LOCUS       NM_014615               7385 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens Gse1 coiled-coil protein (GSE1), transcript variant 1,
            mRNA.
ACCESSION   NM_014615 XM_050495
VERSION     NM_014615.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7385)
  AUTHORS   Meng,Z., Yang,Y., Li,S., Huang,L., Yao,Z., Chen,Y., Wang,J.,
            Shen,Y., Liang,P., Zhang,H., Wang,W. and Wang,F.
  TITLE     GSE1 promotes the proliferation and migration of lung
            adenocarcinoma cells by downregulating KLF6 expression
  JOURNAL   Cell Biol Int 48 (10), 1490-1506 (2024)
   PUBMED   38886911
  REMARK    GeneRIF: GSE1 promotes the proliferation and migration of lung
            adenocarcinoma cells by downregulating KLF6 expression.
REFERENCE   2  (bases 1 to 7385)
  AUTHORS   Vcelkova,T., Reiter,W., Zylka,M., Hollenstein,D.M., Schuckert,S.,
            Hartl,M. and Seiser,C.
  TITLE     GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage
  JOURNAL   Nucleic Acids Res 51 (21), 11748-11769 (2023)
   PUBMED   37878419
  REMARK    GeneRIF: GSE1 links the HDAC1/CoREST co-repressor complex to DNA
            damage.
REFERENCE   3  (bases 1 to 7385)
  AUTHORS   Wang,W., Wang,S., Xu,A.M., Yuan,X., Huang,L. and Li,J.
  TITLE     Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric
            Cancer Cells
  JOURNAL   Biomed Res Int 2021, 8834923 (2021)
   PUBMED   33623790
  REMARK    GeneRIF: Overexpression of GSE1 Related to Trastuzumab Resistance
            in Gastric Cancer Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7385)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7385)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7385)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 7385)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 7385)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 7385)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   10 (bases 1 to 7385)
  AUTHORS   Hakimi,M.A., Dong,Y., Lane,W.S., Speicher,D.W. and Shiekhattar,R.
  TITLE     A candidate X-linked mental retardation gene is a component of a
            new family of histone deacetylase-containing complexes
  JOURNAL   J Biol Chem 278 (9), 7234-7239 (2003)
   PUBMED   12493763
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY041236.1, BC037556.2,
            D80004.2, AC123908.3 and GD138010.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014615.4.
            
            Summary: This gene encodes a proline-rich protein with coiled coil
            domains that may be a subunit of a BRAF35-HDAC (BHC) histone
            deacetylase complex. This gene may function as an oncogene in
            breast cancer and enhanced expression of the encoded protein has
            been observed in breast cancer patients. [provided by RefSeq, May
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253458.12/ ENSP00000253458.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               HY041236.1         65-457
            394-2876            BC037556.2         207-2689
            2877-3625           D80004.2           2628-3376
            3626-4539           BC037556.2         3439-4352
            4540-7189           AC123908.3         90234-92883
            7190-7385           GD138010.1         65-260
FEATURES             Location/Qualifiers
     source          1..7385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..7385
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /note="Gse1 coiled-coil protein"
                     /db_xref="GeneID:23199"
                     /db_xref="HGNC:HGNC:28979"
                     /db_xref="MIM:616886"
     exon            1..77
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3724
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /note="isoform 1 is encoded by transcript variant 1;
                     genetic suppressor element 1; Gse1 coiled-coil protein
                     homolog; CTC-786C10.1"
                     /codon_start=1
                     /product="genetic suppressor element 1 isoform 1"
                     /protein_id="NP_055430.1"
                     /db_xref="CCDS:CCDS10952.1"
