LOCUS       NM_001109763            5128 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens GSG1 like (GSG1L), transcript variant 1, mRNA.
ACCESSION   NM_001109763
VERSION     NM_001109763.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5128)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5128)
  AUTHORS   Yang,H.C., Chu,S.K., Huang,C.L., Kuo,H.W., Wang,S.C., Liu,S.W.,
            Ho,I.K. and Liu,Y.L.
  TITLE     Genome-Wide Pharmacogenomic Study on Methadone Maintenance
            Treatment Identifies SNP rs17180299 and Multiple Haplotypes on
            CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of
            Methadone R- and S-enantiomers in Heroin-Dependent Patients
  JOURNAL   PLoS Genet 12 (3), e1005910 (2016)
   PUBMED   27010727
  REMARK    GeneRIF: gene expression experiment revealed that CYP2B6, SPON1,
            and GSG1L can be activated concomitantly through a constitutive
            androstane receptor (CAR) activation pathway
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5128)
  AUTHORS   Gu,X., Mao,X., Lussier,M.P., Hutchison,M.A., Zhou,L., Hamra,F.K.,
            Roche,K.W. and Lu,W.
  TITLE     GSG1L suppresses AMPA receptor-mediated synaptic transmission and
            uniquely modulates AMPA receptor kinetics in hippocampal neurons
  JOURNAL   Nat Commun 7, 10873 (2016)
   PUBMED   26932439
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5128)
  AUTHORS   Shanks,N.F., Savas,J.N., Maruo,T., Cais,O., Hirao,A., Oe,S.,
            Ghosh,A., Noda,Y., Greger,I.H., Yates,J.R. 3rd and Nakagawa,T.
  TITLE     Differences in AMPA and kainate receptor interactomes facilitate
            identification of AMPA receptor auxiliary subunit GSG1L
  JOURNAL   Cell Rep 1 (6), 590-598 (2012)
   PUBMED   22813734
REFERENCE   5  (bases 1 to 5128)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 5128)
  AUTHORS   Rual,J.F., Hirozane-Kishikawa,T., Hao,T., Bertin,N., Li,S.,
            Dricot,A., Li,N., Rosenberg,J., Lamesch,P., Vidalain,P.O.,
            Clingingsmith,T.R., Hartley,J.L., Esposito,D., Cheo,D., Moore,T.,
            Simmons,B., Sequerra,R., Bosak,S., Doucette-Stamm,L., Le Peuch,C.,
            Vandenhaute,J., Cusick,M.E., Albala,J.S., Hill,D.E. and Vidal,M.
  TITLE     Human ORFeome version 1.1: a platform for reverse proteomics
  JOURNAL   Genome Res 14 (10B), 2128-2135 (2004)
   PUBMED   15489335
REFERENCE   7  (bases 1 to 5128)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009030.10, AI418246.1, AK128775.1, CV024949.1, AC008732.9 and
            DB306756.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001109763.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447459.7/ ENSP00000394954.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC009030.10        103893-104097
            206-666             AI418246.1         1-461
            667-981             AK128775.1         83-397
            982-1126            CV024949.1         227-371
            1127-1551           AK128775.1         543-967
            1552-5003           AC008732.9         166868-170319
            5004-5127           DB306756.1         1-124               c
            5128-5128           AC008732.9         170444-170444
FEATURES             Location/Qualifiers
     source          1..5128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..5128
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /note="GSG1 like"
                     /db_xref="GeneID:146395"
                     /db_xref="HGNC:HGNC:28283"
                     /db_xref="MIM:617161"
     exon            1..639
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1286
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /note="isoform 1 is encoded by transcript variant 1; germ
                     cell-specific gene 1-like protein; KTSR5831; GSG1-like
                     protein"
                     /codon_start=1
                     /product="germ cell-specific gene 1-like protein isoform
                     1"
