LOCUS       NM_000845               3704 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens glutamate metabotropic receptor 8 (GRM8), transcript
            variant 1, mRNA.
ACCESSION   NM_000845 XM_011516091
VERSION     NM_000845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Zhang,Q., Chen,X., Li,S., Yao,T. and Wu,J.
  TITLE     Association between the group III metabotropic glutamate receptor
            gene polymorphisms and attention-deficit/hyperactivity disorder and
            functional exploration of risk loci
  JOURNAL   J Psychiatr Res 132, 65-71 (2021)
   PUBMED   33068816
  REMARK    GeneRIF: Association between the group III metabotropic glutamate
            receptor gene polymorphisms and attention-deficit/hyperactivity
            disorder and functional exploration of risk loci.
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Bauer,L.O. and Covault,J.M.
  TITLE     GRM8 genotype is associated with externalizing disorders and
            greater inter-trial variability in brain activation during a
            response inhibition task
  JOURNAL   Clin Neurophysiol 131 (6), 1180-1186 (2020)
   PUBMED   32299001
  REMARK    GeneRIF: GRM8 genotype is associated with externalizing disorders
            and greater inter-trial variability in brain activation during a
            response inhibition task.
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Zhang,P., Kang,B., Xie,G., Li,S., Gu,Y., Shen,Y., Zhao,X., Ma,Y.,
            Li,F., Si,J., Wang,J., Chen,J., Yang,H., Xu,X. and Yang,Y.
  TITLE     Genomic sequencing and editing revealed the GRM8 signaling pathway
            as potential therapeutic targets of squamous cell lung cancer
  JOURNAL   Cancer Lett 442, 53-67 (2019)
   PUBMED   30391781
  REMARK    GeneRIF: Transcriptional activation of GRM8 lung squamous cell
            carcinoma tumor cells induced cell proliferation by inhibiting cAMP
            pathway and activating MAPK pathway.
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Tavakkoly-Bazzaz,J., Azarnezhad,A., Mousavi,N., Salehipour,P.,
            Shahsavand Ananloo,E. and Alizadeh,F.
  TITLE     TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an
            Iranian population: a case-control study
  JOURNAL   Mol Biol Rep 45 (6), 2403-2409 (2018)
   PUBMED   30288643
  REMARK    GeneRIF: rs712723 in GRM8 was selected for genotyping. The allele C
            and genotype CC (allele C: OR 1.48, 95% CI 1.13-1.94; genotype CC:
            OR 1.71, 95% CI 1.09-2.68) of rs712723 polymorphism was found to
            have a significant association with risk of schizophrenia while
            allele T (P = 0.003) and genotype TT (P = 0.028) frequencies were
            found lower in control patients.
REFERENCE   5  (bases 1 to 3704)
  AUTHORS   Malone,S.M., McGue,M. and Iacono,W.G.
  TITLE     What can time-frequency and phase coherence measures tell us about
            the genetic basis of P3 amplitude?
  JOURNAL   Int J Psychophysiol 115, 40-56 (2017)
   PUBMED   27871913
  REMARK    GeneRIF: This study showed that GRM8 was nominally associated (p <
            0.05) with both delta measures (energy and intertrial phase
            coherence).
REFERENCE   6  (bases 1 to 3704)
  AUTHORS   Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
            and Jane,D.E.
  TITLE     (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
            activates metabotropic glutamate receptors on primary afferent
            terminals in the neonatal rat spinal cord
  JOURNAL   Neuropharmacology 40 (3), 311-318 (2001)
   PUBMED   11166323
REFERENCE   7  (bases 1 to 3704)
  AUTHORS   Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
            and Mutel,V.
