LOCUS       NM_024736               1723 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens gasdermin D (GSDMD), transcript variant 1, mRNA.
ACCESSION   NM_024736
VERSION     NM_024736.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Gao,K., Liu,Y., Sun,C., Wang,Y., Bao,H., Liu,G., Ou,J. and Sun,P.
  TITLE     TNF-a induces mitochondrial dysfunction to drive
            NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells
  JOURNAL   Sci Rep 14 (1), 25880 (2024)
   PUBMED   39468189
  REMARK    GeneRIF: TNF-a induces mitochondrial dysfunction to drive
            NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Chi,Z., Chen,S., Yang,D., Cui,W., Lu,Y., Wang,Z., Li,M., Yu,W.,
            Zhang,J., Jiang,Y., Sun,R., Yu,Q., Hu,T., Lu,X., Deng,Q., Yang,Y.,
            Zhao,T., Chang,M., Li,Y., Zhang,X., Shang,M., Xiao,Q., Ding,K. and
            Wang,D.
  TITLE     Gasdermin D-mediated metabolic crosstalk promotes tissue repair
  JOURNAL   Nature 634 (8036), 1168-1177 (2024)
   PUBMED   39260418
  REMARK    GeneRIF: Gasdermin D-mediated metabolic crosstalk promotes tissue
            repair.
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Liu,Z., Li,S., Wang,C., Vidmar,K.J., Bracey,S., Li,L., Willard,B.,
            Miyagi,M., Lan,T., Dickinson,B.C., Osme,A., Pizarro,T.T. and
            Xiao,T.S.
  TITLE     Palmitoylation at a conserved cysteine residue facilitates
            gasdermin D-mediated pyroptosis and cytokine release
  JOURNAL   Proc Natl Acad Sci U S A 121 (29), e2400883121 (2024)
   PUBMED   38980908
  REMARK    GeneRIF: Palmitoylation at a conserved cysteine residue facilitates
            gasdermin D-mediated pyroptosis and cytokine release.
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Chen,L., Liu,Y., Yue,S., Wang,H., Chen,J., Ma,W., Xu,W., Xu,M.,
            Chen,Z., Chen,X., Zhang,L. and Liang,C.
  TITLE     P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental
            Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell
            Pyroptosis
  JOURNAL   Int J Biol Sci 20 (9), 3393-3411 (2024)
   PUBMED   38993566
  REMARK    GeneRIF: P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate
            Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate
            Epithelial Cell Pyroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Ding,J., Wang,K., Liu,W., She,Y., Sun,Q., Shi,J., Sun,H., Wang,D.C.
            and Shao,F.
  TITLE     Pore-forming activity and structural autoinhibition of the
            gasdermin family
  JOURNAL   Nature 535 (7610), 111-116 (2016)
   PUBMED   27281216
  REMARK    Erratum:[Nature. 2016 Dec 1;540(7631):150. doi:
            10.1038/nature20106.. PMID: 27706141]
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   He,W.T., Wan,H., Hu,L., Chen,P., Wang,X., Huang,Z., Yang,Z.H.,
            Zhong,C.Q. and Han,J.
  TITLE     Gasdermin D is an executor of pyroptosis and required for
            interleukin-1beta secretion
  JOURNAL   Cell Res 25 (12), 1285-1298 (2015)
   PUBMED   26611636
  REMARK    GeneRIF: Gene deletion of GSDMD demonstrated that GSDMD is required
            for pyroptosis and for the secretion but not proteolytic maturation
            of IL-1beta in both canonical and non-canonical inflammasome
            responses.
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y.,
            Cai,T., Wang,F. and Shao,F.
  TITLE     Cleavage of GSDMD by inflammatory caspases determines pyroptotic
            cell death
  JOURNAL   Nature 526 (7575), 660-665 (2015)
   PUBMED   26375003
  REMARK    GeneRIF: caspase-1 and caspase-4/5/11 specifically cleaved the
            linker between the amino-terminal gasdermin-N and carboxy-terminal
            gasdermin-C domains in GSDMD, which was required and sufficient for
            pyroptosis
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Saeki,N., Usui,T., Aoyagi,K., Kim,D.H., Sato,M., Mabuchi,T.,
            Yanagihara,K., Ogawa,K., Sakamoto,H., Yoshida,T. and Sasaki,H.
  TITLE     Distinctive expression and function of four GSDM family genes
            (GSDMA-D) in normal and malignant upper gastrointestinal epithelium
  JOURNAL   Genes Chromosomes Cancer 48 (3), 261-271 (2009)
   PUBMED   19051310
  REMARK    GeneRIF: Study investigated the expression pattern of the GSDM
            family genes in the upper gastrointestinal epithelium and cancers.
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human DFNA5L, mouse Dfna5l,
            and rat Dfna5l genes in silico
  JOURNAL   Int J Oncol 25 (3), 765-770 (2004)
   PUBMED   15289881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008904.2 and BC069000.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024736.6.
