LOCUS       NM_019884               2193 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycogen synthase kinase 3 alpha (GSK3A), mRNA.
ACCESSION   NM_019884
VERSION     NM_019884.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Zheng,X., Yang,L., Shen,X., Pan,J., Chen,Y., Chen,J., Wang,H.,
            Meng,J., Chen,Z., Xie,S., Li,Y., Zhu,B., Zhu,W., Qin,L. and Lu,L.
  TITLE     Targeting Gsk3a reverses immune evasion to enhance immunotherapy in
            hepatocellular carcinoma
  JOURNAL   J Immunother Cancer 12 (8), e009642 (2024)
   PUBMED   39174053
  REMARK    GeneRIF: Targeting Gsk3a reverses immune evasion to enhance
            immunotherapy in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Zhao,J., Wei,M., Guo,M., Wang,M., Niu,H., Xu,T. and Zhou,Y.
  TITLE     GSK3: A potential target and pending issues for treatment of
            Alzheimer's disease
  JOURNAL   CNS Neurosci Ther 30 (7), e14818 (2024)
   PUBMED   38946682
  REMARK    GeneRIF: GSK3: A potential target and pending issues for treatment
            of Alzheimer's disease.
            Review article
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Umbarkar,P., Ejantkar,S., Ruiz Ramirez,S.Y., Toro Cora,A.,
            Zhang,Q., Tousif,S. and Lal,H.
  TITLE     Cardiac fibroblast GSK-3alpha aggravates ischemic cardiac injury by
            promoting fibrosis, inflammation, and impairing angiogenesis
  JOURNAL   Basic Res Cardiol 118 (1), 35 (2023)
   PUBMED   37656238
  REMARK    GeneRIF: Cardiac fibroblast GSK-3alpha aggravates ischemic cardiac
            injury by promoting fibrosis, inflammation, and impairing
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Loxha,L., Ibrahim,N.K., Stasche,A.S., Cinar,B., Dolgner,T.,
            Niessen,J., Schreek,S., Fehlhaber,B., Forster,M., Stanulla,M. and
            Hinze,L.
  TITLE     GSK3alpha Regulates Temporally Dynamic Changes in Ribosomal
            Proteins upon Amino Acid Starvation in Cancer Cells
  JOURNAL   Int J Mol Sci 24 (17), 13260 (2023)
   PUBMED   37686063
  REMARK    GeneRIF: GSK3alpha Regulates Temporally Dynamic Changes in
            Ribosomal Proteins upon Amino Acid Starvation in Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Park,D.S., Nguyen,S.C., Isenhart,R., Shah,P.P., Kim,W.,
            Barnett,R.J., Chandra,A., Luppino,J.M., Harke,J., Wai,M.,
            Walsh,P.J., Abdill,R.J., Yang,R., Lan,Y., Yoon,S., Yunker,R.,
            Kanemaki,M.T., Vahedi,G., Phillips-Cremins,J.E., Jain,R. and
            Joyce,E.F.
  TITLE     High-throughput Oligopaint screen identifies druggable 3D genome
            regulators
  JOURNAL   Nature 620 (7972), 209-217 (2023)
   PUBMED   37438531
  REMARK    GeneRIF: High-throughput Oligopaint screen identifies druggable 3D
            genome regulators.
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Harr,S.D., Hollister,R.D. and Hyman,B.T.
  TITLE     Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with
            neurofibrillary tangles
  JOURNAL   Neurobiol Aging 17 (3), 343-348 (1996)
   PUBMED   8725894
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Cross,D.A., Alessi,D.R., Cohen,P., Andjelkovich,M. and
            Hemmings,B.A.
  TITLE     Inhibition of glycogen synthase kinase-3 by insulin mediated by
            protein kinase B
  JOURNAL   Nature 378 (6559), 785-789 (1995)
   PUBMED   8524413
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   He,X., Saint-Jeannet,J.P., Woodgett,J.R., Varmus,H.E. and
            Dawid,I.B.
  TITLE     Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus
            embryos
  JOURNAL   Nature 374 (6523), 617-622 (1995)
   PUBMED   7715701
  REMARK    Erratum:[Nature 1995 May 18;375(6528):253]
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Yang,S.D., Yu,J.S., Shiah,S.G. and Huang,J.J.
  TITLE     Protein kinase FA/glycogen synthase kinase-3 alpha after heparin
            potentiation phosphorylates tau on sites abnormally phosphorylated
            in Alzheimer's disease brain
  JOURNAL   J Neurochem 63 (4), 1416-1425 (1994)
   PUBMED   7931292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006486.1, BC027984.1, L40027.1 and D63424.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019884.2.