  TITLE     Cloning and functional expression of alternative spliced variants
            of the human metabotropic glutamate receptor 8
  JOURNAL   Brain Res Mol Brain Res 67 (2), 201-210 (1999)
   PUBMED   10216218
REFERENCE   8  (bases 1 to 3704)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   9  (bases 1 to 3704)
  AUTHORS   Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
  TITLE     The human metabotropic glutamate receptor 8 (GRM8) gene: a
            disproportionately large gene located at 7q31.3-q32.1
  JOURNAL   Genomics 44 (2), 232-236 (1997)
   PUBMED   9299241
REFERENCE   10 (bases 1 to 3704)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002424.1, AC000099.1,
            AC000363.2, AC000367.1, AC002533.1, AC002083.2, AC002057.1,
            AC000369.1 and AC000370.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 27, 2019 this sequence version replaced
            XM_011516091.2, NM_000845.2.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), as well as variants 4 and 5,
            encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.303239.1,
                                           SRR1660809.212287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339582.7/ ENSP00000344173.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC002424.1         2178-2322           c
            146-966             AC000099.1         11320-12140
            967-1183            AC000363.2         23746-23962         c
            1184-1319           AC000367.1         36616-36751         c
            1320-1474           AC000367.1         36040-36194         c
            1475-1612           AC000367.1         34610-34747         c
            1613-1813           AC002533.1         39602-39802         c
            1814-1950           AC002083.2         24333-24469         c
            1951-2886           AC002057.1         20839-21774         c
            2887-3133           AC000369.1         3429-3675           c
            3134-3704           AC000370.1         36905-37475         c
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.33"
     gene            1..3704
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="glutamate metabotropic receptor 8"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:HGNC:4600"
                     /db_xref="MIM:601116"
     exon            1..145
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            146..966
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..3183
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; glutamate receptor, metabotropic 8"
                     /codon_start=1
                     /product="metabotropic glutamate receptor 8 isoform a
                     precursor"
                     /protein_id="NP_000836.2"
                     /db_xref="CCDS:CCDS5794.1"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:HGNC:4600"
                     /db_xref="MIM:601116"
                     /translation="MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDG
                     DIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRI
                     LDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSI
                     MVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYV
                     STLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR
                     AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPK
                     RASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIAR
                     DSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN
                     FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHRE
                     HTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNR
                     TGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYV
                     LLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKK
                     SVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVL
                     KCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFI
                     PIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF
                     KAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI"
     exon            967..1183
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1319
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1474
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1612
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1813
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1950
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2886
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3133
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3704
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="hexamer: AATAAA"
     polyA_site      3651
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="hexamer: AATAAA"
