LOCUS       NM_024719               1415 bp    mRNA    linear   PRI 12-JUL-2024
DEFINITION  Homo sapiens growth hormone regulated TBC protein 1 (GRTP1),
            transcript variant 1, mRNA.
ACCESSION   NM_024719
VERSION     NM_024719.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   3  (bases 1 to 1415)
  AUTHORS   Lu,C., Kasik,J., Stephan,D.A., Yang,S., Sperling,M.A. and
            Menon,R.K.
  TITLE     Grtp1, a novel gene regulated by growth hormone
  JOURNAL   Endocrinology 142 (10), 4568-4571 (2001)
   PUBMED   11564724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX788865.1, BC062461.1, AW243250.1 and AL136221.38.
            
            On May 17, 2019 this sequence version replaced NM_024719.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080640.1, SRR7346977.481931.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375431.9/ ENSP00000364580.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               CX788865.1         19-152
            135-1379            BC062461.1         1-1245
            1380-1414           AW243250.1         1-35                c
            1415-1415           AL136221.38        115974-115974       c
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..1415
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /note="growth hormone regulated TBC protein 1"
                     /db_xref="GeneID:79774"
                     /db_xref="HGNC:HGNC:20310"
                     /db_xref="MIM:620890"
     exon            1..111
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1090
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /note="isoform 1 is encoded by transcript variant 1; TBC1
                     domain family member 6"
                     /codon_start=1
                     /product="growth hormone-regulated TBC protein 1 isoform
                     1"
                     /protein_id="NP_078995.2"
                     /db_xref="CCDS:CCDS9534.2"
                     /db_xref="GeneID:79774"
                     /db_xref="HGNC:HGNC:20310"
                     /db_xref="MIM:620890"
                     /translation="MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAI
                     KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGE
                     RNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFI
                     AGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGAL
                     MERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQEL
                     ILEATSVPDICDKFKQITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLA
                     QG"
     exon            112..260
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            261..419
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..544
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            545..641
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..814
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1000
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1415
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1359..1364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
                     /note="major polyA site"
     polyA_site      1415
                     /gene="GRTP1"
                     /gene_synonym="TBC1D6"
ORIGIN      
        1 ggaaggactt aagcgccccg gagccgggag gcgaacttgg gacccgctgg cctcgctcgg
       61 tgcgcgcctc cctccccgca tgcagcccgc cgagcgctcg cgggtcccca ggatcgaccc
      121 gtacggattc gagcggcctg aggacttcga cgacgccgcc tacgagaagt ttttctccag
      181 ctacctggtc acgctcaccc gcagggcgat caaatggtcc cggctgctgc agggcggggg
      241 cgtccccagg agccggacag tgaagcgcta tgtccggaaa ggggtcccgc tggagcaccg
      301 tgcccgcgtc tggatggtgc tgagtggggc ccaggcgcag atggaccaga atcccggcta
      361 ctaccaccag cttctccagg gagagagaaa ccccaggctg gaggacgcca tcaggacaga
      421 cctgaaccgg accttccccg acaacgtgaa gttccggaag accacggacc cctgcttaca
      481 gaggaccctg tacaatgtgc tgctggcata tgggcaccat aaccagggag tgggctactg
      541 ccagggaatg aattttatag caggatatct gattcttata acaaataatg aagaagaatc
      601 tttttggctg ttagatgctc ttgttggaag aatactacca gattactaca gcccggccat
      661 gctgggcctg aagaccgacc aggaggtcct cggggagctg gtgcgggcga agctgccggc
      721 tgtgggggcc ctgatggagc gtctcggtgt gctgtggacg ctgctggtgt cccgctggtt
      781 catctgcctg tttgtggaca tcttgcccgt ggagacagtg cttcggatct gggactgttt
      841 gtttaacgaa ggctcgaaga ttatcttccg ggtggccctg accttaatta agcagcacca
      901 ggagttgatt ttggaagcca ccagcgttcc agacatttgc gataagttta agcagataac
      961 caaagggagt ttcgtgatgg agtgtcacac gtttatgcag aaaatatttt cagaacctgg
     1021 aagcttatcc atggccaccg tcgccaagct ccgcgagagc tgcagggccc ggctgctggc
     1081 acaggggtga gcgtgcctgt cccctgcgtt gctcgtctct acactgacga tgcccctttc
     1141 cagagttgac actggaccaa ctttcactgc tttccttttt agtgttgtaa atacttgaca
     1201 tcactacact ttagttgtga attttttaaa agagcagttt aaaatcaggt cattctacca
     1261 gcttttgatg attagctatg aagtcatact ttttaaagaa aacttatttt tacctgagag
     1321 atcaataata tataaaatgt gagtgtgggt ttgtatctaa taaagtatgc caacacctgt
     1381 gtttgtgatc agtttctcag ctgactggaa attaa
//
