LOCUS       NM_005314               2417 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens gastrin releasing peptide receptor (GRPR), mRNA.
ACCESSION   NM_005314
VERSION     NM_005314.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2417)
  AUTHORS   Li,H., Chen,X., Xu,J., Zhu,L., Li,C., Sun,X., Li,X., Guo,J., Li,J.,
            Wang,S., He,Y., Wang,H., Huang,C., Meng,X.M. and Li,J.
  TITLE     GRP/GRPR enhances alcohol-associated liver injury through the
            IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway
  JOURNAL   Hepatology 79 (2), 392-408 (2024)
   PUBMED   37409771
  REMARK    GeneRIF: GRP/GRPR enhances alcohol-associated liver injury through
            the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS
            pathway.
REFERENCE   2  (bases 1 to 2417)
  AUTHORS   Liu,X., Wang,Y., Zeng,Y., Wang,D., Wen,Y., Fan,L., He,Y., Zhang,J.,
            Sun,W., Liu,Y. and Tao,A.
  TITLE     Microglia-neuron interactions promote chronic itch via the
            NLRP3-IL-1beta-GRPR axis
  JOURNAL   Allergy 78 (6), 1570-1584 (2023)
   PUBMED   36876522
  REMARK    GeneRIF: Microglia-neuron interactions promote chronic itch via the
            NLRP3-IL-1beta-GRPR axis.
REFERENCE   3  (bases 1 to 2417)
  AUTHORS   Pagoto,A., Garello,F., Marini,G.M., Tripepi,M., Arena,F.,
            Bardini,P., Stefania,R., Lanzardo,S., Valbusa,G., Porpiglia,F.,
            Manfredi,M., Aime,S. and Terreno,E.
  TITLE     Novel Gastrin-Releasing Peptide Receptor Targeted Near-Infrared
            Fluorescence Dye for Image-Guided Surgery of Prostate Cancer
  JOURNAL   Mol Imaging Biol 22 (1), 85-93 (2020)
   PUBMED   31025163
  REMARK    GeneRIF: Novel Gastrin-Releasing Peptide Receptor Targeted
            Near-Infrared Fluorescence Dye for Image-Guided Surgery of Prostate
            Cancer.
REFERENCE   4  (bases 1 to 2417)
  AUTHORS   Morgat,C., MacGrogan,G., Brouste,V., Velasco,V., Sevenet,N.,
            Bonnefoi,H., Fernandez,P., Debled,M. and Hindie,E.
  TITLE     Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer
            and Its Association with Pathologic, Biologic, and Clinical
            Parameters: A Study of 1,432 Primary Tumors
  JOURNAL   J Nucl Med 58 (9), 1401-1407 (2017)
   PUBMED   28280221
  REMARK    GeneRIF: Expression of Gastrin-Releasing Peptide Receptor in Breast
            Cancer and Its Association with Pathologic, Biologic, and Clinical
            Parameters
REFERENCE   5  (bases 1 to 2417)
  AUTHORS   Jaeger,N., Czepielewski,R.S., Bagatini,M., Porto,B.N. and
            Bonorino,C.
  TITLE     Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen
            species-dependent migration in lung adenocarcinoma cells
  JOURNAL   Tumour Biol 39 (3), 1010428317694321 (2017)
   PUBMED   28351312
  REMARK    GeneRIF: Our results suggest that, similar to what happens in
            neutrophils, gastrin-releasing peptide is a migratory, rather than
            a proliferative, stimulus, for non-small cell lung carcinoma cells,
            indicating a putative role for gastrin-releasing peptide and
            gastrin-releasing peptide receptor in metastasis
REFERENCE   6  (bases 1 to 2417)
  AUTHORS   Alitalo,T., Francis,F., Kere,J., Lehrach,H., Schlessinger,D. and
            Willard,H.F.
  TITLE     A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2,
            PIGA, GRPR, CALB3, and PHKA2 genes
  JOURNAL   Genomics 25 (3), 691-700 (1995)
   PUBMED   7759104
REFERENCE   7  (bases 1 to 2417)
  AUTHORS   Benya,R.V., Kusui,T., Pradhan,T.K., Battey,J.F. and Jensen,R.T.