                     /protein_id="NP_001103233.1"
                     /db_xref="CCDS:CCDS45450.1"
                     /db_xref="GeneID:146395"
                     /db_xref="HGNC:HGNC:28283"
                     /db_xref="MIM:617161"
                     /translation="MKTSRRGRALLAVALNLLALLFATTAFLTTHWCQGTQRVPKPGC
                     GQGGRANCPNSGANATANGTAAPAAAAAAATASGNGPPGGALYSWETGDDRFLFRNFH
                     TGIWYSCEEELSGLGEKCRSFIDLAPASEKGVLWLSVVSEVLYILLLVVGFSLMCLEL
                     FHSSNVIDGLKLNAFAAVFTVLSGLLGMVAHMMYTQVFQVTVSLGPEDWRPHSWDYGW
                     SFCLAWGSFTCCMAASVTTLNSYTKTVIEFRHKRKVFEQGYREEPTFIDPEAIKYFRE
                     RMEKRDGSEEDFHLDCRHERYPARHQPHMADSWPRSSAQEAPELNRQCWVLGHWV"
     exon            640..687
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     exon            688..840
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     exon            841..952
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1120
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1188
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..5128
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /note="hexamer: AATAAA"
     polyA_site      1762
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /note="major polyA site"
     regulatory      5108..5113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
                     /note="hexamer: AATAAA"
     polyA_site      5128
                     /gene="GSG1L"
                     /gene_synonym="PRO19651"
ORIGIN      
        1 aggcgccagc ggctcctagc cgaggtgcac tcgcgctccg ggctccgggc gcgccgtagc
       61 cgctcctcca ccgccgcccg ccccgccagc ccgccccgca cgccccccgc gccgcgcccc
      121 caccccgggg ttgggggggg catgggcccg cgccgcgtcc gccgccgccg atctcaggca
      181 cccgagcccc ggggcgcggc gggcagcggc cgctgacgcg gggcgccagc tgccaacttc
      241 gcgcgcggag ctccccggcg gtgcagtccc gtcccggcgg cgcgggcggc atgaagacta
      301 gccgccgcgg ccgagcgctc ctggccgtgg ccctgaacct gctggcgctg ctgttcgcca
      361 ccaccgcttt cctcaccacg cactggtgcc agggcacgca gcgggtcccc aagccgggct
      421 gcggccaggg cgggcgcgcc aactgcccca actcgggcgc caacgccacg gccaacggca
      481 ccgccgcccc cgccgccgcc gccgccgccg ccaccgcctc ggggaacggc ccccctggcg
      541 gcgcgctcta cagctgggag accggcgacg accgcttcct cttcaggaat ttccacaccg
      601 gcatctggta ctcgtgcgag gaggagctca gcgggcttgg tgaaaaatgt cgcagcttca
      661 ttgacctggc cccggcatcg gagaaagggg tcctgtggct gtctgtggtc tccgaggtgc
      721 tgtacattct gctgctggtg gttggcttca gcctcatgtg tctcgagctc ttccactcca
      781 gcaatgtcat cgacgggctc aagctcaatg ccttcgcggc tgtcttcacg gtgctctcag
      841 gcctcctggg aatggtcgcc cacatgatgt acacgcaggt gttccaggtc accgtgagcc
      901 tcggtcctga ggactggaga ccccattcct gggactacgg gtggtccttc tgcctggcgt
      961 ggggctcctt tacctgctgc atggcagcct ctgtcaccac gctcaactcc tacaccaaga
     1021 cggtcattga gttccggcac aagcgcaagg tctttgagca gggctaccgg gaagagccga
     1081 ccttcataga ccctgaggcc atcaagtact tccgggagag gatggagaag agggacggga
     1141 gcgaggagga ctttcactta gactgccgcc acgagagata ccctgcccga caccagccac
     1201 acatggcgga ttcctggccc cggagctccg cacaggaagc accagagctg aaccgacagt
     1261 gctgggtctt ggggcactgg gtgtgaccaa gacctcaacc tggcccgcgg acctcaggcc
     1321 atcgctggca ccagcccctg ctgcaagacc accagagtgg tgcccccaga accctggcct
     1381 gtgtgccgtg aactcagtca gcctgcgtgg gagatgccag gcctgtcctg cccatcgctg
     1441 cctgggtccc atggccttgg aaatggggcc agggcaggcc caagggaatg cacagggctg
     1501 cacagagtga ctttgggaca gcagccccgg actcttgcca tcatcacatg agccctgctg
     1561 ggcacagctg cgatgccagg agacacatgg ccactggcca ctgaatggct ggcacccaca
     1621 agccagtcag gtgcccagag gggcagagcc ctttgggggg cagagagtgg cttcctgaag
     1681 gagggggcag tggcgcaggc actgcagggg tgtcacacag caggcacaca gcaggggctc
     1741 aataaatgct tgttgaactt gttttcttgc ggtgtatgga ggccagttgc tctgtgggct
     1801 gtggctgccc tgtcattgcc ccaccccatt actcctcaag gaggctgaag gtgacagcag
     1861 agactgtgca gaggccaggg ccagacactg cagggtggca gggagggagc acagagccca
     1921 ggctggacac aggctggcag ggctgccttg tattccagag agtgggcaag gcaggggcca
