LOCUS       NM_002092               6610 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens G-rich RNA sequence binding factor 1 (GRSF1),
            transcript variant 1, mRNA.
ACCESSION   NM_002092
VERSION     NM_002092.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6610)
  AUTHORS   Wen,C., Jiang,L., Pan,P., Huang,J., Xie,Y., Ou,S. and Li,Y.
  TITLE     GRSF1 deficiency attenuates mitochondrial function in aging
            granulosa cells
  JOURNAL   Reproduction 168 (2), e240015 (2024)
   PUBMED   38819377
  REMARK    GeneRIF: GRSF1 deficiency attenuates mitochondrial function in
            aging granulosa cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6610)
  AUTHORS   Liu,D., Xu,C., Gong,Z., Zhao,Y., Fang,Z., Rao,X., Chen,Q., Li,G.,
            Kong,W. and Chen,J.
  TITLE     GRSF1 antagonizes age-associated hypercoagulability via modulation
            of fibrinogen mRNA stability
  JOURNAL   Cell Death Dis 14 (11), 717 (2023)
   PUBMED   37923734
  REMARK    GeneRIF: GRSF1 antagonizes age-associated hypercoagulability via
            modulation of fibrinogen mRNA stability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6610)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 6610)
  AUTHORS   Wang,B., Wang,L., Lu,Y., Liang,W., Gao,Y., Xi,H. and Chen,L.
  TITLE     GRSF1 promotes tumorigenesis and EMT-mediated metastasis through
            PI3K/AKT pathway in gastric cancer
  JOURNAL   Biochem Biophys Res Commun 555, 61-66 (2021)
   PUBMED   33813277
  REMARK    GeneRIF: GRSF1 promotes tumorigenesis and EMT-mediated metastasis
            through PI3K/AKT pathway in gastric cancer.
REFERENCE   5  (bases 1 to 6610)
  AUTHORS   Dumoulin,B., Ufer,C., Stehling,S., Heydeck,D., Kuhn,H. and Sofi,S.
  TITLE     Identification of the COMM-domain containing protein 1 as specific
            binding partner for the guanine-rich RNA sequence binding factor 1
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129678 (2020)
   PUBMED   32645484
  REMARK    GeneRIF: Identification of the COMM-domain containing protein 1 as
            specific binding partner for the guanine-rich RNA sequence binding
            factor 1.
REFERENCE   6  (bases 1 to 6610)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6610)
  AUTHORS   Kash,J.C., Cunningham,D.M., Smit,M.W., Park,Y., Fritz,D., Wilusz,J.
            and Katze,M.G.
  TITLE     Selective translation of eukaryotic mRNAs: functional molecular
            analysis of GRSF-1, a positive regulator of influenza virus protein
            synthesis
  JOURNAL   J Virol 76 (20), 10417-10426 (2002)
   PUBMED   12239318
  REMARK    GeneRIF: GRSF-1 functions by selectively recruiting cellular and
            viral mRNAs containing 5' UTR GRSF-1 binding sites to
            polyribosomes, which is mediated through interactions with cellular
            proteins
REFERENCE   8  (bases 1 to 6610)
  AUTHORS   Park,Y.W., Wilusz,J. and Katze,M.G.
  TITLE     Regulation of eukaryotic protein synthesis: selective influenza
            viral mRNA translation is mediated by the cellular RNA-binding
            protein GRSF-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6694-6699 (1999)
   PUBMED   10359774
REFERENCE   9  (bases 1 to 6610)
  AUTHORS   Banga,S.S., Ozer,H.L. and Wilusz,J.
  TITLE     Assignment of GRSF1 encoding a poly(A)+ mRNA binding protein to
            human chromosome 4q13
  JOURNAL   Cytogenet Cell Genet 73 (4), 295-296 (1996)
   PUBMED   8751379
REFERENCE   10 (bases 1 to 6610)
  AUTHORS   Qian,Z. and Wilusz,J.