     polyA_site      3704
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="major polyA site"
ORIGIN      
        1 agctcagccc cctcagccca gagatcagcc acaagtgcgg ccgctgtgct cgcctcacgc
       61 ggcggcggcg gcggcggcgg cggcgctgac atggagctgc gggcccccgg cgggcttcct
      121 caccgcgccc tctgcgggga gcagggaata attctgctac aaggctgatt tcaaggacat
      181 gaattgttga cctcatccca acatcagaac ctcagatgtt ctaatttttg caccattcca
      241 ggcaagttga tcttataagg aaataaaatt gaaccttagg ggtctgatgg aaattcactg
      301 tgacattcaa atcaagaaaa cttgctaatg cccacagagc cttttcccca tgggccctga
      361 tggtagcctc cagaaggtgc agcctcaggt ggtgcccttt cttctgtggc aagaataaac
      421 tttgggtctt ggattgcaat accacctgtg gagaaaatgg tatgcgaggg aaagcgatca
      481 gcctcttgcc cttgtttctt cctcttgacc gccaagttct actggatcct cacaatgatg
      541 caaagaactc acagccagga gtatgcccat tccatacggg tggatgggga cattattttg
      601 gggggtctct tccctgtcca cgcaaaggga gagagagggg tgccttgtgg ggagctgaag
      661 aaggaaaagg ggattcacag actggaggcc atgctttatg caattgacca gattaacaag
      721 gaccctgatc tcctttccaa catcactctg ggtgtccgca tcctcgacac gtgctctagg
      781 gacacctatg ctttggagca gtctctaaca ttcgtgcagg cattaataga gaaagatgct
      841 tcggatgtga agtgtgctaa tggagatcca cccattttca ccaagcccga caagatttct
      901 ggcgtcatag gtgctgcagc aagctccgtg tccatcatgg ttgctaacat tttaagactt
      961 tttaagatac ctcaaatcag ctatgcatcc acagccccag agctaagtga taacaccagg
     1021 tatgactttt tctctcgagt ggttccgcct gactcctacc aagcccaagc catggtggac
     1081 atcgtgacag cactgggatg gaattatgtt tcgacactgg cttctgaggg gaactatggt
     1141 gagagcggtg tggaggcctt cacccagatc tcgagggaga ttggtggtgt ttgcattgct
     1201 cagtcacaga aaatcccacg tgaaccaaga cctggagaat ttgaaaaaat tatcaaacgc
     1261 ctgctagaaa cacctaatgc tcgagcagtg attatgtttg ccaatgagga tgacatcagg
     1321 aggatattgg aagcagcaaa aaaactaaac caaagtgggc attttctctg gattggctca
     1381 gatagttggg gatccaaaat agcacctgtc tatcagcaag aggagattgc agaaggggct
     1441 gtgacaattt tgcccaaacg agcatcaatt gatggatttg atcgatactt tagaagccga
     1501 actcttgcca ataatcgaag aaatgtgtgg tttgcagaat tctgggagga gaattttggc
     1561 tgcaagttag gatcacatgg gaaaaggaac agtcatataa agaaatgcac agggctggag
     1621 cgaattgctc gggattcatc ttatgaacag gaaggaaagg tccaatttgt aattgatgct
     1681 gtatattcca tggcttacgc cctgcacaat atgcacaaag atctctgccc tggatacatt
     1741 ggcctttgtc cacgaatgag taccattgat gggaaagagc tacttggtta tattcgggct
     1801 gtaaatttta atggcagtgc tggcactcct gtcactttta atgaaaacgg agatgctcct
     1861 ggacgttatg atatcttcca gtatcaaata accaacaaaa gcacagagta caaagtcatc
     1921 ggccactgga ccaatcagct tcatctaaaa gtggaagaca tgcagtgggc tcatagagaa
     1981 catactcacc cggcgtctgt ctgcagcctg ccgtgtaagc caggggagag gaagaaaacg
     2041 gtgaaagggg tcccttgctg ctggcactgt gaacgctgtg aaggttacaa ctaccaggtg
     2101 gatgagctgt cctgtgaact ttgccctctg gatcagagac ccaacatgaa ccgcacaggc
     2161 tgccagctta tccccatcat caaattggag tggcattctc cctgggctgt ggtgcctgtg
     2221 tttgttgcaa tattgggaat catcgccacc acctttgtga tcgtgacctt tgtccgctat
     2281 aatgacacac ctatcgtgag ggcttcagga cgcgaactta gttacgtgct cctaacgggg
     2341 atttttctct gttattcaat cacgttttta atgattgcag caccagatac aatcatatgc
     2401 tccttccgac gggtcttcct aggacttggc atgtgtttca gctatgcagc ccttctgacc
     2461 aaaacaaacc gtatccaccg aatatttgag caggggaaga aatctgtcac agcgcccaag
     2521 ttcattagtc cagcatctca gctggtgatc accttcagcc tcatctccgt ccagctcctt
     2581 ggagtgtttg tctggtttgt tgtggatccc ccccacatca tcattgacta tggagagcag
     2641 cggacactag atccagagaa ggccagggga gtgctcaagt gtgacatttc tgatctctca
     2701 ctcatttgtt cacttggata cagtatcctc ttgatggtca cttgtactgt ttatgccatt
     2761 aaaacgagag gtgtcccaga gactttcaat gaagccaaac ctattggatt taccatgtat
     2821 accacctgca tcatttggtt agctttcatc cccatctttt ttggtacagc ccagtcagca
     2881 gaaaagatgt acatccagac aacaacactt actgtctcca tgagtttaag tgcttcagta
     2941 tctctgggca tgctctatat gcccaaggtt tatattataa tttttcatcc agaacagaat
     3001 gttcaaaaac gcaagaggag cttcaaggct gtggtgacag ctgccaccat gcaaagcaaa
     3061 ctgatccaaa aaggaaatga cagaccaaat ggcgaggtga aaagtgaact ctgtgagagt
     3121 cttgaaacca acacttcctc taccaagaca acatatatca gttacagcaa tcattcaatc
     3181 tgaaacaggg aaatggcaca atctgaagag atgtggtata tgatcttaaa tgatgaacat
     3241 gagaccgcaa aaattcactc ctggagatct ccgtagacta caatcaatca aatcaatagt
     3301 cagtcttgta aggaacaaaa attagccatg agccaaaagt atcaataaac ggggagtgaa
     3361 gaaacccgtt ttatacaata aaaccaatga gtgtcaagct aaagtattgc ttattcatga
     3421 gcagttaaaa caaatcacaa aaggaaaact aatgttagct cgtgaaaaaa aatgctgttg
     3481 aaataaataa tgtctgatgt tattcttgta tttttctgtg attgtgagaa ctcccgttcc
     3541 tgtcccacat tgtttaactt gtataagaca atgagtctgt ttcttgtaat ggctgaccag
     3601 attgaagccc tgggttgtgc taaaaataaa tgcaatgatt gatgcatgca attttttata
     3661 caaataattt atttctaata ataaaggaat gttttgcaaa tgtt
//