     1981 ggcaagcaag agatgtgggg cgagcaagaa gtgggccccc aaacccaagc cctaagcagg
     2041 gagggtgaag aagccacatt tctcttcaga gctcagcaac atcacaccac cctgaccctg
     2101 aggaggcttt accctgtgcc tagcaccacc tttacagaaa atcccagggc ttagatgcct
     2161 ggagaaacag attcttatta taaagaggag gaaaattagg gtcacagaga tgaatgaagt
     2221 aacttgcctg tgattacaga gctagcaaat ggcagagatg gggtttgaat caggactcct
     2281 gactccaagt tcagtcattt cccaagaggc cttattcctt cccagaagaa tttctagagc
     2341 ttttccccac gtagaatata ttcttctcct ttatccttcc atccttccat ccatcatcca
     2401 tcactcatcc agccattatc cattatccat ccatccattc atcattcgtc catctattat
     2461 ccacccattc atcatctatt atccatccat cattcatcat ccatccatca ttcataattc
     2521 atctttccac tcatccatcc atcattcatt cattcatcca tccttccatc catccatcat
     2581 ctatccattc atccatccat ttgccatcca tccactcatt catcagctat ccatcatcta
     2641 tccatccatc catccatcca gcatctatca ctcatccagc tattgtccat tgtccattca
     2701 tccatttttc attcatccct ccatcatcat taatccatta tccacccact catcatctat
     2761 tatccatcta tagtccatca accatccatc cttcatcatc catccatcca tccttcatcc
     2821 atccatccac ccatccatcc atccatcatc tgtccatcca ttatctatcc attcatccat
     2881 ccattcatca tccacccacc tattcatcag ctatctatcc atcatccatc catccatcat
     2941 ccatccatcc atccatccat ccatcatcta tccattcatt gtctatgctt tcatccatcc
     3001 attcatcatc catccaccca ttcgttagct atttatccat tatccattcc tccatctatc
     3061 catcatccat tcatccctta tccattcaac cattatgcat ttcttcattt atccattatt
     3121 tatccttcca tccatcatcc atcatctttc catccactat ctatccattc atccatctat
     3181 ccatcatcca tccatccttt atccatcatt catcagccat catccctcca tctatccatt
     3241 atccatcatc cactcatcca ttcatccctc catctgccca ttatccatca accatccatc
     3301 catccattat ccgtcatcca cacatccatt catccctcca tctgcccatt atccatcaac
     3361 catccatcca tccattatcc atttctgcat tatccattta ttctttatcc atttcttcat
     3421 ctattcatca tctatccatc cattatcctt acacctatct atcatccatc cattccttca
     3481 tctatccatc atccatcaat tatccatcca ttcatccatc catctatcca tcttctattg
     3541 attgcttgtc atccttcctt gtatcagact tccatccatc ctccttccat gtgtcacaca
     3601 tcctcattac tcaaccatcc agctgtgcat ccatctattc actgatatag ttcactgtgc
     3661 ccctactatg tgccaagcac tgtggtaggc acttgaggtg ggatgctgga gcatccagag
     3721 agggcatcta ttgtcgtgag cctgggttca gattccacct tctccacttg tgaccttggg
     3781 cgagttactt gacctttctg tgcctgtttc ctcatccatt aaatccggat aatcattata
     3841 cctacctctt caagctgttg tgcaaattaa atgagctaac atatttgaag tgtctagaac
     3901 agagcctggc acaagtaaac actttgtggg tgtttactaa caggacaaca aggggaaatc
     3961 ggggctgtgg gagctgtagt ctagggaggc tcctttgaga aaatgatgtc taagccaaga
     4021 catgaagatt gtctgggcat cagccaggca agagtatagc agggaaagaa agtacattag
     4081 aggactttaa aatagtccca atggcaggtg tggagagcag ggaggtcagg aggcagttgt
     4141 gggaaattag gcatcagagg gcagtggagc caggccagga ggaactggaa accttcttag
     4201 ggagcttaga gtttaccctg gggcaatggg gagtgggcag tgagatgctt ttagcagact
     4261 gggatgcgcc tgggtgtaca tttgaggaag atcaccgcaa ctatgggcac agaatagttg
     4321 tgggagatgc ttctcccttc ctcatccctc ttacactcaa gaaagagaag aaagtgggct
     4381 ggcttaggaa agttgccctg gggaggggac catgcgggca gattcaggaa ccaattagga
     4441 gggaatagac tgagtgggag aagaggaaag ttggtgacga ctctcaggtt acagggtcag
     4501 cttgggggat agggaagacg gagacttcgt ggttcagatg tcttgagtct caggggctca
     4561 ggggacagcc agctggaggt ttgtgctcat tcattcacgc attgattcat caagcgaaca
     4621 atttgttaat tcactttcca ttcattcagt aaatattaat gacctactag gtggggctta
     4681 aggcggggct ggaaatgggc ctgggagagc aattatggtc cagctctact gaggccttga
     4741 atgtcagaac aaggaatttg ggctttggcc tcatgcaaga gagggcggct gccatatatg
     4801 ggcctgggca gggacagatc tgacagggat ctagccctgg ccaccaggca tctaggagct
     4861 cttgttctca cccagggtcc ttctgaagtt ggcgagtgga ccgcaggagg tccaggagat
     4921 gattgtagtt gacacatggg gaaaatttta atctatttta atagttgtgt ttatgtaaat
     4981 gtgtattaga aaaaaatgta cagtgggcac atcagtgcta tgacttcaca gacgttactg
     5041 cttaggatga aaccaaaata ggcatttaag taaaagaaaa aaagagttgg cttaaagaaa
     5101 aatattaaat aaataatcgt gcaagtgg
//