  TITLE     GRSF-1: a poly(A)+ mRNA binding protein which interacts with a
            conserved G-rich element
  JOURNAL   Nucleic Acids Res 22 (12), 2334-2343 (1994)
   PUBMED   8036161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021989.8.
            
            On Nov 23, 2018 this sequence version replaced NM_002092.3.
            
            Summary: The protein encoded by this gene is a cellular protein
            that binds RNAs containing the G-rich element. The protein is
            localized in the cytoplasm, and has been shown to stimulate
            translation of viral mRNAs in vitro. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.49588.1,
                                           SRR1803613.204825.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254799.11/ ENSP00000254799.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC021989.8         44715-45134         c
            421-577             AC021989.8         41402-41558         c
            578-733             AC021989.8         38362-38517         c
            734-877             AC021989.8         37551-37694         c
            878-1013            AC021989.8         36783-36918         c
            1014-1198           AC021989.8         33096-33280         c
            1199-1320           AC021989.8         31368-31489         c
            1321-1456           AC021989.8         30540-30675         c
            1457-1531           AC021989.8         29538-29612         c
            1532-6610           AC021989.8         21027-26105         c
FEATURES             Location/Qualifiers
     source          1..6610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..6610
                     /gene="GRSF1"
                     /note="G-rich RNA sequence binding factor 1"
                     /db_xref="GeneID:2926"
                     /db_xref="HGNC:HGNC:4610"
                     /db_xref="MIM:604851"
     exon            1..420
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1506
                     /gene="GRSF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G-rich sequence factor 1"
                     /codon_start=1
                     /product="G-rich sequence factor 1 isoform 1"
                     /protein_id="NP_002083.4"
                     /db_xref="CCDS:CCDS47069.1"
                     /db_xref="GeneID:2926"
                     /db_xref="HGNC:HGNC:4610"
                     /db_xref="MIM:604851"
                     /translation="MAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSAAGSIPSGVS
                     GRRRLLLLLGAAAAAASQTRGLQTGPVPPGRLAGPPAVATSAAAAAAASYSALRASLL
                     PQSLAAAAAVPTRSYSQESKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWS
                     CTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMG
                     QRYVEVYEINNEDVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIV
                     DITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIFPSRRNEVRTHVG
                     SYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAA
                     DFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFETH
                     EDAVAAMLKDRSHVHHRYIELFLNSCPKGK"
     exon            421..577
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..733
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..877
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1013
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1198
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1320
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1456
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1531
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..6610
                     /gene="GRSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRSF1"
                     /note="hexamer: AATAAA"
     polyA_site      2639
                     /gene="GRSF1"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRSF1"
                     /note="hexamer: AATGAA"
     polyA_site      2862
                     /gene="GRSF1"
                     /note="major polyA site"
     regulatory      6585..6590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRSF1"
                     /note="hexamer: AATAAA"
     polyA_site      6610
                     /gene="GRSF1"
ORIGIN      
        1 acttccgttc caccatcgct gctggagcag ctgccttcag gccctgcgcc gcctccggag
       61 tccatggccg gcacgcgctg ggtactcggg gcgctgctcc ggggctgcgg ctgtaactgc
      121 agcagctgcc ggcgcaccgg cgccgcctgc ctgcccttct actccgccgc tggctctatc
      181 ccgtcgggcg tctcgggccg ccgccgcctg ctgctgctgc tcggggccgc cgcggccgct
      241 gcctcccaga cgcgtggcct ccagaccggg cctgtgcctc ccgggaggct ggcggggcct
      301 cccgctgtgg ccacctctgc cgcggccgcg gccgccgcgt cctactctgc cctccgtgcc
      361 tctctgctgc cgcagtcgct ggcggcggcg gccgccgtcc cgacgcgcag ctacagccag
      421 gagtccaaaa ctacttacct ggaagacctt ccaccacccc ctgagtatga attggccccg
      481 tccaagttag aagaggaagt ggatgatgtc tttctcattc gagctcaagg actgccctgg
      541 tcatgcacta tggaagatgt gcttaacttt ttttcagact gcagaatccg caacggtgag
      601 aatggaatac attttctcct aaacagagat gggaaacgaa ggggtgatgc cttaattgaa
      661 atggagtcag agcaggatgt gcagaaagcc ttagagaagc accgcatgta catgggccag
      721 cggtatgtgg aagtatatga gataaacaat gaagatgtgg atgccttaat gaagagcttg
      781 caggtcaaat cttcgcctgt ggtaaatgat ggtgtggttc gtttgagagg acttccttat
      841 agttgcaatg agaaagacat tgtagacttc tttgcaggac tgaatatagt tgacattact
      901 tttgtgatgg actatagagg gaggcgaaaa acaggggaag cctatgtgca atttgaagaa
      961 ccagaaatgg ccaaccaagc cctgttgaaa cacagggaag aaattggtaa tcgatacatc
     1021 gagatatttc caagcagaag gaatgaagtt cgaacacatg tcggttctta taagggaaag
     1081 aaaatcgcat cttttcctac tgctaagtat ataactgagc cagaaatggt ctttgaagaa
     1141 catgaagtaa atgaggatat tcaacccatg acagcttttg aaagtgagaa ggaaatagaa
     1201 ttgcctaagg aggtgccaga aaagcttcca gaggctgctg attttggaac tacgtcttct
     1261 ctgcattttg tccacatgag aggattacct ttccaagcca atgcccaaga cattataaac
     1321 ttttttgctc cactcaagcc tgttagaatc accatggaat acagctccag tgggaaggcc
     1381 actggagaag ctgatgtgca ctttgagacc catgaggatg ctgttgcagc gatgctcaag
     1441 gatcggtccc acgttcatca taggtatatt gaactgttcc tgaattcatg tccaaaagga
     1501 aaataagact ctaggggctc cagataataa gggtgaagca agaagcattt catttgcaca
     1561 tctttcttgg acttgggata tacagttcca gtttattagc agcaactgct agggaaatga
