaaagca gctggtccga ggagaaccca atgtttcgta tatctgttct cggtactata
     1681 gggcaccaga gttgatcttt ggagccactg attatacctc tagtatagat gtatggtctg
     1741 ctggctgtgt gttggctgag ctgttactag gacaaccaat atttccaggg gatagtggtg
     1801 tggatcagtt ggtagaaata atcaaggtcc tgggaactcc aacaagggag caaatcagag
     1861 aaatgaaccc aaactacaca gaatttaaat tccctcaaat taaggcacat ccttggacta
     1921 aggtcttccg accccgaact ccaccggagg caattgcact gtgtagccgt ctgctggagt
     1981 atacaccaac tgcccgacta acaccactgg aagcttgtgc acattcattt tttgatgaat
     2041 tacgggaccc aaatgtcaaa ctaccaaatg ggcgagacac acctgcactc ttcaacttca
     2101 ccactcaaga actgtcaagt aatccacctc tggctaccat ccttattcct cctcatgctc
     2161 ggattcaagc agctgcttca acccccacaa atgccacagc agcgtcagat gctaatactg
     2221 gagaccgtgg acagaccaat aatgctgctt ctgcatcagc ttccaactcc acctgaacag
     2281 tcccgagcag ccagctgcac aggaaaaacc accagttact tgagtgtcac tcagcaacac
     2341 tggtcacgtt tggaaagaat attaaaaaga gaaaaaaatc ctgttcattt tagtgttcaa
     2401 tttttttatt attattgttg ttcttattta accttgtaaa atatctataa atacaaacca
     2461 atttcattgt attctcactt tgagggagat ccagggggtg ggaggggttg tggggagggg
     2521 gaaagcggag cactagaaca tacaatctct ctcccacgac aatctttttt tattaaaagt
     2581 ctgctgttgt atactttaaa aacaggactc ctgcctcatg ccccttccac aaaagaagaa
     2641 aacctttttc tgtgctgatg ggtttttttg aactttgttt tcttttaaag tctagtgtga
     2701 gactttggta tagtgcacag cttgaaattg gttgggagct tagcaggtat aactcaacgg
     2761 ggacttaaat gtcacttgta aaattaatcc atatcttcgg gtatttatag acttgccttt
     2821 ggcatgttgg tggcaggtgt ggcagacaaa gaaatgtgta tcattcgtaa cccagggagg
     2881 tcaataaagt ttggaactct acagggaaga ttcttagtag atttgttaag gttttgtttt
     2941 gctctcagtt agtgctagtg atgtagaggc ttgtacagga ggctgccaga ggggaagcag
     3001 caagcaagac tcaggcacac atgctctaca ggtggctctt tgtttgcctg accaaagttc
     3061 tttgcaaatc ttagcacagt ttcaaactag tgacctggga ggagatggaa ggggtgttga
     3121 gcaggctgag ctagctgctg aggtcaaagg ctgatgagcc cagaggaagg ggacaggtca
     3181 gggatacatc tcaccactgt gaataagttt gtccagattt ttttctaaag ttacttccct
     3241 tggaaagata cacttgagag gacattgtag ttaaataatg tgaactgtaa cagtcatcta
     3301 ctggtttatt tttcatattt tttaattgaa aattgagctt gcagaaatag ccacattcta
     3361 cacatagttc taattttaaa tccaaatcta gaatctgtat ttaatttgtt ttttaacctc
     3421 atgcttttta catttattta ttgatgcatg tcagatggta gaaatattaa aaactacaca
     3481 tcagaatgat acagtcactt atacctgctg actttatagg aaagctgatg atataaatgt
     3541 gtgtatatat gttatatata catatattca atactgcctt tttttttgtc tacagtatca
     3601 aaattgactg gttgaagcat gagaagaatg tttcccccac acccagttaa gagtttttgt
