LOCUS       NM_001371086            3723 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 8 (GRM8), transcript
            variant 7, mRNA.
ACCESSION   NM_001371086
VERSION     NM_001371086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Zhang,Q., Chen,X., Li,S., Yao,T. and Wu,J.
  TITLE     Association between the group III metabotropic glutamate receptor
            gene polymorphisms and attention-deficit/hyperactivity disorder and
            functional exploration of risk loci
  JOURNAL   J Psychiatr Res 132, 65-71 (2021)
   PUBMED   33068816
  REMARK    GeneRIF: Association between the group III metabotropic glutamate
            receptor gene polymorphisms and attention-deficit/hyperactivity
            disorder and functional exploration of risk loci.
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Bauer,L.O. and Covault,J.M.
  TITLE     GRM8 genotype is associated with externalizing disorders and
            greater inter-trial variability in brain activation during a
            response inhibition task
  JOURNAL   Clin Neurophysiol 131 (6), 1180-1186 (2020)
   PUBMED   32299001
  REMARK    GeneRIF: GRM8 genotype is associated with externalizing disorders
            and greater inter-trial variability in brain activation during a
            response inhibition task.
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Zhang,P., Kang,B., Xie,G., Li,S., Gu,Y., Shen,Y., Zhao,X., Ma,Y.,
            Li,F., Si,J., Wang,J., Chen,J., Yang,H., Xu,X. and Yang,Y.
  TITLE     Genomic sequencing and editing revealed the GRM8 signaling pathway
            as potential therapeutic targets of squamous cell lung cancer
  JOURNAL   Cancer Lett 442, 53-67 (2019)
   PUBMED   30391781
  REMARK    GeneRIF: Transcriptional activation of GRM8 lung squamous cell
            carcinoma tumor cells induced cell proliferation by inhibiting cAMP
            pathway and activating MAPK pathway.
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Tavakkoly-Bazzaz,J., Azarnezhad,A., Mousavi,N., Salehipour,P.,
            Shahsavand Ananloo,E. and Alizadeh,F.
  TITLE     TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an
            Iranian population: a case-control study
  JOURNAL   Mol Biol Rep 45 (6), 2403-2409 (2018)
   PUBMED   30288643
  REMARK    GeneRIF: rs712723 in GRM8 was selected for genotyping. The allele C
            and genotype CC (allele C: OR 1.48, 95% CI 1.13-1.94; genotype CC:
            OR 1.71, 95% CI 1.09-2.68) of rs712723 polymorphism was found to
            have a significant association with risk of schizophrenia while
            allele T (P = 0.003) and genotype TT (P = 0.028) frequencies were
            found lower in control patients.
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Malone,S.M., McGue,M. and Iacono,W.G.
  TITLE     What can time-frequency and phase coherence measures tell us about
            the genetic basis of P3 amplitude?
  JOURNAL   Int J Psychophysiol 115, 40-56 (2017)
   PUBMED   27871913
  REMARK    GeneRIF: This study showed that GRM8 was nominally associated (p <
            0.05) with both delta measures (energy and intertrial phase
            coherence).
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
            and Jane,D.E.
  TITLE     (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
            activates metabotropic glutamate receptors on primary afferent
            terminals in the neonatal rat spinal cord
  JOURNAL   Neuropharmacology 40 (3), 311-318 (2001)
   PUBMED   11166323
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
            and Mutel,V.