            
            Summary: Gasdermin D is a member of the gasdermin family. Members
            of this family appear to play a role in regulation of epithelial
            proliferation. Gasdermin D has been suggested to act as a tumor
            suppressor. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008904.2, SRR3476690.260502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262580.9/ ENSP00000262580.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               BC008904.2         25-625
            602-602             BC069000.1         581-581
            603-1723            BC008904.2         627-1747
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1723
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /note="gasdermin D"
                     /db_xref="GeneID:79792"
                     /db_xref="HGNC:HGNC:25697"
                     /db_xref="MIM:617042"
     exon            1..106
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..327
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1565
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /note="gasdermin domain containing 1; gasdermin
                     domain-containing protein 1"
                     /codon_start=1
                     /product="gasdermin-D"
                     /protein_id="NP_079012.3"
                     /db_xref="CCDS:CCDS34956.1"
                     /db_xref="GeneID:79792"
                     /db_xref="HGNC:HGNC:25697"
                     /db_xref="MIM:617042"
                     /translation="MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKP
                     SSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQA
                     KIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVV
                     TEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRV
                     AQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDG
                     VPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALE
                     QGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEA
                     LESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELG
                     EDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH"
     exon            328..520
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..689
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..792
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..846
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..933
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1106
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1248
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1322
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1723
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1700..1705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /note="hexamer: AATAAA"
     polyA_site      1723
                     /gene="GSDMD"
                     /gene_synonym="DF5L; DFNA5L; FKSG10; GSDMDC1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtttcac ttttagctct gggcacctcc agctcctgct cgccggacgg ctcccaggga
       61 gagcagacgc gccagacgcg ccaccctcgg ggcgccgacg gtcacggagc atggggtcgg
      121 cctttgagcg ggtagtccgg agagtggtcc aggagctgga ccatggtggg gagttcatcc
      181 ctgtgaccag cctgcagagc tccactggct tccagcccta ctgcctggtg gttaggaagc
      241 cctcaagctc atggttctgg aaaccccgtt ataagtgtgt caacctgtct atcaaggaca
      301 tcctggagcc ggatgccgcg gaaccagacg tgcagcgtgg caggagcttc cacttctacg
      361 atgccatgga tgggcagata cagggcagcg tggagctggc agccccagga caggcaaaga
      421 tcgcaggcgg ggccgcggtg tctgacagct ccagcacctc aatgaatgtg tactcgctga
      481 gtgtggaccc taacacctgg cagactctgc tccatgagag gcacctgcgg cagccagaac
      541 acaaagtcct gcagcagctg cgcagccgcg gggacaacgt gtacgtggtg actgaggtgc
      601 tgcagacaca gaaggaggtg gaagtcacgc gcacccacaa gcgggagggc tcgggccggt
      661 tttccctgcc cggagccacg tgcttgcagg gtgagggcca gggccatctg agccagaaga
      721 agacggtcac catcccctca ggcagcaccc tcgcattccg ggtggcccag ctggttattg
      781 actctgactt ggacgtcctt ctcttcccgg ataagaagca gaggaccttc cagccacccg
      841 cgacaggcca caagcgttcc acgagcgaag gcgcctggcc acagctgccc tctggcctct
      901 ccatgatgag gtgcctccac aacttcctga cagatggggt ccctgcggag ggggcgttca
      961 ctgaagactt ccagggccta cgggcagagg tggagaccat ctccaaggaa ctggagcttt
     1021 tggacagaga gctgtgccag ctgctgctgg agggcctgga gggggtgctg cgggaccagc
     1081 tggccctgcg agccttggag gaggcgctgg agcagggcca gagccttggg ccggtggagc
     1141 ccctggacgg tccagcaggt gctgtcctgg agtgcctggt gttgtcctcc ggaatgctgg
     1201 tgccggaact cgctatccct gttgtctacc tgctgggggc actgaccatg ctgagtgaaa
     1261 cgcagcacaa gctgctggcg gaggcgctgg agtcgcagac cctgttgggg ccgctcgagc
     1321 tggtgggcag cctcttggag cagagtgccc cgtggcagga gcgcagcacc atgtccctgc
     1381 cccccgggct cctggggaac agctggggcg aaggagcacc ggcctgggtc ttgctggacg
     1441 agtgtggcct agagctgggg gaggacactc cccacgtgtg ctgggagccg caggcccagg
     1501 gccgcatgtg tgcactctac gcctccctgg cactgctatc aggactgagc caggagcccc
     1561 actagcctgt gcccgggcat ggcctggcag ctctccagca gggcagagtg tttgcccacc
     1621 agctgctagc cctaggaagg ccaggagccc agtagccatg tggccagtct accatggggc
     1681 ccaggagttg gggaaacaca ataaaggtgg catacgaagg aaa
//
