LOCUS       NM_001080555            2613 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens germ cell associated 1 (GSG1), transcript variant 4,
            mRNA.
ACCESSION   NM_001080555
VERSION     NM_001080555.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079628.20 and AC023790.21.
            
            On Jun 2, 2019 this sequence version replaced NM_001080555.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region, includes an alternate in-frame exon in the central
            coding region, and uses an alternate splice site that causes a
            frameshift in the 3' coding region, compared to variant 1. The
            encoded isoform (4) has distinct N- and C-termini and is longer
            than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.164868.1,
                                           SRR5189667.125828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651961.1/ ENSP00000498528.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC079628.20        7087-7289           c
            204-519             AC023790.21        7566-7881
            520-588             AC023790.21        9108-9176
            589-636             AC023790.21        9475-9522
            637-789             AC023790.21        10325-10477
            790-901             AC023790.21        11121-11232
            902-2613            AC023790.21        13141-14852
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..2613
                     /gene="GSG1"
                     /note="germ cell associated 1"
                     /db_xref="GeneID:83445"
                     /db_xref="HGNC:HGNC:19716"
     exon            1..203
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1244
                     /gene="GSG1"
                     /note="isoform 4 is encoded by transcript variant 4; germ
                     cell-specific gene 1 protein; testicular secretory protein
                     Li 20"
                     /codon_start=1
                     /product="germ cell-specific gene 1 protein isoform 4"
                     /protein_id="NP_001074024.1"
                     /db_xref="GeneID:83445"
                     /db_xref="HGNC:HGNC:19716"
                     /translation="MSDPSQLTQNVCLTQEMELSKAFSGQRTLLSAILSMLSLSFSTT
                     SLLSNYWFVGTQKVPKPLCEKGLAAKCFDMPVSLDGDTNTSTQEVVQYNWETGDDRFS
                     FRSFRSGMWLSCEETVEEPALLHPQSWKQFRALRSSGTAAAKGERCRSFIELTPPAKR
                     EILWLSLGTQITYIGLQFISFLLLLTDLLLTGNPACGLKLSAFAAVSSVLSGLLGMVA
                     HMMYSQVFQATVNLGPEDWRPHVWNYGWAFYMAWLSFTCCMASAVTTFNTYTRMVLEF
                     KCKHSKSFKENPNCLPHHHQCFPRRLSSAAPTVGPLTSYHQYHNQPIHSVSEGVDFYS
                     ELRNKGFQRGASQELKEAVRSSVEEEQC"
     exon            204..519
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..588
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..636
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..789
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..901
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..2613
                     /gene="GSG1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1320
                     /gene="GSG1"
                     /note="major polyA site"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSG1"
                     /note="hexamer: AATACA"
     polyA_site      1560
                     /gene="GSG1"
ORIGIN      
        1 aggacatcct ctccaatcca ccacacacca ccttacccct ctgctggcaa gaggggacct
       61 gattcatcct cacgctaaac actcattcta cccaactgat tgagacagaa cagaagataa
      121 actgaaactt ctctgccttc ccgctgcaag agtgaatgag cgatccctct caactgactc
      181 aaaatgtttg cctcacccag gagatggagc tctcgaaggc cttctctggc cagcggacac
      241 tcctatctgc catcctcagc atgctatcac tcagcttctc cacaacatcc ctgctcagca
      301 actactggtt tgtgggcaca cagaaggtgc ccaagcccct gtgcgagaaa ggtctggcag
      361 ccaagtgctt tgacatgcca gtgtccctgg atggagatac caacacatcc acccaggagg
      421 tggtacaata caactgggag actggggatg accggttctc cttccggagc ttccggagtg
      481 gcatgtggct atcctgtgag gaaactgtgg aagaaccagc actgctccat ccccagtcct
      541 ggaaacaatt tagagccctt cggtccagtg gtacagcggc agcaaaaggg gagaggtgcc
      601 gaagtttcat tgaacttaca ccaccagcca agagagaaat cctatggtta tccctgggaa
      661 cgcagatcac ctacatcgga cttcaattca tcagcttcct cctgctacta acagacttgc
      721 tactcactgg gaaccctgcc tgtgggctca aactgagcgc ctttgctgct gtttcctctg
      781 tcctgtcagg tctcctgggg atggtggccc acatgatgta ttcacaagtc ttccaagcga
      841 ctgtcaactt gggtccagaa gactggagac cacatgtttg gaattatggc tgggccttct
      901 acatggcctg gctctccttc acctgctgca tggcgtcggc tgtcaccacc ttcaacacgt
      961 acaccaggat ggtgctggag ttcaagtgca agcatagtaa gagcttcaag gaaaacccga
     1021 actgcctacc acatcaccat cagtgtttcc ctcggcggct gtcaagtgca gcccccaccg
     1081 tgggtccttt gaccagctac caccagtatc ataatcagcc catccactct gtctctgagg
     1141 gagtcgactt ctactccgag ctgcggaaca agggatttca aagaggggcc agccaggagc
     1201 tgaaagaagc agttaggtca tctgtagagg aagagcagtg ttaggagtta agcgggtttg
     1261 gggagtaggc ttgagcccta ccttacacgt ctgctgatta tcaacatgtg cttaagccaa
     1321 catccgtctc ttgagcatgg tttttagagg ctacgaataa ggctatgaat aagggttatc
     1381 tttaagtcct aagggattcc tgggtgccac tgctctcttt tcctctacag ctccatcttg
     1441 tttcacccac cccacatctc acacatccag aattcccttc tttactgata gtttctgtgc
     1501 caggttctgg gctaaaccat ggagataaaa agaagagtaa aatacacttc ccgaccttaa
     1561 ggatctgata catctagtta ttggtctgga aattggagaa atggaggtga gcaaattaac
     1621 ggtagtgtga ctgtggctca actttccatg gtacgcgcga attgttctgg aagtcacaga
     1681 tgggaagaca gaagcgcccc tgagtgcttt gtcatatagc acagaagtcc tccacactgc
     1741 ctgggacagt gtcctgcatc cacacagtag gtacccagta aaagtgttat taaatattgt
     1801 cccaggagcc cttaggagag tggtttaaca tgagaaggcg ccaacagcac acagggtcag
     1861 ggtcacttct agaaatagcc caccaaggct attcagattg gactgtggtt cccttctgga
     1921 cagtcacacc agggacttcc cagtgaacaa gggggcatag gctcctctct ggatcccacc
     1981 ttttcatccc ttctgagaaa tgtaccctat tatttccttc ataaagaatg ccacccatct
     2041 gattcctcaa gaatctagac ctagaaatac catttgaccc agccatccca ttactgggta
     2101 gatacccaaa ggattacaaa tcatgctgct ataaagacac atgcacacat atgtttatta
     2161 cggcactatt tataatagca aagacttgga accaacccaa atgtccatca gtgatagact
     2221 ggattaagaa aatgtggcac atatacacca tggaatacta tgcagccata aagaaggatg
     2281 agtttatgcc ctttgtaggg acatggatga agctggaaac catcattctg agcaaactat
     2341 cgcaaggata gaaaaccaaa cactgcatat tctcactcac aggtgggaat tgaacaataa
     2401 aaacacttgg acacagggtg gggaacatca cacaccgggc ctgtcatggg gtggggggag
     2461 gggggaggga tagcattagg agatatacta acgtaaatga cgagttaatg ggtgcagcac
     2521 accaacatgg cacatgtata catatgtaac aaatctgcac gttgtgcaca tgtaccctag
     2581 aacttaaaaa aaaaaaaaaa agaatgccac cca
//
