LOCUS       NM_001165958            1584 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens gasdermin B (GSDMB), transcript variant 3, mRNA.
ACCESSION   NM_001165958
VERSION     NM_001165958.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1584)
  AUTHORS   Xie,X., Shen,X., Liu,Y., Zuo,Y., Wang,S., Zhou,Y., Li,X., Wang,K.,
            Li,B. and Wang,Z.
  TITLE     GSDMB involvement in the pathogenesis of abdominal aortic aneurysm
            through regulation of macrophage non-canonical pyroptosis
  JOURNAL   Arch Biochem Biophys 759, 110102 (2024)
   PUBMED   39029644
  REMARK    GeneRIF: GSDMB involvement in the pathogenesis of abdominal aortic
            aneurysm through regulation of macrophage non-canonical pyroptosis.
REFERENCE   2  (bases 1 to 1584)
  AUTHORS   Colomo,S., Ros-Pardo,D., Oltra,S.S., Gomez-Puertas,P., Sarrio,D.
            and Moreno-Bueno,G.
  TITLE     Structural and functional insights into GSDMB isoforms complex
            roles in pathogenesis
  JOURNAL   Cell Cycle 22 (20), 2346-2359 (2023)
   PUBMED   38037340
  REMARK    GeneRIF: Structural and functional insights into GSDMB isoforms
            complex roles in pathogenesis.
            Review article
REFERENCE   3  (bases 1 to 1584)
  AUTHORS   Oltra,S.S., Colomo,S., Sin,L., Perez-Lopez,M., Lazaro,S.,
            Molina-Crespo,A., Choi,K.H., Ros-Pardo,D., Martinez,L., Morales,S.,
            Gonzalez-Paramos,C., Orantes,A., Soriano,M., Hernandez,A.,
            Lluch,A., Rojo,F., Albanell,J., Gomez-Puertas,P., Ko,J.K.,
            Sarrio,D. and Moreno-Bueno,G.
  TITLE     Distinct GSDMB protein isoforms and protease cleavage processes
            differentially control pyroptotic cell death and mitochondrial
            damage in cancer cells
  JOURNAL   Cell Death Differ 30 (5), 1366-1381 (2023)
   PUBMED   36899106
REFERENCE   4  (bases 1 to 1584)
  AUTHORS   Zhong,X., Zeng,H., Zhou,Z., Su,Y., Cheng,H., Hou,Y., She,Y.,
            Feng,N., Wang,J., Shao,F. and Ding,J.
  TITLE     Structural mechanisms for regulation of GSDMB pore-forming activity
  JOURNAL   Nature 616 (7957), 598-605 (2023)
   PUBMED   36991125
REFERENCE   5  (bases 1 to 1584)
  AUTHORS   Wang,C., Shivcharan,S., Tian,T., Wright,S., Ma,D., Chang,J., Li,K.,
            Song,K., Xu,C., Rathinam,V.A. and Ruan,J.
  TITLE     Structural basis for GSDMB pore formation and its targeting by
            IpaH7.8
  JOURNAL   Nature 616 (7957), 590-597 (2023)
   PUBMED   36991122
  REMARK    GeneRIF: Structural basis for GSDMB pore formation and its
            targeting by IpaH7.8.
REFERENCE   6  (bases 1 to 1584)
  AUTHORS   Huh,J.W., Kim,D.S., Kang,D.W., Ha,H.S., Ahn,K., Noh,Y.N., Min,D.S.,
            Chang,K.T. and Kim,H.S.
  TITLE     Transcriptional regulation of GSDML gene by antisense-oriented
            HERV-H LTR element
  JOURNAL   Arch Virol 153 (6), 1201-1205 (2008)
   PUBMED   18478180
REFERENCE   7  (bases 1 to 1584)
  AUTHORS   Sin,H.S., Huh,J.W., Kim,D.S., Kang,D.W., Min,D.S., Kim,T.H.,
            Ha,H.S., Kim,H.H., Lee,S.Y. and Kim,H.S.
  TITLE     Transcriptional control of the HERV-H LTR element of the GSDML gene
            in human tissues and cancer cells
  JOURNAL   Arch Virol 151 (10), 1985-1994 (2006)
   PUBMED   16625320
REFERENCE   8  (bases 1 to 1584)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1584)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Evolutionary recombination hotspot around GSDML-GSDM locus is
            closely linked to the oncogenomic recombination hotspot around the
            PPP1R1B-ERBB2-GRB7 amplicon
  JOURNAL   Int J Oncol 24 (4), 757-763 (2004)
   PUBMED   15010812
  REMARK    GeneRIF: Evolutionary recombination hotspot around the GSDML-GSDM
            locus is closely linked to oncogenomic recombination hotspot around
            the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at
            human chromosome 17q12.
REFERENCE   10 (bases 1 to 1584)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human ZPBP-like gene in
            silico
  JOURNAL   Int J Mol Med 12 (3), 399-404 (2003)
   PUBMED   12883658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB136981.1, AK000409.1 and
            BX538068.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001165958.1.