  TITLE     Expression and characterization of cloned human bombesin receptors
  JOURNAL   Mol Pharmacol 47 (1), 10-20 (1995)
   PUBMED   7838118
REFERENCE   8  (bases 1 to 2417)
  AUTHORS   Maslen,G.L. and Boyd,Y.
  TITLE     Comparative mapping of the Grpr locus on the X chromosomes of man
            and mouse
  JOURNAL   Genomics 17 (1), 106-109 (1993)
   PUBMED   8406441
REFERENCE   9  (bases 1 to 2417)
  AUTHORS   Giladi,E., Nagalla,S.R. and Spindel,E.R.
  TITLE     Molecular cloning and characterization of receptors for the
            mammalian bombesin-like peptides
  JOURNAL   J Mol Neurosci 4 (1), 41-54 (1993)
   PUBMED   8391296
REFERENCE   10 (bases 1 to 2417)
  AUTHORS   Corjay,M.H., Dobrzanski,D.J., Way,J.M., Viallet,J., Shapira,H.,
            Worland,P., Sausville,E.A. and Battey,J.F.
  TITLE     Two distinct bombesin receptor subtypes are expressed and
            functional in human lung carcinoma cells
  JOURNAL   J Biol Chem 266 (28), 18771-18779 (1991)
   PUBMED   1655761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M73481.1, AU125660.1 and
            AC078993.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005314.2.
            
            Summary: Gastrin-releasing peptide (GRP) regulates numerous
            functions of the gastrointestinal and central nervous systems,
            including release of gastrointestinal hormones, smooth muscle cell
            contraction, and epithelial cell proliferation and is a potent
            mitogen for neoplastic tissues. The effects of GRP are mediated
            through the gastrin-releasing peptide receptor. This receptor is a
            glycosylated, 7-transmembrane G-protein coupled receptor that
            activates the phospholipase C signaling pathway. The receptor is
            aberrantly expressed in numerous cancers such as those of the lung,
            colon, and prostate. An individual with autism and multiple
            exostoses was found to have a balanced translocation between
            chromosome 8 and a chromosome X breakpoint located within the
            gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.307263.1, M73481.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380289.3/ ENSP00000369643.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-841               M73481.1           10-850
            842-1119            AU125660.1         275-552
            1120-1717           M73481.1           1129-1726
            1718-2417           AC078993.20        52214-52913
FEATURES             Location/Qualifiers
     source          1..2417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2417
                     /gene="GRPR"
                     /gene_synonym="BB2; BB2R; BRS2"
                     /note="gastrin releasing peptide receptor"
                     /db_xref="GeneID:2925"
                     /db_xref="HGNC:HGNC:4609"
                     /db_xref="MIM:305670"
     exon            1..802
                     /gene="GRPR"
                     /gene_synonym="BB2; BB2R; BRS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1544
                     /gene="GRPR"
                     /gene_synonym="BB2; BB2R; BRS2"
                     /note="GRP-preferring bombesin receptor; GRP-R; bombesin
                     receptor 2"
                     /codon_start=1
                     /product="gastrin-releasing peptide receptor"
                     /protein_id="NP_005305.1"
                     /db_xref="CCDS:CCDS14174.1"
                     /db_xref="GeneID:2925"
                     /db_xref="HGNC:HGNC:4609"
                     /db_xref="MIM:305670"
                     /translation="MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIP
                     AVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYL
                     ADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLK
                     AAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVF
                     YVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFC
                     WLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFN
                     TQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV"
     exon            803..1154
                     /gene="GRPR"
                     /gene_synonym="BB2; BB2R; BRS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..2417
                     /gene="GRPR"
                     /gene_synonym="BB2; BB2R; BRS2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatatcagg aaagacgctg tgggaaaata gcaggccaaa agttcttagt aaactgcagc
       61 cagggagact cagactagaa tggaggtaga aagaactgat gcagagtggg tttaattcta
      121 agcctttttg tggctaagtt ttgttgttgt taacttattg aatttagagt tgtattgcac
      181 tggtcatgtg aaagccagag cagcaccagt gtcaaaatag tgacagagag ttttgaatac
      241 catagttagt atatatgtac tcagagtatt tttattaaag aaggcaaaga gcccggcata
      301 gatcttatct tcatcttcac tcggttgcaa aatcaatagt taagaaatag catctaaggg
      361 aacttttagg tgggaaaaaa aatctagaga tggctctaaa tgactgtttc cttctgaact
      421 tggaggtgga ccatttcatg cactgcaaca tctccagtca cagtgcggat ctccccgtga
      481 acgatgactg gtcccacccg gggatcctct atgtcatccc tgcagtttat ggggttatca
      541 ttctgatagg cctcattggc aacatcactt tgatcaagat cttctgtaca gtcaagtcca
      601 tgcgaaacgt tccaaacctg ttcatttcca gtctggcttt gggagacctg ctcctcctaa
      661 taacgtgtgc tccagtggat gccagcaggt acctggctga cagatggcta tttggcagga
      721 ttggctgcaa actgatcccc tttatacagc ttacctctgt tggggtgtct gtcttcacac
      781 tcacggcgct ctcggcagac agatacaaag ccattgtccg gccaatggat atccaggcct
      841 ctcatgccct gatgaagatc tgcctcaaag ccgcctttat ctggatcatc tccatgctgc
      901 tggccattcc agaggccgtg ttttctgacc tccatccctt ccatgaggaa agcaccaacc
      961 agaccttcat tagctgtgcc ccatacccac actctaatga gcttcacccc aaaatccatt
     1021 ctatggcttc ctttctggtc ttctacgtca ttccactgtc gatcatctct gtttactact
     1081 acttcattgc taaaaatctg atccagagtg cttacaatct tcccgtggaa gggaatatac
     1141 atgtcaagaa gcagattgaa tcccggaagc gacttgccaa gacagtgctg gtgtttgtgg
     1201 gcctgttcgc cttctgctgg ctccccaatc atgtcatcta cctgtaccgc tcctaccact
     1261 actctgaggt ggacacctcc atgctccact ttgtcaccag catctgtgcc cgcctcctgg
     1321 ccttcaccaa ctcctgcgtg aacccctttg ccctctacct gctgagcaag agtttcagga
     1381 aacagttcaa cactcagctg ctctgttgcc agcctggcct gatcatccgg tctcacagca
     1441 ctggaaggag tacaacctgc atgacctccc tcaagagtac caacccctcc gtggccacct
     1501 ttagcctcat caatggaaac atctgtcacg agcggtatgt ctagattgac ccttgatttt
     1561 gccccctgag ggacggtttt gctttatggc tagacaggaa cccttgcatc cattgttgtg
     1621 tctgtgccct ccaaagagcc ttcagaatgc tcctgagtgg tgtaggtggg ggtggggagg
     1681 cccaaatgat ggatcaccat tatattttga aagaagccat caagtcttaa gtttttcatt
     1741 tcaacttgtg aacgtttctt ctgatgtgaa gcaaaccttc ccttttcaga aaagggaaca
     1801 agtagaaaat tattttttaa gcctcaagcc ctgttaaatg gtcgtggcca attatgtcat
     1861 agaaactgta tgaacaacca gatttacata gcagagaaat catacattga atgcttactt
     1921 tgtgaaagac ttcaccttgt catttcttta agcagacgct agtactttag aaatataact
     1981 tgactctgtt ttcaggaata tctgtaatac acaaaccaag gaacaacttt tatttacact
     2041 cctaatatga aaagtcaatc ctgtgagaga gctccatgta tgagggacac tctccaagtt
     2101 gataacaatg gaagcgagtt taatataaaa caattcccta agcatttatt ttttttttaa
     2161 aaagatgtta ctgaggacct agaagaaatg ctcaatacat actttgaaag caaaaataca
     2221 atcaaacaca ttgacacgta tataaagatc cacgcgtggc tgtgcgtgat atctcacact
     2281 ctgaattctt acttgatgga ggttttgttt gctgctacgg ttttaatcat ccagggtgcc
     2341 attccaccat agaagagcaa tccttttagg aaaaaaaaaa tcatgctatt aattaatcaa
     2401 atatctataa atgcata
//