  TITLE     Cloning and functional expression of alternative spliced variants
            of the human metabotropic glutamate receptor 8
  JOURNAL   Brain Res Mol Brain Res 67 (2), 201-210 (1999)
   PUBMED   10216218
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
  TITLE     The human metabotropic glutamate receptor 8 (GRM8) gene: a
            disproportionately large gene located at 7q31.3-q32.1
  JOURNAL   Genomics 44 (2), 232-236 (1997)
   PUBMED   9299241
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002424.1, AC000099.1,
            AC000363.2, AC000367.1, AC002533.1, AC002083.2, AC002057.1,
            AC000369.1 and AC000370.1.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) encodes the longest isoform
            (c).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC002424.1         1510-1636           c
            128-948             AC000099.1         11320-12140
            949-1165            AC000363.2         23746-23962         c
            1166-1301           AC000367.1         36616-36751         c
            1302-1456           AC000367.1         36040-36194         c
            1457-1594           AC000367.1         34610-34747         c
            1595-1795           AC002533.1         39602-39802         c
            1796-1932           AC002083.2         24333-24469         c
            1933-2868           AC002057.1         20839-21774         c
            2869-3115           AC000369.1         3429-3675           c
            3116-3152           AC000369.1         2539-2575           c
            3153-3723           AC000370.1         36905-37475         c
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.33"
     gene            1..3723
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="glutamate metabotropic receptor 8"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:HGNC:4600"
                     /db_xref="MIM:601116"
     exon            1..127
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            128..948
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3225
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="isoform c precursor is encoded by transcript
                     variant 7; glutamate receptor, metabotropic 8"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 8 isoform c
                     precursor"
                     /protein_id="NP_001358015.1"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:HGNC:4600"
                     /db_xref="MIM:601116"
                     /translation="MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDG
                     DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI
                     LDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI
                     MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYV
                     STLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR
                     AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPK
                     RASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIAR
                     DSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN
                     FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHRE
                     HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNR
                     TGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYV
                     LLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKK
                     SVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVL
                     KCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFI
                     PIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF
                     KAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSSTDESKKKEKQSFLYQDNIYQ
                     LQQSFNLKQGNGTI"
     exon            949..1165
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1301
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1456
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1594
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1795
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1932
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2868
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3115
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3152
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3723
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3644..3649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="hexamer: AATAAA"
     polyA_site      3670
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="hexamer: AATAAA"
     polyA_site      3723
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcggcg ctctgactgg gcgtgcggcg gcaggatttt aaagcgctct gcctcggatc
