LOCUS       NM_178171               2135 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens gasdermin A (GSDMA), mRNA.
ACCESSION   NM_178171
VERSION     NM_178171.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Li,X., Li,X., Xiang,C., Cao,J., Guo,J., Zhu,S., Tan,J., Wang,L.,
            Gao,C., Liu,S., Zhao,L., Yuan,B., Xu,P., Yang,B., Li,D., Zhao,B.
            and Feng,X.H.
  TITLE     Starvation-induced phosphorylation activates gasdermin A to
            initiate pyroptosis
  JOURNAL   Cell Rep 43 (9), 114728 (2024)
   PUBMED   39264808
  REMARK    GeneRIF: Starvation-induced phosphorylation activates gasdermin A
            to initiate pyroptosis.
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Wang,H., Wang,H., Chen,J., Liu,P. and Xiao,X.
  TITLE     Overexpressed FAM111B degrades GSDMA to promote esophageal cancer
            tumorigenesis and cisplatin resistance
  JOURNAL   Cell Oncol (Dordr) 47 (1), 343-359 (2024)
   PUBMED   37672204
  REMARK    GeneRIF: Overexpressed FAM111B degrades GSDMA to promote esophageal
            cancer tumorigenesis and cisplatin resistance.
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Liu,X., Zhang,L., Zhu,B., Liu,Y., Li,L., Hou,J., Qian,M., Zheng,N.,
            Zeng,Y., Chen,C., Goel,A. and Wang,X.
  TITLE     Role of GSDM family members in airway epithelial cells of lung
            diseases: a systematic and comprehensive transcriptomic analysis
  JOURNAL   Cell Biol Toxicol 39 (6), 2743-2760 (2023)
   PUBMED   37462807
  REMARK    GeneRIF: Role of GSDM family members in airway epithelial cells of
            lung diseases: a systematic and comprehensive transcriptomic
            analysis.
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Huang,L.Y., Li,S.T., Lin,S.C., Kao,C.H., Hong,C.H., Lee,C.H. and
            Yang,L.T.
  TITLE     Gasdermin A Is Required for Epidermal Cornification during Skin
            Barrier Regeneration and in an Atopic Dermatitis-Like Model
  JOURNAL   J Invest Dermatol 143 (9), 1735-1745 (2023)
   PUBMED   36965577
  REMARK    GeneRIF: Gasdermin A Is Required for Epidermal Cornification during
            Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   LaRock,D.L., Johnson,A.F., Wilde,S., Sands,J.S., Monteiro,M.P. and
            LaRock,C.N.
  TITLE     Group A Streptococcus induces GSDMA-dependent pyroptosis in
            keratinocytes
  JOURNAL   Nature 605 (7910), 527-531 (2022)
   PUBMED   35545676
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Saeki,N., Kim,D.H., Usui,T., Aoyagi,K., Tatsuta,T., Aoki,K.,
            Yanagihara,K., Tamura,M., Mizushima,H., Sakamoto,H., Ogawa,K.,
            Ohki,M., Shiroishi,T., Yoshida,T. and Sasaki,H.
  TITLE     GASDERMIN, suppressed frequently in gastric cancer, is a target of
            LMO1 in TGF-beta-dependent apoptotic signalling
  JOURNAL   Oncogene 26 (45), 6488-6498 (2007)
   PUBMED   17471240
  REMARK    GeneRIF: The present data suggest that TGF-beta, LMO1, possibly
            RUNX3, and GSDM form a regulatory pathway for directing the pit
            cells to apoptosis.
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Tamura,M., Tanaka,S., Fujii,T., Aoki,A., Komiyama,H., Ezawa,K.,
            Sumiyama,K., Sagai,T. and Shiroishi,T.
  TITLE     Members of a novel gene family, Gsdm, are expressed exclusively in
            the epithelium of the skin and gastrointestinal tract in a highly
            tissue-specific manner
  JOURNAL   Genomics 89 (5), 618-629 (2007)
   PUBMED   17350798
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Evolutionary recombination hotspot around GSDML-GSDM locus is
            closely linked to the oncogenomic recombination hotspot around the
            PPP1R1B-ERBB2-GRB7 amplicon
  JOURNAL   Int J Oncol 24 (4), 757-763 (2004)
   PUBMED   15010812
  REMARK    GeneRIF: Evolutionary recombination hotspot around the GSDML-GSDM
            locus is closely linked to oncogenomic recombination hotspot around
            the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at
            human chromosome 17q12.
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human ZPBP-like gene in
            silico
  JOURNAL   Int J Mol Med 12 (3), 399-404 (2003)
   PUBMED   12883658
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Saeki,N., Kuwahara,Y., Sasaki,H., Satoh,H. and Shiroishi,T.
  TITLE     Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly
            expressed in upper gastrointestinal tract but significantly
            suppressed in human gastric cancer cells
  JOURNAL   Mamm Genome 11 (9), 718-724 (2000)
   PUBMED   10967128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096439.1, AF307953.1, AC090844.7 and AA826386.1.