     1621 ttttggtgtt ttgggttaat tgcttctaag aaaagtttca tagtggactg tttagaagaa
     1681 gaaatgaaag atccagtttg ggattatgaa ataaaccaca aattaaaatt tttgtttaaa
     1741 ctgtccagga tctgatttaa aaatatggtc tttgttttat atgattaaat ggtttgtttt
     1801 catagatgat atgttactca ttgtaaagac cacatatttt tattcagcag tgttctttaa
     1861 acggtttcat ttaaaaagta actttttttt tttgcctgtg aattgagtgc tctgatgtaa
     1921 aacttctcat ggagtgaaac agtgatttat tttaaccaaa cattcaccaa agcaaagaac
     1981 ggtttcagac ctttgaactg gtatggtttg gcagaatagt tttaaatttt gctgtatttg
     2041 attacttaga gataggaatt tttaaaaatc aaaacaaaaa ataccacagc ttagtgtaaa
     2101 tgacaatttg gcggttttat gtctttagaa atgttttgcc tttctaagcc ttgtgctaaa
     2161 ggcgtataac ggtggtgcct atctacttaa gggggcattc tagtcttaac ttaaaagttg
     2221 tctaaactgt ccctccctgg ctttttttgg tttggggtag acctaagggt gtttgttagt
     2281 ctcaaaactg tgaagtgaca tgtcagaaca gtccagactg gtaagaaaat taatggcttc
     2341 acttgaattt aaaccagctc tagataggaa aaaaatcagt ctcctcattt gctttttaaa
     2401 tggagtagta catcccatat tttagaacaa gtaggggtgc cttgcttaaa taaaaatagc
     2461 atttaatgta taattgtgtg aagggtttat ggataaagct gtacttctgt cacaatgtgg
     2521 cagtactttc tgctttaata ttaaacagct tgttatttaa atattggaca aaatggctgg
     2581 cttcaaaata tagtcattaa taaactaact ttatgtgcac ctgtgtagga gaatcaaaat
     2641 cctgtatgct ttctttgcct tgttcctgtt ctcagggtga cgactgccac caggagatgc
     2701 agttctagtt cttaaaatta aatttgccca ggtttctgac aggtgatacc tggaagagag
     2761 actatgtctt ctcttactta atacataacc atctttgatt accagctaag atgcgaaatc
     2821 actgtactgt agtcaataaa tgaagacttg tttcaggctg aagattacct aagagtattt
     2881 attattggag tctgtgagtc aactgaatat attattacct caagtcctgc tatattaata
     2941 taagtagtaa gggttaattt tcgtgtgtgt gttctctaaa atcctgtgaa catgacttaa
     3001 ccagcttaac atcatcagta gtactgccta gatggaaatg cgttttcata tatggttgaa
     3061 tatgccaagc tatgagaact ggtatctgta gttgtacgaa ctattagaat gtgatctttg
     3121 ttgctctttc acatttggta tctgatttgc tgtggaaaag atctgtgggg cctactgtga
     3181 ggaattcatc tgcaattgat ttaagctaat gagttttatt tgcacatctc tggaaaaaga
     3241 atgcaagcaa agcattaaaa tgctatatga tggatgggta aggttgaaag gatatatctt
     3301 cttggcacgc tacaggctga gttttctgta caaaatgtgg ccattattgg gaaatcattt
     3361 tatgtatttg aatgctccct tttgtttttg ttcatgatct aggctagtac gtaagtgatt
     3421 gctaaggtgg atgtagttat gggaaaggaa gagaagcaca taatacagta aaagtaatct
     3481 tatttccatg caagtggaag acggtaccgt ctccccacat ttgagaagac tgttttgcat
     3541 cactctttgc tattgaagga agcagtgatg gtgaatttcc ttctgtttgg gttccttgtg
     3601 tctataactt cctttgtggt aaagccatca ggaagaatag tgggagtggg gcatatggtc
     3661 agggtgctca tatcctgctt tagcctagct gctgcttacg gagtgcaagg gagaactctg
     3721 agaagcagta tgtaaatacc agggagctga ttgctgaata ttgtggtctc atctgaatat
     3781 tgtggtctca tctaaatatt gacaccaggc aatgaagcag aaatagagta tgtgtccctt
     3841 tatgcgtggg taacttaagc ttctgtcatg tgggaagggg gaccgaatct tccctgggag
     3901 gaaggctcca aattctcact acttctgtgt tacttgaagg gggaagcata aggaacccag
     3961 tttgaaggca acattgtgtg ccatgaatct gcttattaat caacatgcct tgttaatgtc
     4021 ctctgccctg aacagccctt actcagttct catttggaaa gttatttttt ggggttacat