            
            Summary: This gene encodes a multifunctional Ser/Thr protein kinase
            that is implicated in the control of several regulatory proteins
            including glycogen synthase, and transcription factors, such as
            JUN. It also plays a role in the WNT and PI3K signaling pathways,
            as well as regulates the production of beta-amyloid peptides
            associated with Alzheimer's disease. [provided by RefSeq, Oct
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027984.1, L40027.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222330.8/ ENSP00000222330.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC006486.1         34440-34457         c
            19-1456             BC027984.1         20-1457
            1457-1458           L40027.1           1434-1435
            1459-2193           D63424.1           1413-2147
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2193
                     /gene="GSK3A"
                     /note="glycogen synthase kinase 3 alpha"
                     /db_xref="GeneID:2931"
                     /db_xref="HGNC:HGNC:4616"
                     /db_xref="MIM:606784"
     exon            1..420
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1589
                     /gene="GSK3A"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="GSK-3 alpha; serine/threonine-protein kinase GSK3A"
                     /codon_start=1
                     /product="glycogen synthase kinase-3 alpha"
                     /protein_id="NP_063937.2"
                     /db_xref="CCDS:CCDS12599.1"
                     /db_xref="GeneID:2931"
                     /db_xref="HGNC:HGNC:4616"
                     /db_xref="MIM:606784"
                     /translation="MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPG
                     GTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTT
                     VVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRE
                     LQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPI
                     LYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN
                     VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIK
                     VLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRL
                     SPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAG
                     TTTLTPSSQALTETPTSSDWQSTDATPTLTNSS"
     exon            421..608
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            609..692
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            693..803
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            804..934
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1041
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1139
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1235
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1422
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1515
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2193
                     /gene="GSK3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSK3A"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="GSK3A"
                     /note="major polyA site"
ORIGIN      
        1 gctgggccgg agccggagcc caagccagag cggcgcggcc tggaagaggc cagggcccgg
       61 gggaggcggc ggcagcggcg gcggctgggg cagcccgggc agcccgagcc ccgcagcctg
      121 ggcctgtgct cggcgccatg agcggcggcg ggccttcggg aggcggccct gggggctcgg
      181 gcagggcgcg gactagctcg ttcgcggagc ccggcggcgg aggcggagga ggcggcggcg
      241 gccccggagg ctcggcctcc ggcccaggcg gcaccggcgg cggaaaggca tctgtcgggg
      301 ccatgggtgg gggcgtcggg gcctcgagct ccgggggtgg acccggcggc agcggcggag
      361 gaggcagcgg aggccccggc gcaggcacta gcttcccgcc gcccggggtg aagctgggcc
      421 gtgacagcgg gaaggtgacc acagtcgtag ccactctagg ccaaggccca gagcgctccc
      481 aagaagtggc ttacacggac atcaaagtga ttggcaatgg ctcatttggg gtcgtgtacc
      541 aggcacggct ggcagagacc agggaactag tcgccatcaa gaaggttctc caggacaaga
      601 ggttcaagaa ccgagagctg cagatcatgc gtaagctgga ccactgcaat attgtgaggc
      661 tgagatactt tttctactcc agtggcgaga agaaagacga gctttaccta aatctggtgc
      721 tggaatatgt gcccgagaca gtgtaccggg tggcccgcca cttcaccaag gccaagttga
      781 ccatccctat cctctatgtc aaggtgtaca tgtaccagct cttccgcagc ttggcctaca
      841 tccactccca gggcgtgtgt caccgcgaca tcaagcccca gaacctgctg gtggaccctg
      901 acactgctgt cctcaagctc tgcgattttg gcagtgcaaa gcagttggtc cgaggggagc
      961 ccaatgtctc ctacatctgt tctcgctact accgggcccc agagctcatc tttggagcca
     1021 ctgattacac ctcatccatc gatgtttggt cagctggctg tgtactggca gagctcctct
     1081 tgggccagcc catcttccct ggggacagtg gggtggacca gctggtggag atcatcaagg
     1141 tgctgggaac accaacccgg gaacaaatcc gagagatgaa ccccaactac acggagttca
     1201 agttccctca gattaaagct cacccctgga caaaggtgtt caaatctcga acgccgccag
     1261 aggccatcgc gctctgctct agcctgctgg agtacacccc atcctcaagg ctctccccac
     1321 tagaggcctg tgcgcacagc ttctttgatg aactgcgatg tctgggaacc cagctgccta
     1381 acaaccgccc acttccccct ctcttcaact tcagtgctgg tgaactctcc atccaaccgt
     1441 ctctcaacgc cattctcatc cctcctcact tgaggtcccc agcgggcact accaccctca
     1501 ccccgtcctc acaagcttta actgagactc cgaccagctc agactggcag tcgaccgatg
     1561 ccacacctac cctcactaac tcctcctgag ggccccacca agcacccttc cacttccatc
     1621 tgggagcccc aagaggggct gggaaggggg gccatagccc atcaagctcc tgccctggct
     1681 gggcccctag actagagggc agaggtaaat gagtccctgt ccccacctcc agtccctccc
     1741 tcaccagcct cacccctgtg gtgggctttt taagaggatt ttaactggtt gtggggaggg
     1801 aagagaagga cagggtgttg gggggatgag gacctcctac ccccttggcc ccctcccctc
     1861 ccccagacct ccacctcctc cagaccccct cccctcctgt gtcccttgta aatagaacca
     1921 gcccagcccg tctcctcttc ccttccctgg cccccgggtg taaatagatt gttataattt
     1981 ttttcttaaa gaaaacgtcg attcgcaccg tccaacctgg ccccgcccct cctacagctg
     2041 taactcccct cctgtcctct gcccccaagg tctactccct cctcacccca ccctggaggg
     2101 ccaggggagt ggagagagct cctgatgtct tagtttccac agtaaggttt gcctgtgtac
     2161 agacctccgt tcaataaatt attggcatga aaa
//