                     /db_xref="GeneID:23199"
                     /db_xref="HGNC:HGNC:28979"
                     /db_xref="MIM:616886"
                     /translation="MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSP
                     ATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKR
                     VPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEP
                     PLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDY
                     LRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSAL
                     RSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMD
                     EELRREREREREREREREADREREKEREREREKEREQEKEREREKERERELERQREQR
                     AREKELLAAKALEPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKP
                     VQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEK
                     EDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGG
                     PPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVK
                     VERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKST
                     QTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKL
                     DLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQL
                     FGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNN
                     SPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLTNSPRDSP
                     AVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGE
                     KARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHES
                     VLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTA
                     RKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQV
                     LQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPA
                     MHWPRGYLKGYPR"
     exon            78..296
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            297..496
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            497..669
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            670..867
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1059
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1382
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1710
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2330
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2443
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2714
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2828
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3200
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3485
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3589
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..7385
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7366..7371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /note="hexamer: AATAAA"
     polyA_site      7385
                     /gene="GSE1"
                     /gene_synonym="CRHSP24; KIAA0182"
                     /note="major polyA site"
ORIGIN      
        1 agtttagaca aacactgggc gacggtggct ccagcatgta tcagccgagg tggagctgcg
       61 gggccctggc atgaaaggca tgagccatga gcccaagtcc ccttcgctag ggatgctttc
      121 caccgcgacc aggaccaccg ccaccgtcaa ccccctcacc ccctcgccgc tcaatggcgc
      181 cctggtgccc agcggcagcc ccgccaccag cagcgcgctg tcggcccagg ccgcgccatc
      241 ctccagcttt gccgccgcgc tgcgcaagct cgccaaacag gcggaggagc ccagagggtc
      301 ctcactgagc agcgagtcgt cccccgtgtc ctctccggcc accaaccaca gctcccccgc
      361 cagcacaccc aagcgcgtgc ccatgggccc tatcatcgtc ccccctgggg gccacagcgt
      421 gcccagcacc ccccccgtgg tgaccatcgc tccaaccaaa accgtgaatg gtgtctggag
      481 gagtgagagc cggcaggatg ccggctccag gagcagcagt ggaggtcggg aacgcctcat
      541 tgtggagccc ccgctccctc aggagaaggc agggggacca gccatcccct cgcacctgct
      601 cagcaccccc taccccttcg gcctctcccc cagctcagtt gtgcaggatt cccgcttccc
      661 gccactcaac ctccagcggc ccgtgcacca cgtggtgccc cccagtaccg tgaccgagga
      721 ctacctgaga agcttccggc cctaccacac caccgacgac ctccgcatgt cctcactgcc
      781 tcccctcggc ctggacccgg ccactgctgc agcctactac caccccagct acctggcccc