            
            On May 17, 2019 this sequence version replaced NM_178171.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096439.1, BC109197.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301659.9/ ENSP00000301659.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AK096439.1         34-501
            469-479             AF307953.1         412-422
            480-1396            AK096439.1         513-1429
            1397-1485           AF307953.1         1343-1431
            1486-1658           AK096439.1         1519-1691
            1659-1659           AC090844.7         47784-47784         c
            1660-1676           AK096439.1         1693-1709
            1677-1689           AK096439.1         1712-1724
            1690-1690           AC090844.7         47753-47753         c
            1691-1762           AK096439.1         1726-1797
            1763-1763           AC090844.7         47680-47680         c
            1764-1855           AK096439.1         1799-1890
            1856-1905           AA826386.1         18-67
            1906-2133           AK096439.1         1941-2168
            2134-2135           AC090844.7         47308-47309         c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..2135
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /note="gasdermin A"
                     /db_xref="GeneID:284110"
                     /db_xref="HGNC:HGNC:13311"
                     /db_xref="MIM:611218"
     exon            1..82
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..301
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1425
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /note="gasdermin-1"
                     /codon_start=1
                     /product="gasdermin-A"
                     /protein_id="NP_835465.2"
                     /db_xref="CCDS:CCDS45669.1"
                     /db_xref="GeneID:284110"
                     /db_xref="HGNC:HGNC:13311"
                     /db_xref="MIM:611218"
                     /translation="MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRK
                     STLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVK
                     GTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETV
                     QEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEW
                     DIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSR
                     VGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILY
                     FVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSL
                     GDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS"
     exon            302..479
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..645
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..742
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..790
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..817
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..838
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..993
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1108
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1182
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2135
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2135
                     /gene="GSDMA"
                     /gene_synonym="FKSG9; GSDM; GSDM1"
                     /note="major polyA site"
ORIGIN      
        1 atcctctcaa cctacagacc cagtgagccc taggccctca ccccagaccc agctgctgga
       61 taggacccag ccccgctccc agagacaatg accatgtttg aaaatgtcac ccgggccctg
      121 gccagacagc taaaccctcg aggggacctg acaccacttg acagcctcat cgacttcaag
      181 cgcttccatc ccttctgcct ggtgctgagg aagaggaaga gcacgctctt ctggggggcc
      241 cggtacgtcc gcaccgacta cacgctgctg gatgtgcttg agcccggcag ctcaccttca
      301 gacccaacag acactgggaa ttttggcttt aagaatatgc tggacacccg agtggaggga
      361 gatgtggatg taccaaagac ggtgaaggtg aagggaacgg cagggctctc gcagaacagc
      421 actctggagg tccagacact cagtgtggct cccaaggccc tggagaccgt gcaggagagg
      481 aagctggcag cagaccaccc attcctgaag gagatgcaag atcaagggga gaacctgtat
      541 gtggtgatgg aggtggtgga gacggtgcag gaggtcacac tggagcgagc cggcaaggca
      601 gaggcctgct tctccctccc cttcttcgcc ccattggggc tacagggatc cataaatcac
      661 aaggaggctg taaccatccc caagggctgc gtcctggcct ttcgagtgag acagctgatg
      721 gtcaaaggca aagatgagtg ggatattcca catatctgca atgataacat gcaaaccttc
      781 cctcctggag aaaagtcagg agaggagaag gtcatcctta tccaggcatc tgatgttggg
      841 gacgtacacg aaggcttcag gacactaaaa gaagaagttc agagagagac ccaacaagtg
      901 gagaagctga gccgagtagg gcaaagctcc ctgctcagct ccctcagcaa acttctaggg
      961 aagaaaaagg agctacaaga ccttgagctc gcacttgaag gggctctaga caagggacat
     1021 gaagtgaccc tggaggcact cccaaaagat gtcctgctat caaaggaggc cgtgggcgcc
     1081 atcctctatt tcgttggagc cctaacagag ctaagtgaag cccaacagaa gctgctggtg
     1141 aaatccatgg agaaaaagat cctacccgtg cagctaaagc tggtggagag cacgatggaa
     1201 cagaacttcc tgctggataa agagggtgtt ttccccctgc aacctgagct gctctcctcc
     1261 cttggggacg aggagctgac cctcacggag gctctagtcg ggctgagtgg cctggaagtg
     1321 cagagatcgg gcccccaata tatgtgggac ccagacaccc tccctcgcct ctgtgctctt
     1381 tatgcaggcc tctctctcct tcagcagctt accaaggcct cctaatttgc cttttacgtc
     1441 tgcttcatga ctccctaatg ccttcccaac ctcgtggtgc tgtgtcctta ccacctaagg
     1501 gcatttcaga gccatcagct gaagacatct gaaatctcag ctggtcaccc atgataacca
     1561 acttccacct gcccaaccat atatcacccc ctacccctcc agctccgcaa cccactaagc
     1621 ccatctgctg atgcttaaat tttctttact tttcttttct tttttttttt ttttttgaga
     1681 tggaggctca ctctgtcacc caggctggag tgcagtggct tgatcttggc tcactgcaac
     1741 ctccgcctcc caggttcaag caattctcct gcctcagcct ctcgagcagc tggaattaca
     1801 ggcacgtgcc acgacaccca gctaattttt gtatttttag tagagacggg gtttcaccat
     1861 gttgcccagg ttggtctcga actcctggcc tcaagtgatc tgcccgcctc ggcctcccaa
     1921 agtgctggga ttacaggcgt gagccaccgt gcccggcctg tgcttaaata ttctaggagt
     1981 agaagcactc agacttttaa aactatgagc cgtttcagca aaactgagaa aaaaagaaga
     2041 ttaattaatt tcctatccta atccctccta cttatacttc cccaaaaaac aagctttact
     2101 ggaattaatg gaaaatatta tgtcaatctt aggaa
//
