LOCUS       NP_079472                217 aa            linear   PRI 12-NOV-2024
DEFINITION  grpE protein homolog 1, mitochondrial precursor [Homo sapiens].
ACCESSION   NP_079472
VERSION     NP_079472.1
DBSOURCE    REFSEQ: accession NM_025196.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 217)
  AUTHORS   Manjunath,P., Stojkovic,G., Euro,L., Konovalova,S., Wanrooij,S.,
            Koski,K. and Tyynismaa,H.
  TITLE     Preferential binding of ADP-bound mitochondrial HSP70 to the
            nucleotide exchange factor GRPEL1 over GRPEL2
  JOURNAL   Protein Sci 33 (11), e5190 (2024)
   PUBMED   39445986
  REMARK    GeneRIF: Preferential binding of ADP-bound mitochondrial HSP70 to
            the nucleotide exchange factor GRPEL1 over GRPEL2.
REFERENCE   2  (residues 1 to 217)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 217)
  AUTHORS   Chen,P., Wang,B., Mo,Q., Wu,P., Fang,Y., Tian,Y., Jin,X., Gao,Y.,
            Wu,Y., Cao,Y., Zhang,Y., Xi,L., Wang,S., Hu,J., Ma,D., Zhou,J.,
            Gao,Q. and Chen,G.
  TITLE     The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic
            agent-damaged mitosis
  JOURNAL   EBioMedicine 49, 26-39 (2019)
   PUBMED   31636012
  REMARK    GeneRIF: These data demonstrate that LIV-1-GRPEL1 axis dually
            regulates mitotic exit as well as apoptosis by interacting with
            PP2A B55alpha and AIF.
REFERENCE   6  (residues 1 to 217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (residues 1 to 217)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 217)
  AUTHORS   Borges,J.C., Fischer,H., Craievich,A.F., Hansen,L.D. and Ramos,C.H.
  TITLE     Free human mitochondrial GrpE is a symmetric dimer in solution
  JOURNAL   J Biol Chem 278 (37), 35337-35344 (2003)
   PUBMED   12840016
  REMARK    GeneRIF: The low resolution structure of human GrpE presented
            suggests that GrpE is a symmetric dimer when not bound to DnaK
REFERENCE   9  (residues 1 to 217)
  AUTHORS   Choglay,A.A., Chapple,J.P., Blatch,G.L. and Cheetham,M.E.
  TITLE     Identification and characterization of a human mitochondrial
            homologue of the bacterial co-chaperone GrpE
  JOURNAL   Gene 267 (1), 125-134 (2001)
   PUBMED   11311562
REFERENCE   10 (residues 1 to 217)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024242.2, AF070525.1 and AC097382.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.54823.1,
                                           SRR1660803.222171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000264954.5/
                                                  ENSP00000264954.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     Protein         1..217
                     /product="grpE protein homolog 1, mitochondrial precursor"
                     /note="GrpE-like protein cochaperone; grpE protein homolog
                     1, mitochondrial"
                     /calculated_mol_wt=21337
     transit_peptide 1..27
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9HAV7.2)"
                     /calculated_mol_wt=2961
     mat_peptide     28..217
                     /product="GrpE protein homolog 1, mitochondrial.
                     /id=PRO_0000013049"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HAV7.2)"
                     /calculated_mol_wt=21337
     Region          29..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HAV7.2)"
     Region          72..213
                     /region_name="GrpE"
                     /note="nucleotide exchange factor GrpE; cd00446"
                     /db_xref="CDD:271355"
     Region          72..122
                     /region_name="2-helical coiled coil"
                     /note="2-helical coiled coil [structural motif]"
                     /db_xref="CDD:271355"
     Site            order(74,77..78,81..82,84..85,88..90,92,95..96,99..100,
                     103..104,106..107,110..112,114..118,120..121,143..144,
                     146..148,151,157..158)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271355"
     Site            order(90,98,120,123,170,172..173,175..179,195,204,208,210,
                     213)
                     /site_type="other"
                     /note="Hsp70 (ATPase domain) interactions [polypeptide
                     binding]"
                     /db_xref="CDD:271355"
     Site            94
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q99LP6; propagated from
                     UniProtKB/Swiss-Prot (Q9HAV7.2)"
     Site            100
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99LP6; propagated from
                     UniProtKB/Swiss-Prot (Q9HAV7.2)"
     Region          143..158
                     /region_name="2-helical coiled coil"
                     /note="2-helical coiled coil [structural motif]"
                     /db_xref="CDD:271355"
     Site            215
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9HAV7.2)"
     CDS             1..217
                     /gene="GRPEL1"
                     /gene_synonym="GrpE; HMGE; mt-GrpE#1"
                     /coded_by="NM_025196.4:33..686"
                     /db_xref="CCDS:CCDS3396.1"
                     /db_xref="GeneID:80273"
                     /db_xref="HGNC:HGNC:19696"
                     /db_xref="MIM:606173"
ORIGIN      
        1 maaqcvrlar rslpalalsl rpsprllcta tkqknsgqnl eedmgqseqk adppatektl
       61 leekvkleeq lketvekykr aladtenlrq rsqklveeak lygiqafckd llevadvlek
      121 atqcvpkeei kddnphlknl yeglvmtevq iqkvftkhgl lklnpvgakf dpyehealfh
      181 tpvegkepgt valvskvgyk lhgrtlrpal vgvvkea
//
