LOCUS       NM_025196               2653 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens GrpE like 1, mitochondrial (GRPEL1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_025196
VERSION     NM_025196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Manjunath,P., Stojkovic,G., Euro,L., Konovalova,S., Wanrooij,S.,
            Koski,K. and Tyynismaa,H.
  TITLE     Preferential binding of ADP-bound mitochondrial HSP70 to the
            nucleotide exchange factor GRPEL1 over GRPEL2
  JOURNAL   Protein Sci 33 (11), e5190 (2024)
   PUBMED   39445986
  REMARK    GeneRIF: Preferential binding of ADP-bound mitochondrial HSP70 to
            the nucleotide exchange factor GRPEL1 over GRPEL2.
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Chen,P., Wang,B., Mo,Q., Wu,P., Fang,Y., Tian,Y., Jin,X., Gao,Y.,
            Wu,Y., Cao,Y., Zhang,Y., Xi,L., Wang,S., Hu,J., Ma,D., Zhou,J.,
            Gao,Q. and Chen,G.
  TITLE     The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic
            agent-damaged mitosis
  JOURNAL   EBioMedicine 49, 26-39 (2019)
   PUBMED   31636012
  REMARK    GeneRIF: These data demonstrate that LIV-1-GRPEL1 axis dually
            regulates mitotic exit as well as apoptosis by interacting with
            PP2A B55alpha and AIF.
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Borges,J.C., Fischer,H., Craievich,A.F., Hansen,L.D. and Ramos,C.H.
  TITLE     Free human mitochondrial GrpE is a symmetric dimer in solution
  JOURNAL   J Biol Chem 278 (37), 35337-35344 (2003)
   PUBMED   12840016
  REMARK    GeneRIF: The low resolution structure of human GrpE presented
            suggests that GrpE is a symmetric dimer when not bound to DnaK
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   Choglay,A.A., Chapple,J.P., Blatch,G.L. and Cheetham,M.E.
  TITLE     Identification and characterization of a human mitochondrial
            homologue of the bacterial co-chaperone GrpE
  JOURNAL   Gene 267 (1), 125-134 (2001)
   PUBMED   11311562
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024242.2, AF070525.1 and AC097382.3.
            
            On Nov 23, 2018 this sequence version replaced NM_025196.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.54823.1,
                                           SRR1660803.222171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000264954.5/
                                                  ENSP00000264954.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1494              BC024242.2         10-1503
            1495-1896           AF070525.1         768-1169
            1897-1897           AC097382.3         73231-73231         c
            1898-2055           AF070525.1         1171-1328
            2056-2056           AC097382.3         73072-73072         c
            2057-2339           AF070525.1         1330-1612
            2340-2340           AC097382.3         72788-72788         c
            2341-2653           AF070525.1         1614-1926
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..2653
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="GrpE like 1, mitochondrial"
                     /db_xref="GeneID:80273"
                     /db_xref="HGNC:HGNC:19696"
                     /db_xref="MIM:606173"
     exon            1..94
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..686
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="GrpE-like protein cochaperone; grpE protein homolog
                     1, mitochondrial"
                     /codon_start=1
                     /product="grpE protein homolog 1, mitochondrial precursor"
                     /protein_id="NP_079472.1"
                     /db_xref="CCDS:CCDS3396.1"
                     /db_xref="GeneID:80273"
                     /db_xref="HGNC:HGNC:19696"
                     /db_xref="MIM:606173"
                     /translation="MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDM
                     GQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLY
                     GIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGL
                     LKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA"