       61 gtctgccctg ggtgacctcc cggacctgcc ctggtggaat ccggacttgc cccgccgaga
      121 tgacgaggaa taattctgct acaaggctga tttcaaggac atgaattgtt gacctcatcc
      181 caacatcaga acctcagatg ttctaatttt tgcaccattc caggcaagtt gatcttataa
      241 ggaaataaaa ttgaacctta ggggtctgat ggaaattcac tgtgacattc aaatcaagaa
      301 aacttgctaa tgcccacaga gccttttccc catgggccct gatggtagcc tccagaaggt
      361 gcagcctcag gtggtgccct ttcttctgtg gcaagaataa actttgggtc ttggattgca
      421 ataccacctg tggagaaaat ggtatgcgag ggaaagcgat cagcctcttg cccttgtttc
      481 ttcctcttga ccgccaagtt ctactggatc ctcacaatga tgcaaagaac tcacagccag
      541 gagtatgccc attccatacg ggtggatggg gacattattt tggggggtct cttccctgtc
      601 cacgcaaagg gagagagagg ggtgccttgt ggggagctga agaaggaaaa ggggattcac
      661 agactggagg ccatgcttta tgcaattgac cagattaaca aggaccctga tctcctttcc
      721 aacatcactc tgggtgtccg catcctcgac acgtgctcta gggacaccta tgctttggag
      781 cagtctctaa cattcgtgca ggcattaata gagaaagatg cttcggatgt gaagtgtgct
      841 aatggagatc cacccatttt caccaagccc gacaagattt ctggcgtcat aggtgctgca
      901 gcaagctccg tgtccatcat ggttgctaac attttaagac tttttaagat acctcaaatc
      961 agctatgcat ccacagcccc agagctaagt gataacacca ggtatgactt tttctctcga
     1021 gtggttccgc ctgactccta ccaagcccaa gccatggtgg acatcgtgac agcactggga
     1081 tggaattatg tttcgacact ggcttctgag gggaactatg gtgagagcgg tgtggaggcc
     1141 ttcacccaga tctcgaggga gattggtggt gtttgcattg ctcagtcaca gaaaatccca
     1201 cgtgaaccaa gacctggaga atttgaaaaa attatcaaac gcctgctaga aacacctaat
     1261 gctcgagcag tgattatgtt tgccaatgag gatgacatca ggaggatatt ggaagcagca
     1321 aaaaaactaa accaaagtgg gcattttctc tggattggct cagatagttg gggatccaaa
     1381 atagcacctg tctatcagca agaggagatt gcagaagggg ctgtgacaat tttgcccaaa
     1441 cgagcatcaa ttgatggatt tgatcgatac tttagaagcc gaactcttgc caataatcga
     1501 agaaatgtgt ggtttgcaga attctgggag gagaattttg gctgcaagtt aggatcacat
     1561 gggaaaagga acagtcatat aaagaaatgc acagggctgg agcgaattgc tcgggattca
     1621 tcttatgaac aggaaggaaa ggtccaattt gtaattgatg ctgtatattc catggcttac
     1681 gccctgcaca atatgcacaa agatctctgc cctggataca ttggcctttg tccacgaatg
     1741 agtaccattg atgggaaaga gctacttggt tatattcggg ctgtaaattt taatggcagt
     1801 gctggcactc ctgtcacttt taatgaaaac ggagatgctc ctggacgtta tgatatcttc
     1861 cagtatcaaa taaccaacaa aagcacagag tacaaagtca tcggccactg gaccaatcag
     1921 cttcatctaa aagtggaaga catgcagtgg gctcatagag aacatactca cccggcgtct
     1981 gtctgcagcc tgccgtgtaa gccaggggag aggaagaaaa cggtgaaagg ggtcccttgc
     2041 tgctggcact gtgaacgctg tgaaggttac aactaccagg tggatgagct gtcctgtgaa
     2101 ctttgccctc tggatcagag acccaacatg aaccgcacag gctgccagct tatccccatc
     2161 atcaaattgg agtggcattc tccctgggct gtggtgcctg tgtttgttgc aatattggga
     2221 atcatcgcca ccacctttgt gatcgtgacc tttgtccgct ataatgacac acctatcgtg
     2281 agggcttcag gacgcgaact tagttacgtg ctcctaacgg ggatttttct ctgttattca
     2341 atcacgtttt taatgattgc agcaccagat acaatcatat gctccttccg acgggtcttc
     2401 ctaggacttg gcatgtgttt cagctatgca gcccttctga ccaaaacaaa ccgtatccac
     2461 cgaatatttg agcaggggaa gaaatctgtc acagcgccca agttcattag tccagcatct
     2521 cagctggtga tcaccttcag cctcatctcc gtccagctcc ttggagtgtt tgtctggttt
     2581 gttgtggatc ccccccacat catcattgac tatggagagc agcggacact agatccagag
     2641 aaggccaggg gagtgctcaa gtgtgacatt tctgatctct cactcatttg ttcacttgga
     2701 tacagtatcc tcttgatggt cacttgtact gtttatgcca ttaaaacgag aggtgtccca
     2761 gagactttca atgaagccaa acctattgga tttaccatgt ataccacctg catcatttgg
     2821 ttagctttca tccccatctt ttttggtaca gcccagtcag cagaaaagat gtacatccag
     2881 acaacaacac ttactgtctc catgagttta agtgcttcag tatctctggg catgctctat
     2941 atgcccaagg tttatattat aatttttcat ccagaacaga atgttcaaaa acgcaagagg
     3001 agcttcaagg ctgtggtgac agctgccacc atgcaaagca aactgatcca aaaaggaaat
     3061 gacagaccaa atggcgaggt gaaaagtgaa ctctgtgaga gtcttgaaac caacagttct
     3121 acagatgaat caaaaaagaa agaaaagcaa agcttcctct accaagacaa catatatcag
     3181 ttacagcaat cattcaatct gaaacaggga aatggcacaa tctgaagaga tgtggtatat
     3241 gatcttaaat gatgaacatg agaccgcaaa aattcactcc tggagatctc cgtagactac
     3301 aatcaatcaa atcaatagtc agtcttgtaa ggaacaaaaa ttagccatga gccaaaagta
     3361 tcaataaacg gggagtgaag aaacccgttt tatacaataa aaccaatgag tgtcaagcta
     3421 aagtattgct tattcatgag cagttaaaac aaatcacaaa aggaaaacta atgttagctc
     3481 gtgaaaaaaa atgctgttga aataaataat gtctgatgtt attcttgtat ttttctgtga
     3541 ttgtgagaac tcccgttcct gtcccacatt gtttaacttg tataagacaa tgagtctgtt
     3601 tcttgtaatg gctgaccaga ttgaagccct gggttgtgct aaaaataaat gcaatgattg
     3661 atgcatgcaa ttttttatac aaataattta tttctaataa taaaggaatg ttttgcaaat
     3721 gtt
//