            
            Summary: This gene encodes a member of the gasdermin-domain
            containing protein family. Other gasdermin-family genes are
            implicated in the regulation of apoptosis in epithelial cells, and
            are linked to cancer. Alternative splicing and the use of
            alternative promoters results in multiple transcript variants.
            Additional variants have been described, but they are candidates
            for nonsense-mediated mRNA decay (NMD) and are unlikely to be
            protein-coding. [provided by RefSeq, Nov 2016].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.12093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418519.6/ ENSP00000415049.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CB136981.1         16-60
            46-321              AK000409.1         1-276
            322-1584            BX538068.1         1-1263
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..1584
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /note="gasdermin B"
                     /db_xref="GeneID:55876"
                     /db_xref="HGNC:HGNC:23690"
                     /db_xref="MIM:611221"
     exon            1..102
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            103..351
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1367
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /note="isoform 3 is encoded by transcript variant 3;
                     gasdermin-like protein; gasderminB-1"
                     /codon_start=1
                     /product="gasdermin-B isoform 3"
                     /protein_id="NP_001159430.1"
                     /db_xref="CCDS:CCDS54120.1"
                     /db_xref="GeneID:55876"
                     /db_xref="HGNC:HGNC:23690"
                     /db_xref="MIM:611221"
                     /translation="MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKR
                     TFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPK
                     EITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTE
                     TLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKE
                     TMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDV
                     LNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAI
                     LDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEAR
                     ILCALYVVVSILLELAEGPTSVSS"
     exon            352..523
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            524..692
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            693..777
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            778..816
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            817..843
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1004
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1143
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1214
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1584
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /note="hexamer: ATTAAA"
     polyA_site      1584
                     /gene="GSDMB"
                     /gene_synonym="GSDMB-1; GSDML; PP4052; PRO2521"
                     /note="major polyA site"
ORIGIN      
        1 attattttag cttcctgaga ttcagaggcc aggaactgtg cagagatctg tggggattct
       61 cacaacttcc atttctggtg aacagctgag gtcagagagg agttggtcca ggcgcaatgt
      121 tcagcgtatt tgaggaaatc acaagaattg tagttaagga gatggatgct ggaggggata
      181 tgattgccgt tagaagcctt gttgatgctg atagattccg ctgcttccat ctggtggggg
      241 agaagagaac tttctttgga tgccggcact acacaacagg cctcaccctg atggacattc
      301 tggacacaga tggggacaag tggttagatg aactggattc tgggctccaa ggtcaaaagg
      361 ctgagtttca aattctggat aatgtagact caacgggaga gttgatagtg agattaccca
      421 aagaaataac aatttcaggc agtttccagg gcttccacca tcagaaaatc aagatatcgg
      481 agaaccggat atcccagcag tatctggcta cccttgaaaa caggaagctg aagagggaac
      541 tacccttttc attccgatca attaatacga gagaaaacct gtatctggtg acagaaactc
      601 tggagacggt aaaggaggaa accctgaaaa gcgaccggca atataaattt tggagccaga
      661 tctctcaggg ccatctcagc tataaacaca agggccaaag ggaagtgacc atccccccaa
      721 atcgggtcct gagctatcga gtaaagcagc ttgtcttccc caacaaggag acgatgaata
      781 ttcatttcag gggcaaaaca aaatcctttc cagaagagaa ggatggtgct tcatcctgtt
      841 taggaaagtc tttgggttcg gaggattcca gaaacatgaa ggagaagttg gaggacatgg
      901 agagtgtcct caaggacctg acagaggaga agagaaaaga tgtgctaaac tccctcgcta
      961 agtgcctcgg caaggaggat attcggcagg atctagagca aagagtatct gaggtcctga
     1021 tttccgggga gctacacatg gaggacccag acaagcctct cctaagcagc ctttttaatg
     1081 ctgctggggt cttggtagaa gcgcgtgcaa aagccattct ggacttcctg gatgccctgc
     1141 tagagctgtc tgaagagcag cagtttgtgg ctgaggccct ggagaagggg acccttcctc
     1201 tgttgaagga ccaggtgaaa tctgtcatgg agcagaactg ggatgagctg gccagcagtc
     1261 ctcctgacat ggactatgac cctgaggcac gaattctctg tgcgctgtat gttgttgtct
     1321 ctatcctgct ggagctggct gaggggccta cctctgtctc ttcctaacta caaaagccct
     1381 ttctccccac aagcctctgg gttttccctt taccagtctg tcctcactgc catcgccact
     1441 accatcctgt caccagtggg acctctttaa aacaagcagc caaccattct ttgatgtatc
     1501 ccattcgctc catgttaaca tccaaaacca gcctggattt catacatgga cttctgatta
     1561 aaagtggcag gttgtgcatg ttaa
//