     3661 gtctgttttc tttgtgtatc agtgaacgat gttaagaatc agtctctctt tttgaagaaa
     3721 aagcaatatt ccttggaaag caaggagaat tgaaggacta tgtttgccgt gaggaaatag
     3781 attttcatga ctagtttgtt ttatactttt aaggttggca tctatgtggg ccttatatac
     3841 tctaaaatga actttagtca ccttggtgct tatgggccat tacttgacct atgaatcttt
     3901 aaggcacaat cagttgtact ttacatttaa agatcacttg agtgatggcc gcctttccct
     3961 cctacccgct ccttccccac atgccttcca aggttagctg gtaactgtag ggctgcagag
     4021 ctgagcccat ggttgtgtgt aacttgccct caccctcctc attgccacct taggtcactt
     4081 tatgggtctc gtcctccaga gggttcggaa gtggagtctg ttggcagccc tcctgcaggc
     4141 cctagcaccc tgtcctgctc cttaactgtg tgtgtgactc tccaagagag ttgtcctgcc
     4201 tgctgaagtg aaccagtacc cagaaagaca actgtgagcc atcttggttt tcactcgctg
     4261 tttagctgag gtcttgggcc acaaaagggg tttcacaaac ctctggatat atcagagttt
     4321 atgagaaagg aaacatgctc agtcaaacca aatcaaacaa attgaatttt atgttttata
     4381 aagtgcttct gaaagctaag atttgaaaga agtctgaaat caaagtattt ggcagcataa
     4441 ctccttaaag gtagtggcgt tgatagacca ttttcagaca gaatttataa agaatctgaa
     4501 aaggcaggtc tgtgatagag aaatggacct gcattcagat ccaactgccc agcaagcgtt
     4561 tggatgcaga cactgctctg gacgtggtat actccccaga gtccataaaa atcagtgctt
     4621 attttaggaa acaggttgcc ccccacaact ggggtaaaag aagagagaaa agtcacgctt
     4681 ttctctcatt tcattgtgtg tgcatgtgtg cgtgtgtgtg tgtgtgtgtg tgtgctgaga
     4741 tgtgtgattt ttctttctca aggatcatgg tgggatcaca gaactctttt atacaagtga
     4801 gatccaggtc tctgaatatc tttttgtata taataataat aaaaagctcc tcaccaaatt
     4861 caagcttgta cattatattt tctttctgtg tttttaaatt taagttttat tgttttgtat
     4921 gtaaatatgt ggacccagga actgttatta atgagcaaaa agttactgtt cagggcagtg
     4981 attctgttta ataatcagac aaaatgtaga cgagcttttt aaagccatat agttttaact
     5041 ctgtacagta ggtaccggcc tgtattattg taacaataac tctagcaatg tatagtgtat
     5101 ctatatagtt tggagtgcct tcgcttccat gtgttttttt ttttaatttg ttctttttta
     5161 aattttaatt ggtttccttt atccatgtct ccctgtccac cccctttccc tttgaaataa
     5221 taactcactc ataacagtat ctttgcccct tccacagtta agtttcagtg ataccatact
     5281 caggagtggg aagaggaaat catattcgta atttcatttc gttgaagccc tgcctttgtt
     5341 ttggttctga atgtctttcc tcctcggtag cagtgagacc ggtttcattt catacttagt
     5401 ccattcaggg acttagtgta gcaccaggga gccctagagc tggaggatat cgaatagatt
     5461 aaattttgct cgtctcttcc acaagcccta accatgggtc ttaaaaacag cagattctgg
     5521 gagccttcca tgctctctct ctctcctctt ttatctactt ccctcccaaa tgagagagtg
     5581 acagagaatt gtttttttat aaatcgaagt ttcttaatag tatcaggttt tgatacgtca
     5641 gtggtctaaa atgctatagt gcaattacta gcagttactg cacggagtgc caccgtgcca