     exon            95..257
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..339
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..2653
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      736
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="major polyA site"
     regulatory      1003..1008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="hexamer: AATAAA"
     polyA_site      1021
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="major polyA site"
     polyA_site      1176
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="hexamer: ATTAAA"
     polyA_site      1494
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /note="hexamer: AGTAAA"
     polyA_site      2653
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
ORIGIN      
        1 gtgcgcggcg actgcgacgg gcagtggcag tcatggcggc tcagtgcgtg aggttggcgc
       61 ggcgcagtct tcctgctttg gcgttgtctc tcaggccatc tccccggttg ttgtgcacag
      121 ccacgaaaca aaagaacagt ggccagaacc tggaagagga catgggtcag agtgaacaga
      181 aggcagatcc tcctgctaca gagaagaccc tcctggaaga gaaggtcaag ttggaggaac
      241 agctgaagga gactgtggaa aaatataaac gagctttggc agacactgag aacttacggc
      301 agaggagcca gaaattggtg gaggaggcaa aattatacgg cattcaagcc ttctgcaagg
      361 acttgttgga ggtggcagac gttctggaga aggcaacaca gtgtgttcca aaagaagaaa
      421 ttaaagacga taaccctcac ctgaagaacc tctatgaggg gctggtcatg actgaagtcc
      481 agatccagaa ggtgttcaca aagcatggct tgctcaagtt gaaccctgtc ggagccaagt
      541 tcgaccctta tgaacatgag gccttgttcc acacaccggt tgaggggaag gagccaggca
      601 cagtggccct agttagcaaa gtggggtaca agctgcatgg gcgcactctg agacccgccc
      661 tggtgggggt ggtgaaggaa gcttagctgc tgttgatggg gtgggtgttt ttaaactcac
      721 ttgatgtaac tctcaaggct ggttcattgt ttctcatcta tgagtacgtg tgaccttttc
      781 ccaaacctta ttggaaacct taagtaacca gtggctaaac agaaaagccg gttgcccaac
      841 tgcattaatg aactctaatt cgggagtctg ttccctttta gtgccacgcg ttgaatagtt
      901 ccacatactt tcagaagagc tcagcagggc cctgcctggt ctcccgagca tcatgagtaa
      961 cgtgtctgct cagactctgc tgacaccaaa gtattttaaa caaataaaag gtcttgggga
     1021 attctgtttg gctacctggg cacgccagtc tgcaccatgt gtccctgcgg cgcatgagtg
     1081 actggcgtat ttagcccgtc acatttcatt cgctgaagga aaggcaagag agttgaaaca
     1141 tttttcttac ttaaaaaaaa tgatctttgt gaagaacata gtgagttcgt ttgtcttcag
     1201 tcaacagcgg ctgaaactga ccactgagaa atgggtgtgg gcactgacag ttctccccca
     1261 ttatttggcc aggaattgag cttggcttgg caaagttcct tttaccctgt tctgttcatc
     1321 taaatgcaga catatttaaa tcatattcaa ctagttacta atgacctcaa gttgtattcc
     1381 ctggcaaaat ggactttctc aaaataggac tgcacgcttg gtgtacttta aatgttaatg
     1441 tttaatttaa aatttttatt taagaggatt aaagccctaa tgtttatttt cctactttct
     1501 gaaaacaatt ttgtgtcctc tcatggagat ccttgccgct gaggcaagca tggcttagcc
     1561 ttcccattct ctactccagc ccagaagctg tcagcttgac acgtgcgtgc gtgcacattc
     1621 acgtacacac atatacaggc ttctacacag aaagggagag ccacactccc ccagtgcagc
     1681 tgcagcccgt ccggtaagaa tacgaaacac ccaggagcca cagcaagggc acaggatttg
     1741 caaaatcatc ttgccaaagg gctgttcctc atttacacgg tcatccaggg cttagaaaaa
     1801 ggctgaatga ttggcgtctg ttacaaaaaa gagaaaagaa cctttcgctg cctttgcttc
     1861 tagaatggaa gatacttgtg aaagccattt gctgcacagg aaagatgggg cagtttattt
     1921 cacttctaat tttaaaagac gcaagtaatg gtcccataat acttcatctt gggataccat
     1981 tcccaaacat gttccacctt taagatgcct taagttaatt tggtcagaaa caactaaagg
     2041 cagcatcgtg tattgaagaa aacatgactg ggagctccag cgctgcctgt tttcacgctg
     2101 tggggttgtg agtgcatcat cacccctgga gctcccgagt taaatggagg ctaagaaaag
     2161 taatttatca actcatttct gtgaatgttt gcagtctcct accgtctcaa ctacagctgc
     2221 agttgctaaa aagcacttaa ctcgtaacct agaggcaata tagcttaagt agcaaaatat
     2281 ttttttacag taagcttcag tcatccatag tcactataag ttggttatca tctgaaatgc
     2341 ttagaaccag aattgtttca aacttggggg gttttcggat tttggaatat agtcaagcat
     2401 ggcttaacca cagggatgtg ttctgagaaa tgcgctgtca ggcagttttt cctgtgaaca
     2461 ccatgtgtac ctacatggac ctaaaaaaca ggtggtggag cctcctccac acctaggcta
     2521 tatggtgtat gtagcctgtt gctctagact ggagggcacg ttactgtact gatactgtag
     2581 gcaactgtta acacaatggt atctgtgtat ctgaacataa catagtaaag gtacagtgca
     2641 aactgtgttc taa
//