     4081 cctgtttgtt tcagaattta aaaccctcca tggtgggtca cttgaggtca ggagttcaag
     4141 attagcctgg ccaacttagt gaaactccgg ctctactgaa aatgcaaaaa ttagccaggt
     4201 gtggcacacg cctgtaatcc cagttacttg ggaggccaag gcaggagaat cgcttgaacc
     4261 tgggaggcag aggttgtagc gagccaagat cacaccattg cactccagcc tgggcaacag
     4321 agtgagactc tgtcaaaatc aaaaaaacca aaatacaaaa aactccattg ttctgagagt
     4381 ttcccctaaa ttatcggaag acactcacat tgaattggta ggacctatag tatagaggag
     4441 aatggtatgt atgtcagcag tagagttcca atccaaattg cgctatcgca ttagaaatac
     4501 attaccctcc cactccccaa gttcagcaaa ttagaagaga atctgaagtt tgtaggaagg
     4561 gaataaagct gctataaaca tttatgtgca ggtttttgtg tagactcgtt ttcagctcct
     4621 ttgggtaaat accaaggaac caggttgctg gattgtaagt taagagtatg tttagttttg
     4681 gaagaaactg ccaaactgtt ccaacatgac tattttgaat tcccattgac aatgaataag
     4741 agttcctgta gctcctcacc ctcattagta tttggtgatg tcactcttgc attttagcta
     4801 atgggtgaat agtggtctca tcgttttaat tcccaatccc atagtgatgt ggagcacctt
     4861 ttcatatact taatctgcca tccttatatc atcattggtg aggtgtctgg attttctgtc
     4921 cagaatttta gttctagtgg ttttcttatt tttagaaagg aagtatagga aggaaggttt
     4981 aatctgtctt aagcctgatt atatgaaaat caagaatagg ctaggtgtgg tggctgacat
     5041 ctgtaatccc cgcactttgt gaggctgaag tgggaggact gcttgagcct gggaagtcaa
     5101 gcctgcagtg agccatgact gttgctgcac tccagcctga gtgacagagt gagaccctgt
     5161 ctcagaaaaa aaaaaagcag gctcatttta aagttgttta tattttattt tttgaaggaa
     5221 ataaacttga agagatacaa acggtagtga agattctcct tcccctcctg taattcagct
     5281 gtttagtttc tattctcgca cagccctgtt atcagtttct agtgtaagct tgcagtgact
     5341 tttactttat ttataagcaa gtgttagtgg gtgttgtcat ttcttttaaa aatataaatt
     5401 atactgtaca tgctattttg tattttggct tttctcccac ctaaacaccc taaagatcat
     5461 tttctgtcag tatataaaat cttggtgatg ccaataccca tcccttagat tgtacaagca
     5521 gcattttgcc atgctttatc ccatagcctg cctcctgcag tctcatcttt ttttctatat
     5581 gcatgtccaa gtaagttgta gacatttttc acttttaatc ctttcagcat acatgtcatg
     5641 ggaatttgtt tttgtttttg ttttttgtgt ttgagacagt cgctctgtca cccaggctgg
     5701 agttatagtg acgtgatccc agctcattac agcctccacc tcccagtttc aagcaattct
     5761 catgcctcag attcccgagt agctgggatt acagatgtgc accaccacgc ctgactaatt
     5821 tttgtatttt tagtagagat ggggtttcat catgttggcc aggctggtct ggaactcctg
     5881 gcctccagtc atttgcctgc ctcggcctcc caaagtgctg ggattacagg catcagccac
     5941 cacacccagc cgtcattgga gtttttttga gggagatttg cagtaaggtg aataaatgtt
     6001 aagtgtatca tttgatgagg ttttttcttt tttttttttt ttttttgaga tggagtcttg
     6061 tatcgcccag gctagagtgc agtggcctgg tcttggctca ctgcaacctc cacctcctgg
     6121 gttcaaggga gtctcctgcc tcagcctccc gagtagctgg gattacaggt gtgagccacc
     6181 atacccagac tcatttgatg agttttgatg taaaagcatg taactcaaac ccctatgtct
     6241 ggaacatctg tattacatct gaattttttc acctagtcaa ttcctgcacc tctctctcct
     6301 gtcccttctt ccctcccctg gcagtcagct actgttagga ttttgttcac tgtagattaa
     6361 ttttgcctat tctagaactt catataacgg actcacttat gcagtatgta ttctgtaagt
     6421 tccttttact cagcatgttt gtatgttcat cagtgtgttt aagctttgtt cctttttatg
     6481 gctgagcagt gttctatgta tgaatgccac attttaacgt ttcacctgtt aggtgaacaa
     6541 ctaactggtg aacaatgggc tgtttctagt ttggggctat catgaataaa gttggtatga
     6601 acatgtacaa
//