     5701 atagaggact gttgttttaa caagggaact cttagcccat ttcctccctc ccgccatctc
     5761 tacccttgct caatgaaata tcattttaat ttcttttaaa aaaaatcagt ttaattctta
     5821 ctgtgtgccc aacacgaagg ccttttttga aagaaaaata gaatgttttg cctcaaagta
     5881 gtccatataa aatgtcttga atagaagaaa aaactaccaa accaaaggtt actatttttg
     5941 aaacatcgtg tgttcattcc agcaaggcag aagactgcac cttctttcca gtgacatgct
     6001 gtgtcatttt ttttaagtcc tcttaatttt tagacacatt tttggtttat gttttaacaa
     6061 tgtatgccta accagtcatc ttgtctgcac caatgcaaag gtttctgaga ggagtattct
     6121 ctatccctgt ggatatgaag acactggcat ttcatctatt tttccctttc ctttttaaag
     6181 gatttaactt tggaatcttc caaaggaagt ttggccaatg ccagatcccc aggaatttgg
     6241 ggggttttct ttcttttcaa ctgaaattgt atctgattcc tactgttcat gttagtgatc
     6301 atctaatcac agagccaaac acttttctcc cctgtgtgga aaagtaggta tgctttacaa
     6361 taaaatctgt cttttctggt agaaacctga gccactgaaa ataaaagaga caactagaag
     6421 cacagtagag tcccagactg agatctacct ttgagaggct ttgaaagtaa tccctggggt
     6481 ttggattatt ttcacaaggg ttatgccgtt ttattcaagt ttgttgctcc gttttgcacc
     6541 tctgcaataa aagcaaaatg acaaccagta cataaggggt tagcttgaca aagtagactt
     6601 ccttgtgtta atttttaagt ttttttttcc ttaactatat ctgtctacag gcagatacag
     6661 atagttgtat gaaaatctgc ttgcctgtaa aatttgcatt tataaatgtg ttgccgatgg
     6721 atcacttggg cctgtacaca taccaattag cgtgaccact tccatcttaa aaacaaacct
     6781 aaaaaacaaa atttattata tatatatata tatatatata aaggactgtg ggttgtatac
     6841 aaactattgc aaacacttgt gcaaatctgt cttgatataa aggaaaagca aaatctgtat
     6901 aacattatta ctacttgaat gcctctgtga ctgatttttt tttcatttta aatataaact
     6961 tttttgtgaa aagtatgctc aatgtttttt ttccctttcc ccattccctt gtaaatacat
     7021 tttgttctat gtgacttggt ttggaaatag ttaactggta ctgtaatttg cattaaataa
     7081 aaagtaggtt agcctggaaa tgaaattaaa attcacaagt gtgtggtctt tatttcagta
     7141 cccaaccctc ttccttcacc ctactatttt gccgctgcaa tatgtagtca catcaccatt
     7201 tccattcctc taattaggga aacattaatc tttgttatac agaacaagat atcaatacca
     7261 cttcttgttc tttccaatga ttttattcca ttgtgtagcc ccaagaggtg cagcttccac
     7321 cttggaaacc tttggatttg atgtagagga agctttgcag acactgctta gaaaagaaag
     7381 aaaacaactc tgaaagggac agtttttaaa tgtgtataag ctgctgtctt tgattactgt
     7441 gttcatgatt tggtgtggct gtattttctt ttaactttca tcctattagt aatggtcttt
     7501 gggggtctct gtaaaatata tggacaccac gaacagtggg gctgtacctc ccaggtaacc
     7561 aacacatgtt gtgtttgagt ctgctcattt ccaatactgg atgatgtatg taaacatgtt
     7621 atgtctctta gtgcaaaaag aaacatcatt tttttagggc tggctcactc tgtcaggcct
     7681 aatctaaagg ctagatataa ggtcatgtga ctgctgcttc aataaaaaca aatttatatt
     7741 cga
//