      841 acaccccttc ccccacccgg ccttcaggat ggacgactcc tactgcctgt ctgccctgag
      901 gtccccgttc taccccatcc ccacccccgg ctccctgccc ccactgcacc catcagcgat
      961 gcacctgcac ctctctgggg tccgctaccc tcccgagctc tcccactcat ccctggcagc
     1021 gctgcactcg gagcgcatgt ctggcctcag cgcggagagg ctgcagatgg acgaggagct
     1081 aaggcgggag agggagcgcg agcgcgagcg cgagcgtgag cgtgaggctg accgcgagcg
     1141 ggagaaggaa cgtgagcgcg aacgcgagaa ggagcgcgag caagagaagg agcgtgagcg
     1201 tgagaaggag cgcgagcgcg agctggagcg ccagcgggag cagcgggccc gggagaagga
     1261 gctgctggcc gccaaggccc tggagcccag cttcctgccc gtggccgagc tgcatgggct
     1321 gcgtggccat gccactgagg agcggggcaa gccctcggag cagctgaccc caacccgagc
     1381 agagaagctg aaggatgccg gcctgcaggc gcccaagccc gtccaacacc ccttgcatcc
     1441 ggtgcccacc ccacaccaca cggtgcccag cctcatctcc aaccatggca tcttctctct
     1501 gcctagcagc agtgctgcca cagccctgct gatccagcgc accaatgagg aggagaagtg
     1561 gctggcgcgg cagcggcggc tgcggcagga gaaggaggac cggcagtctc aggtgtccga
     1621 gttccggcag caggtgctgg agcagcacct ggatatgggc cggcccccgg tgccggcgga
     1681 ggcagagcac aggccggaga gcaccaccag gccaggacca aaccgtcacg agccaggtgg
     1741 ccgtgaccct ccgcagcact ttggggggcc accacctctg atttcgccca agccccagct
     1801 ccatgctgca cccacggccc tctggaaccc cgtgtccctg atggacaaca ccttggagac
     1861 gcggcgggcc gaaagccact ctctgcacag ccacccggct gcatttgagc ccagccgcca
     1921 ggcagccgtg ccgctggtga aggtggagcg ggtcttctgc ccggagaaag cagaggaggg
     1981 gccacggaag cgtgagcctg cccctctgga caagtaccag ccacctccgc cgccaccacg
     2041 agagggaggg agcctggagc accagccctt cctgcccggg cccgggccct tcctggctga
     2101 gctcgagaag tccacccaga ccatcctggg ccagcagcgg gcctccctcc cacaggcggc
     2161 caccttcggg gagctcagcg gacccctgaa gcctggctcg ccctaccggc ccccagtgcc
     2221 acgggccccc gaccctgcct acatctatga tgagttcctg cagcagcgcc ggaggctggt
     2281 cagcaagctg gacctggagg agcgcaggcg gcgggaggcc caggagaaag ggtactacta
     2341 cgacctcgat gactcttacg acgagagcga tgaggaggag gtcagggccc acctccgttg
     2401 cgtggccgag cagccgcccc tcaaactgga cacgtcctct gagaagctag agtttttgca
     2461 actttttggc ttgaccaccc aacagcagaa ggaggaattg gtggcccaga agcggaggaa
     2521 gcggcggagg atgctgcgag agagaagccc gtcgccccca acaattcaga gcaagcggca
     2581 gacgccttca ccgagactgg cgctgtctac ccgctacagc cctgatgaga tgaacaacag
     2641 tcccaacttc gaagaaaaga agaagttcct gaccatcttc aacctgaccc acatcagcgc
     2701 tgagaagagg aaagacaaag agagacttgt tgaaatgctc cgtgccatga agcagaaggc
     2761 actgtcagca gcagtggccg actccttgac aaactctccg agggacagtc ctgccgtctc
     2821 cctgagtgaa ccagccacgc agcaagcctc tctggatgtg gagaagccgg ttggtgttgc
     2881 tgcttccttg tctgacatcc caaaggccgc ggagcctggg aagctggaac aggtccggcc
     2941 ccaggagctg tcgagagtcc aggagctagc tcctgccagc ggggagaagg ccaggctgag
     3001 cgaggcccct ggaggcaaaa agagtctgag catgcttcac tatatccggg gcgctgcacc
     3061 caaggacatt cctgtgccgc tgtcccacag caccaatggg aagagcaagc cgtgggagcc
     3121 ctttgtggca gaagagtttg cacatcagtt ccacgagtca gtgctgcagt ccacccagaa
     3181 ggccctgcag aagcataaag ggagcgtggc tgtgctgtct gcagagcaga accacaaggt
     3241 tgacacgtcc gtccactaca acattcctga gctgcagtcc tccagccgcg cccctccacc
     3301 ccagcacaat gggcagcagg agccccccac tgcaaggaag ggccccccaa cccaggagtt
     3361 ggaccgggac tcggaggagg aggaagagga ggatgatgaa gatggagaag atgaggagga
     3421 agtccccaag cgcaagtggc aagggatcga ggccgttttt gaagcttacc aggaacacat
     3481 agaagagcaa aatctggagc ggcaggtgtt acagacacaa tgtagacgac tggaggcccg
     3541 gcactacagc ctcagcctga cggcagagca gctctcccac agcgtggcgg agttgaggag
     3601 ccagaaacag aagatggtct cagaaaggga gcggctccag gcagaactgg accacttacg
     3661 aaagtgcctt gccttgcctg caatgcactg gcctaggggc tacctgaagg gatatcccag
     3721 gtgacggttt cccttgcact aggccgaacc tatagtatag aaatattatc tattttatta
     3781 ccttgaatat ttaatatttt tcactgggag gtttgaagct tacaaaatga gaatgtgcca
     3841 tgcatgaagc aaaggattcc aggctccaga aaaaatgaat gaactcacct tgacgtcaat
     3901 gcaattgaat caccgttgtc attcagcgag caaccaatgt aggattgccc acagtttttc
     3961 tttttaaagg tggttttcgc ccttcctctc ccacattatt tcttaatctg aacatgaagg
     4021 ctccattagc aacactaaaa cttgatcatt aacagccccc tgtgcatatg agtggatcaa
     4081 accggttctg ttctttcttg tgttgccatg ttactatgcc tcaagcccag tttgcttttg
     4141 ccgcagcgat ggggccagtc tcattcctcc ccaggagtga aacttgcttc agctgaaaag
     4201 gttgggtgca ttgtcagtaa aaagggctta tttgtttcat tttactttcc tgcaaaattt
     4261 tcttcaaagc aacaagtcct aggagcacac aaagcaaccc aaaggctttt ccctggaaaa
     4321 gctctttctt acctaaagat aaaaccaatt cacaaactga aggtagcttt ttattactcc
     4381 gtggggagca tgtacagagc tctgtgtata cacagcttca cacccaccag attgttacta
     4441 cagtgggttg ggttttcata cagacgtaaa ttttgagaga aaagtcaaag gtgcttcagc
     4501 cttgtactgt gtatatatat taaaaaaaaa acaaagtttt gtatgttttt attactttaa
     4561 ctattgttat aaaaagcctg ccatttttaa tatgtggttt gggggatttt tgtttgtttt
     4621 tcctgtttgg gggttttgtt tgttgttttg gttttttttg ggcaaaaaaa aaaaaaaaac
     4681 cttgctttta gtgtttgtac tgctgctggt caggacatta aaatattgaa gtgtttttaa
     4741 aaattaaaga agaagaaaag taaaagagct taccactggc gcctatgcga tcacttcatt
     4801 tttagtttga gttgcaccag aagctgccgt agaaagccat gcgctactgc ttacctcctc
     4861 cactccccct gcctgccccc agcatctgga caagctaata gcaaatatta cccattgcta
     4921 tcaagggagg agggggtagt ctgtagaacc catgtgtgac agtcatgtgc acacatgggc
     4981 gggggctttt aaaaaccttt caggaagtca atgatttctg tgattgatat aattctaagg
     5041 tgtctgagag caggtacaga ataggaactt cagaggcttt gtttaaacgc aaagctttgt
     5101 aaaagccaca aggtctgagc tgaacccctc ctttttgaac ttactgtgac aagcacagga
     5161 acggtcagaa actgggctca tcacaccaag gcaaagcaac gggcgagtct tcctccttgt
     5221 cctagttact gcctatggag gcagtgttta gatcaagaag gcctctcttg ctcccaaggg
     5281 ccctcaccag aggccagggc tgccagtcac tggtctgggg ggtggaggcc tgagctgagg
     5341 gcagggtgcc tgacctgtgt gccggctgct cactgctgtg accagcagcc gagcccttgg
     5401 ccctagccct tgctgcgcag aacagcttgc tggcagctgg catcgtgtcg ctttatctgc
     5461 ccccgcacag tttgctttgt acgtctgcca agaatcttcc agttattagc aaactcagac
     5521 gaatgtaccg ccagtattat cagcagtcaa caagcacctt cctctccaca gaagcagctg
     5581 gaagagaact cgaggggctg tgctgcaggc ctcccctcga aagacactgg gaggtcagca
     5641 tgttccacag gtgttcagag ggagtctgct acaaactatc agggcaaaat ctcactggat
     5701 ttctccactg aaaacctact tgaggtttct ggtctgaagg cttaagagtc acatcttagc
     5761 acttccgctc tcaggcctcc tcctccatca cagatgtctg gatgcttttg gaaatggcct
     5821 tggctaaagt aaaagggaaa agtagatccg ataacttaaa aacgtagctc atcccttacc
     5881 atccaagggg cactcccttg gttggatttt ctatgacagc acaggggaca ggtggcacac
     5941 catgagaggt ctgcccaggg tgggagcagt gtcactgtgc tagcaatagt tggcttctcc
     6001 cctgtcagtg gaaaccccac ttctgcccgg cccttgagct tcttgcccac tgtctcccca
     6061 tccttccacc tacttgtggc gatctgagta ctctactctt gctcaagaag taatacgaca
     6121 atcagaatac aaaccagtaa ggcaacacga ataaactaag aaaaaggtaa gaactgtctc
     6181 aaaaacgaaa gcacaccacc caagacacag tacccagtca tggtttcccc atccaactat
     6241 tagtttcata ctttgaaaac ttactttcag attattctca aagaacacag tagcacctaa
     6301 atctgttttc aattgggctt aaaaattgac atgcaatctc ttaagttttt tgttcagcta
     6361 cttcacactg agtacctcaa atctgctctg gagtcgatta tgccacctgt gtgtcaggat
     6421 gcacctgaaa gccctcggct cggtccttag accatcttcc tacattacct ggaagggagc
     6481 tgccatctgt ccctctgcag agggatacct tccaatagta aattatctgg ttcctcactg
     6541 aaacaagtta tttttgcttc atatagtcag agtcagactg acatgataaa atatcatgtt
     6601 cctaatctgt tgtctcagat aagtgaccaa gacgggactt tccacatttt agtctacatt
     6661 ctaatcttaa aggaataaag cactgaattg ggactaacat tctgataggt tgcaccctta
     6721 agagtattca gagagcatca aaaggagccc acaccttcag cagtgaagga ttctaacaca
     6781 gggaatctgc agtttgtagc agaatggtat tttcctcaag tagctcataa tactgccaaa
     6841 tctcaaaagt taagctgaat ttcacaccag atcctacccc tttccctgag ccacatgttt
     6901 cacacaagtg tagaaaatgc cagggatcca ccacaagatg gagatggtca gcacaaaccg
     6961 attctgttcc tctttaaagt gtatattagc cacttagcaa tctctatatt ctttcaagta
     7021 accaagctgt tgactttctt actacttgca gtagcctgtc cccaactttt ccatccagtg
     7081 cttaacctaa aaaactcctt aactctgcct tgacctgagg aagaccatgc taactggtgt
     7141 tattttgtat gtaccctgtg cttaattcta taacagtaaa ccccatacgc aggtgggagg
     7201 gaggaacacc ggtgcctcgg tcactctggg ggcagtttag atgctgtgaa attaaacctg
     7261 ttctaagtgt acttgtttga attaattgta ttgtaatatt atttgttgaa tgtagtaatt
     7321 aggtatttat gaatatattg ctgtaatttc tgacaacatc caaaaaataa aatcttccta
     7381 aatta
//
